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The map label for this gene is eif2g

Identifier: 20094883

GI number: 20094883

Start: 1478058

End: 1479296

Strand: Direct

Name: eif2g

Synonym: MK1447

Alternate gene names: 20094883

Gene position: 1478058-1479296 (Clockwise)

Preceding gene: 20094882

Following gene: 20094884

Centisome position: 87.2

GC content: 61.99

Gene sequence:

>1239_bases
GTGGACGACGAGCGGTTCCAACAGGCCGAAATGAACATCGGAATGGTGGGGCACGTAGACCACGGTAAGACCACGCTGAC
GAAGGCCCTCTCCGGCGTGTGGACGGACACGCACAGCGAGGAGACCAGACGCGGCATCTCCATCCGACTGGGTTACGCGG
ACACCGTCCTCACGCGATGTCCCGAGTGCGACACCTATTCGGTGGAGGAGAAGTGTCCGGAGTGCGGAGCCGAAACCGAG
TGGCTCCGGCGGGTCTCCTTCGTCGACTCCCCGGGCCACGAGACGTTGATGGCGACGATGCTCTCCGGTGCCGCGATCAT
GGACGCAGCCATCCTGGTGATCGCCGCGAACGAGCCCTGCCCGCAGCCTCAGACCCGAGAGCACCTGATGGCACTGGAAA
TCATCGGAACCGAAGACGTGATCGTCGTTCAGAACAAGATCGACTTAGTCACCCCGGAGGAAGCCAGGGAGCATTACGAG
CAGATCGTACAGTTCCTGGAGGAGGAGACGCACCTCGACCCCGATAAGACCCCCATAATCCCCGTCTCCGCCCAGCATAA
GGCGAACTTAGACGTCTTAGTCGAGGCCATGTACGAGCACTTCGAGCCCCCCGAGTACGATCTGGACGCACCGTTCCGCA
TGTACATCGCCCGATCGTTCGACGTCAACAAGCCCGGTACCAGACCGAGCGACCTCAAGGGCGGCGTGATAGGAGGAGCC
ATCGTCCAGGGAGAGGTCGAGATCGGTGACGAAATCGAGATACGGCCGGGAATCCGGGTGGAGCGATACGGTCGTACCGA
GTGGGAACCGGTGTACACGGAGGTGGTGAGCCTCCACGCGAACGTGACGCCGGTGGAGCGTGCGAGACCCGGCGGTCTGG
TCGGTATAGGCACGAAGCTAGACCCCACCATGACCAAAGCGGACCGGTTGTCGGGCCAAGTGGCCGGAGAACCCGACACA
TTGCCGCCCGTCCGTCACGAGCTGCTGTTGGAGGTGGAACTGCTCGAGCGGGTGGTAGGAACCGAAGAGGAGCGTAAGGT
GGAACCCATCCGGACGAACGAGGTACTGATGCTCACCGTGGGTACGGCGACTACAGTGGGCGTGGTGACCAGTGCACGGG
ACGACGAGATTGAGATCAAGCTGAAACAACCGGTGTGCGCCGAAGAAGGCGACAGGGTCGCGATAAGCCGTAGGATCCAG
CGGTGGCGTCTGATAGGCCACGGTGTCATCAAAGGGTGA

Upstream 100 bases:

>100_bases
CGTCATCGTCGAGTACGGCGACAAGCCCGTGGAGGAGTTACTCGGCGAGGGCGGCGAGGAGTAACCGCGGGTGGGTACCG
TGCCCGTCGACTTACGACGA

Downstream 100 bases:

>100_bases
AGGGGCGTGACCATCAGAGTCGTGTTGGACGCTAACTTCCTCATGATACCGCATCAGGAAGGGGTGGACGTGTTCTCCGA
ACTCGACCGCCTCTTGGGCT

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDDERFQQAEMNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRCPECDTYSVEEKCPECGAETE
WLRRVSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPCPQPQTREHLMALEIIGTEDVIVVQNKIDLVTPEEAREHYE
QIVQFLEEETHLDPDKTPIIPVSAQHKANLDVLVEAMYEHFEPPEYDLDAPFRMYIARSFDVNKPGTRPSDLKGGVIGGA
IVQGEVEIGDEIEIRPGIRVERYGRTEWEPVYTEVVSLHANVTPVERARPGGLVGIGTKLDPTMTKADRLSGQVAGEPDT
LPPVRHELLLEVELLERVVGTEEERKVEPIRTNEVLMLTVGTATTVGVVTSARDDEIEIKLKQPVCAEEGDRVAISRRIQ
RWRLIGHGVIKG

Sequences:

>Translated_412_residues
MDDERFQQAEMNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRCPECDTYSVEEKCPECGAETE
WLRRVSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPCPQPQTREHLMALEIIGTEDVIVVQNKIDLVTPEEAREHYE
QIVQFLEEETHLDPDKTPIIPVSAQHKANLDVLVEAMYEHFEPPEYDLDAPFRMYIARSFDVNKPGTRPSDLKGGVIGGA
IVQGEVEIGDEIEIRPGIRVERYGRTEWEPVYTEVVSLHANVTPVERARPGGLVGIGTKLDPTMTKADRLSGQVAGEPDT
LPPVRHELLLEVELLERVVGTEEERKVEPIRTNEVLMLTVGTATTVGVVTSARDDEIEIKLKQPVCAEEGDRVAISRRIQ
RWRLIGHGVIKG
>Mature_412_residues
MDDERFQQAEMNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRCPECDTYSVEEKCPECGAETE
WLRRVSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPCPQPQTREHLMALEIIGTEDVIVVQNKIDLVTPEEAREHYE
QIVQFLEEETHLDPDKTPIIPVSAQHKANLDVLVEAMYEHFEPPEYDLDAPFRMYIARSFDVNKPGTRPSDLKGGVIGGA
IVQGEVEIGDEIEIRPGIRVERYGRTEWEPVYTEVVSLHANVTPVERARPGGLVGIGTKLDPTMTKADRLSGQVAGEPDT
LPPVRHELLLEVELLERVVGTEEERKVEPIRTNEVLMLTVGTATTVGVVTSARDDEIEIKLKQPVCAEEGDRVAISRRIQ
RWRLIGHGVIKG

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasmic, and membrane-associated [C]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

Homologues:

Organism=Homo sapiens, GI4503507, Length=432, Percent_Identity=43.9814814814815, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI34147630, Length=432, Percent_Identity=27.0833333333333, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI54607086, Length=387, Percent_Identity=27.906976744186, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4503471, Length=370, Percent_Identity=25.1351351351351, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4503475, Length=380, Percent_Identity=23.9473684210526, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI223555963, Length=275, Percent_Identity=24.7272727272727, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI5729864, Length=275, Percent_Identity=24.7272727272727, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789737, Length=438, Percent_Identity=28.5388127853881, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790412, Length=438, Percent_Identity=28.5388127853881, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI2367247, Length=403, Percent_Identity=27.2952853598015, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17509919, Length=428, Percent_Identity=43.4579439252336, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17556456, Length=298, Percent_Identity=28.5234899328859, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25141371, Length=267, Percent_Identity=30.3370786516854, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17506081, Length=274, Percent_Identity=26.6423357664234, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115532067, Length=273, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115532065, Length=273, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320863, Length=425, Percent_Identity=44.2352941176471, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324761, Length=254, Percent_Identity=33.4645669291339, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325337, Length=361, Percent_Identity=24.9307479224377, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319594, Length=361, Percent_Identity=24.9307479224377, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24647046, Length=427, Percent_Identity=44.9648711943794, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24647048, Length=427, Percent_Identity=44.9648711943794, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19922690, Length=376, Percent_Identity=28.4574468085106, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI19921738, Length=245, Percent_Identity=32.6530612244898, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281363316, Length=255, Percent_Identity=32.156862745098, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17864358, Length=255, Percent_Identity=32.156862745098, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553807, Length=380, Percent_Identity=23.6842105263158, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45553816, Length=380, Percent_Identity=23.6842105263158, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651721, Length=380, Percent_Identity=23.6842105263158, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17864154, Length=380, Percent_Identity=23.6842105263158, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652838, Length=369, Percent_Identity=24.390243902439, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17137572, Length=369, Percent_Identity=24.390243902439, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: 20568 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): IF2G_METKA (Q8TVE5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614730.1
- ProteinModelPortal:   Q8TVE5
- SMR:   Q8TVE5
- GeneID:   1478042
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1447
- NMPDR:   fig|190192.1.peg.1443
- HOGENOM:   HBG307581
- OMA:   IAANEPC
- ProtClustDB:   PRK04000
- BioCyc:   MKAN190192:MK1447-MONOMER
- HAMAP:   MF_00119
- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR03680

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF50465 Elong_init_C; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 45777; Mature: 45777

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDERFQQAEMNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRC
CCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEECCHHHHHHHC
PECDTYSVEEKCPECGAETEWLRRVSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPC
CCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCEEEEEEECCCCC
PQPQTREHLMALEIIGTEDVIVVQNKIDLVTPEEAREHYEQIVQFLEEETHLDPDKTPII
CCCCHHHHEEEEEEECCCCEEEEECCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEE
PVSAQHKANLDVLVEAMYEHFEPPEYDLDAPFRMYIARSFDVNKPGTRPSDLKGGVIGGA
ECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEECE
IVQGEVEIGDEIEIRPGIRVERYGRTEWEPVYTEVVSLHANVTPVERARPGGLVGIGTKL
EEEEEEECCCEEEECCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHCCCCCEEEECCCC
DPTMTKADRLSGQVAGEPDTLPPVRHELLLEVELLERVVGTEEERKVEPIRTNEVLMLTV
CCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEE
GTATTVGVVTSARDDEIEIKLKQPVCAEEGDRVAISRRIQRWRLIGHGVIKG
CCCEEEEEEECCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDDERFQQAEMNIGMVGHVDHGKTTLTKALSGVWTDTHSEETRRGISIRLGYADTVLTRC
CCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEECCHHHHHHHC
PECDTYSVEEKCPECGAETEWLRRVSFVDSPGHETLMATMLSGAAIMDAAILVIAANEPC
CCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCHHHHCEEEEEEECCCCC
PQPQTREHLMALEIIGTEDVIVVQNKIDLVTPEEAREHYEQIVQFLEEETHLDPDKTPII
CCCCHHHHEEEEEEECCCCEEEEECCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEE
PVSAQHKANLDVLVEAMYEHFEPPEYDLDAPFRMYIARSFDVNKPGTRPSDLKGGVIGGA
ECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEECE
IVQGEVEIGDEIEIRPGIRVERYGRTEWEPVYTEVVSLHANVTPVERARPGGLVGIGTKL
EEEEEEECCCEEEECCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHCCCCCEEEECCCC
DPTMTKADRLSGQVAGEPDTLPPVRHELLLEVELLERVVGTEEERKVEPIRTNEVLMLTV
CCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEE
GTATTVGVVTSARDDEIEIKLKQPVCAEEGDRVAISRRIQRWRLIGHGVIKG
CCCEEEEEEECCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11930014