Click here to switch to the map view.

The map label for this gene is ArgS

Identifier: 20094195

GI number: 20094195

Start: 720849

End: 722627

Strand: Reverse

Name: ArgS

Synonym: MK0758

Alternate gene names: 20094195

Gene position: 722627-720849 (Counterclockwise)

Preceding gene: 20094196

Following gene: 20094194

Centisome position: 42.63

GC content: 58.74

Gene sequence:

>1779_bases
TTGGCCGAGGAAACCACACCTCGCGACCCGTTTTCGGTTACGATTCGCACCATAAGAACATCGATCCGGGACGCGATCTC
GTCCGTGTACGAAGTAGACGAGCTGATAGAGGTTCCTATCGACGAGAACCCACCCGTCGAAGGTGCCGATCTGGCCACGC
CGGTGGCACTCTCCCTAGCTAAAGAGCTGGACGAGAACCCCAGAGAGCTGGCTGAAACGATCGTCGAGGAGTCTGACCTC
GACGACGTGGTGTTCGTGGAAAAGGCTTGGGTGGAAGGCCCGGGCTTCATCAACTTGAAGCTCGACAGGTCCCAGTACGC
GGCGCTGACGCTCAGGTCGATATTCTACTACGGCGAAGAGTACGGCTCGCTCGACCTCGGTATGGGTCGCCCCGTAATCT
TGGAGCACACTAGCGCGAACCCCAACGGTCCTTTACACATCGGCCACGGTAGAAACGCTGTCATCGGGGACATTCTCGCG
AGGTGCATGGTCTTCACGAACTACGGGGTGGAAGTGCAGTATTACGTGAACGATATGGGTAAGCAGATCGCGATGCTCGC
GTGGAAGTACATAAAGGAGGGGCGGCCCGAAGTACCCGAGGGCGAAAAACCGGACGAGTTCTTCGGTAAGCTGTACACTG
AAGCCGCGCGTGAGATCGAGGAAGATCCCGAGCTGGAGGAAGTAGTCGAGAGGTTCCTGAGATCGTACGAACGTTACCTA
GTGGAGGAAGAATCTCGAGCGGAGCGCATCGCCGACGCGTTCCAGACCGTAGTGGAGGAGTGTCTGAGAGGGCACATCCA
AACGCTGGAGCGCCTCCGGGTGGCGCATGACCGATTCGTGTACGAGAGCGAGTTCGCGCGCGATGCACTGGAGATCGTGG
AGAAGCTGCTGGACATGGGAGTCGCGGAGGAGCGCGAGGATGGAGCCGTGGTAGTCGACCTGGAAGACTACGGAATCGAC
AAGGAGCTCGTACTCACGCGCAGCGACGGCACTACGCTGTACACCACCCGTGACATCGCCTATCACCTCTGGAAGCTCGG
ACGAGCCACGTTCGTGGTAGACGTGCTAGGAGCGGATCACAAGTTAGCGGTCGAACAGCTACGGGCCGTACTGGACATGC
TCGAGGAGAACCCCGACCGTATCGACGTGGTGTTCTACGAGTTCATCCATCTGCCGGAAGGATCGATGTCTACTAGGAAG
GGTAGATACGTGACGCTCGACGAGTTCCTGGAGGAAGCCAAGAAGCGCGCACTCGAGAAGATGAAGGCAGCGGGCGTAGC
GGAGGAACTGAGCGACGAGGAGCGAGAGAAGATCGCGGAGGAGATCGCCATAGGGGCCGTACGCTTCGCTATCGCCAGAG
TGAGTCCCAACAAACCGATAGAGTTCGACTGGGACGAAGCCCTCGACTTCCGTCGTGGTGGACCGTTCATCCAGTACGCT
TACGCGAGGGCCAAGTCGATCCTCCGGAAGGCAGACGAGGAGGTGAACCGCTTCGATGCGGCATACTTGAACGACGATCA
CTCGTTCGAGTTGATCCTCAAGATGTCGAAGTTCCCACGCCACGTAGCCCAGTGCGTGCGCAAGCGGCGCCCGGACATCC
TCGCCGAGTACGCGTACGACCTGGCGAAGACGTTCCACACGTTCTACGAGGAGGTTCCCGTGCTGCACGTTGAGGACGAT
GAAGTACGGGAGGCGCGACTGAAGCTCGTAGAGGCATTCACGATCGTGGCGGAGAACCTGATGAATCTCCTCGGAATTCC
GACGCTGGAGCGGATGTAA

Upstream 100 bases:

>100_bases
CATCTCAACCGAGACCGAAGAGGGCGCTCAGTTTTATAACGCGTTTCGGGGACTCGGAGCCCTGCTCAGGTTCCGACCCA
AGTGAAGGGGTTCGCCCACG

Downstream 100 bases:

>100_bases
TGTGTCAACTCCTTCCTCCAACCCAATTGTTATGGAAATCGTAACGATTGAACTCGACCCACACAAGGTTTACCCCGAAC
CGTTCGAATGTTATGATCTT

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MAEETTPRDPFSVTIRTIRTSIRDAISSVYEVDELIEVPIDENPPVEGADLATPVALSLAKELDENPRELAETIVEESDL
DDVVFVEKAWVEGPGFINLKLDRSQYAALTLRSIFYYGEEYGSLDLGMGRPVILEHTSANPNGPLHIGHGRNAVIGDILA
RCMVFTNYGVEVQYYVNDMGKQIAMLAWKYIKEGRPEVPEGEKPDEFFGKLYTEAAREIEEDPELEEVVERFLRSYERYL
VEEESRAERIADAFQTVVEECLRGHIQTLERLRVAHDRFVYESEFARDALEIVEKLLDMGVAEEREDGAVVVDLEDYGID
KELVLTRSDGTTLYTTRDIAYHLWKLGRATFVVDVLGADHKLAVEQLRAVLDMLEENPDRIDVVFYEFIHLPEGSMSTRK
GRYVTLDEFLEEAKKRALEKMKAAGVAEELSDEEREKIAEEIAIGAVRFAIARVSPNKPIEFDWDEALDFRRGGPFIQYA
YARAKSILRKADEEVNRFDAAYLNDDHSFELILKMSKFPRHVAQCVRKRRPDILAEYAYDLAKTFHTFYEEVPVLHVEDD
EVREARLKLVEAFTIVAENLMNLLGIPTLERM

Sequences:

>Translated_592_residues
MAEETTPRDPFSVTIRTIRTSIRDAISSVYEVDELIEVPIDENPPVEGADLATPVALSLAKELDENPRELAETIVEESDL
DDVVFVEKAWVEGPGFINLKLDRSQYAALTLRSIFYYGEEYGSLDLGMGRPVILEHTSANPNGPLHIGHGRNAVIGDILA
RCMVFTNYGVEVQYYVNDMGKQIAMLAWKYIKEGRPEVPEGEKPDEFFGKLYTEAAREIEEDPELEEVVERFLRSYERYL
VEEESRAERIADAFQTVVEECLRGHIQTLERLRVAHDRFVYESEFARDALEIVEKLLDMGVAEEREDGAVVVDLEDYGID
KELVLTRSDGTTLYTTRDIAYHLWKLGRATFVVDVLGADHKLAVEQLRAVLDMLEENPDRIDVVFYEFIHLPEGSMSTRK
GRYVTLDEFLEEAKKRALEKMKAAGVAEELSDEEREKIAEEIAIGAVRFAIARVSPNKPIEFDWDEALDFRRGGPFIQYA
YARAKSILRKADEEVNRFDAAYLNDDHSFELILKMSKFPRHVAQCVRKRRPDILAEYAYDLAKTFHTFYEEVPVLHVEDD
EVREARLKLVEAFTIVAENLMNLLGIPTLERM
>Mature_591_residues
AEETTPRDPFSVTIRTIRTSIRDAISSVYEVDELIEVPIDENPPVEGADLATPVALSLAKELDENPRELAETIVEESDLD
DVVFVEKAWVEGPGFINLKLDRSQYAALTLRSIFYYGEEYGSLDLGMGRPVILEHTSANPNGPLHIGHGRNAVIGDILAR
CMVFTNYGVEVQYYVNDMGKQIAMLAWKYIKEGRPEVPEGEKPDEFFGKLYTEAAREIEEDPELEEVVERFLRSYERYLV
EEESRAERIADAFQTVVEECLRGHIQTLERLRVAHDRFVYESEFARDALEIVEKLLDMGVAEEREDGAVVVDLEDYGIDK
ELVLTRSDGTTLYTTRDIAYHLWKLGRATFVVDVLGADHKLAVEQLRAVLDMLEENPDRIDVVFYEFIHLPEGSMSTRKG
RYVTLDEFLEEAKKRALEKMKAAGVAEELSDEEREKIAEEIAIGAVRFAIARVSPNKPIEFDWDEALDFRRGGPFIQYAY
ARAKSILRKADEEVNRFDAAYLNDDHSFELILKMSKFPRHVAQCVRKRRPDILAEYAYDLAKTFHTFYEEVPVLHVEDDE
VREARLKLVEAFTIVAENLMNLLGIPTLERM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15149476, Length=627, Percent_Identity=25.518341307815, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI197100773, Length=581, Percent_Identity=25.473321858864, Blast_Score=133, Evalue=4e-31,
Organism=Escherichia coli, GI1788184, Length=580, Percent_Identity=28.9655172413793, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71985061, Length=566, Percent_Identity=24.9116607773852, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71985068, Length=526, Percent_Identity=25.0950570342205, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17532153, Length=424, Percent_Identity=24.2924528301887, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320548, Length=611, Percent_Identity=28.1505728314239, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321883, Length=588, Percent_Identity=24.1496598639456, Blast_Score=149, Evalue=9e-37,
Organism=Drosophila melanogaster, GI28571570, Length=478, Percent_Identity=25.1046025104602, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI18859963, Length=627, Percent_Identity=23.444976076555, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYR_METKA (Q8TXB6)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614042.1
- ProteinModelPortal:   Q8TXB6
- SMR:   Q8TXB6
- GeneID:   1476859
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0758
- NMPDR:   fig|190192.1.peg.755
- HOGENOM:   HBG695395
- OMA:   FDVYFHE
- BioCyc:   MKAN190192:MK0758-MONOMER
- BRENDA:   6.1.1.19
- GO:   GO:0005737
- HAMAP:   MF_00123
- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.30.1360.70
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11956
- PRINTS:   PR01038
- SMART:   SM00836
- TIGRFAMs:   TIGR00456

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d; SSF55190 Arg-tRNA-synth_Ic_N; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.19

Molecular weight: Translated: 67767; Mature: 67636

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEETTPRDPFSVTIRTIRTSIRDAISSVYEVDELIEVPIDENPPVEGADLATPVALSLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
KELDENPRELAETIVEESDLDDVVFVEKAWVEGPGFINLKLDRSQYAALTLRSIFYYGEE
HHHCCCHHHHHHHHHHCCCCCCEEEHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
YGSLDLGMGRPVILEHTSANPNGPLHIGHGRNAVIGDILARCMVFTNYGVEVQYYVNDMG
CCCEECCCCCCEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHH
KQIAMLAWKYIKEGRPEVPEGEKPDEFFGKLYTEAAREIEEDPELEEVVERFLRSYERYL
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VEEESRAERIADAFQTVVEECLRGHIQTLERLRVAHDRFVYESEFARDALEIVEKLLDMG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VAEEREDGAVVVDLEDYGIDKELVLTRSDGTTLYTTRDIAYHLWKLGRATFVVDVLGADH
CCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHCCHHEEEEECCCCH
KLAVEQLRAVLDMLEENPDRIDVVFYEFIHLPEGSMSTRKGRYVTLDEFLEEAKKRALEK
HHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
MKAAGVAEELSDEEREKIAEEIAIGAVRFAIARVSPNKPIEFDWDEALDFRRGGPFIQYA
HHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHH
YARAKSILRKADEEVNRFDAAYLNDDHSFELILKMSKFPRHVAQCVRKRRPDILAEYAYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LAKTFHTFYEEVPVLHVEDDEVREARLKLVEAFTIVAENLMNLLGIPTLERM
HHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AEETTPRDPFSVTIRTIRTSIRDAISSVYEVDELIEVPIDENPPVEGADLATPVALSLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
KELDENPRELAETIVEESDLDDVVFVEKAWVEGPGFINLKLDRSQYAALTLRSIFYYGEE
HHHCCCHHHHHHHHHHCCCCCCEEEHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
YGSLDLGMGRPVILEHTSANPNGPLHIGHGRNAVIGDILARCMVFTNYGVEVQYYVNDMG
CCCEECCCCCCEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHH
KQIAMLAWKYIKEGRPEVPEGEKPDEFFGKLYTEAAREIEEDPELEEVVERFLRSYERYL
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VEEESRAERIADAFQTVVEECLRGHIQTLERLRVAHDRFVYESEFARDALEIVEKLLDMG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VAEEREDGAVVVDLEDYGIDKELVLTRSDGTTLYTTRDIAYHLWKLGRATFVVDVLGADH
CCCCCCCCEEEEEECCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHCCHHEEEEECCCCH
KLAVEQLRAVLDMLEENPDRIDVVFYEFIHLPEGSMSTRKGRYVTLDEFLEEAKKRALEK
HHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
MKAAGVAEELSDEEREKIAEEIAIGAVRFAIARVSPNKPIEFDWDEALDFRRGGPFIQYA
HHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHH
YARAKSILRKADEEVNRFDAAYLNDDHSFELILKMSKFPRHVAQCVRKRRPDILAEYAYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LAKTFHTFYEEVPVLHVEDDEVREARLKLVEAFTIVAENLMNLLGIPTLERM
HHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014