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The map label for this gene is SbcC

Identifier: 20094127

GI number: 20094127

Start: 650789

End: 653419

Strand: Reverse

Name: SbcC

Synonym: MK0690

Alternate gene names: 20094127

Gene position: 653419-650789 (Counterclockwise)

Preceding gene: 20094128

Following gene: 20094126

Centisome position: 38.55

GC content: 61.04

Gene sequence:

>2631_bases
ATGATAGAGCGTGTGAAGATAGAGAACCTGAGGTCCCACAGCAGCACCGAGATCGAGTTCCGCGAGGGCATCAACGTACT
CGTAGGTCCGAACGGCGCCGGTAAGACCACCGTGCTGGAGGCCATCACCCTGGCCCTCTTCCCGCGCACGTTCCGGAGCT
ACGACCACATGATCAGGGAGGGCGAGCGCAGGGCCGTGGTGGAAGTCGTGTTCTGGGGCGCGGACGGGCACAAGTACAAG
GTGCGGCGCGAGTTCTACCGGGGCGGTGGGCAGAGGAACCCGAGACTGTACAGGGAGGAGGGTGACGGTTGGAAGGTCGT
GGCCTCGGGGCGGGCCGAGGACGTCGACCGAGAGGTCATGAACGCGCTGGGTGGAGTGGACCGGGACGTGTTCCGGGAGG
CGGTGTACATCAGGCAGGGTGAGATCGCGAAGCTCGTGGAAGCGACGCGGGAGGAGAGGAAGAGGATCGTCGACAGGACG
CTCGGGTTGGCGGAGTTCAAGAAGGCCCGCGAGCAGGCACACGAGCTGCTCCGGGTGGCGGAAGCCAAGCTCGAGACCTT
CCGCGAGCGCGTCCGCGACCTGAAGGGGTCGAAGAAGGAGCTCAAGAGGGTCGAGCGGGAGCTCGAGGAGCTGAAACGAG
AGGTGAAGGAGCTGGAGCCCGAGGTCGAGGAGCTTAAGGAGCGACTGAACGAGCTGCGCGAGGCGAAGAGAGAGTTCGAG
AGGCTGGAAGGCGAGCTACGACTGCTTGAGAACAAGATCGAGAGCCTTAAGGGACGTCGTGACGATCTCCGGAAGCTGGT
CGAAGAAGGAAAGGAAGCCGAGAGGGAGCTGCAGAGACTGGGTGATGTTCCTTCCAAAGTACGTGAGCTCGAGAACGAGG
AGGCGGAACTACGGAGACGCATCGAGGAGCTGAGGAACCTCCTGGACGACCTCCGCAGTCTCCGGAACAGGTTGGAGTCC
GCCGAGGAGGAACTCGAAGGTGTGAAGCGGGAGCTCGAGGAGCTGAAGGATGAAGCCGGGGTCGATCCGGAGCGTCTGGT
GGAGTTCAAAGACAAGATCGTGGAGGCTTCCGAACGGTTACGTGACCTGAGGCGTGAAGAGGAGCTCAAGAGGAAGCTGG
AGAAAGTCTCCGACGAGTTAAGCGAGCTGGGGGACCGGGAGGAGACGCTGCAGAGCGAGTACGAGGAGCTCCAAGAGCGT
CTCGACGAGATCCAAGGGGAACTGAAGGAGATTAGGGTCAAAGAGAAGGAGCTCCTGGAACGCATCGAGAGTCTCAGGGA
GGCCGAGGGCGAGTGTCCCGTCTGCCTCCGGAAACTGCCACGAGAGCGCGCCGAGAAGTTGTTGCGTGATGCGGAGAAGG
AGCTCGAACGTCTTCAAGGGCGTGAGGAGGATCTACGGAAGGAACGGAGAGAGCTGAAAGATAGGCTCGAGTCGGTTAGG
AGGGAGTTGGAGGGTACCAAGGAAAGGATGTGGCGTCTTAGGGAGCGTCGTGAGGAGCTCGAGCGGGAGTTGGAGGAGAT
CGAGGAGCTCAAGGAGGAACTCGCGGACTTATCGCGCGAGCTGGGTGTGGAAGAAGATCGGTTACCCGAGCTGCGCGATC
TGGCCGTGAGGGCGGAGAGTCTGCTGAGAGACCTGGAGCGTCGGCGCGGGGACGTGCTCCGGCTGGAGAAGGAACTGGAA
CGTACGCTGGACCGTTGCGAGAAAGTAATCGGAAGAACGCCGAGCGGTGTGGAAGACGTCGAAGAGGAGCTACGACGCCT
CGAGGAGGAGCGAGATCACGTAGGGCAGAAGCTCCGAGAGGCGGAGGGGGAGCTCGAACGTTATCACAACCTGGAGGAGA
AGGTGAAGAGGGCTCGGGAAGCCCGTAAGGAGTTGAAGAGGATCGAACGAGATCTCGAAGATGCTAAGGGTAGGTTAGAG
CAAGTGGAGCGTAATCTCGAGGGGTTACGGGAACGCTACGGGTCCGAGGATCGACTGGAGGAGGAACTCGAGAGCGTCGA
AAAGAAGTACGAGAGGGTCAGGGATAAGCTGAGCGAGGTCAAAGGAAGGCTGAACGGAATGGAAAAACGCAGAGAAGAGT
TGAAGAAACAGGTGCGGAAGTACCGGGAGGCGAAGGAGCGCAAGGAGAGGTTGGAGCGGGTCGTGGAGGTGCTCAGTCTC
TGCAAGGAGGTGTTCAGATATTCCCGTGACGTCGCCAGGGAGAAGGTGCTGCCCGCCGTGGAGCGGGAGGCCTCGAAGAT
CCTGCAGGATCTCTCGGACCGGTACGGATCGTTGAGGATCGAGGACGACGGGGCCGTGATACGGGTCTCCGTGCCGGGTG
GTCATTTCATAGAGGCCGACCGGATGAGCGGTGGGGAAAAAATTATAATCGGGCTGGCGCTGCGCCTGGCGCTCGCCATG
GTGGGGTCGAGCTTCGCCCCCTTCATAATGTTAGACGAGCCGACGGTGCACTTGGACGCGGAACACCGGGAGCGATTAGC
GCAAGCCTTAAGAGAGCTGGATCTGGGCAAGGGGCGCGTACGCCAAGCCATCGTCGTCACCCACGACGAGGAGCTCGAGG
ACGCCGCGGACGAGCTTTGGAGGATAGAGAACCGGGCCGGCGAATCCCGAGTAGAACGATACTCCGGGTAA

Upstream 100 bases:

>100_bases
GAGAGCCGTGGGACGTCGTCCGAAGGGATGAGTCGTGCGGGATCGAAGCTCGGGTCCTCCGGCCGACCCTCCCTGGATCG
CTGGATCGGGTGACGGTCGA

Downstream 100 bases:

>100_bases
TCGGACTTTGTATCGGGATTTCCGTGAGTTCCGGCCGGACCTGGAGTTCCGGGCATGCGTAGCCTGCGGTGAGTGCGCCG
CGGTGTGTCCCGCTGGTTCA

Product: SMC1-family ATPase

Products: 5'-phosphomonoesters [C]

Alternate protein names: NA

Number of amino acids: Translated: 876; Mature: 876

Protein sequence:

>876_residues
MIERVKIENLRSHSSTEIEFREGINVLVGPNGAGKTTVLEAITLALFPRTFRSYDHMIREGERRAVVEVVFWGADGHKYK
VRREFYRGGGQRNPRLYREEGDGWKVVASGRAEDVDREVMNALGGVDRDVFREAVYIRQGEIAKLVEATREERKRIVDRT
LGLAEFKKAREQAHELLRVAEAKLETFRERVRDLKGSKKELKRVERELEELKREVKELEPEVEELKERLNELREAKREFE
RLEGELRLLENKIESLKGRRDDLRKLVEEGKEAERELQRLGDVPSKVRELENEEAELRRRIEELRNLLDDLRSLRNRLES
AEEELEGVKRELEELKDEAGVDPERLVEFKDKIVEASERLRDLRREEELKRKLEKVSDELSELGDREETLQSEYEELQER
LDEIQGELKEIRVKEKELLERIESLREAEGECPVCLRKLPRERAEKLLRDAEKELERLQGREEDLRKERRELKDRLESVR
RELEGTKERMWRLRERREELERELEEIEELKEELADLSRELGVEEDRLPELRDLAVRAESLLRDLERRRGDVLRLEKELE
RTLDRCEKVIGRTPSGVEDVEEELRRLEEERDHVGQKLREAEGELERYHNLEEKVKRAREARKELKRIERDLEDAKGRLE
QVERNLEGLRERYGSEDRLEEELESVEKKYERVRDKLSEVKGRLNGMEKRREELKKQVRKYREAKERKERLERVVEVLSL
CKEVFRYSRDVAREKVLPAVEREASKILQDLSDRYGSLRIEDDGAVIRVSVPGGHFIEADRMSGGEKIIIGLALRLALAM
VGSSFAPFIMLDEPTVHLDAEHRERLAQALRELDLGKGRVRQAIVVTHDEELEDAADELWRIENRAGESRVERYSG

Sequences:

>Translated_876_residues
MIERVKIENLRSHSSTEIEFREGINVLVGPNGAGKTTVLEAITLALFPRTFRSYDHMIREGERRAVVEVVFWGADGHKYK
VRREFYRGGGQRNPRLYREEGDGWKVVASGRAEDVDREVMNALGGVDRDVFREAVYIRQGEIAKLVEATREERKRIVDRT
LGLAEFKKAREQAHELLRVAEAKLETFRERVRDLKGSKKELKRVERELEELKREVKELEPEVEELKERLNELREAKREFE
RLEGELRLLENKIESLKGRRDDLRKLVEEGKEAERELQRLGDVPSKVRELENEEAELRRRIEELRNLLDDLRSLRNRLES
AEEELEGVKRELEELKDEAGVDPERLVEFKDKIVEASERLRDLRREEELKRKLEKVSDELSELGDREETLQSEYEELQER
LDEIQGELKEIRVKEKELLERIESLREAEGECPVCLRKLPRERAEKLLRDAEKELERLQGREEDLRKERRELKDRLESVR
RELEGTKERMWRLRERREELERELEEIEELKEELADLSRELGVEEDRLPELRDLAVRAESLLRDLERRRGDVLRLEKELE
RTLDRCEKVIGRTPSGVEDVEEELRRLEEERDHVGQKLREAEGELERYHNLEEKVKRAREARKELKRIERDLEDAKGRLE
QVERNLEGLRERYGSEDRLEEELESVEKKYERVRDKLSEVKGRLNGMEKRREELKKQVRKYREAKERKERLERVVEVLSL
CKEVFRYSRDVAREKVLPAVEREASKILQDLSDRYGSLRIEDDGAVIRVSVPGGHFIEADRMSGGEKIIIGLALRLALAM
VGSSFAPFIMLDEPTVHLDAEHRERLAQALRELDLGKGRVRQAIVVTHDEELEDAADELWRIENRAGESRVERYSG
>Mature_876_residues
MIERVKIENLRSHSSTEIEFREGINVLVGPNGAGKTTVLEAITLALFPRTFRSYDHMIREGERRAVVEVVFWGADGHKYK
VRREFYRGGGQRNPRLYREEGDGWKVVASGRAEDVDREVMNALGGVDRDVFREAVYIRQGEIAKLVEATREERKRIVDRT
LGLAEFKKAREQAHELLRVAEAKLETFRERVRDLKGSKKELKRVERELEELKREVKELEPEVEELKERLNELREAKREFE
RLEGELRLLENKIESLKGRRDDLRKLVEEGKEAERELQRLGDVPSKVRELENEEAELRRRIEELRNLLDDLRSLRNRLES
AEEELEGVKRELEELKDEAGVDPERLVEFKDKIVEASERLRDLRREEELKRKLEKVSDELSELGDREETLQSEYEELQER
LDEIQGELKEIRVKEKELLERIESLREAEGECPVCLRKLPRERAEKLLRDAEKELERLQGREEDLRKERRELKDRLESVR
RELEGTKERMWRLRERREELERELEEIEELKEELADLSRELGVEEDRLPELRDLAVRAESLLRDLERRRGDVLRLEKELE
RTLDRCEKVIGRTPSGVEDVEEELRRLEEERDHVGQKLREAEGELERYHNLEEKVKRAREARKELKRIERDLEDAKGRLE
QVERNLEGLRERYGSEDRLEEELESVEKKYERVRDKLSEVKGRLNGMEKRREELKKQVRKYREAKERKERLERVVEVLSL
CKEVFRYSRDVAREKVLPAVEREASKILQDLSDRYGSLRIEDDGAVIRVSVPGGHFIEADRMSGGEKIIIGLALRLALAM
VGSSFAPFIMLDEPTVHLDAEHRERLAQALRELDLGKGRVRQAIVVTHDEELEDAADELWRIENRAGESRVERYSG

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and

COG id: COG0419

COG function: function code L; ATPase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 zinc-hook domain

Homologues:

Organism=Homo sapiens, GI119466532, Length=575, Percent_Identity=21.5652173913043, Blast_Score=84, Evalue=8e-16,
Organism=Homo sapiens, GI28559088, Length=575, Percent_Identity=21.5652173913043, Blast_Score=84, Evalue=8e-16,
Organism=Homo sapiens, GI19924129, Length=741, Percent_Identity=24.1565452091768, Blast_Score=74, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193208595, Length=481, Percent_Identity=23.7006237006237, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17563838, Length=481, Percent_Identity=23.7006237006237, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324079, Length=680, Percent_Identity=23.0882352941176, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RAD50_METKA (Q8TXI4)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613974.1
- ProteinModelPortal:   Q8TXI4
- GeneID:   1476791
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0690
- NMPDR:   fig|190192.1.peg.687
- OMA:   MMRGIGV
- BioCyc:   MKAN190192:MK0690-MONOMER
- GO:   GO:0005694
- HAMAP:   MF_00449
- InterPro:   IPR003593
- InterPro:   IPR009053
- InterPro:   IPR022982
- InterPro:   IPR007517
- InterPro:   IPR003395
- InterPro:   IPR018159
- InterPro:   IPR013134
- SMART:   SM00382
- SMART:   SM00150

Pfam domain/function: PF04423 Rad50_zn_hook; PF02463 SMC_N; SSF46579 Prefoldin

EC number: NA

Molecular weight: Translated: 103708; Mature: 103708

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS51131 ZN_HOOK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERVKIENLRSHSSTEIEFREGINVLVGPNGAGKTTVLEAITLALFPRTFRSYDHMIRE
CCCCCHHHHHHCCCCCCEEHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GERRAVVEVVFWGADGHKYKVRREFYRGGGQRNPRLYREEGDGWKVVASGRAEDVDREVM
CCHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
NALGGVDRDVFREAVYIRQGEIAKLVEATREERKRIVDRTLGLAEFKKAREQAHELLRVA
HHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAKLETFRERVRDLKGSKKELKRVERELEELKREVKELEPEVEELKERLNELREAKREFE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLEGELRLLENKIESLKGRRDDLRKLVEEGKEAERELQRLGDVPSKVRELENEEAELRRR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHH
IEELRNLLDDLRSLRNRLESAEEELEGVKRELEELKDEAGVDPERLVEFKDKIVEASERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RDLRREEELKRKLEKVSDELSELGDREETLQSEYEELQERLDEIQGELKEIRVKEKELLE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIESLREAEGECPVCLRKLPRERAEKLLRDAEKELERLQGREEDLRKERRELKDRLESVR
HHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RELEGTKERMWRLRERREELERELEEIEELKEELADLSRELGVEEDRLPELRDLAVRAES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLRDLERRRGDVLRLEKELERTLDRCEKVIGRTPSGVEDVEEELRRLEEERDHVGQKLRE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AEGELERYHNLEEKVKRAREARKELKRIERDLEDAKGRLEQVERNLEGLRERYGSEDRLE
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EELESVEKKYERVRDKLSEVKGRLNGMEKRREELKKQVRKYREAKERKERLERVVEVLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CKEVFRYSRDVAREKVLPAVEREASKILQDLSDRYGSLRIEDDGAVIRVSVPGGHFIEAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCEEEHH
RMSGGEKIIIGLALRLALAMVGSSFAPFIMLDEPTVHLDAEHRERLAQALRELDLGKGRV
HCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEECHHHHHHHHHHHHHHCCCCHHH
RQAIVVTHDEELEDAADELWRIENRAGESRVERYSG
HHHHHEECCHHHHHHHHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MIERVKIENLRSHSSTEIEFREGINVLVGPNGAGKTTVLEAITLALFPRTFRSYDHMIRE
CCCCCHHHHHHCCCCCCEEHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GERRAVVEVVFWGADGHKYKVRREFYRGGGQRNPRLYREEGDGWKVVASGRAEDVDREVM
CCHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHH
NALGGVDRDVFREAVYIRQGEIAKLVEATREERKRIVDRTLGLAEFKKAREQAHELLRVA
HHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAKLETFRERVRDLKGSKKELKRVERELEELKREVKELEPEVEELKERLNELREAKREFE
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLEGELRLLENKIESLKGRRDDLRKLVEEGKEAERELQRLGDVPSKVRELENEEAELRRR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHH
IEELRNLLDDLRSLRNRLESAEEELEGVKRELEELKDEAGVDPERLVEFKDKIVEASERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
RDLRREEELKRKLEKVSDELSELGDREETLQSEYEELQERLDEIQGELKEIRVKEKELLE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIESLREAEGECPVCLRKLPRERAEKLLRDAEKELERLQGREEDLRKERRELKDRLESVR
HHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RELEGTKERMWRLRERREELERELEEIEELKEELADLSRELGVEEDRLPELRDLAVRAES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LLRDLERRRGDVLRLEKELERTLDRCEKVIGRTPSGVEDVEEELRRLEEERDHVGQKLRE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AEGELERYHNLEEKVKRAREARKELKRIERDLEDAKGRLEQVERNLEGLRERYGSEDRLE
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
EELESVEKKYERVRDKLSEVKGRLNGMEKRREELKKQVRKYREAKERKERLERVVEVLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CKEVFRYSRDVAREKVLPAVEREASKILQDLSDRYGSLRIEDDGAVIRVSVPGGHFIEAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCEEEHH
RMSGGEKIIIGLALRLALAMVGSSFAPFIMLDEPTVHLDAEHRERLAQALRELDLGKGRV
HCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEECHHHHHHHHHHHHHHCCCCHHH
RQAIVVTHDEELEDAADELWRIENRAGESRVERYSG
HHHHHEECCHHHHHHHHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribo- or deoxyribonucleic acids [C]

Specific reaction: ribo- or deoxyribonucleic acids = 5'-phosphomonoesters [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014