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The map label for this gene is SbcD

Identifier: 20094128

GI number: 20094128

Start: 653427

End: 654782

Strand: Reverse

Name: SbcD

Synonym: MK0691

Alternate gene names: 20094128

Gene position: 654782-653427 (Counterclockwise)

Preceding gene: 20094129

Following gene: 20094127

Centisome position: 38.63

GC content: 66.67

Gene sequence:

>1356_bases
TTGAGGATGGCCCACGTGGCGGACGTCCACCTGGGCCACGCCCTGATGAACCTGCGGTCCCGAGAGGAGGCCGTGATGGA
GACGTTCGAGCGGCTGATGGAGGAGGTTCGCGAGTGCTCCGTGGACGTCCTCGTGATCGCCGGCGATCTCTTCGAGCACG
CGCGGCCCAAGACCGAGGCCCTATACCTGGCCGTGGAGAAGCTCTCGGAGCTGAAGGAGGACGGCGTCGAGATCGTCGCG
ACCGCGGGCAACCACGAGATCCGCCGGCGGAAAGGGGCCGTTTCTCCTATCTCCGTATTGGAGCGGATGGGATTGGTCCG
ACACCTCTACTACTCGGAACGGCGCCCGGAGAGGCACCGGTACACGGCCACCTTCGACGGCGTACGCGTGACGTTCCACG
GGCTCCAGTACCTGCCGAAGAACTCGTTCGTGGAGAGGGCGAAGGTCATCAGGGCCAAGTACAGGCCGGATCCCGAGGCG
GACGTCAACGTGGCGATCTTCCATCAGGCCCTACCCGGGACGATCCCCGACGAGTCCGAGATCGTGGAACCCGCGTACTT
CCCGGAGGGGCACGATTACTACGCGATGGGACACGTCCACGTCCCGAGTCGTGAGGAGAAGATCCACGGGAGTCCGGCGC
CCTACCCCGGGAGTCCCGAGCCGCTGACGTTCCTGGAGGTCAAGGACGAGCGCGGTGCGCACAAGCGGCGCGGTTTCTTC
CTCGTGGAGTTCGACCGGGGCGGGCTCGTCGAGTACGAGTTCGTCGAGGTGGAGTGGAGCCGCGAGCTCTCGGTCGTGGA
GGTCAGTGGCGAGCGCTGGGAGGAGGAGCTGCGTCGAAGGGTCAGACGGGGACAGATCGTGAAGGTGGTGGCCAAGGACA
CGGGTGCGTCCCCGGAGGAGGTCGAGAAGGTCGCCATCGAGGCCGGGGCCGATCGGTGCGTGGTGGAGCTCCGGGAGCGG
AGGCGCGAGGTCGAGGAAGGCGACGAGACCGAGGGGCCGCTGGACCTCGAGGGTATAATCCGAGAGGGTGTGAAGCGGGC
CAGGGCCGCGACCCTGACCCGCGTGGACGTGCCGGACGATGTGGTGGTCGAGGTGGCGCTGGAGATCCTGAGGGGCGTCC
GGGAGGACAACCCTCCCGACCTGGGGGACGTCGAAGGTATCGTCGCGGGAGAACCCCCGTCGGAAGGTTCGGAGGAGTCC
TCGGAAGAGCCAGAAGAATCCGATGGAGAGGAGGTAGGTCTCGAGGTGGAGGAGGTGAAGGTCGAGAGCCGTGGGACGTC
GTCCGAAGGGATGAGTCGTGCGGGATCGAAGCTCGGGTCCTCCGGCCGACCCTCCCTGGATCGCTGGATCGGGTGA

Upstream 100 bases:

>100_bases
GGATGACCCGTCACGGCGGCGAGACGCCGGACGTCCGCGAGATCGTGGAGCGGTGGAAGGAGGACGATGCGGAGGAGGAC
CTGGACCTGGGGATCTGACC

Downstream 100 bases:

>100_bases
CGGTCGAATGATAGAGCGTGTGAAGATAGAGAACCTGAGGTCCCACAGCAGCACCGAGATCGAGTTCCGCGAGGGCATCA
ACGTACTCGTAGGTCCGAAC

Product: SbcD/Mre11 family DNA repair exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRMAHVADVHLGHALMNLRSREEAVMETFERLMEEVRECSVDVLVIAGDLFEHARPKTEALYLAVEKLSELKEDGVEIVA
TAGNHEIRRRKGAVSPISVLERMGLVRHLYYSERRPERHRYTATFDGVRVTFHGLQYLPKNSFVERAKVIRAKYRPDPEA
DVNVAIFHQALPGTIPDESEIVEPAYFPEGHDYYAMGHVHVPSREEKIHGSPAPYPGSPEPLTFLEVKDERGAHKRRGFF
LVEFDRGGLVEYEFVEVEWSRELSVVEVSGERWEEELRRRVRRGQIVKVVAKDTGASPEEVEKVAIEAGADRCVVELRER
RREVEEGDETEGPLDLEGIIREGVKRARAATLTRVDVPDDVVVEVALEILRGVREDNPPDLGDVEGIVAGEPPSEGSEES
SEEPEESDGEEVGLEVEEVKVESRGTSSEGMSRAGSKLGSSGRPSLDRWIG

Sequences:

>Translated_451_residues
MRMAHVADVHLGHALMNLRSREEAVMETFERLMEEVRECSVDVLVIAGDLFEHARPKTEALYLAVEKLSELKEDGVEIVA
TAGNHEIRRRKGAVSPISVLERMGLVRHLYYSERRPERHRYTATFDGVRVTFHGLQYLPKNSFVERAKVIRAKYRPDPEA
DVNVAIFHQALPGTIPDESEIVEPAYFPEGHDYYAMGHVHVPSREEKIHGSPAPYPGSPEPLTFLEVKDERGAHKRRGFF
LVEFDRGGLVEYEFVEVEWSRELSVVEVSGERWEEELRRRVRRGQIVKVVAKDTGASPEEVEKVAIEAGADRCVVELRER
RREVEEGDETEGPLDLEGIIREGVKRARAATLTRVDVPDDVVVEVALEILRGVREDNPPDLGDVEGIVAGEPPSEGSEES
SEEPEESDGEEVGLEVEEVKVESRGTSSEGMSRAGSKLGSSGRPSLDRWIG
>Mature_451_residues
MRMAHVADVHLGHALMNLRSREEAVMETFERLMEEVRECSVDVLVIAGDLFEHARPKTEALYLAVEKLSELKEDGVEIVA
TAGNHEIRRRKGAVSPISVLERMGLVRHLYYSERRPERHRYTATFDGVRVTFHGLQYLPKNSFVERAKVIRAKYRPDPEA
DVNVAIFHQALPGTIPDESEIVEPAYFPEGHDYYAMGHVHVPSREEKIHGSPAPYPGSPEPLTFLEVKDERGAHKRRGFF
LVEFDRGGLVEYEFVEVEWSRELSVVEVSGERWEEELRRRVRRGQIVKVVAKDTGASPEEVEKVAIEAGADRCVVELRER
RREVEEGDETEGPLDLEGIIREGVKRARAATLTRVDVPDDVVVEVALEILRGVREDNPPDLGDVEGIVAGEPPSEGSEES
SEEPEESDGEEVGLEVEEVKVESRGTSSEGMSRAGSKLGSSGRPSLDRWIG

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRE11_METKA (Q8TXI3)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613975.1
- ProteinModelPortal:   Q8TXI3
- GeneID:   1476792
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0691
- NMPDR:   fig|190192.1.peg.688
- OMA:   VEEINTP
- BioCyc:   MKAN190192:MK0691-MONOMER
- InterPro:   IPR004843

Pfam domain/function: PF00149 Metallophos

EC number: NA

Molecular weight: Translated: 50627; Mature: 50627

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: ACT_SITE 85-85

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMAHVADVHLGHALMNLRSREEAVMETFERLMEEVRECSVDVLVIAGDLFEHARPKTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCCHHH
LYLAVEKLSELKEDGVEIVATAGNHEIRRRKGAVSPISVLERMGLVRHLYYSERRPERHR
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
YTATFDGVRVTFHGLQYLPKNSFVERAKVIRAKYRPDPEADVNVAIFHQALPGTIPDESE
EEEEECCEEEEEECHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHH
IVEPAYFPEGHDYYAMGHVHVPSREEKIHGSPAPYPGSPEPLTFLEVKDERGAHKRRGFF
CCCCCCCCCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCEE
LVEFDRGGLVEYEFVEVEWSRELSVVEVSGERWEEELRRRVRRGQIVKVVAKDTGASPEE
EEEECCCCEEEEEEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VEKVAIEAGADRCVVELRERRREVEEGDETEGPLDLEGIIREGVKRARAATLTRVDVPDD
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCHH
VVVEVALEILRGVREDNPPDLGDVEGIVAGEPPSEGSEESSEEPEESDGEEVGLEVEEVK
HHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEE
VESRGTSSEGMSRAGSKLGSSGRPSLDRWIG
ECCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
>Mature Secondary Structure
MRMAHVADVHLGHALMNLRSREEAVMETFERLMEEVRECSVDVLVIAGDLFEHARPKTEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCCHHH
LYLAVEKLSELKEDGVEIVATAGNHEIRRRKGAVSPISVLERMGLVRHLYYSERRPERHR
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
YTATFDGVRVTFHGLQYLPKNSFVERAKVIRAKYRPDPEADVNVAIFHQALPGTIPDESE
EEEEECCEEEEEECHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHH
IVEPAYFPEGHDYYAMGHVHVPSREEKIHGSPAPYPGSPEPLTFLEVKDERGAHKRRGFF
CCCCCCCCCCCCEEEEEEEECCCCHHHCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCEE
LVEFDRGGLVEYEFVEVEWSRELSVVEVSGERWEEELRRRVRRGQIVKVVAKDTGASPEE
EEEECCCCEEEEEEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VEKVAIEAGADRCVVELRERRREVEEGDETEGPLDLEGIIREGVKRARAATLTRVDVPDD
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCHH
VVVEVALEILRGVREDNPPDLGDVEGIVAGEPPSEGSEESSEEPEESDGEEVGLEVEEVK
HHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEE
VESRGTSSEGMSRAGSKLGSSGRPSLDRWIG
ECCCCCCHHHHHHHHHHCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014