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The map label for this gene is DapD

Identifier: 20093873

GI number: 20093873

Start: 406436

End: 407173

Strand: Reverse

Name: DapD

Synonym: MK0435

Alternate gene names: 20093873

Gene position: 407173-406436 (Counterclockwise)

Preceding gene: 20093874

Following gene: 20093872

Centisome position: 24.02

GC content: 60.57

Gene sequence:

>738_bases
GTGAGACCGTTGTCGGAGCTGGATCCAGAAGAGCTAATTCGATACATTTCCGAGAGTCCCAAGCGTACGATCGCCAAATT
CTACGTCAAAACGGACGATCCCGAAGGACTGGCCGAGCGCTTGGAGGAGCGCCTGGAGGATGCCAAGGTGTTCACGGGTG
TCGACCACGTCATCGTGATCGGCGAGCACGACGATGTTGTCGAAGTGCTCGAGAGCGAGGACTCGGTGGAGTACTATCAC
AAAGAGCTGGATCACCGCAACAGGGCCGTGCCGTTGGCGGATTACTCCGAGTTCGAGGACGTCAGGATCGAGCCGGGTGC
GATAATCCGGGAGAAGGTGAAGTTGGGTAAAGGAGTCGTGGTGATGATGGGTGCCGTGATCAACATCGGTGCCAAGATAG
GCGACGGTACCATGGTCGACATGAACGCGGTCGTGGGTTCCCGGGCGGAGGTCGGGAAGAACGTACACATCGGCGCCGGC
GCGGTCATCGCCGGTGTTCTCGAGCCCCCTAGCGCTAAACCCGTCGTGATCGAAGACGACGTCGTCATCGGGGCGAACGC
CGTCATTCTCGAGGGGGTGAGGGTAGGAAAGGGAGCCGTGGTCGCGGCCGGCGCCGTCGTCACCGAGGATGTGCCGCCGA
GTAAAGTGGTGGCCGGCGTACCCGCGCGAGTTGTCAAAGACGTGGACAAGAAGACCGAGGCTAAGACCCAGATAGTCGAT
GCGCTCCGCTGCCTCTGA

Upstream 100 bases:

>100_bases
GGCACGCCGACTACGACGTGTACGGGGTGCAATTCCATCCTGAAAGCTTCATGACCGAGGGCGGGGATCGGATCGCCCGC
AACTTCCTAGAGCTGCTGGG

Downstream 100 bases:

>100_bases
AACCCTGCCACTACCTGGGGGAAGTACCATGCAATTCTGGAAAGTCCATGGCGCTCGGAACGACTTCGTCTTAGTCGATG
AAACAGAGGAAGAAGTGGTT

Product: tetrahydrodipicolinate N-succinyltransferase

Products: NA

Alternate protein names: Tetrahydrodipicolinate N-acetyltransferase; THP acetyltransferase; Tetrahydropicolinate acetylase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MRPLSELDPEELIRYISESPKRTIAKFYVKTDDPEGLAERLEERLEDAKVFTGVDHVIVIGEHDDVVEVLESEDSVEYYH
KELDHRNRAVPLADYSEFEDVRIEPGAIIREKVKLGKGVVVMMGAVINIGAKIGDGTMVDMNAVVGSRAEVGKNVHIGAG
AVIAGVLEPPSAKPVVIEDDVVIGANAVILEGVRVGKGAVVAAGAVVTEDVPPSKVVAGVPARVVKDVDKKTEAKTQIVD
ALRCL

Sequences:

>Translated_245_residues
MRPLSELDPEELIRYISESPKRTIAKFYVKTDDPEGLAERLEERLEDAKVFTGVDHVIVIGEHDDVVEVLESEDSVEYYH
KELDHRNRAVPLADYSEFEDVRIEPGAIIREKVKLGKGVVVMMGAVINIGAKIGDGTMVDMNAVVGSRAEVGKNVHIGAG
AVIAGVLEPPSAKPVVIEDDVVIGANAVILEGVRVGKGAVVAAGAVVTEDVPPSKVVAGVPARVVKDVDKKTEAKTQIVD
ALRCL
>Mature_245_residues
MRPLSELDPEELIRYISESPKRTIAKFYVKTDDPEGLAERLEERLEDAKVFTGVDHVIVIGEHDDVVEVLESEDSVEYYH
KELDHRNRAVPLADYSEFEDVRIEPGAIIREKVKLGKGVVVMMGAVINIGAKIGDGTMVDMNAVVGSRAEVGKNVHIGAG
AVIAGVLEPPSAKPVVIEDDVVIGANAVILEGVRVGKGAVVAAGAVVTEDVPPSKVVAGVPARVVKDVDKKTEAKTQIVD
ALRCL

Specific function: Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate

COG id: COG2171

COG function: function code E; Tetrahydrodipicolinate N-succinyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. DapH subfamily

Homologues:

Organism=Escherichia coli, GI1786362, Length=185, Percent_Identity=37.2972972972973, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786664, Length=172, Percent_Identity=32.5581395348837, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790035, Length=110, Percent_Identity=40, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786537, Length=58, Percent_Identity=43.1034482758621, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322243, Length=117, Percent_Identity=34.1880341880342, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPH_METKA (Q8TY70)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613720.1
- HSSP:   P43886
- ProteinModelPortal:   Q8TY70
- SMR:   Q8TY70
- GeneID:   1477738
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0435
- NMPDR:   fig|190192.1.peg.433
- HOGENOM:   HBG704071
- OMA:   DTREINA
- BioCyc:   MKAN190192:MK0435-MONOMER
- HAMAP:   MF_01691
- InterPro:   IPR013710
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR019873
- InterPro:   IPR011004
- TIGRFAMs:   TIGR03532

Pfam domain/function: PF08503 DapD_N; PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.89

Molecular weight: Translated: 26275; Mature: 26275

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLSELDPEELIRYISESPKRTIAKFYVKTDDPEGLAERLEERLEDAKVFTGVDHVIVI
CCCCCCCCHHHHHHHHHCCHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHEECCCEEEEE
GEHDDVVEVLESEDSVEYYHKELDHRNRAVPLADYSEFEDVRIEPGAIIREKVKLGKGVV
CCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCHH
VMMGAVINIGAKIGDGTMVDMNAVVGSRAEVGKNVHIGAGAVIAGVLEPPSAKPVVIEDD
HHHHHHHHCCCCCCCCEEEEHHHHHCCHHHCCCEEEECCCHHEEEECCCCCCCCEEEECC
VVIGANAVILEGVRVGKGAVVAAGAVVTEDVPPSKVVAGVPARVVKDVDKKTEAKTQIVD
EEECCCEEEEECEEECCCEEEEECEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALRCL
HHHCC
>Mature Secondary Structure
MRPLSELDPEELIRYISESPKRTIAKFYVKTDDPEGLAERLEERLEDAKVFTGVDHVIVI
CCCCCCCCHHHHHHHHHCCHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHEECCCEEEEE
GEHDDVVEVLESEDSVEYYHKELDHRNRAVPLADYSEFEDVRIEPGAIIREKVKLGKGVV
CCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCHH
VMMGAVINIGAKIGDGTMVDMNAVVGSRAEVGKNVHIGAGAVIAGVLEPPSAKPVVIEDD
HHHHHHHHCCCCCCCCEEEEHHHHHCCHHHCCCEEEECCCHHEEEECCCCCCCCEEEECC
VVIGANAVILEGVRVGKGAVVAAGAVVTEDVPPSKVVAGVPARVVKDVDKKTEAKTQIVD
EEECCCEEEEECEEECCCEEEEECEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
ALRCL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014