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The map label for this gene is PabA [H]

Identifier: 20093874

GI number: 20093874

Start: 407170

End: 407748

Strand: Reverse

Name: PabA [H]

Synonym: MK0436

Alternate gene names: 20093874

Gene position: 407748-407170 (Counterclockwise)

Preceding gene: 20093875

Following gene: 20093873

Centisome position: 24.06

GC content: 59.07

Gene sequence:

>579_bases
TTGAGGAGACTAGTTCTGATAAATAACAAGGATAGTTTCGTGTATAATCTCTACCATTTGTTCGCCTCATATGATCTCGA
TTTGAAAGTTGTCTCCAACAAGGTTCCGCTCTCCAGGCTCGAGCGGCTGCGTCCCGACGGTCTCGTCGTCAGTCCCGGGC
CCGGACACCCGGAACGAGACGCTGGAGTGTCCGTGCCAGCTATCCGGAGGTTCGCGGGAGAGATCCCGATCCTGGGGGTG
TGCCTAGGTCACCAGTGCATCGGAGTGGCGTACGGAGCGCAGATCCGCCGGGCTAAACGCATCGTCCACGGGAAGACGTC
GCCGATAGAACACGACGGGTCCGGGATCCTCTCAGGGCTCGAAAGCCCCTTCCAAGGGATGAGGTACCACTCACTGGTCA
TCGAGGAATCCTCCTTGCCCGAAGAGCTGCTACCGTGCGCATGGTCGGGAGACGACGGAGAACTCATGGCCGTCAGGCAC
GCCGACTACGACGTGTACGGGGTGCAATTCCATCCTGAAAGCTTCATGACCGAGGGCGGGGATCGGATCGCCCGCAACTT
CCTAGAGCTGCTGGGGTGA

Upstream 100 bases:

>100_bases
TGGTTCACGCAGGCGGGTGCCGGTATCGTGTACGACTCGGTGCCCGAAAACGAGTGGTTCGAAACTGAAAATAAAATGAA
AGCGATGGTGGGAGCTATCC

Downstream 100 bases:

>100_bases
GACCGTTGTCGGAGCTGGATCCAGAAGAGCTAATTCGATACATTTCCGAGAGTCCCAAGCGTACGATCGCCAAATTCTAC
GTCAAAACGGACGATCCCGA

Product: anthranilate/para-aminobenzoate synthase component II

Products: NA

Alternate protein names: Glutamine amidotransferase; Anthranilate phosphoribosyltransferase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MRRLVLINNKDSFVYNLYHLFASYDLDLKVVSNKVPLSRLERLRPDGLVVSPGPGHPERDAGVSVPAIRRFAGEIPILGV
CLGHQCIGVAYGAQIRRAKRIVHGKTSPIEHDGSGILSGLESPFQGMRYHSLVIEESSLPEELLPCAWSGDDGELMAVRH
ADYDVYGVQFHPESFMTEGGDRIARNFLELLG

Sequences:

>Translated_192_residues
MRRLVLINNKDSFVYNLYHLFASYDLDLKVVSNKVPLSRLERLRPDGLVVSPGPGHPERDAGVSVPAIRRFAGEIPILGV
CLGHQCIGVAYGAQIRRAKRIVHGKTSPIEHDGSGILSGLESPFQGMRYHSLVIEESSLPEELLPCAWSGDDGELMAVRH
ADYDVYGVQFHPESFMTEGGDRIARNFLELLG
>Mature_192_residues
MRRLVLINNKDSFVYNLYHLFASYDLDLKVVSNKVPLSRLERLRPDGLVVSPGPGHPERDAGVSVPAIRRFAGEIPILGV
CLGHQCIGVAYGAQIRRAKRIVHGKTSPIEHDGSGILSGLESPFQGMRYHSLVIEESSLPEELLPCAWSGDDGELMAVRH
ADYDVYGVQFHPESFMTEGGDRIARNFLELLG

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=131, Percent_Identity=32.0610687022901, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=46.7741935483871, Blast_Score=180, Evalue=5e-47,
Organism=Escherichia coli, GI1787517, Length=192, Percent_Identity=41.1458333333333, Blast_Score=131, Evalue=2e-32,
Organism=Escherichia coli, GI1786215, Length=160, Percent_Identity=26.875, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193204318, Length=133, Percent_Identity=30.8270676691729, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322638, Length=192, Percent_Identity=44.2708333333333, Blast_Score=171, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324361, Length=212, Percent_Identity=31.6037735849057, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005940
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase; PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3 [H]

EC number: =4.1.3.27; =2.4.2.18 [H]

Molecular weight: Translated: 21237; Mature: 21237

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLVLINNKDSFVYNLYHLFASYDLDLKVVSNKVPLSRLERLRPDGLVVSPGPGHPERD
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCEEECCCCCCCCCC
AGVSVPAIRRFAGEIPILGVCLGHQCIGVAYGAQIRRAKRIVHGKTSPIEHDGSGILSGL
CCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ESPFQGMRYHSLVIEESSLPEELLPCAWSGDDGELMAVRHADYDVYGVQFHPESFMTEGG
CCHHHCCEEEEEEEECCCCCHHHCCCCCCCCCCCEEEEEECCCEEEEEEECCHHHHHCCH
DRIARNFLELLG
HHHHHHHHHHHC
>Mature Secondary Structure
MRRLVLINNKDSFVYNLYHLFASYDLDLKVVSNKVPLSRLERLRPDGLVVSPGPGHPERD
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCEEECCCCCCCCCC
AGVSVPAIRRFAGEIPILGVCLGHQCIGVAYGAQIRRAKRIVHGKTSPIEHDGSGILSGL
CCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ESPFQGMRYHSLVIEESSLPEELLPCAWSGDDGELMAVRHADYDVYGVQFHPESFMTEGG
CCHHHCCEEEEEEEECCCCCHHHCCCCCCCCCCCEEEEEECCCEEEEEEECCHHHHHCCH
DRIARNFLELLG
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685830; 10360571; 7556082 [H]