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The map label for this gene is lhr [C]

Identifier: 20093551

GI number: 20093551

Start: 105387

End: 107522

Strand: Reverse

Name: lhr [C]

Synonym: MK0111

Alternate gene names: 20093551

Gene position: 107522-105387 (Counterclockwise)

Preceding gene: 20093553

Following gene: 20093548

Centisome position: 6.34

GC content: 61.05

Gene sequence:

>2136_bases
ATGTACGCGCCGGTCCGACGAGGGTGTTCGAAGTTGAAACTACCTGAGCACGTGCGGGAGTACCTCGATCGTAAGGGGAT
CTGGGAGCTCTTCCCCCCTCAGCGCGAGGCCGTCGAGAAGGGTCTGTTCGACGATGAGAACCTCTTGATCGCCGCCCCAA
CGGCCAGCGGTAAGACGCTCCTCGCGGAGATGCGCGCATTACACGAGCTCATCGAATCCCATGGGGAGACCAGAGTAGTC
TACGTCGTGCCCTTCCGGGCTCTGGCGAGGGAGAAATACGAGGAACTCACGAACGTCATCGAGTTCTGCCGGGAAAAGGG
GCTAGAACCCACTATTGAGATCTCAACGGGCGACGTCAGACGCCCCATCCGAGAGTTGCGGCCCGGAATCACGGTGACAA
CGGCGGAGAAACTCGACGCCAGCCTGCGCTCACGACCGAGCTTAGTGGAAGAGGTGGACTTGCTGGTCTTGGACGAGGTG
CATATAGTCGGGGATCGGAACCGAGGCGCCACGTACGAGGCACTGATAGCCCTCGTCAGAACCTTCCGGGAAAAGGTTTC
GCTGCTCGCTCTATCCGCCACGGTGGGTAACGCCGAGGAGCTGGCGGACTGGCTCGACGCCACTCCCGTGATCAGCGACT
GGAGACCCGTCAAACTCGAGCATAGGATCGTGGAAGTCCCCTCCGCGTCGGAGAAAGACGCTAAGGTCCGGAAGCTGATC
CGAAAGTGCCTCCGTGAAGGTGGGCAAGCGTTAGTGTTCCTGTACTCCAGGAGGCGCGCGATGACGGAAGCCAAGAACCT
ATCTCGGACGGTGTCCGGACTGCTGTCGGAGGACGAGAAGAAGGAACTTCGGACACTCGCGGAGCGCGTCAGTGAGCTGG
GGGAGGGTGAAGAGACCGAGATCTTGGCTTACGCCGTGATGCGTGGAGTCGCTTTCCATCACGCGGGGCTCACCGCCGAG
CAGCGCGCTCTAGTGGAGGACGCGTTCCGGGAAGGCCTCCTGAAGGTTGTGGTATCGACGCCGACGCTCGCGGCGGGTGT
GAACCTGCCGGCTAGGTACGTGATCATCAAGGACTTCGGGATGCGGTTGGGAAACGAGATCAAGCCCACGAAGAACGAGT
TCAAGCAGATGGCGGGTAGGGCGGGTAGGCCGGGCTACGACGATATGGGTCTCGTGTTCGTTCTCACTACCTCAAACTGG
AAGGAGTTGGCTGAGGAGTACGTGCACTCCGAGGCGGACCCCGTCCAAAGTAGGATCTGGGTGAGCGGGCCCCAGTTGCG
GCGTTTCCTCCTGGGTCTTGTGGCAGCGGGATTCTGCCGTCAGATCGCGGACGTCATGCGGGTAGCGCTTAACACGTTCA
TGTCCTCGGTGAACATCCGCCCGGAGGACGCGGTGTTATCCTCGCTGAAGATGCTGGTAGATTGGGGGTTCTTGGAGGAG
CTGGAGGGGGAACTCACGGCGACGAAGGTGGGTCACGCCGTATCGCAAAGCTACCTGACGCCTGACTCCGCCAAGTTCCT
CCTACGATGCATGGAGGAGGTGGGTACCGAGGAGAACGTGGTGTTGCCGTCCATCACGCTCTGCCCAGACTTCCAACCGG
CCCCTATCTCCTCGAAATCACGCGAGCTGAGCACGCTGGACGCGTTCATGGGAGGGTCGCCCTCGATAGAGGCGGACGAG
GTCCTGGAACTGGCCGTCGAAGAGTTCGGCTATGATGACTGGGAACTCGAGCGCAGGTTGGCCTGGGCGGAAGCGTTGAG
CGATTGGGTTTCGGGGTCCCCGGACAGGAGTATCCTACGGAAATACGACCTATACCCGGGCGACCTATATAGGGCCAAGG
ACGACGCCGCGTGGATCGCTTGGGGTATGTCCAGGTTGGCCCGCGCCGCGGGGATCACGTGGCGTTCTCCGCTTCTAAGC
CGTAGGCTGGAATACGGGGTTCCGAAGGAAGCCCTCGAACTGACCGAGGTGGAAGGCGTCGGGAGGACGTTGGCGATGAG
ATTATACCGGGCGGGTTATCACTCCGTCCGGGATCTGGCCGAAGCCACTGTCCCGGAGCTGACGAGGGTGAGAGGGATAG
GAGAACAACTTGCCCGGAAAATCCTTGAGAGCGCTCGACGACTCACAGGAACCTGA

Upstream 100 bases:

>100_bases
TCGCCGAGGACCGTGGCGGTGGGATGGATGTAAGCTCGCCCCTCGATCTTCAGCCTCCTCAACGGTCGAGGGCCCCCGAC
GTGAGCCGCCGACCGCCCTA

Downstream 100 bases:

>100_bases
GCCTCCGCCCCACCTCCTTCGATACGGCCCGTTCCCATCGCATCACGTCCACGGAGCTTATCGGAAACACCTCCTCACCT
TCGCGTGGAATCCTTCGGAG

Product: superfamily II helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 711; Mature: 711

Protein sequence:

>711_residues
MYAPVRRGCSKLKLPEHVREYLDRKGIWELFPPQREAVEKGLFDDENLLIAAPTASGKTLLAEMRALHELIESHGETRVV
YVVPFRALAREKYEELTNVIEFCREKGLEPTIEISTGDVRRPIRELRPGITVTTAEKLDASLRSRPSLVEEVDLLVLDEV
HIVGDRNRGATYEALIALVRTFREKVSLLALSATVGNAEELADWLDATPVISDWRPVKLEHRIVEVPSASEKDAKVRKLI
RKCLREGGQALVFLYSRRRAMTEAKNLSRTVSGLLSEDEKKELRTLAERVSELGEGEETEILAYAVMRGVAFHHAGLTAE
QRALVEDAFREGLLKVVVSTPTLAAGVNLPARYVIIKDFGMRLGNEIKPTKNEFKQMAGRAGRPGYDDMGLVFVLTTSNW
KELAEEYVHSEADPVQSRIWVSGPQLRRFLLGLVAAGFCRQIADVMRVALNTFMSSVNIRPEDAVLSSLKMLVDWGFLEE
LEGELTATKVGHAVSQSYLTPDSAKFLLRCMEEVGTEENVVLPSITLCPDFQPAPISSKSRELSTLDAFMGGSPSIEADE
VLELAVEEFGYDDWELERRLAWAEALSDWVSGSPDRSILRKYDLYPGDLYRAKDDAAWIAWGMSRLARAAGITWRSPLLS
RRLEYGVPKEALELTEVEGVGRTLAMRLYRAGYHSVRDLAEATVPELTRVRGIGEQLARKILESARRLTGT

Sequences:

>Translated_711_residues
MYAPVRRGCSKLKLPEHVREYLDRKGIWELFPPQREAVEKGLFDDENLLIAAPTASGKTLLAEMRALHELIESHGETRVV
YVVPFRALAREKYEELTNVIEFCREKGLEPTIEISTGDVRRPIRELRPGITVTTAEKLDASLRSRPSLVEEVDLLVLDEV
HIVGDRNRGATYEALIALVRTFREKVSLLALSATVGNAEELADWLDATPVISDWRPVKLEHRIVEVPSASEKDAKVRKLI
RKCLREGGQALVFLYSRRRAMTEAKNLSRTVSGLLSEDEKKELRTLAERVSELGEGEETEILAYAVMRGVAFHHAGLTAE
QRALVEDAFREGLLKVVVSTPTLAAGVNLPARYVIIKDFGMRLGNEIKPTKNEFKQMAGRAGRPGYDDMGLVFVLTTSNW
KELAEEYVHSEADPVQSRIWVSGPQLRRFLLGLVAAGFCRQIADVMRVALNTFMSSVNIRPEDAVLSSLKMLVDWGFLEE
LEGELTATKVGHAVSQSYLTPDSAKFLLRCMEEVGTEENVVLPSITLCPDFQPAPISSKSRELSTLDAFMGGSPSIEADE
VLELAVEEFGYDDWELERRLAWAEALSDWVSGSPDRSILRKYDLYPGDLYRAKDDAAWIAWGMSRLARAAGITWRSPLLS
RRLEYGVPKEALELTEVEGVGRTLAMRLYRAGYHSVRDLAEATVPELTRVRGIGEQLARKILESARRLTGT
>Mature_711_residues
MYAPVRRGCSKLKLPEHVREYLDRKGIWELFPPQREAVEKGLFDDENLLIAAPTASGKTLLAEMRALHELIESHGETRVV
YVVPFRALAREKYEELTNVIEFCREKGLEPTIEISTGDVRRPIRELRPGITVTTAEKLDASLRSRPSLVEEVDLLVLDEV
HIVGDRNRGATYEALIALVRTFREKVSLLALSATVGNAEELADWLDATPVISDWRPVKLEHRIVEVPSASEKDAKVRKLI
RKCLREGGQALVFLYSRRRAMTEAKNLSRTVSGLLSEDEKKELRTLAERVSELGEGEETEILAYAVMRGVAFHHAGLTAE
QRALVEDAFREGLLKVVVSTPTLAAGVNLPARYVIIKDFGMRLGNEIKPTKNEFKQMAGRAGRPGYDDMGLVFVLTTSNW
KELAEEYVHSEADPVQSRIWVSGPQLRRFLLGLVAAGFCRQIADVMRVALNTFMSSVNIRPEDAVLSSLKMLVDWGFLEE
LEGELTATKVGHAVSQSYLTPDSAKFLLRCMEEVGTEENVVLPSITLCPDFQPAPISSKSRELSTLDAFMGGSPSIEADE
VLELAVEEFGYDDWELERRLAWAEALSDWVSGSPDRSILRKYDLYPGDLYRAKDDAAWIAWGMSRLARAAGITWRSPLLS
RRLEYGVPKEALELTEVEGVGRTLAMRLYRAGYHSVRDLAEATVPELTRVRGIGEQLARKILESARRLTGT

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI139394648, Length=778, Percent_Identity=26.6066838046273, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI110556640, Length=776, Percent_Identity=25.5154639175258, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI76880486, Length=415, Percent_Identity=31.0843373493976, Blast_Score=156, Evalue=8e-38,
Organism=Homo sapiens, GI130484567, Length=416, Percent_Identity=30.5288461538462, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI169218225, Length=444, Percent_Identity=33.1081081081081, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI40217847, Length=444, Percent_Identity=32.8828828828829, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI67782311, Length=509, Percent_Identity=26.7190569744597, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI193211480, Length=444, Percent_Identity=27.2522522522523, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI222831595, Length=113, Percent_Identity=38.0530973451327, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1787942, Length=359, Percent_Identity=28.133704735376, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71995032, Length=771, Percent_Identity=26.1997405966278, Blast_Score=168, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17537519, Length=566, Percent_Identity=28.0918727915194, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI86563272, Length=531, Percent_Identity=28.8135593220339, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17537127, Length=413, Percent_Identity=32.4455205811138, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17542826, Length=451, Percent_Identity=27.9379157427938, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71995036, Length=450, Percent_Identity=27.3333333333333, Blast_Score=102, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI133930973, Length=244, Percent_Identity=28.6885245901639, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17552356, Length=100, Percent_Identity=41, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321020, Length=424, Percent_Identity=31.6037735849057, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI9755332, Length=399, Percent_Identity=30.0751879699248, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6321710, Length=424, Percent_Identity=26.8867924528302, Blast_Score=143, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322411, Length=474, Percent_Identity=27.0042194092827, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323430, Length=205, Percent_Identity=31.219512195122, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17933644, Length=774, Percent_Identity=25.5813953488372, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24660651, Length=485, Percent_Identity=29.8969072164948, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24647182, Length=554, Percent_Identity=27.6173285198556, Blast_Score=156, Evalue=6e-38,
Organism=Drosophila melanogaster, GI28574898, Length=455, Percent_Identity=32.0879120879121, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17864608, Length=454, Percent_Identity=26.6519823788546, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17933658, Length=99, Percent_Identity=41.4141414141414, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR010995
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR003583 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: 3.6.1.-

Molecular weight: Translated: 79589; Mature: 79589

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYAPVRRGCSKLKLPEHVREYLDRKGIWELFPPQREAVEKGLFDDENLLIAAPTASGKTL
CCCCHHHCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCCHHH
LAEMRALHELIESHGETRVVYVVPFRALAREKYEELTNVIEFCREKGLEPTIEISTGDVR
HHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
RPIRELRPGITVTTAEKLDASLRSRPSLVEEVDLLVLDEVHIVGDRNRGATYEALIALVR
HHHHHHCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHEECEEEECCCCCCCHHHHHHHHHH
TFREKVSLLALSATVGNAEELADWLDATPVISDWRPVKLEHRIVEVPSASEKDAKVRKLI
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCEEHHHEEECCCCCCCHHHHHHHH
RKCLREGGQALVFLYSRRRAMTEAKNLSRTVSGLLSEDEKKELRTLAERVSELGEGEETE
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
ILAYAVMRGVAFHHAGLTAEQRALVEDAFREGLLKVVVSTPTLAAGVNLPARYVIIKDFG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEHHH
MRLGNEIKPTKNEFKQMAGRAGRPGYDDMGLVFVLTTSNWKELAEEYVHSEADPVQSRIW
HHCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHEE
VSGPQLRRFLLGLVAAGFCRQIADVMRVALNTFMSSVNIRPEDAVLSSLKMLVDWGFLEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LEGELTATKVGHAVSQSYLTPDSAKFLLRCMEEVGTEENVVLPSITLCPDFQPAPISSKS
HCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCEEEECCCCCCCCCCCCC
RELSTLDAFMGGSPSIEADEVLELAVEEFGYDDWELERRLAWAEALSDWVSGSPDRSILR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KYDLYPGDLYRAKDDAAWIAWGMSRLARAAGITWRSPLLSRRLEYGVPKEALELTEVEGV
HHCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
GRTLAMRLYRAGYHSVRDLAEATVPELTRVRGIGEQLARKILESARRLTGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYAPVRRGCSKLKLPEHVREYLDRKGIWELFPPQREAVEKGLFDDENLLIAAPTASGKTL
CCCCHHHCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCCHHH
LAEMRALHELIESHGETRVVYVVPFRALAREKYEELTNVIEFCREKGLEPTIEISTGDVR
HHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
RPIRELRPGITVTTAEKLDASLRSRPSLVEEVDLLVLDEVHIVGDRNRGATYEALIALVR
HHHHHHCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHEECEEEECCCCCCCHHHHHHHHHH
TFREKVSLLALSATVGNAEELADWLDATPVISDWRPVKLEHRIVEVPSASEKDAKVRKLI
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCEEHHHEEECCCCCCCHHHHHHHH
RKCLREGGQALVFLYSRRRAMTEAKNLSRTVSGLLSEDEKKELRTLAERVSELGEGEETE
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHH
ILAYAVMRGVAFHHAGLTAEQRALVEDAFREGLLKVVVSTPTLAAGVNLPARYVIIKDFG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEHHH
MRLGNEIKPTKNEFKQMAGRAGRPGYDDMGLVFVLTTSNWKELAEEYVHSEADPVQSRIW
HHCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHEE
VSGPQLRRFLLGLVAAGFCRQIADVMRVALNTFMSSVNIRPEDAVLSSLKMLVDWGFLEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LEGELTATKVGHAVSQSYLTPDSAKFLLRCMEEVGTEENVVLPSITLCPDFQPAPISSKS
HCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCEEEECCCCCCCCCCCCC
RELSTLDAFMGGSPSIEADEVLELAVEEFGYDDWELERRLAWAEALSDWVSGSPDRSILR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
KYDLYPGDLYRAKDDAAWIAWGMSRLARAAGITWRSPLLSRRLEYGVPKEALELTEVEGV
HHCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
GRTLAMRLYRAGYHSVRDLAEATVPELTRVRGIGEQLARKILESARRLTGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA