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The map label for this gene is hyl

Identifier: 19746528

GI number: 19746528

Start: 1330442

End: 1332136

Strand: Reverse

Name: hyl

Synonym: spyM18_1606

Alternate gene names: NA

Gene position: 1332136-1330442 (Counterclockwise)

Preceding gene: 19746529

Following gene: 19746527

Centisome position: 70.3

GC content: 42.24

Gene sequence:

>1695_bases
ATGACCATTTATCACGCCTTAAAGGATTATCAAGAAGTCATGACAAGAGGAGACTATCTTGTCCTTGACATGCCGTTGAC
ATGCCGATTTGTCGGTCGTTTTTTCCGCTTTGAAAATCAAAAAGCCCTGCTGGCAGAATTGGCAACGTCAAAGTATTTTC
AGTGGATTGAAGAAGGCCAAGCAGAGGTGACGATGAAACACTTTTTTAACCGTCAGCTGGCTAAGGATGCCTTTACCCTG
AAGGTTTCAGAAGATAAGGAAATCATTATTGAAAGCCAAAACCTTAGAGGTTTTCGTTACGCCCAAGAAGCTTTGCTTAA
AGTCATGACCTTCAAAGGGGATAAACTTTATTTGCCCATTGTTTCTGTCAAGCACAGCCCGTCATTTCCTATGCGGGGGA
TAATTGAAGGCTTTTATGGAACACCGTGGACACGAGAAGAGCGGTTAGATTGCCTACGTTTTATTGGAAATAAAAGGATG
AATACTTACATGTATGCTCCGAAAGATGATGATTACCAGCGAAAACTGTGGCGCGATCTTTATCCTGAGGATTGGGTGAC
TTATTTCAAAGAGCTACTTGCAGTAGCCAAGGAAGAAGGGATTGATTTTTGGTATATGATTAGTCCGGGACTTGATTTTG
ATTATACCAAGGAAGCTGACTATCAGTTGCTCTATCAAAAATTGCAACAACTTCTAGCGTTAGGTGTCTGTCATTTTGGG
CTTTTGCTGGATGATATTGACTACCAAATTGTAGATGCTGTTGAGAGACGATTCAAAAAGACTGCCTATGCCCAGGCCCA
CTTGGCAACTGAGGTTCATCACTTTTTAAACCAACAACATGCGGCGCCAGAATTGGTGATCTGTCCGACAGAATACGACA
ACCACCATGATTCTATCTATTTGCAAGAGCTGTCAGAAAGGATTCCTAAAGAAGTCGCCTTTTTCTGGACAGGCCCAAGC
ACGCTAGCGAGTCAAATATCGCAAGCAGATATTGAAACTATGGCAGCAGTATATCAACGGCCTATCATTATTTGGGACAA
TATTCCTGTTAATGATTATCAAAAAGATCCAGAACGTCTCTTTTTAACCCCTTTTGCTAATCGCTCGCCATTTTTATGCC
AGCCAGACTATCAGGTCAAGGGGATTGTTTCTAACCCTATGATTAGTTGGGAATTATCTAAGCTGACCTTGACAGATATG
AGCCATTATCTGTGGGATGCTAACCGTTATCAGCCTAGTCATTCTTGGCTAGAAACCTTAACAGACTATACAGAAGATAC
TGAATTAGCCCTAGCTTTACAGGCATTTGCTTGGCATAATGGCAATCGTCATCTGCACAGGGACCTTCCTTTTGAAGTGG
AAGAAGCTCTCCTGGCTAAGGATGTATCAACGTTATCAGCTTGGGTAGCTGAATTGGTCGAACGTGTCAATACCTTGAGA
AAGCTAGATAAGCCAGCGTTTCAACAAGCTATTGCTCCTTGGTTTGAACGGGTGGCCAAAGACCAAGATTTTTGGCAGGC
TATGTTAAATCAGGAGCCTCAGTTGGAAACACTCTATGCTGACTTACAAGAAGATAAACACCGTATTGGAAGTGACATTC
CAAGTCGTTACTATCGCATCTACTATCAACAGCAAGATAAACTAACAGCTAATCAAGGTCAAGTTACCCAAGCAAGACCG
GAAGACTATGCTTAG

Upstream 100 bases:

>100_bases
TGTCTTGCCAGTTACCTGTTCAAGTATTTATCAGAGAAAGTAGTCACTAAAAAAGACGTTACTAGCATGAGTTGGTTAGC
TCAGGTAAAGGAGACCAGAA

Downstream 100 bases:

>100_bases
CATACGAGCTAGAAAGGAATGATATGTTAGCATTTCCAAAAGAGTTTTGGTGGGGAGGAGCCACCTCAGGCCCTCAAAGT
GAGGGGCGTTTTGCTAAGCA

Product: hyaluronidase

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; Beta-hexosaminidase; GH84; Hexosaminidase B; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MTIYHALKDYQEVMTRGDYLVLDMPLTCRFVGRFFRFENQKALLAELATSKYFQWIEEGQAEVTMKHFFNRQLAKDAFTL
KVSEDKEIIIESQNLRGFRYAQEALLKVMTFKGDKLYLPIVSVKHSPSFPMRGIIEGFYGTPWTREERLDCLRFIGNKRM
NTYMYAPKDDDYQRKLWRDLYPEDWVTYFKELLAVAKEEGIDFWYMISPGLDFDYTKEADYQLLYQKLQQLLALGVCHFG
LLLDDIDYQIVDAVERRFKKTAYAQAHLATEVHHFLNQQHAAPELVICPTEYDNHHDSIYLQELSERIPKEVAFFWTGPS
TLASQISQADIETMAAVYQRPIIIWDNIPVNDYQKDPERLFLTPFANRSPFLCQPDYQVKGIVSNPMISWELSKLTLTDM
SHYLWDANRYQPSHSWLETLTDYTEDTELALALQAFAWHNGNRHLHRDLPFEVEEALLAKDVSTLSAWVAELVERVNTLR
KLDKPAFQQAIAPWFERVAKDQDFWQAMLNQEPQLETLYADLQEDKHRIGSDIPSRYYRIYYQQQDKLTANQGQVTQARP
EDYA

Sequences:

>Translated_564_residues
MTIYHALKDYQEVMTRGDYLVLDMPLTCRFVGRFFRFENQKALLAELATSKYFQWIEEGQAEVTMKHFFNRQLAKDAFTL
KVSEDKEIIIESQNLRGFRYAQEALLKVMTFKGDKLYLPIVSVKHSPSFPMRGIIEGFYGTPWTREERLDCLRFIGNKRM
NTYMYAPKDDDYQRKLWRDLYPEDWVTYFKELLAVAKEEGIDFWYMISPGLDFDYTKEADYQLLYQKLQQLLALGVCHFG
LLLDDIDYQIVDAVERRFKKTAYAQAHLATEVHHFLNQQHAAPELVICPTEYDNHHDSIYLQELSERIPKEVAFFWTGPS
TLASQISQADIETMAAVYQRPIIIWDNIPVNDYQKDPERLFLTPFANRSPFLCQPDYQVKGIVSNPMISWELSKLTLTDM
SHYLWDANRYQPSHSWLETLTDYTEDTELALALQAFAWHNGNRHLHRDLPFEVEEALLAKDVSTLSAWVAELVERVNTLR
KLDKPAFQQAIAPWFERVAKDQDFWQAMLNQEPQLETLYADLQEDKHRIGSDIPSRYYRIYYQQQDKLTANQGQVTQARP
EDYA
>Mature_563_residues
TIYHALKDYQEVMTRGDYLVLDMPLTCRFVGRFFRFENQKALLAELATSKYFQWIEEGQAEVTMKHFFNRQLAKDAFTLK
VSEDKEIIIESQNLRGFRYAQEALLKVMTFKGDKLYLPIVSVKHSPSFPMRGIIEGFYGTPWTREERLDCLRFIGNKRMN
TYMYAPKDDDYQRKLWRDLYPEDWVTYFKELLAVAKEEGIDFWYMISPGLDFDYTKEADYQLLYQKLQQLLALGVCHFGL
LLDDIDYQIVDAVERRFKKTAYAQAHLATEVHHFLNQQHAAPELVICPTEYDNHHDSIYLQELSERIPKEVAFFWTGPST
LASQISQADIETMAAVYQRPIIIWDNIPVNDYQKDPERLFLTPFANRSPFLCQPDYQVKGIVSNPMISWELSKLTLTDMS
HYLWDANRYQPSHSWLETLTDYTEDTELALALQAFAWHNGNRHLHRDLPFEVEEALLAKDVSTLSAWVAELVERVNTLRK
LDKPAFQQAIAPWFERVAKDQDFWQAMLNQEPQLETLYADLQEDKHRIGSDIPSRYYRIYYQQQDKLTANQGQVTQARPE
DYA

Specific function: Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 84 family [H]

Homologues:

Organism=Homo sapiens, GI11024698, Length=265, Percent_Identity=35.8490566037736, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI215490056, Length=265, Percent_Identity=35.8490566037736, Blast_Score=182, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI193211004, Length=281, Percent_Identity=33.0960854092527, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193211002, Length=281, Percent_Identity=33.0960854092527, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24648670, Length=263, Percent_Identity=36.5019011406844, Blast_Score=180, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR011496
- InterPro:   IPR017853 [H]

Pfam domain/function: PF02838 Glyco_hydro_20b; PF07555 NAGidase [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 66417; Mature: 66286

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIYHALKDYQEVMTRGDYLVLDMPLTCRFVGRFFRFENQKALLAELATSKYFQWIEEGQ
CCHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
AEVTMKHFFNRQLAKDAFTLKVSEDKEIIIESQNLRGFRYAQEALLKVMTFKGDKLYLPI
HHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEE
VSVKHSPSFPMRGIIEGFYGTPWTREERLDCLRFIGNKRMNTYMYAPKDDDYQRKLWRDL
EEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHC
YPEDWVTYFKELLAVAKEEGIDFWYMISPGLDFDYTKEADYQLLYQKLQQLLALGVCHFG
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLLDDIDYQIVDAVERRFKKTAYAQAHLATEVHHFLNQQHAAPELVICPTEYDNHHDSIY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHH
LQELSERIPKEVAFFWTGPSTLASQISQADIETMAAVYQRPIIIWDNIPVNDYQKDPERL
HHHHHHHCCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEE
FLTPFANRSPFLCQPDYQVKGIVSNPMISWELSKLTLTDMSHYLWDANRYQPSHSWLETL
EEEECCCCCCCEECCCCCEEEEECCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TDYTEDTELALALQAFAWHNGNRHLHRDLPFEVEEALLAKDVSTLSAWVAELVERVNTLR
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLDKPAFQQAIAPWFERVAKDQDFWQAMLNQEPQLETLYADLQEDKHRIGSDIPSRYYRI
HHCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHEE
YYQQQDKLTANQGQVTQARPEDYA
EEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TIYHALKDYQEVMTRGDYLVLDMPLTCRFVGRFFRFENQKALLAELATSKYFQWIEEGQ
CHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
AEVTMKHFFNRQLAKDAFTLKVSEDKEIIIESQNLRGFRYAQEALLKVMTFKGDKLYLPI
HHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEE
VSVKHSPSFPMRGIIEGFYGTPWTREERLDCLRFIGNKRMNTYMYAPKDDDYQRKLWRDL
EEECCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHC
YPEDWVTYFKELLAVAKEEGIDFWYMISPGLDFDYTKEADYQLLYQKLQQLLALGVCHFG
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLLDDIDYQIVDAVERRFKKTAYAQAHLATEVHHFLNQQHAAPELVICPTEYDNHHDSIY
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHH
LQELSERIPKEVAFFWTGPSTLASQISQADIETMAAVYQRPIIIWDNIPVNDYQKDPERL
HHHHHHHCCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEE
FLTPFANRSPFLCQPDYQVKGIVSNPMISWELSKLTLTDMSHYLWDANRYQPSHSWLETL
EEEECCCCCCCEECCCCCEEEEECCCEEEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TDYTEDTELALALQAFAWHNGNRHLHRDLPFEVEEALLAKDVSTLSAWVAELVERVNTLR
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLDKPAFQQAIAPWFERVAKDQDFWQAMLNQEPQLETLYADLQEDKHRIGSDIPSRYYRI
HHCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHEE
YYQQQDKLTANQGQVTQARPEDYA
EEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]