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The map label for this gene is mvaS2 [H]

Identifier: 19745949

GI number: 19745949

Start: 769830

End: 771005

Strand: Reverse

Name: mvaS2 [H]

Synonym: spyM18_0942

Alternate gene names: 19745949

Gene position: 771005-769830 (Counterclockwise)

Preceding gene: 19745956

Following gene: 19745948

Centisome position: 40.69

GC content: 37.59

Gene sequence:

>1176_bases
ATGACAATTGGAATTGATAAGATTGGTTTTGCAACCAGTCAATATGTCTTGAAATTGGAAGATTTAGCGCTTGCACGCCA
AGTGGATCCAGCAAAATTTAGTCAAGGGCTACTCATTGAATCTTTTAGTGTGGCACCAATCACTGAAGACATTATTACTT
TAGCTGCTTCTGCAGCAGATCAAATCTTAACTGACGAAGATCGAGCTAAGATTGATATGGTTATTTTGGCAACTGAATCG
AGTACTGATCAGTCAAAGGCATCAGCTATCTATGTACATCACTTAGTTGGTATCCAGCCTTTTGCACGTTCCTTTGAAGT
AAAACAAGCCTGCTATAGCGCAACTGCTGCTCTAGACTATGCTAAACTGCATGTGGCTTCTAAGCCAGATTCTCGTGTCC
TTGTTATTGCTAGTGATATTGCTAGATACGGTGTAGGATCTCCTGGCGAATCAACTCAAGGCTCTGGTAGTATTGCTCTT
TTGGTAACTGCTAACCCTCGTATTCTTGCTCTAAATAAAGATAATGTGGCTCAAACTAGGGATATTATGGACTTTTGGAG
GCCTAACTATAGTTTCACACCTTATGTTGATGGTATTTACTCTACCAAGCAATATCTCAATTGCTTAGAAACCACGTGGC
AAGCTTATCAGAAAAGAGAAAACCTTCAGTTATCTGATTTTGCTGCAGTTTGTTTCCATATTCCATTTCCCAAGTTAGCC
CTAAAAGGTCTAAATAACATTATGGATAACACAGTACCTCCTGAACACAGGGAAAAACTAATAGAAGCCTTTCAAGCTTC
TATTACTTATAGCAAACAAATTGGAAATATTTATACTGGCTCACTTTATCTAGGATTGTTATCTTTACTTGAAAATAGTA
AAGTATTACAATCTGGAGATAAAATTGGTTTTTTTAGCTATGGTTCCGGTGCCGTAAGTGAATTTTATTCCGGTCAGTTA
GTTGCTGGGTACGATAAAATGTTAATGACTAATCGACAAGCTTTACTGGATCAACGAACACGTCTTTCCGTTTCTAAATA
CGAAGACCTTTTCTACGAACAAGTCCAATTAGATGATAATGGTAATGCCAATTTTGACATTTACTTAACTGGAAAATTTG
CTCTAACAGCCATCAAGGAGCATCAAAGGATCTATCGTACCAATGACAAAAACTAA

Upstream 100 bases:

>100_bases
AACTATTAAAGGATAAAACAAATAACTTTATCAGTCTAATTTTGCAGTAAAATGTGATAGAATGAGTAAGACTATAAAAA
TAACTAAAAGAAGGACAAAT

Downstream 100 bases:

>100_bases
TCTTAACTGGAGCGGTTTTTCAAAGAAAACATTCGAAGAACGCCTCCAACTTATCGAAAAATTTAAACTACTTAATGCTG
AAAACTTAAATCAACTCAAA

Product: HMG-CoA synthase

Products: (S)-3-hydroxy-3-methylglutaryl-CoA; CoA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAADQILTDEDRAKIDMVILATES
STDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIAL
LVTANPRILALNKDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDFAAVCFHIPFPKLA
LKGLNNIMDNTVPPEHREKLIEAFQASITYSKQIGNIYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQL
VAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHQRIYRTNDKN

Sequences:

>Translated_391_residues
MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAADQILTDEDRAKIDMVILATES
STDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIAL
LVTANPRILALNKDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDFAAVCFHIPFPKLA
LKGLNNIMDNTVPPEHREKLIEAFQASITYSKQIGNIYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQL
VAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHQRIYRTNDKN
>Mature_390_residues
TIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAADQILTDEDRAKIDMVILATESS
TDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIALL
VTANPRILALNKDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDFAAVCFHIPFPKLAL
KGLNNIMDNTVPPEHREKLIEAFQASITYSKQIGNIYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQLV
AGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHQRIYRTNDKN

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Homo sapiens, GI148298764, Length=450, Percent_Identity=26.8888888888889, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI148298677, Length=450, Percent_Identity=26.8888888888889, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI5031751, Length=448, Percent_Identity=26.5625, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560126, Length=392, Percent_Identity=23.9795918367347, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323509, Length=377, Percent_Identity=24.6684350132626, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24654139, Length=403, Percent_Identity=27.5434243176179, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654137, Length=403, Percent_Identity=27.5434243176179, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654133, Length=403, Percent_Identity=27.5434243176179, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654135, Length=403, Percent_Identity=27.5434243176179, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17933694, Length=403, Percent_Identity=27.5434243176179, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.3.10

Molecular weight: Translated: 43395; Mature: 43263

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAAD
CEECCCCCCCCCHHHHEEHHHHHHHHCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
QILTDEDRAKIDMVILATESSTDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDY
HHCCCCCCCEEEEEEEEECCCCCCHHHHEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIALLVTANPRILALNKDNVAQTR
HEEEECCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
DIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDFAAVCFHIPFPKLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
LKGLNNIMDNTVPPEHREKLIEAFQASITYSKQIGNIYTGSLYLGLLSLLENSKVLQSGD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCHHHHCCC
KIGFFSYGSGAVSEFYSGQLVAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDN
CEEEEECCCCHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GNANFDIYLTGKFALTAIKEHQRIYRTNDKN
CCCEEEEEEECHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAAD
EECCCCCCCCCHHHHEEHHHHHHHHCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
QILTDEDRAKIDMVILATESSTDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDY
HHCCCCCCCEEEEEEEEECCCCCCHHHHEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIALLVTANPRILALNKDNVAQTR
HEEEECCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
DIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDFAAVCFHIPFPKLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
LKGLNNIMDNTVPPEHREKLIEAFQASITYSKQIGNIYTGSLYLGLLSLLENSKVLQSGD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCHHHHCCC
KIGFFSYGSGAVSEFYSGQLVAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDN
CEEEEECCCCHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GNANFDIYLTGKFALTAIKEHQRIYRTNDKN
CCCEEEEEEECHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA; H2O; acetoacetyl-CoA

Specific reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]