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The map label for this gene is mvaS1 [H]

Identifier: 19745948

GI number: 19745948

Start: 768566

End: 769843

Strand: Reverse

Name: mvaS1 [H]

Synonym: spyM18_0941

Alternate gene names: 19745948

Gene position: 769843-768566 (Counterclockwise)

Preceding gene: 19745949

Following gene: 19745940

Centisome position: 40.62

GC content: 40.3

Gene sequence:

>1278_bases
ATGACAAAAACTAATCTTAACTGGAGCGGTTTTTCAAAGAAAACATTCGAAGAACGCCTCCAACTTATCGAAAAATTTAA
ACTACTTAATGCTGAAAACTTAAATCAACTCAAAACAGACGTTCTTTTGCCTATCCAAACAGCTAATCAAATGACTGAAA
ACGTCTTAGGACGATTGGCTTTGCCCTTTAGCATAGCTCCTGATTTTCTTGTCAACGGCTCAACTTATCAGATGCCTTTT
GTCACGGAAGAACCTTCTGTTGTTGCTGCAGCATCTTTCGCAGCAAAACTAATCAAACGCTCAGGTGGTTTTAAAGCTCA
AACCCTAAACCGACAAATGATTGGTCAAATTGTTCTTTACGATATCGACCAAATAGATAACGCTAAAGCCGCCATCCTTC
ATAAAACAAAAAAGCTAATTGCATTGGCAAATAAAGCTTATCCTTCCATTGTTAAAAGAGGTGGAGGCGCTAGAACCATT
CATTTGGAAGAAAAAGGAGAGTTTTTGATTTTCTATCTGACTGTTGATACCCAAGAAGCTATGGGAGCAAATATGGTCAA
TACTATGATGGAAGCTCTTGTTCCTGATTTAACAAGACTGTCTAAGGGGCATTGTCTAATGGCGATTTTATCTAATTACG
CAACAGAGTCGCTTGTTACTACTAGTTGTGAGATTCCCGTGCGCCTTTTAGATCGCGATAAAACAAAATCCCTACAGTTA
GCTCAAAAAATAGAGCTAGCCAGCCGACTAGCTCAAGTAGATCCTTACCGGGCTGCTACTCATAATAAAGGTATTTTTAA
TGGTATTGATGCAGTGGTAATAGCCACAGGAAATGACTGGCGTGCTATTGAAGCAGGGGCCCATGCTTATGCCTCAAGAA
ATGGTAGCTATCAAGGACTTAGTCAGTGGCATTTTGACCAAGATAAACAAGTTCTGCTTGGCCAAATGACCCTCCCTATG
CCTATTGCTAGTAAGGGGGGATCTATCGGGCTTAACCCTACTGTTTCTATCGCACATGATCTTCTTAATCAACCTGATGC
CAAAACATTAGCCCAATTGATTGCATCTGTGGGGTTAGCTCAAAACTTTGCTGCACTAAAAGCTCTGACCTCATCTGGCA
TCCAAGCTGGTCACATGAAACTACATGCGAAATCATTAGCTCTTTTGGCGGGGGCAACCCAAGACGAAATTGCTCCTTTA
GTTAATGCTTTACTAGCTGATAAACCAATAAATCTAGAAAAAGCACATTTTTACTTATCTCAGCTAAGACAGTCTTAG

Upstream 100 bases:

>100_bases
GTCCAATTAGATGATAATGGTAATGCCAATTTTGACATTTACTTAACTGGAAAATTTGCTCTAACAGCCATCAAGGAGCA
TCAAAGGATCTATCGTACCA

Downstream 100 bases:

>100_bases
ATTTAAACAACTAATATAAGGCAATCACCCATGTAAACAATTGGTTTACATGGGTGTTTAATCTTTGTTTCTATACATAC
AAGTCTTAGAAATAGTCTCC

Product: HMG-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTKTNLNWSGFSKKTFEERLQLIEKFKLLNAENLNQLKTDVLLPIQTANQMTENVLGRLALPFSIAPDFLVNGSTYQMPF
VTEEPSVVAAASFAAKLIKRSGGFKAQTLNRQMIGQIVLYDIDQIDNAKAAILHKTKKLIALANKAYPSIVKRGGGARTI
HLEEKGEFLIFYLTVDTQEAMGANMVNTMMEALVPDLTRLSKGHCLMAILSNYATESLVTTSCEIPVRLLDRDKTKSLQL
AQKIELASRLAQVDPYRAATHNKGIFNGIDAVVIATGNDWRAIEAGAHAYASRNGSYQGLSQWHFDQDKQVLLGQMTLPM
PIASKGGSIGLNPTVSIAHDLLNQPDAKTLAQLIASVGLAQNFAALKALTSSGIQAGHMKLHAKSLALLAGATQDEIAPL
VNALLADKPINLEKAHFYLSQLRQS

Sequences:

>Translated_425_residues
MTKTNLNWSGFSKKTFEERLQLIEKFKLLNAENLNQLKTDVLLPIQTANQMTENVLGRLALPFSIAPDFLVNGSTYQMPF
VTEEPSVVAAASFAAKLIKRSGGFKAQTLNRQMIGQIVLYDIDQIDNAKAAILHKTKKLIALANKAYPSIVKRGGGARTI
HLEEKGEFLIFYLTVDTQEAMGANMVNTMMEALVPDLTRLSKGHCLMAILSNYATESLVTTSCEIPVRLLDRDKTKSLQL
AQKIELASRLAQVDPYRAATHNKGIFNGIDAVVIATGNDWRAIEAGAHAYASRNGSYQGLSQWHFDQDKQVLLGQMTLPM
PIASKGGSIGLNPTVSIAHDLLNQPDAKTLAQLIASVGLAQNFAALKALTSSGIQAGHMKLHAKSLALLAGATQDEIAPL
VNALLADKPINLEKAHFYLSQLRQS
>Mature_424_residues
TKTNLNWSGFSKKTFEERLQLIEKFKLLNAENLNQLKTDVLLPIQTANQMTENVLGRLALPFSIAPDFLVNGSTYQMPFV
TEEPSVVAAASFAAKLIKRSGGFKAQTLNRQMIGQIVLYDIDQIDNAKAAILHKTKKLIALANKAYPSIVKRGGGARTIH
LEEKGEFLIFYLTVDTQEAMGANMVNTMMEALVPDLTRLSKGHCLMAILSNYATESLVTTSCEIPVRLLDRDKTKSLQLA
QKIELASRLAQVDPYRAATHNKGIFNGIDAVVIATGNDWRAIEAGAHAYASRNGSYQGLSQWHFDQDKQVLLGQMTLPMP
IASKGGSIGLNPTVSIAHDLLNQPDAKTLAQLIASVGLAQNFAALKALTSSGIQAGHMKLHAKSLALLAGATQDEIAPLV
NALLADKPINLEKAHFYLSQLRQS

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 46289; Mature: 46158

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTNLNWSGFSKKTFEERLQLIEKFKLLNAENLNQLKTDVLLPIQTANQMTENVLGRLA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEHHHHHHHHHHHHHHC
LPFSIAPDFLVNGSTYQMPFVTEEPSVVAAASFAAKLIKRSGGFKAQTLNRQMIGQIVLY
CCCCCCCCCEECCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHEEEE
DIDQIDNAKAAILHKTKKLIALANKAYPSIVKRGGGARTIHLEEKGEFLIFYLTVDTQEA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCHHH
MGANMVNTMMEALVPDLTRLSKGHCLMAILSNYATESLVTTSCEIPVRLLDRDKTKSLQL
HCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCHHHHCCCCHHHHHH
AQKIELASRLAQVDPYRAATHNKGIFNGIDAVVIATGNDWRAIEAGAHAYASRNGSYQGL
HHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCCEEEHHCHHHHHCCCCCCCCC
SQWHFDQDKQVLLGQMTLPMPIASKGGSIGLNPTVSIAHDLLNQPDAKTLAQLIASVGLA
HHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
QNFAALKALTSSGIQAGHMKLHAKSLALLAGATQDEIAPLVNALLADKPINLEKAHFYLS
HHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
QLRQS
HHHCC
>Mature Secondary Structure 
TKTNLNWSGFSKKTFEERLQLIEKFKLLNAENLNQLKTDVLLPIQTANQMTENVLGRLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEHHHHHHHHHHHHHHC
LPFSIAPDFLVNGSTYQMPFVTEEPSVVAAASFAAKLIKRSGGFKAQTLNRQMIGQIVLY
CCCCCCCCCEECCCEEECCEECCCCCHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHEEEE
DIDQIDNAKAAILHKTKKLIALANKAYPSIVKRGGGARTIHLEEKGEFLIFYLTVDTQEA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCHHH
MGANMVNTMMEALVPDLTRLSKGHCLMAILSNYATESLVTTSCEIPVRLLDRDKTKSLQL
HCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCHHHHCCCCHHHHHH
AQKIELASRLAQVDPYRAATHNKGIFNGIDAVVIATGNDWRAIEAGAHAYASRNGSYQGL
HHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCCEEEHHCHHHHHCCCCCCCCC
SQWHFDQDKQVLLGQMTLPMPIASKGGSIGLNPTVSIAHDLLNQPDAKTLAQLIASVGLA
HHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
QNFAALKALTSSGIQAGHMKLHAKSLALLAGATQDEIAPLVNALLADKPINLEKAHFYLS
HHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
QLRQS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]