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The map label for this gene is clpC [H]

Identifier: 19745956

GI number: 19745956

Start: 775737

End: 777836

Strand: Reverse

Name: clpC [H]

Synonym: spyM18_0949

Alternate gene names: 19745956

Gene position: 777836-775737 (Counterclockwise)

Preceding gene: 19745963

Following gene: 19745949

Centisome position: 41.05

GC content: 38.62

Gene sequence:

>2100_bases
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCATCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCCGCTATTAAAAACAAGGAAATCGTATCAATTGACATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTTGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGTCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTTACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTCGCAGCAGT
AGCACGTGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGAGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGAGTCTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Upstream 100 bases:

>100_bases
TTTATTAGCAAAGGGTTTCCTATCATGTGAAATCCTAACAACGATTCTGCGACTGCTTACAAACATCTTATAGTCTATTT
TTTATTGCGAGGTAACTGAT

Downstream 100 bases:

>100_bases
TAAACTTCTTCAATTGAATAATTTTCAAAACATGAAAAAATCCGTCTTGTGACTACGTTATACACTTGACGGACTTTTTT
TTAGCGCTTTTTTAAAAATA

Product: ATP-dependent Clp proteinase (ATP-binding subunit)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEAHQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Sequences:

>Translated_699_residues
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEAHQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ
>Mature_698_residues
THFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLGT
NLTQEAHQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSLE
AGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTIL
KNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAAQ
HPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGTN
DLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLDM
SEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNTV
IIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDAK
AHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Specific function: Part Of A Stress-Induced Multi-Chaperone System, It Is Involved In The Recovery Of The Cell From Heat-Induced Damage, In Cooperation With Dnak, Dnaj And Grpe. Acts Before Dnak, In The Processing Of Protein Aggregates. Protein Binding Stimulates The Atpase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family. ClpC subfamily [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=303, Percent_Identity=34.6534653465347, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788943, Length=678, Percent_Identity=41.1504424778761, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1787109, Length=602, Percent_Identity=40.0332225913621, Blast_Score=444, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6323002, Length=708, Percent_Identity=38.2768361581921, Blast_Score=460, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320464, Length=711, Percent_Identity=37.2714486638537, Blast_Score=430, Evalue=1e-121,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR019489 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 77312; Mature: 77181

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATT
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEE
KATNSQMLTPKADSVLTQLGTNLTQEAHQGHLDPVIGRNKEIQDTAEILARRTKNNPVLV
CCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSLEAGTQYRGSFEETIQNLIQE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQ
HHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCC
RSLPDKAIDLLDMTAAHLAAQHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRI
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGTNDLERLKGISSRLKSHVIGQ
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEE
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQ
HHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
VLDDGRLTDGQGNTINFKNTVIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNS
HHCCCCEECCCCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDAKAHLIDLGYNHAMGARPLRR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCHHHHHH
IIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
THFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATT
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEE
KATNSQMLTPKADSVLTQLGTNLTQEAHQGHLDPVIGRNKEIQDTAEILARRTKNNPVLV
CCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSLEAGTQYRGSFEETIQNLIQE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQ
HHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCC
RSLPDKAIDLLDMTAAHLAAQHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRI
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGTNDLERLKGISSRLKSHVIGQ
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEE
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQ
HHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
VLDDGRLTDGQGNTINFKNTVIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNS
HHCCCCEECCCCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDAKAHLIDLGYNHAMGARPLRR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCHHHHHH
IIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA