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The map label for this gene is aroE

Identifier: 18978065

GI number: 18978065

Start: 1572989

End: 1573804

Strand: Direct

Name: aroE

Synonym: PF1693

Alternate gene names: 18978065

Gene position: 1572989-1573804 (Clockwise)

Preceding gene: 18978064

Following gene: 18978066

Centisome position: 82.43

GC content: 40.81

Gene sequence:

>816_bases
ATGATAAACGGAGAAACAAAAATTTATGGAATAATTGGCAATCCAGTAAAACACTCCTTGAGCCCAATAATGCACAACGC
CCTATTCAAAAAATTTGGAATAAATGCCATTTACGTCCCATTCGAAGTGAAAAAAGATCTAAAGAATGCAATAAACGGTG
TTAAGGCACTTGACATTCAGGGAGTAAACGTTACAATGCCCTACAAAGAAGAAGTTATAAAATTCCTTGATGAGCTCTCC
GAAGACTCTCAAAATATAGGAAGCGTAAACACTGTTGTGAACCTTGAAGGAAAGCTAGTGGGGTATACAACGGATGGAAT
AGGAGCCAGAAGAGCATTGGAGCGATTTACTCAGGTAGATGGGGCCAACATTTTAATTCTAGGAGCAGGAGGTGCTGGAA
AAGCAATTGCATATGAACTCTCAAAAGTTGCAAATGTCGTAGTCTTAAACAGAACCATAGAGAAAGCCAAGAGGTTAGAA
AAGTTTGGAATAGTGGGAGACTCCCTAGAAGCCCTCCCATATTATGTCGAGTGGGCAGATATACTGATTAATGCAACCTC
AGTTGGAATGAATGAAGAAAAAAGTCTAGTACCAAAGAATCTCCTAAGACCTGGGCTAGTTGTTATGGATATAGTCTACA
AACCACTAAACACCCTACTTCTTAGATATGCTCAGGAAAAGGGATGTATAGCTATTGATGGACTTTGGATGCTAGTCTAT
CAAGGAGCAGAGAGTTTTAGACTTTGGACTGGAGAGGAGGGAGACGTAGAACTTATGAGGAGGGTCGCCCTTGCGTGGCT
TAGGGAAAGGAAGTAG

Upstream 100 bases:

>100_bases
ACTCTCCTTTTACGTATGTTAGCATTGACAATAGCGTAGCTCCTGGACAATTTACAGTTGGAGAGATGAGAAAAATCCTA
GAATTGCTAGGTGAGACAAA

Downstream 100 bases:

>100_bases
TGCAATAACTGTCGTTAATGCTTTTGCAACTGGAAAAGGCGGAGCTATTGGAATAGACCTATGGACTGAGGCCAAGGTAA
AGATAACAGACGGAGAAGTT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MINGETKIYGIIGNPVKHSLSPIMHNALFKKFGINAIYVPFEVKKDLKNAINGVKALDIQGVNVTMPYKEEVIKFLDELS
EDSQNIGSVNTVVNLEGKLVGYTTDGIGARRALERFTQVDGANILILGAGGAGKAIAYELSKVANVVVLNRTIEKAKRLE
KFGIVGDSLEALPYYVEWADILINATSVGMNEEKSLVPKNLLRPGLVVMDIVYKPLNTLLLRYAQEKGCIAIDGLWMLVY
QGAESFRLWTGEEGDVELMRRVALAWLRERK

Sequences:

>Translated_271_residues
MINGETKIYGIIGNPVKHSLSPIMHNALFKKFGINAIYVPFEVKKDLKNAINGVKALDIQGVNVTMPYKEEVIKFLDELS
EDSQNIGSVNTVVNLEGKLVGYTTDGIGARRALERFTQVDGANILILGAGGAGKAIAYELSKVANVVVLNRTIEKAKRLE
KFGIVGDSLEALPYYVEWADILINATSVGMNEEKSLVPKNLLRPGLVVMDIVYKPLNTLLLRYAQEKGCIAIDGLWMLVY
QGAESFRLWTGEEGDVELMRRVALAWLRERK
>Mature_271_residues
MINGETKIYGIIGNPVKHSLSPIMHNALFKKFGINAIYVPFEVKKDLKNAINGVKALDIQGVNVTMPYKEEVIKFLDELS
EDSQNIGSVNTVVNLEGKLVGYTTDGIGARRALERFTQVDGANILILGAGGAGKAIAYELSKVANVVVLNRTIEKAKRLE
KFGIVGDSLEALPYYVEWADILINATSVGMNEEKSLVPKNLLRPGLVVMDIVYKPLNTLLLRYAQEKGCIAIDGLWMLVY
QGAESFRLWTGEEGDVELMRRVALAWLRERK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=281, Percent_Identity=38.0782918149466, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI1789675, Length=262, Percent_Identity=35.8778625954198, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320332, Length=280, Percent_Identity=30.7142857142857, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_PYRFU (Q8U0A6)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579422.1
- ProteinModelPortal:   Q8U0A6
- SMR:   Q8U0A6
- EnsemblBacteria:   EBPYRT00000004317
- GeneID:   1469570
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1693
- NMPDR:   fig|186497.1.peg.1741
- GeneTree:   EBGT00050000022681
- HOGENOM:   HBG553408
- OMA:   SIYIDAT
- ProtClustDB:   PRK00258
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29997; Mature: 29997

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: ACT_SITE 69-69

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINGETKIYGIIGNPVKHSLSPIMHNALFKKFGINAIYVPFEVKKDLKNAINGVKALDIQ
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCEEEEEC
GVNVTMPYKEEVIKFLDELSEDSQNIGSVNTVVNLEGKLVGYTTDGIGARRALERFTQVD
CCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCHHHHHHHHHHHHCC
GANILILGAGGAGKAIAYELSKVANVVVLNRTIEKAKRLEKFGIVGDSLEALPYYVEWAD
CCCEEEEECCCCCCHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCHHHHHHHEEHHH
ILINATSVGMNEEKSLVPKNLLRPGLVVMDIVYKPLNTLLLRYAQEKGCIAIDGLWMLVY
HHEEHHHCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHEEEC
QGAESFRLWTGEEGDVELMRRVALAWLRERK
CCCCCEEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MINGETKIYGIIGNPVKHSLSPIMHNALFKKFGINAIYVPFEVKKDLKNAINGVKALDIQ
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCEEEEEC
GVNVTMPYKEEVIKFLDELSEDSQNIGSVNTVVNLEGKLVGYTTDGIGARRALERFTQVD
CCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEECCCHHHHHHHHHHHHCC
GANILILGAGGAGKAIAYELSKVANVVVLNRTIEKAKRLEKFGIVGDSLEALPYYVEWAD
CCCEEEEECCCCCCHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCHHHHHHHEEHHH
ILINATSVGMNEEKSLVPKNLLRPGLVVMDIVYKPLNTLLLRYAQEKGCIAIDGLWMLVY
HHEEHHHCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHEEEC
QGAESFRLWTGEEGDVELMRRVALAWLRERK
CCCCCEEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA