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The map label for this gene is aroD

Identifier: 18978064

GI number: 18978064

Start: 1572339

End: 1572992

Strand: Direct

Name: aroD

Synonym: PF1692

Alternate gene names: 18978064

Gene position: 1572339-1572992 (Clockwise)

Preceding gene: 18978063

Following gene: 18978065

Centisome position: 82.4

GC content: 37.61

Gene sequence:

>654_bases
ATGCCTAAATTGGCCGGAGTTATAATAGCTAAAACCATTGAAGAAGCTGTAAAAAAGATAAAGCTACATGAAGCCGACCT
TTATGAGCTTAGAGTAGATTACCTGGAGAGCATGGAGAACATTGAACTCCTCTTACCTCATTCAAACAAGCTGATAGTGA
CCGTGAGGAAAGTAGAAGAGGGAGGAGCAAAACGCATTGAAGAACAAGAAAGGTTAAAATTATTTGAGAAGTTTGCAAAA
ATTAAACCTGCATATTTCGATGTTGAACTTTACTCAAATATCGTGGAGGATGTAATAAACCTCTCCTCAAAAATAGGGAG
CAAAGTAATCCTATCATACCATAACTTTTCTAAAACTCCTTCATACCAAACTCTCCAATCAATTTTGGATTCGATGATAG
AGCTTGAACCAGATATAATAAAAATCGTGACCTATGCGAGGGATTTTCGAGACAACATAGAGGTGATCAAACTCTACGAG
AACAGCGAAAATCTAATTGCGTTTTGCATGGGCGAGAAGGGAAAAATTTCAAGAATATTTAGCGCCCTCTACTCTCCTTT
TACGTATGTTAGCATTGACAATAGCGTAGCTCCTGGACAATTTACAGTTGGAGAGATGAGAAAAATCCTAGAATTGCTAG
GTGAGACAAAATGA

Upstream 100 bases:

>100_bases
TACGGAAAGATAGTTATTGTTGTTCCGGTTGAGATTGGAAAAGCCAATATTGAGGAGGTAGATGAAAAGATAATTCTACA
AGCGCTGGAGGAAGCTAAAA

Downstream 100 bases:

>100_bases
TAAACGGAGAAACAAAAATTTATGGAATAATTGGCAATCCAGTAAAACACTCCTTGAGCCCAATAATGCACAACGCCCTA
TTCAAAAAATTTGGAATAAA

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MPKLAGVIIAKTIEEAVKKIKLHEADLYELRVDYLESMENIELLLPHSNKLIVTVRKVEEGGAKRIEEQERLKLFEKFAK
IKPAYFDVELYSNIVEDVINLSSKIGSKVILSYHNFSKTPSYQTLQSILDSMIELEPDIIKIVTYARDFRDNIEVIKLYE
NSENLIAFCMGEKGKISRIFSALYSPFTYVSIDNSVAPGQFTVGEMRKILELLGETK

Sequences:

>Translated_217_residues
MPKLAGVIIAKTIEEAVKKIKLHEADLYELRVDYLESMENIELLLPHSNKLIVTVRKVEEGGAKRIEEQERLKLFEKFAK
IKPAYFDVELYSNIVEDVINLSSKIGSKVILSYHNFSKTPSYQTLQSILDSMIELEPDIIKIVTYARDFRDNIEVIKLYE
NSENLIAFCMGEKGKISRIFSALYSPFTYVSIDNSVAPGQFTVGEMRKILELLGETK
>Mature_216_residues
PKLAGVIIAKTIEEAVKKIKLHEADLYELRVDYLESMENIELLLPHSNKLIVTVRKVEEGGAKRIEEQERLKLFEKFAKI
KPAYFDVELYSNIVEDVINLSSKIGSKVILSYHNFSKTPSYQTLQSILDSMIELEPDIIKIVTYARDFRDNIEVIKLYEN
SENLIAFCMGEKGKISRIFSALYSPFTYVSIDNSVAPGQFTVGEMRKILELLGETK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=212, Percent_Identity=25.4716981132075, Blast_Score=68, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320332, Length=201, Percent_Identity=29.8507462686567, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_PYRFU (Q8U0A7)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579421.1
- ProteinModelPortal:   Q8U0A7
- SMR:   Q8U0A7
- EnsemblBacteria:   EBPYRT00000005824
- GeneID:   1469569
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1692
- NMPDR:   fig|186497.1.peg.1740
- GeneTree:   EBGT00050000022269
- HOGENOM:   HBG732926
- OMA:   SYHNFDE
- ProtClustDB:   PRK02412
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR018508
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 24830; Mature: 24699

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLAGVIIAKTIEEAVKKIKLHEADLYELRVDYLESMENIELLLPHSNKLIVTVRKVEE
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCC
GGAKRIEEQERLKLFEKFAKIKPAYFDVELYSNIVEDVINLSSKIGSKVILSYHNFSKTP
CCHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
SYQTLQSILDSMIELEPDIIKIVTYARDFRDNIEVIKLYENSENLIAFCMGEKGKISRIF
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHH
SALYSPFTYVSIDNSVAPGQFTVGEMRKILELLGETK
HHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PKLAGVIIAKTIEEAVKKIKLHEADLYELRVDYLESMENIELLLPHSNKLIVTVRKVEE
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCC
GGAKRIEEQERLKLFEKFAKIKPAYFDVELYSNIVEDVINLSSKIGSKVILSYHNFSKTP
CCHHCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
SYQTLQSILDSMIELEPDIIKIVTYARDFRDNIEVIKLYENSENLIAFCMGEKGKISRIF
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCHHHHHH
SALYSPFTYVSIDNSVAPGQFTVGEMRKILELLGETK
HHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA