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The map label for this gene is pyrD

Identifier: 18977911

GI number: 18977911

Start: 1438255

End: 1439157

Strand: Direct

Name: pyrD

Synonym: PF1539

Alternate gene names: 18977911

Gene position: 1438255-1439157 (Clockwise)

Preceding gene: 18977906

Following gene: 18977912

Centisome position: 75.37

GC content: 39.87

Gene sequence:

>903_bases
ATGAGCATAAAAATAGAGCTTTTTGGAATTACTTTCGAAAATCCGCTCATATTAGCCTCGGGAGTTGTTGACATGACACC
AGAGTTGCTAAGAAGAGCCCACAAAGAAGGAGCAGGAGGAGTAGTGACTAAATCAATCGGAATAGAACCCAGAAAAGGAT
ATGATAACCCAACTGTAGTAGAAGTCCCATGTGGATTAATAAATGCTATGGGACTACCAAACCCTGGATGGAAAGCATTT
CTTGAGGAATTTGAGAAAGAGTCATTCGATTTTCCAGTTATAGTCTCAATCTTTGGAGGGAATCCCGAAGAGTTTGCATT
CCTTGCGGAGAAACTTGAACGTGTAGGAGATGCCTTTGAATTGAACTTAAGTTGTCCCCATGCAAAAGGATATGGATTGG
AGATAGGACAAGATCCAGAAAACGTATATAGGGTTGTTAAAGCTGTTAAAGATGTTACAGATAAACCCGTAATAGCAAAA
CTAACTCCAAACACGAGTGATATAACCAAGCTGGGCCTAGCTGCAGAAAAAGCTGAAGCAGATGGAGTTTCTGCCATAAA
CACACTAAAGGCTATTGCAATTGATATCTATGCTAAAAGACCGATACTCAGCAACAAATTTGGGGGATACTCTGGCCCAG
GGATCAAACCAATAGCACTTAGAGCTGTTTATGATCTGGCTTCAAAACTAGATATTCCGATTATTGGAATCGGAGGCATA
ACTACTTGGCAAGATGCAGTAGAATTCCTATTAGCCGGAGCTTCTGCAGTTCAAATTGGAACTGCTGTTTATTTAAAAGG
ATTTTCTGTATTTAGGGAGATTGCAGAAGGGATTAGAAAATACTTGGAGGAAGAAGGATTTTCCAGTGTAAAGGAAATAA
TAGGGCTTGCCCAAAAAGTTTAA

Upstream 100 bases:

>100_bases
TTCCATTTTTAATTATCACTGACAATGATACATCACCTACTTAAGAATTAAGCGGACAAATATAAAAACCTTGCCCAGTT
TTTTCATGAGGGGATAATTA

Downstream 100 bases:

>100_bases
CATCTGCCGATCAAAAGTTCGTTAAAAGCAGAAGGATAAAGTTATAATATTAAGAGAGAACGGATAGATGGAAGCAATTT
CAGAGGTGATTTAAATGAGT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSIKIELFGITFENPLILASGVVDMTPELLRRAHKEGAGGVVTKSIGIEPRKGYDNPTVVEVPCGLINAMGLPNPGWKAF
LEEFEKESFDFPVIVSIFGGNPEEFAFLAEKLERVGDAFELNLSCPHAKGYGLEIGQDPENVYRVVKAVKDVTDKPVIAK
LTPNTSDITKLGLAAEKAEADGVSAINTLKAIAIDIYAKRPILSNKFGGYSGPGIKPIALRAVYDLASKLDIPIIGIGGI
TTWQDAVEFLLAGASAVQIGTAVYLKGFSVFREIAEGIRKYLEEEGFSSVKEIIGLAQKV

Sequences:

>Translated_300_residues
MSIKIELFGITFENPLILASGVVDMTPELLRRAHKEGAGGVVTKSIGIEPRKGYDNPTVVEVPCGLINAMGLPNPGWKAF
LEEFEKESFDFPVIVSIFGGNPEEFAFLAEKLERVGDAFELNLSCPHAKGYGLEIGQDPENVYRVVKAVKDVTDKPVIAK
LTPNTSDITKLGLAAEKAEADGVSAINTLKAIAIDIYAKRPILSNKFGGYSGPGIKPIALRAVYDLASKLDIPIIGIGGI
TTWQDAVEFLLAGASAVQIGTAVYLKGFSVFREIAEGIRKYLEEEGFSSVKEIIGLAQKV
>Mature_299_residues
SIKIELFGITFENPLILASGVVDMTPELLRRAHKEGAGGVVTKSIGIEPRKGYDNPTVVEVPCGLINAMGLPNPGWKAFL
EEFEKESFDFPVIVSIFGGNPEEFAFLAEKLERVGDAFELNLSCPHAKGYGLEIGQDPENVYRVVKAVKDVTDKPVIAKL
TPNTSDITKLGLAAEKAEADGVSAINTLKAIAIDIYAKRPILSNKFGGYSGPGIKPIALRAVYDLASKLDIPIIGIGGIT
TWQDAVEFLLAGASAVQIGTAVYLKGFSVFREIAEGIRKYLEEEGFSSVKEIIGLAQKV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=319, Percent_Identity=34.1692789968652, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI45006951, Length=325, Percent_Identity=26.7692307692308, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082059, Length=320, Percent_Identity=36.875, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1787177, Length=298, Percent_Identity=26.8456375838926, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71984108, Length=327, Percent_Identity=33.0275229357798, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17509475, Length=323, Percent_Identity=28.4829721362229, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322633, Length=308, Percent_Identity=30.8441558441558, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24640763, Length=309, Percent_Identity=35.5987055016181, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI18858217, Length=309, Percent_Identity=35.5987055016181, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281361352, Length=329, Percent_Identity=26.7477203647416, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17137316, Length=329, Percent_Identity=26.7477203647416, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PYRFU (Q8U0P6)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579268.1
- ProteinModelPortal:   Q8U0P6
- EnsemblBacteria:   EBPYRT00000004832
- GeneID:   1469415
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1539
- NMPDR:   fig|186497.1.peg.1586
- GeneTree:   EBGT00050000023023
- HOGENOM:   HBG472415
- OMA:   VTKSIGP
- ProtClustDB:   PRK07259
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_A
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32242; Mature: 32110

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKIELFGITFENPLILASGVVDMTPELLRRAHKEGAGGVVTKSIGIEPRKGYDNPTVV
CEEEEEEEEEEECCCEEEECCCHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEE
EVPCGLINAMGLPNPGWKAFLEEFEKESFDFPVIVSIFGGNPEEFAFLAEKLERVGDAFE
EECCHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEE
LNLSCPHAKGYGLEIGQDPENVYRVVKAVKDVTDKPVIAKLTPNTSDITKLGLAAEKAEA
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCC
DGVSAINTLKAIAIDIYAKRPILSNKFGGYSGPGIKPIALRAVYDLASKLDIPIIGIGGI
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
TTWQDAVEFLLAGASAVQIGTAVYLKGFSVFREIAEGIRKYLEEEGFSSVKEIIGLAQKV
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIKIELFGITFENPLILASGVVDMTPELLRRAHKEGAGGVVTKSIGIEPRKGYDNPTVV
EEEEEEEEEEECCCEEEECCCHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCEEE
EVPCGLINAMGLPNPGWKAFLEEFEKESFDFPVIVSIFGGNPEEFAFLAEKLERVGDAFE
EECCHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEE
LNLSCPHAKGYGLEIGQDPENVYRVVKAVKDVTDKPVIAKLTPNTSDITKLGLAAEKAEA
EECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCC
DGVSAINTLKAIAIDIYAKRPILSNKFGGYSGPGIKPIALRAVYDLASKLDIPIIGIGGI
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
TTWQDAVEFLLAGASAVQIGTAVYLKGFSVFREIAEGIRKYLEEEGFSSVKEIIGLAQKV
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA