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The map label for this gene is cobY [H]

Identifier: 18976672

GI number: 18976672

Start: 316044

End: 316595

Strand: Direct

Name: cobY [H]

Synonym: PF0300

Alternate gene names: 18976672

Gene position: 316044-316595 (Clockwise)

Preceding gene: 18976671

Following gene: 18976675

Centisome position: 16.56

GC content: 47.64

Gene sequence:

>552_bases
ATGATAATCATCATGGCTGGCGGGAAGTCCAGTAGGATGGGAAGGGAAAAGCCCGTTCTTAAGATAGCTGGAAAGGAGAT
GCTTCTCTGGGTTTATGAGCAGGCTGAGGCCGTTGGAGAAGTTTTGGTTGCCCTGTCAAGGCACACTCCCAGGACGAGAG
AGCTCTGTCTAAGGGAAGGGATTGAATTCGTCGATACCCCAGGGAGGGGGTATGTGAAGGATGTTCAATGGTTGCTAAGG
GAGTTTGGCCCCTTCATAAGCTTATCCTCAGATATACCCTTTGTCAAGTCCTCCGATATATATTCTCTACTTAAGGAATT
TGACGGAAAGGTGAGCTTAACTGGGGTTTTGCCTCTGGAGGTTGTCCCCAAAGACCTGACGCCATACTCTTACATGGGTT
ACGCGATAGTTGGAATTAATGGTGTTGCCAAGGAAGGAGAGAAATTCTTCGTTTTTTCAAACCCTCTCCTAGCCCTCAAT
GTGAACACTCCCAGGGAGCTAGAGCTTGCAAAGAGAGTAGCGGAAATAATTAGAGTCCGAGGAATTCGATGA

Upstream 100 bases:

>100_bases
AGATAAGCTTGGACAACTTTGGAGGACTAAATGGTGATTGCATAGGGGCCGTGGGGGAGATAACTAGGGGCGCAACGCTC
TTAATCCTGGGGGTTTGGGC

Downstream 100 bases:

>100_bases
TGTAATCTACGTCTATGCTCTCCCGAACGATCTTTGCAAATCTATTTATCTCATCCTCAATGCTCCACTCCCGAATTTTT
ATTGGTTCGAGCCCCTTCTC

Product: hypothetical protein

Products: NA

Alternate protein names: AdoCbi-P guanylyltransferase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MIIIMAGGKSSRMGREKPVLKIAGKEMLLWVYEQAEAVGEVLVALSRHTPRTRELCLREGIEFVDTPGRGYVKDVQWLLR
EFGPFISLSSDIPFVKSSDIYSLLKEFDGKVSLTGVLPLEVVPKDLTPYSYMGYAIVGINGVAKEGEKFFVFSNPLLALN
VNTPRELELAKRVAEIIRVRGIR

Sequences:

>Translated_183_residues
MIIIMAGGKSSRMGREKPVLKIAGKEMLLWVYEQAEAVGEVLVALSRHTPRTRELCLREGIEFVDTPGRGYVKDVQWLLR
EFGPFISLSSDIPFVKSSDIYSLLKEFDGKVSLTGVLPLEVVPKDLTPYSYMGYAIVGINGVAKEGEKFFVFSNPLLALN
VNTPRELELAKRVAEIIRVRGIR
>Mature_183_residues
MIIIMAGGKSSRMGREKPVLKIAGKEMLLWVYEQAEAVGEVLVALSRHTPRTRELCLREGIEFVDTPGRGYVKDVQWLLR
EFGPFISLSSDIPFVKSSDIYSLLKEFDGKVSLTGVLPLEVVPKDLTPYSYMGYAIVGINGVAKEGEKFFVFSNPLLALN
VNTPRELELAKRVAEIIRVRGIR

Specific function: Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide- phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Can not use other NTPs or GDP. Does not

COG id: COG2266

COG function: function code H; GTP:adenosylcobinamide-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005245
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.62 [H]

Molecular weight: Translated: 20458; Mature: 20458

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIIMAGGKSSRMGREKPVLKIAGKEMLLWVYEQAEAVGEVLVALSRHTPRTRELCLREG
CEEEEECCCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
IEFVDTPGRGYVKDVQWLLREFGPFISLSSDIPFVKSSDIYSLLKEFDGKVSLTGVLPLE
CCEEECCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEEEHE
VVPKDLTPYSYMGYAIVGINGVAKEGEKFFVFSNPLLALNVNTPRELELAKRVAEIIRVR
ECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHC
GIR
CCC
>Mature Secondary Structure
MIIIMAGGKSSRMGREKPVLKIAGKEMLLWVYEQAEAVGEVLVALSRHTPRTRELCLREG
CEEEEECCCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
IEFVDTPGRGYVKDVQWLLREFGPFISLSSDIPFVKSSDIYSLLKEFDGKVSLTGVLPLE
CCEEECCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEEEHE
VVPKDLTPYSYMGYAIVGINGVAKEGEKFFVFSNPLLALNVNTPRELELAKRVAEIIRVR
ECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHC
GIR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]