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The map label for this gene is 18976380

Identifier: 18976380

GI number: 18976380

Start: 8054

End: 8548

Strand: Direct

Name: 18976380

Synonym: PF0008

Alternate gene names: NA

Gene position: 8054-8548 (Clockwise)

Preceding gene: 18976379

Following gene: 18976381

Centisome position: 0.42

GC content: 46.46

Gene sequence:

>495_bases
ATGAAGATACTGTGGGCCCCATGGCGAATTGAGTACATAAGGGCACCGAAGCATGAAGGTTGCATATTCTGCGACTTTCC
CAGGGAGAACAGGGACAGGGAAAGGCTCATCCTCTACAGGGGGAAGCACGCGTTCATCATAATGAACAATTACCCATACA
ACCCAGGGCACGTTATGGTGGCTCCTTACAGGCACGTTGCTAGTGTAGAGGACCTAACCGATGAGGAGATGTTAGAAATA
ATGAAGCTCGCTGCACTTATAATGAAGGCAATAAGGAAAGTTATGAAGCCAGATGGCTTTAACCTCGGCTTCAACATAGG
GAAGGTTGCAGGGGCAGGAGTTGATGGACATGTTCATCTTCACATAGTTCCCAGGTGGAATGGAGATACAAACTTCATGC
CAGTAATAGCGGACACAAAAGTAATTCCTGAGTCACTGGAGCAAGCATATGAAGAGCTCAAGAAAGCTTTAGAGGAGATA
GAAAATGCTGAGTGA

Upstream 100 bases:

>100_bases
AATAAGAATCGAAAGGCGTAAATAAATGCAAGGAGCTGTATCGAGAAGCATGCCTAAATCCTTTTAAAAATAAATAATAT
TCCTAAAATCGGGTGGTGAG

Downstream 100 bases:

>100_bases
AAGAGAGCTTGAGCGATACGACAGACAGATAATGATCTTCGGCATTGAAGGACAGGAAAAGCTGAAAAAAGCCAATGTTG
CTGTTGTTGGAGTAGGAGGA

Product: hit family protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MKILWAPWRIEYIRAPKHEGCIFCDFPRENRDRERLILYRGKHAFIIMNNYPYNPGHVMVAPYRHVASVEDLTDEEMLEI
MKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVHLHIVPRWNGDTNFMPVIADTKVIPESLEQAYEELKKALEEI
ENAE

Sequences:

>Translated_164_residues
MKILWAPWRIEYIRAPKHEGCIFCDFPRENRDRERLILYRGKHAFIIMNNYPYNPGHVMVAPYRHVASVEDLTDEEMLEI
MKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVHLHIVPRWNGDTNFMPVIADTKVIPESLEQAYEELKKALEEI
ENAE
>Mature_164_residues
MKILWAPWRIEYIRAPKHEGCIFCDFPRENRDRERLILYRGKHAFIIMNNYPYNPGHVMVAPYRHVASVEDLTDEEMLEI
MKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVHLHIVPRWNGDTNFMPVIADTKVIPESLEQAYEELKKALEEI
ENAE

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320078, Length=114, Percent_Identity=30.7017543859649, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18928; Mature: 18928

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00133 CARBOXYPEPT_ZN_2 ; PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILWAPWRIEYIRAPKHEGCIFCDFPRENRDRERLILYRGKHAFIIMNNYPYNPGHVMV
CEEEECCCEEEEEECCCCCCCEEEECCCCCCCCEEEEEEECCEEEEEECCCCCCCCEEEE
APYRHVASVEDLTDEEMLEIMKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVHL
ECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEE
HIVPRWNGDTNFMPVIADTKVIPESLEQAYEELKKALEEIENAE
EEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKILWAPWRIEYIRAPKHEGCIFCDFPRENRDRERLILYRGKHAFIIMNNYPYNPGHVMV
CEEEECCCEEEEEECCCCCCCEEEECCCCCCCCEEEEEEECCEEEEEECCCCCCCCEEEE
APYRHVASVEDLTDEEMLEIMKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVHL
ECCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEE
HIVPRWNGDTNFMPVIADTKVIPESLEQAYEELKKALEEIENAE
EEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]