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The map label for this gene is cvrA [H]

Identifier: 18311577

GI number: 18311577

Start: 2973480

End: 2974913

Strand: Reverse

Name: cvrA [H]

Synonym: CPE2595

Alternate gene names: 18311577

Gene position: 2974913-2973480 (Counterclockwise)

Preceding gene: 18311578

Following gene: 18311576

Centisome position: 98.14

GC content: 27.27

Gene sequence:

>1434_bases
ATGGTTAATCTAATGATACTAAGTGGTATAGTACTACTTACATGTATAATATCTAGTAAAATTTTCTATAAATGGGGCGT
GCCTGTACTTTTAGTATTTATTATAATAGGAATGTTATTTGGATCTGATGGAATTGGTGGTATATATTTTGATAACTATA
ATATTACTTATTCTTTATCATCTATAGCGTTAGTATTTATAATGTTTTATGGTGGTTTTTGTACTGAATGGAAAAAAGCA
AGGTCTGTAGCTATACCTTCAATTATGTTATCTACACTAGGTGTTATAATAACAGCAGGGCTTACAGGATTGTTTTGTCA
TTTTGTATTAAAAACAAGTATATTTGAGGGTTTATTATTAGGATGTATTGTTGCTTCTACAGATGCTGCTTCAGTTATAT
CTATTCTTCGTTCAAGGAATTTAAAATTAAAAAATAATATTGATACATTAGTAGAGTTTGAAAGTGGTAGTAATGATCCA
ACGGCATACATGCTGACAAGTGTTATGTTAATTTTTATTACTAGTAATGAATCAGTAGGTATTGGTCTTTTAGGAATGAT
TTTTAAACAAATAGTTTTTGGAGTGACAGTAGGATTATTTCTATCAAAACTTGCAGTTTTTATATTAAGAAAAGTGGAAT
TTGAAATTGAGGGTTTATATCCTATTTTTACTATAACTGTAGCTATTTTAGCTTATTCAATAAGTGAATTCTTAGGTGGA
AATGGTTATTTAAGTGTATTTATTGCTGGTATAGTAATGGGAAATTCAAAAATACCTCATAAGAAGAGTTTGAATCATTT
TTTTGATGGATTATCATGGATAATGCAAATAATTTTATTTTTCATGTTAGGACTTTTAGCCTTTCCATCACAATTACCAA
GCATAGCATTTGAGGGAATAGCTATTTCAATATTTTTAATATTAGTAGGCAGACCTATAGCAGTCTTTACTATATTAAGT
TGGTTTAAAGTTCCAATTAAAGAGCAGATGTTTATATCTTGGGTTGGACTTAGAGGGGCAGGTTCATTAGTTTTTGCAAT
ATATGCAATTACTAAGACCTCAGCTATTGAAAATGATATTTTTCATATTATATTTTTTATAGCATTATTCTCAGTAGCAA
TTCAGGGAACGTTAATACCTTGGTTTGCAAAGAAGCTAGATTTAATATGTTATGAAGATGATAACCATGAAGATAATATG
AAAAATAATATAAAAGATTACATTTTTGAAGTTAAAGTTGGAGAAAATAATAAGATTGTAAATAAAGCTATTATGGATTC
AGAAATTCCAGATGAGATTTTAATTGTTATGATAAAAAGAGATAATAAAGTTGTTATTCCAAAAGGTTTTACAATAATTA
AGCCTAATGATACTCTTGTTTTAACAAGTAAGAATAACGAAATTATGAATAGCTTTTTAGATGAAATAAGATAA

Upstream 100 bases:

>100_bases
TCTTAAGATTTCTATATTAAGATAAACAGAGATTTAGAAATTAAGTTTATAATATAAATATGATTAGCTTGTGATTAAGA
GCTTAAGGGGGTGATTTATT

Downstream 100 bases:

>100_bases
TAAAAAATAGGATACTTTTATTTAAAAGTATCCTATTTTTTTATTAATATTTAAAGTGTGTGATGTTATAATATTATGGA
TAAAAAATAGAATTAAAAGA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MVNLMILSGIVLLTCIISSKIFYKWGVPVLLVFIIIGMLFGSDGIGGIYFDNYNITYSLSSIALVFIMFYGGFCTEWKKA
RSVAIPSIMLSTLGVIITAGLTGLFCHFVLKTSIFEGLLLGCIVASTDAASVISILRSRNLKLKNNIDTLVEFESGSNDP
TAYMLTSVMLIFITSNESVGIGLLGMIFKQIVFGVTVGLFLSKLAVFILRKVEFEIEGLYPIFTITVAILAYSISEFLGG
NGYLSVFIAGIVMGNSKIPHKKSLNHFFDGLSWIMQIILFFMLGLLAFPSQLPSIAFEGIAISIFLILVGRPIAVFTILS
WFKVPIKEQMFISWVGLRGAGSLVFAIYAITKTSAIENDIFHIIFFIALFSVAIQGTLIPWFAKKLDLICYEDDNHEDNM
KNNIKDYIFEVKVGENNKIVNKAIMDSEIPDEILIVMIKRDNKVVIPKGFTIIKPNDTLVLTSKNNEIMNSFLDEIR

Sequences:

>Translated_477_residues
MVNLMILSGIVLLTCIISSKIFYKWGVPVLLVFIIIGMLFGSDGIGGIYFDNYNITYSLSSIALVFIMFYGGFCTEWKKA
RSVAIPSIMLSTLGVIITAGLTGLFCHFVLKTSIFEGLLLGCIVASTDAASVISILRSRNLKLKNNIDTLVEFESGSNDP
TAYMLTSVMLIFITSNESVGIGLLGMIFKQIVFGVTVGLFLSKLAVFILRKVEFEIEGLYPIFTITVAILAYSISEFLGG
NGYLSVFIAGIVMGNSKIPHKKSLNHFFDGLSWIMQIILFFMLGLLAFPSQLPSIAFEGIAISIFLILVGRPIAVFTILS
WFKVPIKEQMFISWVGLRGAGSLVFAIYAITKTSAIENDIFHIIFFIALFSVAIQGTLIPWFAKKLDLICYEDDNHEDNM
KNNIKDYIFEVKVGENNKIVNKAIMDSEIPDEILIVMIKRDNKVVIPKGFTIIKPNDTLVLTSKNNEIMNSFLDEIR
>Mature_477_residues
MVNLMILSGIVLLTCIISSKIFYKWGVPVLLVFIIIGMLFGSDGIGGIYFDNYNITYSLSSIALVFIMFYGGFCTEWKKA
RSVAIPSIMLSTLGVIITAGLTGLFCHFVLKTSIFEGLLLGCIVASTDAASVISILRSRNLKLKNNIDTLVEFESGSNDP
TAYMLTSVMLIFITSNESVGIGLLGMIFKQIVFGVTVGLFLSKLAVFILRKVEFEIEGLYPIFTITVAILAYSISEFLGG
NGYLSVFIAGIVMGNSKIPHKKSLNHFFDGLSWIMQIILFFMLGLLAFPSQLPSIAFEGIAISIFLILVGRPIAVFTILS
WFKVPIKEQMFISWVGLRGAGSLVFAIYAITKTSAIENDIFHIIFFIALFSVAIQGTLIPWFAKKLDLICYEDDNHEDNM
KNNIKDYIFEVKVGENNKIVNKAIMDSEIPDEILIVMIKRDNKVVIPKGFTIIKPNDTLVLTSKNNEIMNSFLDEIR

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=481, Percent_Identity=34.5114345114345, Blast_Score=259, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71992107, Length=389, Percent_Identity=24.4215938303342, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=389, Percent_Identity=24.4215938303342, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 52948; Mature: 52948

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNLMILSGIVLLTCIISSKIFYKWGVPVLLVFIIIGMLFGSDGIGGIYFDNYNITYSLS
CEEHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEEEEHH
SIALVFIMFYGGFCTEWKKARSVAIPSIMLSTLGVIITAGLTGLFCHFVLKTSIFEGLLL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCIVASTDAASVISILRSRNLKLKNNIDTLVEFESGSNDPTAYMLTSVMLIFITSNESVG
HHHHHCCCHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCHHHHHHHHHEEEEECCCCCC
IGLLGMIFKQIVFGVTVGLFLSKLAVFILRKVEFEIEGLYPIFTITVAILAYSISEFLGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCC
NGYLSVFIAGIVMGNSKIPHKKSLNHFFDGLSWIMQIILFFMLGLLAFPSQLPSIAFEGI
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHH
AISIFLILVGRPIAVFTILSWFKVPIKEQMFISWVGLRGAGSLVFAIYAITKTSAIENDI
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHH
FHIIFFIALFSVAIQGTLIPWFAKKLDLICYEDDNHEDNMKNNIKDYIFEVKVGENNKIV
HHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHEEEEEEECCCCCHH
NKAIMDSEIPDEILIVMIKRDNKVVIPKGFTIIKPNDTLVLTSKNNEIMNSFLDEIR
HHHHHCCCCCCEEEEEEEECCCEEECCCCEEEECCCCEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MVNLMILSGIVLLTCIISSKIFYKWGVPVLLVFIIIGMLFGSDGIGGIYFDNYNITYSLS
CEEHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEEEEHH
SIALVFIMFYGGFCTEWKKARSVAIPSIMLSTLGVIITAGLTGLFCHFVLKTSIFEGLLL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCIVASTDAASVISILRSRNLKLKNNIDTLVEFESGSNDPTAYMLTSVMLIFITSNESVG
HHHHHCCCHHHHHHHHHHCCCEECCCCCCEEEECCCCCCCHHHHHHHHHEEEEECCCCCC
IGLLGMIFKQIVFGVTVGLFLSKLAVFILRKVEFEIEGLYPIFTITVAILAYSISEFLGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCC
NGYLSVFIAGIVMGNSKIPHKKSLNHFFDGLSWIMQIILFFMLGLLAFPSQLPSIAFEGI
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCHHHHHHH
AISIFLILVGRPIAVFTILSWFKVPIKEQMFISWVGLRGAGSLVFAIYAITKTSAIENDI
HHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHH
FHIIFFIALFSVAIQGTLIPWFAKKLDLICYEDDNHEDNMKNNIKDYIFEVKVGENNKIV
HHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHEEEEEEECCCCCHH
NKAIMDSEIPDEILIVMIKRDNKVVIPKGFTIIKPNDTLVLTSKNNEIMNSFLDEIR
HHHHHCCCCCCEEEEEEEECCCEEECCCCEEEECCCCEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA