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The map label for this gene is crp [C]

Identifier: 18311504

GI number: 18311504

Start: 2886992

End: 2887672

Strand: Direct

Name: crp [C]

Synonym: CPE2522

Alternate gene names: 18311504

Gene position: 2886992-2887672 (Clockwise)

Preceding gene: 18311492

Following gene: 18311507

Centisome position: 95.24

GC content: 28.63

Gene sequence:

>681_bases
ATGGATTTTAAAAAATTATCTAATATAAAAGAGTGTAGGTTATTTTCCCACTTCAGCGATCAAGATATTCAAGAATTATT
AAGCTCTGGTTTCGCTTCAGTAAAATCCTATTCAAAGGAAGACTTACTGTTTTCTGAAGGAGAATATTGTGATTTTTTAA
GTGTAGTTATAGAAGGGAAAATAGAAATTCAAAAGTTAGATTCTAACGGAAACATATTAGTGGTTGCAACCTTAAATAGA
GGAAATGTTTTTGGAGAAAATCTTCTTTTTGGAGATAGGAACTTTTACCCAATGTCTGTTGTGGCTAAAGAAAATTCTCA
AGTTTTACATATAAAAAAGGATTATATATATAAACTATGCTCTTCAAATGAAGCTTTTTTAAGAGAGTTACTTAGAATTC
TTTCAAATAAAGCTCTTAATCTAAGTTCTAAACTTAAACAAGTGACAATGAAATCTATTAGAGAAATGATTTGCAATTAC
TTATTAAAAAAATATAACAAAGAAAAATCTACAACTATAAAGTTAGAGTTTTCAAGAAAGGACTGGGCTGACAAACTTGG
AGTCCAACGTCCTTCATTGTCTAGAGAGCTTATGAAAATGAGAGATGCAGGGCTTATAGACTTTTCAAAAAACATAATAG
AAATAAAAGATTTAGAAGGGTTAAAGGGTTATTTACTTTAA

Upstream 100 bases:

>100_bases
TATTTTCACTCCTATCAATTTAAAATTCACTTAAATAGTGTAAAATATTATATATTTATATTAATATAATACTACTTATT
TTTTAAGGGTGGTGAATAAA

Downstream 100 bases:

>100_bases
ATTAAATGTTAATATTTTTGTACACTTTTTGACACATAAATGCCACATAAGAAGCTTAATATAATAATTGTAACGTAGCT
AAAACACTAATTTAATTTTA

Product: cyclic nucleotide-binding domain protein

Products: NA

Alternate protein names: Transcriptional Regulator; Crp/FNR Family Transcriptional Regulator; CRP/FNR Family Transcriptional Regulator; Transcriptional Regulatory Protein; Transcriptional Regulator Crp Family; Crp/Fnr Family Transcriptional Regulator; Transcription Regulator; Transcriptional Regulator DnrS; DnrE Protein; Regulatory Protein; Fnr-Like Transcriptional Activator; FNR Family Transcriptional Regulatory Protein; CAMP-Bindin Transcriptional Regulator; CAMP-Regulatory Protein

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MDFKKLSNIKECRLFSHFSDQDIQELLSSGFASVKSYSKEDLLFSEGEYCDFLSVVIEGKIEIQKLDSNGNILVVATLNR
GNVFGENLLFGDRNFYPMSVVAKENSQVLHIKKDYIYKLCSSNEAFLRELLRILSNKALNLSSKLKQVTMKSIREMICNY
LLKKYNKEKSTTIKLEFSRKDWADKLGVQRPSLSRELMKMRDAGLIDFSKNIIEIKDLEGLKGYLL

Sequences:

>Translated_226_residues
MDFKKLSNIKECRLFSHFSDQDIQELLSSGFASVKSYSKEDLLFSEGEYCDFLSVVIEGKIEIQKLDSNGNILVVATLNR
GNVFGENLLFGDRNFYPMSVVAKENSQVLHIKKDYIYKLCSSNEAFLRELLRILSNKALNLSSKLKQVTMKSIREMICNY
LLKKYNKEKSTTIKLEFSRKDWADKLGVQRPSLSRELMKMRDAGLIDFSKNIIEIKDLEGLKGYLL
>Mature_226_residues
MDFKKLSNIKECRLFSHFSDQDIQELLSSGFASVKSYSKEDLLFSEGEYCDFLSVVIEGKIEIQKLDSNGNILVVATLNR
GNVFGENLLFGDRNFYPMSVVAKENSQVLHIKKDYIYKLCSSNEAFLRELLRILSNKALNLSSKLKQVTMKSIREMICNY
LLKKYNKEKSTTIKLEFSRKDWADKLGVQRPSLSRELMKMRDAGLIDFSKNIIEIKDLEGLKGYLL

Specific function: This Protein Complexes With Cyclic AMP And Binds To Specific DNA Sites Near The Promoter To Regulate The Transcription Of Several Catabolite-Sensitive Operons. The Protein Induces A Severe Bend In The DNA. Acts As A Negative Regulator Of Its Own Synthesi

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 26038; Mature: 26038

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKKLSNIKECRLFSHFSDQDIQELLSSGFASVKSYSKEDLLFSEGEYCDFLSVVIEGK
CCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCC
IEIQKLDSNGNILVVATLNRGNVFGENLLFGDRNFYPMSVVAKENSQVLHIKKDYIYKLC
EEEEEECCCCCEEEEEEECCCCCCCCCEEECCCCCCEEEEEECCCCCEEEEHHHHHHHHH
SSNEAFLRELLRILSNKALNLSSKLKQVTMKSIREMICNYLLKKYNKEKSTTIKLEFSRK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCH
DWADKLGVQRPSLSRELMKMRDAGLIDFSKNIIEIKDLEGLKGYLL
HHHHHHCCCCCCHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MDFKKLSNIKECRLFSHFSDQDIQELLSSGFASVKSYSKEDLLFSEGEYCDFLSVVIEGK
CCHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHCCC
IEIQKLDSNGNILVVATLNRGNVFGENLLFGDRNFYPMSVVAKENSQVLHIKKDYIYKLC
EEEEEECCCCCEEEEEEECCCCCCCCCEEECCCCCCEEEEEECCCCCEEEEHHHHHHHHH
SSNEAFLRELLRILSNKALNLSSKLKQVTMKSIREMICNYLLKKYNKEKSTTIKLEFSRK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCH
DWADKLGVQRPSLSRELMKMRDAGLIDFSKNIIEIKDLEGLKGYLL
HHHHHHCCCCCCHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA