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The map label for this gene is thyX

Identifier: 18311407

GI number: 18311407

Start: 2772894

End: 2773631

Strand: Reverse

Name: thyX

Synonym: CPE2425

Alternate gene names: 18311407

Gene position: 2773631-2772894 (Counterclockwise)

Preceding gene: 18311408

Following gene: 18311406

Centisome position: 91.5

GC content: 32.38

Gene sequence:

>738_bases
ATGTTAAAAGTTAAATTATTACAATATACACCAGAACCAGAAAAGACCATAGCAGCAGCGGCTAAATTATGCTATAGTCC
TGTAGGTGTTGATGATATATTAGAAAATTTAACTGATGAAGGCGCGGAAAAGTTTTTAAATATGCTTATGTCATATGGTC
ATATGTCACCAATAGAGCATGTTTCATTTACTTTTGCAGTAGAAGGAGTTTCAAGAAGCTTAACTCATCAGTTAGTTAGA
CATAGAATAGCATCTTACTCACAGCAATCTCAAAGATATGTTAAGTTAGATCAATTTGAATACATAGTACCACCAGCTAT
AGAAAATGATGAAGTTGCTAAAAAGCTATTTATTGACCAAATGCAAGGTGCACAAAAAGCATATGATGAAATAGTTGAAA
GATTAAAAGATAAATATATTAGTGAAGGAATTGGTGAAAAACCAGCTGAGAAAAAAGCTATAGAGGATGCAAGATATGTT
TTTCCTAATGCTTGTGAAACAAAAATTGTATTTACTATGAATGCTAGAAGTTTAATGAACTTCTTCCATCATAGATGTTG
TGATAGAGCTCAATGGGAAATAAGAACTATGGCAGAAAAAATGGTTAATGAAGTTAAAAAGGTTGCCCCAATATTATTTA
AGAATGCAGGTCCAAGTTGTGTAGCAGGTCCATGTCCTGAAGGAAAAATGTGTTGTGGAAAGCTTAAAGAGATGAGAACA
TTATATCTTGGAAAATAG

Upstream 100 bases:

>100_bases
GGCTTTAGTAGGTTATTTATATCTTACTGGAAAAGAAGAAAGATTAAATGAGTTCTTATTGAAATGTATAGAAGTTCACG
TTTAGGAAGGAGAAATATTA

Downstream 100 bases:

>100_bases
GAATTTTTAAGGAGAGAACAAAATGACAAAGTCAGAAAATAAATATAAACAATTAACTCGTAAGCAAAAGTATGCTTTAG
AAAGAGAACAAAGAGCAAGA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLKVKLLQYTPEPEKTIAAAAKLCYSPVGVDDILENLTDEGAEKFLNMLMSYGHMSPIEHVSFTFAVEGVSRSLTHQLVR
HRIASYSQQSQRYVKLDQFEYIVPPAIENDEVAKKLFIDQMQGAQKAYDEIVERLKDKYISEGIGEKPAEKKAIEDARYV
FPNACETKIVFTMNARSLMNFFHHRCCDRAQWEIRTMAEKMVNEVKKVAPILFKNAGPSCVAGPCPEGKMCCGKLKEMRT
LYLGK

Sequences:

>Translated_245_residues
MLKVKLLQYTPEPEKTIAAAAKLCYSPVGVDDILENLTDEGAEKFLNMLMSYGHMSPIEHVSFTFAVEGVSRSLTHQLVR
HRIASYSQQSQRYVKLDQFEYIVPPAIENDEVAKKLFIDQMQGAQKAYDEIVERLKDKYISEGIGEKPAEKKAIEDARYV
FPNACETKIVFTMNARSLMNFFHHRCCDRAQWEIRTMAEKMVNEVKKVAPILFKNAGPSCVAGPCPEGKMCCGKLKEMRT
LYLGK
>Mature_245_residues
MLKVKLLQYTPEPEKTIAAAAKLCYSPVGVDDILENLTDEGAEKFLNMLMSYGHMSPIEHVSFTFAVEGVSRSLTHQLVR
HRIASYSQQSQRYVKLDQFEYIVPPAIENDEVAKKLFIDQMQGAQKAYDEIVERLKDKYISEGIGEKPAEKKAIEDARYV
FPNACETKIVFTMNARSLMNFFHHRCCDRAQWEIRTMAEKMVNEVKKVAPILFKNAGPSCVAGPCPEGKMCCGKLKEMRT
LYLGK

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_CLOPE (Q8XHQ7)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_563341.1
- ProteinModelPortal:   Q8XHQ7
- SMR:   Q8XHQ7
- GeneID:   990787
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2425
- NMPDR:   fig|195102.1.peg.2488
- HOGENOM:   HBG458114
- OMA:   TSHQLVR
- ProtClustDB:   PRK00847
- BioCyc:   CPER195102:CPE2425-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 27855; Mature: 27855

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVKLLQYTPEPEKTIAAAAKLCYSPVGVDDILENLTDEGAEKFLNMLMSYGHMSPIEH
CCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VSFTFAVEGVSRSLTHQLVRHRIASYSQQSQRYVKLDQFEYIVPPAIENDEVAKKLFIDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCHHHHHHHHHHH
MQGAQKAYDEIVERLKDKYISEGIGEKPAEKKAIEDARYVFPNACETKIVFTMNARSLMN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
FFHHRCCDRAQWEIRTMAEKMVNEVKKVAPILFKNAGPSCVAGPCPEGKMCCGKLKEMRT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
LYLGK
HHCCC
>Mature Secondary Structure
MLKVKLLQYTPEPEKTIAAAAKLCYSPVGVDDILENLTDEGAEKFLNMLMSYGHMSPIEH
CCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VSFTFAVEGVSRSLTHQLVRHRIASYSQQSQRYVKLDQFEYIVPPAIENDEVAKKLFIDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCCHHHHHHHHHHH
MQGAQKAYDEIVERLKDKYISEGIGEKPAEKKAIEDARYVFPNACETKIVFTMNARSLMN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHH
FFHHRCCDRAQWEIRTMAEKMVNEVKKVAPILFKNAGPSCVAGPCPEGKMCCGKLKEMRT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
LYLGK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842