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The map label for this gene is hisS [H]

Identifier: 18310916

GI number: 18310916

Start: 2215668

End: 2216915

Strand: Reverse

Name: hisS [H]

Synonym: CPE1934

Alternate gene names: 18310916

Gene position: 2216915-2215668 (Counterclockwise)

Preceding gene: 18310917

Following gene: 18310915

Centisome position: 73.13

GC content: 31.73

Gene sequence:

>1248_bases
ATGGCGATACAAGCTCAAAAGGGTACAAAGGATATGTTACCTAATGACGCTTATAAATGGCATTATATAGAAGAAAAGTT
AAGAAAAATATCAGCTGAATATGGAATTAGAGAGATCAGAACTCCTATGTTTGAGGCAACTGAACTTTTCAAAAGAGGAG
TTGGAGAAACTACTGACGTGGTTCAAAAGGAAATGTATACTTTTGAAGACAAAGGTGGAAGAAGTATAACTCTTAAACCA
GAGGGGACAGCTCCAGCTGTTAGAGCATTTATTGAAAATAGTTTATATGCTGATGCTCAGCCAACAAAAATGTTCTATTT
TACTCCATGTTTTAGATATGAAAAAATGCAAAAAGGAAGATTAAGAGAATTCCATCAATATGGAATAGAAGTTTTTGGTT
CACAAGAAGCTTCTATTGATGCAGAAATCTTATCTTTAGTTATGAGAGCATTAACAGAGGATTTTGGAATAAAAGGATTA
AGCTTAAATATAAACAGTTTAGGATGTCCAAAATGTAGAGCAAAATTCAATGAAGCTTTAAAACAATATTTAAAAGAGAA
CTATGATAATCTTTGTGAAACTTGTAAAACAAGATTTGAAAAGAATCCTATGAGAATCATAGACTGTAAAGAAAAGAGAT
GTAAGGAAATAGTTAAGGAAGCTCCTTCAATACTAGATTACATCTGCGAAGAGTGCAGTGATCACTTTAGCAAGTTAAAA
GCTTACTTAGATGTTATGGGAATAGAATATAACATAGATCCACAAATAGTAAGAGGATTAGATTACTATAGTAAAACTGT
TTTTGAAGTTATAAAAGATGGATTAACAGTATGTGGTGGAGGAAGATATGATTATCTAGTAGAAGAAGTAGATGGTCCTA
AAACTCCAGCTATGGGATTTGGATTAGGTTTAGAAAGACTTCTTTTAATATTAGATGAAGAAGGAATAGAAATTCCTGAG
CCTGTTAGATGCGAAGTTTATATTGGATCAATGGGAGATAGGGCTAGGCTTGAAGCTATGAAATTAGCATTTAATCTTAG
AAAATCTGGTATTAAGGCTGAAATAGATCACTTAGGAAAGAGTGTTAAGGCTCAAATGAAGTATGCTAATAAAATAGGAG
CTAAATATACTTTTGTTATAGGTGACTCTGAAATAGAAGAAAACAAAATTAAAATTAAGAGAATGAGCGATGGAGAACAA
TTCGAAGTCAGCTTAGATATAAATGAAATAGTAAATATAGTTAAGTAG

Upstream 100 bases:

>100_bases
GAATATGTAAAAAGAATAGAGGAAATGGTTGAAGGTAAGATAGAATTACTTGATACTTTATATAAATAAAAAATTTAATA
TTATGTAGGAGGAGTTGTTT

Downstream 100 bases:

>100_bases
TAGACAGGAGGAGAATTAAAATGGGTGAAGCTTTAAATGGATTAAAGCGTAACATAATGTGTGGCGACGCTAGAGAAAGC
CATATTGGACAAAAAGTAAC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MAIQAQKGTKDMLPNDAYKWHYIEEKLRKISAEYGIREIRTPMFEATELFKRGVGETTDVVQKEMYTFEDKGGRSITLKP
EGTAPAVRAFIENSLYADAQPTKMFYFTPCFRYEKMQKGRLREFHQYGIEVFGSQEASIDAEILSLVMRALTEDFGIKGL
SLNINSLGCPKCRAKFNEALKQYLKENYDNLCETCKTRFEKNPMRIIDCKEKRCKEIVKEAPSILDYICEECSDHFSKLK
AYLDVMGIEYNIDPQIVRGLDYYSKTVFEVIKDGLTVCGGGRYDYLVEEVDGPKTPAMGFGLGLERLLLILDEEGIEIPE
PVRCEVYIGSMGDRARLEAMKLAFNLRKSGIKAEIDHLGKSVKAQMKYANKIGAKYTFVIGDSEIEENKIKIKRMSDGEQ
FEVSLDINEIVNIVK

Sequences:

>Translated_415_residues
MAIQAQKGTKDMLPNDAYKWHYIEEKLRKISAEYGIREIRTPMFEATELFKRGVGETTDVVQKEMYTFEDKGGRSITLKP
EGTAPAVRAFIENSLYADAQPTKMFYFTPCFRYEKMQKGRLREFHQYGIEVFGSQEASIDAEILSLVMRALTEDFGIKGL
SLNINSLGCPKCRAKFNEALKQYLKENYDNLCETCKTRFEKNPMRIIDCKEKRCKEIVKEAPSILDYICEECSDHFSKLK
AYLDVMGIEYNIDPQIVRGLDYYSKTVFEVIKDGLTVCGGGRYDYLVEEVDGPKTPAMGFGLGLERLLLILDEEGIEIPE
PVRCEVYIGSMGDRARLEAMKLAFNLRKSGIKAEIDHLGKSVKAQMKYANKIGAKYTFVIGDSEIEENKIKIKRMSDGEQ
FEVSLDINEIVNIVK
>Mature_414_residues
AIQAQKGTKDMLPNDAYKWHYIEEKLRKISAEYGIREIRTPMFEATELFKRGVGETTDVVQKEMYTFEDKGGRSITLKPE
GTAPAVRAFIENSLYADAQPTKMFYFTPCFRYEKMQKGRLREFHQYGIEVFGSQEASIDAEILSLVMRALTEDFGIKGLS
LNINSLGCPKCRAKFNEALKQYLKENYDNLCETCKTRFEKNPMRIIDCKEKRCKEIVKEAPSILDYICEECSDHFSKLKA
YLDVMGIEYNIDPQIVRGLDYYSKTVFEVIKDGLTVCGGGRYDYLVEEVDGPKTPAMGFGLGLERLLLILDEEGIEIPEP
VRCEVYIGSMGDRARLEAMKLAFNLRKSGIKAEIDHLGKSVKAQMKYANKIGAKYTFVIGDSEIEENKIKIKRMSDGEQF
EVSLDINEIVNIVK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=460, Percent_Identity=24.3478260869565, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI15029520, Length=458, Percent_Identity=24.6724890829694, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788861, Length=411, Percent_Identity=42.8223844282238, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI71993693, Length=460, Percent_Identity=24.7826086956522, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71993686, Length=460, Percent_Identity=25, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325290, Length=469, Percent_Identity=24.5202558635394, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643061, Length=464, Percent_Identity=24.1379310344828, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24643059, Length=485, Percent_Identity=22.680412371134, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47390; Mature: 47259

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQAQKGTKDMLPNDAYKWHYIEEKLRKISAEYGIREIRTPMFEATELFKRGVGETTDV
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHCCCCCHHHH
VQKEMYTFEDKGGRSITLKPEGTAPAVRAFIENSLYADAQPTKMFYFTPCFRYEKMQKGR
HHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHH
LREFHQYGIEVFGSQEASIDAEILSLVMRALTEDFGIKGLSLNINSLGCPKCRAKFNEAL
HHHHHHHCHHEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
KQYLKENYDNLCETCKTRFEKNPMRIIDCKEKRCKEIVKEAPSILDYICEECSDHFSKLK
HHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYLDVMGIEYNIDPQIVRGLDYYSKTVFEVIKDGLTVCGGGRYDYLVEEVDGPKTPAMGF
HHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCCCCCHH
GLGLERLLLILDEEGIEIPEPVRCEVYIGSMGDRARLEAMKLAFNLRKSGIKAEIDHLGK
HHCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
SVKAQMKYANKIGAKYTFVIGDSEIEENKIKIKRMSDGEQFEVSLDINEIVNIVK
HHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEECHHHHHHHCC
>Mature Secondary Structure 
AIQAQKGTKDMLPNDAYKWHYIEEKLRKISAEYGIREIRTPMFEATELFKRGVGETTDV
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHCCCCCHHHH
VQKEMYTFEDKGGRSITLKPEGTAPAVRAFIENSLYADAQPTKMFYFTPCFRYEKMQKGR
HHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHH
LREFHQYGIEVFGSQEASIDAEILSLVMRALTEDFGIKGLSLNINSLGCPKCRAKFNEAL
HHHHHHHCHHEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
KQYLKENYDNLCETCKTRFEKNPMRIIDCKEKRCKEIVKEAPSILDYICEECSDHFSKLK
HHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYLDVMGIEYNIDPQIVRGLDYYSKTVFEVIKDGLTVCGGGRYDYLVEEVDGPKTPAMGF
HHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCCCCCHH
GLGLERLLLILDEEGIEIPEPVRCEVYIGSMGDRARLEAMKLAFNLRKSGIKAEIDHLGK
HHCHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
SVKAQMKYANKIGAKYTFVIGDSEIEENKIKIKRMSDGEQFEVSLDINEIVNIVK
HHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA