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The map label for this gene is hemZ [H]

Identifier: 18310917

GI number: 18310917

Start: 2216947

End: 2218389

Strand: Reverse

Name: hemZ [H]

Synonym: CPE1935

Alternate gene names: 18310917

Gene position: 2218389-2216947 (Counterclockwise)

Preceding gene: 18310918

Following gene: 18310916

Centisome position: 73.18

GC content: 28.48

Gene sequence:

>1443_bases
ATGTATATTAAAATATATCTTAATGACTTAAAGTATAGATATGACGTTTATCAAATGTTTAATATATTCTATACTTTTAA
GGAATTAAAGTTTGTAAATGAAGATGAAGAGAGAGACTATGATGTCTTTATATCTGAAAATATGGTTAAAATTTCAGAGG
GAGACAATAGTTTTTCTTATGAATTCAAAGAAGGATACGGATTTAAAACTGAACTTAAAAAGGGAATATTCAAATTTTTA
TCTGAAACTCTTAAGGATGAATATCCTTGGGGAACATTAGTTGGAATAAGACCAAGTAAAATAGCATTATCTCTAATAAG
AGAAGGAAAATCTGAGGAAGAGATAATAAAATATTTTGAAGATAATTATATGGCTAGGGAAGAAAAAGCTAAGCTTTGCA
TAGAAGTTGCAGAAAGAGAAGAAAGTTTTGTAAACAAAGAGGAAAAAAACATAAGTATATATGTTGGTATGCCTTTTTGT
CCTACAAGATGCCTTTATTGTTCCTTTGCAGCAAATCCTATAGCTGGATGCAAGAAAGATGTTGAGCCTTATTTAGAAGC
TTTAAGCAAAGAAATTTCAGCTATAAGTGATTATGTATCAAAGAAAGGCTTAAAGATAGAAACTGTTTATTTTGGTGGAG
GTACTCCAACATCAGTAAATAATGAACAGTTTGAAGTATTAATGAAACATATATATGATAGTTTCGTTAATAATAAAGGA
ATAAAGGAGTTCACTGTTGAATGTGGAAGACCTGATTCTATAACTGAAGAAAAATTAAAAACTATGAAGAGATATGAAGT
ATCTAGAATATCTATAAATCCTCAAAGTATGAACGATAAAACCTTGAAATCAATAGGTAGAGGGCATTTAACAGAGGATG
TAGTGGATAAATTCAATTTGGCAAGAAGCCTAGACTTTGATAACATAAATATGGATATTATAATAGGTCTTCCAAATGAA
GATATTTCAGAGGTTTCTAAAACATGCTCTATGATAAAGGGGCTTAATCCAGATAGTTTAACTATTCATGGAATGTCTAT
TAAAAGAGCATCAAGACTTCATGAAAATTTAGTTTTACATAATACTATAACTATTGCGGAGCAAAAAAATCTTAATAAGA
TGTATGAGATGAGTAAAGTTTTAGGTAGAGAACTAAATATGCATCCATATTATATGTATAGACAAAAAAATATGGTTGGT
AACATGGAGAATGTAGGATATTCAAAAGATAACAAGGAATGTATCTACAATATTCAAATGATTGAAGATAAGCAGACTAT
AATTGCATTAGGAGCAGATGCAGTTTCTAAGGTAGTATTTTTAGAAGAAGATAAAAATCGTATAGAAAGATTTGCAAATG
TTAAAGATGTAAAGGAATATGTAAAAAGAATAGAGGAAATGGTTGAAGGTAAGATAGAATTACTTGATACTTTATATAAA
TAA

Upstream 100 bases:

>100_bases
GTACCATTAGGTGATGATATAGTAGTATATCCAGGACACGGACCAAGTTCAACTATTAAACACGAAAGACAAAGAAACCC
ATTTTTAGCAGGAGATTTTT

Downstream 100 bases:

>100_bases
AAAATTTAATATTATGTAGGAGGAGTTGTTTATGGCGATACAAGCTCAAAAGGGTACAAAGGATATGTTACCTAATGACG
CTTATAAATGGCATTATATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MYIKIYLNDLKYRYDVYQMFNIFYTFKELKFVNEDEERDYDVFISENMVKISEGDNSFSYEFKEGYGFKTELKKGIFKFL
SETLKDEYPWGTLVGIRPSKIALSLIREGKSEEEIIKYFEDNYMAREEKAKLCIEVAEREESFVNKEEKNISIYVGMPFC
PTRCLYCSFAANPIAGCKKDVEPYLEALSKEISAISDYVSKKGLKIETVYFGGGTPTSVNNEQFEVLMKHIYDSFVNNKG
IKEFTVECGRPDSITEEKLKTMKRYEVSRISINPQSMNDKTLKSIGRGHLTEDVVDKFNLARSLDFDNINMDIIIGLPNE
DISEVSKTCSMIKGLNPDSLTIHGMSIKRASRLHENLVLHNTITIAEQKNLNKMYEMSKVLGRELNMHPYYMYRQKNMVG
NMENVGYSKDNKECIYNIQMIEDKQTIIALGADAVSKVVFLEEDKNRIERFANVKDVKEYVKRIEEMVEGKIELLDTLYK

Sequences:

>Translated_480_residues
MYIKIYLNDLKYRYDVYQMFNIFYTFKELKFVNEDEERDYDVFISENMVKISEGDNSFSYEFKEGYGFKTELKKGIFKFL
SETLKDEYPWGTLVGIRPSKIALSLIREGKSEEEIIKYFEDNYMAREEKAKLCIEVAEREESFVNKEEKNISIYVGMPFC
PTRCLYCSFAANPIAGCKKDVEPYLEALSKEISAISDYVSKKGLKIETVYFGGGTPTSVNNEQFEVLMKHIYDSFVNNKG
IKEFTVECGRPDSITEEKLKTMKRYEVSRISINPQSMNDKTLKSIGRGHLTEDVVDKFNLARSLDFDNINMDIIIGLPNE
DISEVSKTCSMIKGLNPDSLTIHGMSIKRASRLHENLVLHNTITIAEQKNLNKMYEMSKVLGRELNMHPYYMYRQKNMVG
NMENVGYSKDNKECIYNIQMIEDKQTIIALGADAVSKVVFLEEDKNRIERFANVKDVKEYVKRIEEMVEGKIELLDTLYK
>Mature_480_residues
MYIKIYLNDLKYRYDVYQMFNIFYTFKELKFVNEDEERDYDVFISENMVKISEGDNSFSYEFKEGYGFKTELKKGIFKFL
SETLKDEYPWGTLVGIRPSKIALSLIREGKSEEEIIKYFEDNYMAREEKAKLCIEVAEREESFVNKEEKNISIYVGMPFC
PTRCLYCSFAANPIAGCKKDVEPYLEALSKEISAISDYVSKKGLKIETVYFGGGTPTSVNNEQFEVLMKHIYDSFVNNKG
IKEFTVECGRPDSITEEKLKTMKRYEVSRISINPQSMNDKTLKSIGRGHLTEDVVDKFNLARSLDFDNINMDIIIGLPNE
DISEVSKTCSMIKGLNPDSLTIHGMSIKRASRLHENLVLHNTITIAEQKNLNKMYEMSKVLGRELNMHPYYMYRQKNMVG
NMENVGYSKDNKECIYNIQMIEDKQTIIALGADAVSKVVFLEEDKNRIERFANVKDVKEYVKRIEEMVEGKIELLDTLYK

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=246, Percent_Identity=23.5772357723577, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789325, Length=312, Percent_Identity=23.0769230769231, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082341, Length=214, Percent_Identity=28.9719626168224, Blast_Score=93, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 55760; Mature: 55760

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIKIYLNDLKYRYDVYQMFNIFYTFKELKFVNEDEERDYDVFISENMVKISEGDNSFSY
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCEEE
EFKEGYGFKTELKKGIFKFLSETLKDEYPWGTLVGIRPSKIALSLIREGKSEEEIIKYFE
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHH
DNYMAREEKAKLCIEVAEREESFVNKEEKNISIYVGMPFCPTRCLYCSFAANPIAGCKKD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHEEEECCCCCCCCCHHH
VEPYLEALSKEISAISDYVSKKGLKIETVYFGGGTPTSVNNEQFEVLMKHIYDSFVNNKG
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IKEFTVECGRPDSITEEKLKTMKRYEVSRISINPQSMNDKTLKSIGRGHLTEDVVDKFNL
CHHHEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHH
ARSLDFDNINMDIIIGLPNEDISEVSKTCSMIKGLNPDSLTIHGMSIKRASRLHENLVLH
HHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHEEEE
NTITIAEQKNLNKMYEMSKVLGRELNMHPYYMYRQKNMVGNMENVGYSKDNKECIYNIQM
EEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCCCCCCCCCEEEEEEE
IEDKQTIIALGADAVSKVVFLEEDKNRIERFANVKDVKEYVKRIEEMVEGKIELLDTLYK
EECCCEEEEECHHHHHHEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYIKIYLNDLKYRYDVYQMFNIFYTFKELKFVNEDEERDYDVFISENMVKISEGDNSFSY
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCCCCEEE
EFKEGYGFKTELKKGIFKFLSETLKDEYPWGTLVGIRPSKIALSLIREGKSEEEIIKYFE
ECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCHHHHHHHHH
DNYMAREEKAKLCIEVAEREESFVNKEEKNISIYVGMPFCPTRCLYCSFAANPIAGCKKD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHEEEECCCCCCCCCHHH
VEPYLEALSKEISAISDYVSKKGLKIETVYFGGGTPTSVNNEQFEVLMKHIYDSFVNNKG
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
IKEFTVECGRPDSITEEKLKTMKRYEVSRISINPQSMNDKTLKSIGRGHLTEDVVDKFNL
CHHHEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHH
ARSLDFDNINMDIIIGLPNEDISEVSKTCSMIKGLNPDSLTIHGMSIKRASRLHENLVLH
HHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHEEEE
NTITIAEQKNLNKMYEMSKVLGRELNMHPYYMYRQKNMVGNMENVGYSKDNKECIYNIQM
EEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHCCCCCCCCCEEEEEEE
IEDKQTIIALGADAVSKVVFLEEDKNRIERFANVKDVKEYVKRIEEMVEGKIELLDTLYK
EECCCEEEEECHHHHHHEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]