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The map label for this gene is phoR [H]

Identifier: 18310908

GI number: 18310908

Start: 2206684

End: 2208207

Strand: Direct

Name: phoR [H]

Synonym: CPE1926

Alternate gene names: 18310908

Gene position: 2206684-2208207 (Clockwise)

Preceding gene: 18310907

Following gene: 18310912

Centisome position: 72.79

GC content: 27.62

Gene sequence:

>1524_bases
GTGAAAAAAAGTATTTCAAAAAGATTATTTATAATAACTTTTGGTATAATAATATTCTTAACCTTGTTTACAATGATATT
CCAAATTACATTTTTCCAAGAATTTTATTATAAAAGAAAAAGTAATGATTTAAGCAATGCAGTTTTAAAGTTTAGAGCTC
TATATTCTTATGACATAAAAAATACAGACTCTTTATATAGGGCTTTAAGCCTTTTTGAACTTGAAAATAACGCTAAAATA
GGAATTTATTCCATAGATAGTACACCAAAATATGTTCCTGATCCAGCTAATAAAAACTCAGAGGCTGTAGATTTATTAAA
CGATATTTTTAATGAGTTATATAGTGACCAAGATTTTGCAAAAACCTTATTAAATTCAAATTCTGGAGTAACTACAGAAT
TTAAAAGCAGAAAATACTCAACAAAATATATTGTTTATATGGTGCCATTTTCTCTTAATTCTAAGAACGATTCTATTATT
ATAGCCATAACATCATTCCAAGCAATTGAAGAAGCAAGCGCCTTAATAAAGGATTTTTATAAATACATAATTCTTATAGT
CATAGTGATTGGATTAATTTTATCCTATGTATTTTCAAACTTAATTTCTAAACCTCTAGTGAAATTAAATAAATCTGCAA
AGAAAATGAGTGCTATGGACTTCTCTGAAAAGTGTGATATAGAACGTGAAGATGAAATAGGAAACCTAGCTAAAACTTTA
AACTTTTTATCTAAAAATCTATCTAATGCCTTAGATGATTTAAAAATAAAAAATAAAAAGTTAGAAGAGGATATAGAAAA
GGAAAGAGAACTAGAAAAACTTAGAAAAGATTTTATTGCTGGAGCATCCCATGAACTTAAAACTCCTATTGGTATAATAT
CTGGATATGCTGAAGGAATAAAAGACGGTATAGTGGATCATAAGGATCAAGGAGTTTACTTAGATATAATAATTGATGAA
GCAGAAAAAATGAACAAATTAGTTATGGATATGCTTGAACTTTCAAAGCTTGAGGCTGGAAAAATTGATTTACATATAAT
AGATTTTTCCCTTACTGAACTTACTGAGGAAGTTTTAGTAAAGAATTCTGTCGACATAAACAAAAATAATTTAACTGTAA
TAAAAAACTACTCTCCTAATGAAGATTTATATGTTCAAGGAGATGACTTTAAAATAGAACAGGTACTAACTAATTTTGTT
ACCAATGCTATAAAATATTCTGAACCTAACAACCAAATAATAATAGATATAAAGCCAGTTGAGGAAGATAAAATCTACTT
CTCAATTGAAAATACTGGTGCCCATATTCCTGATTCAGATATAAATAAGATTTGGACTCAATTTTATAGGGGAGATACCT
CAAGAAATAGAGGCTCTAGAAGTACTGGACTTGGACTATCCATAGTTAAAAATCTACTTCAAGCTCATGAAAGTGAATTC
GGAGTTATGAATACAGAAAACGGGGTTAAATTCTACTTTACCCTAAAAAAATCTAAAGAAATAGATGAAGTAGAAGAAAT
CTAA

Upstream 100 bases:

>100_bases
CAGTTGATACGAACATAAAAAGACTTAGAGAGAAATTACTAGATAAAGCTAATTATATAGCTACTGTTAGGGGAAGTGGC
TATAAGTTTGAGGTGAAATA

Downstream 100 bases:

>100_bases
AGGTAATGTATCAAAGTAACTTTTATCTTACAAACATATTCCGAGAATTACTAGATTTCGCTAAGAATTTATAATTATTA
CTGCGAAGATATCACTAAAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MKKSISKRLFIITFGIIIFLTLFTMIFQITFFQEFYYKRKSNDLSNAVLKFRALYSYDIKNTDSLYRALSLFELENNAKI
GIYSIDSTPKYVPDPANKNSEAVDLLNDIFNELYSDQDFAKTLLNSNSGVTTEFKSRKYSTKYIVYMVPFSLNSKNDSII
IAITSFQAIEEASALIKDFYKYIILIVIVIGLILSYVFSNLISKPLVKLNKSAKKMSAMDFSEKCDIEREDEIGNLAKTL
NFLSKNLSNALDDLKIKNKKLEEDIEKERELEKLRKDFIAGASHELKTPIGIISGYAEGIKDGIVDHKDQGVYLDIIIDE
AEKMNKLVMDMLELSKLEAGKIDLHIIDFSLTELTEEVLVKNSVDINKNNLTVIKNYSPNEDLYVQGDDFKIEQVLTNFV
TNAIKYSEPNNQIIIDIKPVEEDKIYFSIENTGAHIPDSDINKIWTQFYRGDTSRNRGSRSTGLGLSIVKNLLQAHESEF
GVMNTENGVKFYFTLKKSKEIDEVEEI

Sequences:

>Translated_507_residues
MKKSISKRLFIITFGIIIFLTLFTMIFQITFFQEFYYKRKSNDLSNAVLKFRALYSYDIKNTDSLYRALSLFELENNAKI
GIYSIDSTPKYVPDPANKNSEAVDLLNDIFNELYSDQDFAKTLLNSNSGVTTEFKSRKYSTKYIVYMVPFSLNSKNDSII
IAITSFQAIEEASALIKDFYKYIILIVIVIGLILSYVFSNLISKPLVKLNKSAKKMSAMDFSEKCDIEREDEIGNLAKTL
NFLSKNLSNALDDLKIKNKKLEEDIEKERELEKLRKDFIAGASHELKTPIGIISGYAEGIKDGIVDHKDQGVYLDIIIDE
AEKMNKLVMDMLELSKLEAGKIDLHIIDFSLTELTEEVLVKNSVDINKNNLTVIKNYSPNEDLYVQGDDFKIEQVLTNFV
TNAIKYSEPNNQIIIDIKPVEEDKIYFSIENTGAHIPDSDINKIWTQFYRGDTSRNRGSRSTGLGLSIVKNLLQAHESEF
GVMNTENGVKFYFTLKKSKEIDEVEEI
>Mature_507_residues
MKKSISKRLFIITFGIIIFLTLFTMIFQITFFQEFYYKRKSNDLSNAVLKFRALYSYDIKNTDSLYRALSLFELENNAKI
GIYSIDSTPKYVPDPANKNSEAVDLLNDIFNELYSDQDFAKTLLNSNSGVTTEFKSRKYSTKYIVYMVPFSLNSKNDSII
IAITSFQAIEEASALIKDFYKYIILIVIVIGLILSYVFSNLISKPLVKLNKSAKKMSAMDFSEKCDIEREDEIGNLAKTL
NFLSKNLSNALDDLKIKNKKLEEDIEKERELEKLRKDFIAGASHELKTPIGIISGYAEGIKDGIVDHKDQGVYLDIIIDE
AEKMNKLVMDMLELSKLEAGKIDLHIIDFSLTELTEEVLVKNSVDINKNNLTVIKNYSPNEDLYVQGDDFKIEQVLTNFV
TNAIKYSEPNNQIIIDIKPVEEDKIYFSIENTGAHIPDSDINKIWTQFYRGDTSRNRGSRSTGLGLSIVKNLLQAHESEF
GVMNTENGVKFYFTLKKSKEIDEVEEI

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=28.2352941176471, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=27.1062271062271, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=27.6150627615063, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081816, Length=350, Percent_Identity=25.4285714285714, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=23.0452674897119, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=267, Percent_Identity=26.2172284644195, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=319, Percent_Identity=25.0783699059561, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=25, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=24.5901639344262, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI48994928, Length=243, Percent_Identity=24.6913580246914, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=281, Percent_Identity=25.2669039145907, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=344, Percent_Identity=21.5116279069767, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=26.1603375527426, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790300, Length=234, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=26.4227642276423, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57966; Mature: 57966

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSISKRLFIITFGIIIFLTLFTMIFQITFFQEFYYKRKSNDLSNAVLKFRALYSYDIK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCC
NTDSLYRALSLFELENNAKIGIYSIDSTPKYVPDPANKNSEAVDLLNDIFNELYSDQDFA
CHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
KTLLNSNSGVTTEFKSRKYSTKYIVYMVPFSLNSKNDSIIIAITSFQAIEEASALIKDFY
HHHHCCCCCCCCHHHCCCCCCEEEEEEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHHH
KYIILIVIVIGLILSYVFSNLISKPLVKLNKSAKKMSAMDFSEKCDIEREDEIGNLAKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
NFLSKNLSNALDDLKIKNKKLEEDIEKERELEKLRKDFIAGASHELKTPIGIISGYAEGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KDGIVDHKDQGVYLDIIIDEAEKMNKLVMDMLELSKLEAGKIDLHIIDFSLTELTEEVLV
HHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHH
KNSVDINKNNLTVIKNYSPNEDLYVQGDDFKIEQVLTNFVTNAIKYSEPNNQIIIDIKPV
HCCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHEECCCCCEEEEEEEEC
EEDKIYFSIENTGAHIPDSDINKIWTQFYRGDTSRNRGSRSTGLGLSIVKNLLQAHESEF
CCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GVMNTENGVKFYFTLKKSKEIDEVEEI
CCEECCCCEEEEEEECCCCCCHHHHCC
>Mature Secondary Structure
MKKSISKRLFIITFGIIIFLTLFTMIFQITFFQEFYYKRKSNDLSNAVLKFRALYSYDIK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCC
NTDSLYRALSLFELENNAKIGIYSIDSTPKYVPDPANKNSEAVDLLNDIFNELYSDQDFA
CHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
KTLLNSNSGVTTEFKSRKYSTKYIVYMVPFSLNSKNDSIIIAITSFQAIEEASALIKDFY
HHHHCCCCCCCCHHHCCCCCCEEEEEEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHHH
KYIILIVIVIGLILSYVFSNLISKPLVKLNKSAKKMSAMDFSEKCDIEREDEIGNLAKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHH
NFLSKNLSNALDDLKIKNKKLEEDIEKERELEKLRKDFIAGASHELKTPIGIISGYAEGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
KDGIVDHKDQGVYLDIIIDEAEKMNKLVMDMLELSKLEAGKIDLHIIDFSLTELTEEVLV
HHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHH
KNSVDINKNNLTVIKNYSPNEDLYVQGDDFKIEQVLTNFVTNAIKYSEPNNQIIIDIKPV
HCCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHEECCCCCEEEEEEEEC
EEDKIYFSIENTGAHIPDSDINKIWTQFYRGDTSRNRGSRSTGLGLSIVKNLLQAHESEF
CCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GVMNTENGVKFYFTLKKSKEIDEVEEI
CCEECCCCEEEEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]