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The map label for this gene is srrA [H]

Identifier: 18310907

GI number: 18310907

Start: 2205887

End: 2206684

Strand: Direct

Name: srrA [H]

Synonym: CPE1925

Alternate gene names: 18310907

Gene position: 2205887-2206684 (Clockwise)

Preceding gene: 18310902

Following gene: 18310908

Centisome position: 72.77

GC content: 28.32

Gene sequence:

>798_bases
ATGGTATTTTCATCAAATGTCCATCTTTTCATTAAAAACTCCCCTAAAATTATTTATATAAACCTTAGTTTTCATTGTAT
AATATTAAGTAAGTTAAAACAATATTTTTTAAAGGTTGGTGGTTATATGAATAAAACGGTACTTATTGTAGAAGATGAAA
TACGTATAAGATTTCTTGTAAGAGATTACTTCAAGAAAGAGGGATTTAATGTGTTAGAAGCTTCTGATGGTGAGGAAGCT
CTTAGGATATTTTCTGAAAATATAGTTGATTTAGCAATATTAGATATAATGATGCCAAAATTAGATGGACTTGCTGTTTG
TAGAAATATAAGGGAAGTTTCCAATACTCCTATAATATTATTAACAGCTAAAAGCCAAGAAGAAGATAAACTTTTAGGTT
ATGAGCTTGGAGCTGATGACTATATGACTAAACCTTTTAGTCCTAAGGTTTTATTAGCAAAGGCTAAAGCATTATTAAGA
AGAACAGGTACATTAAATGATAAAAACATTTTAGATTTTAATGGATTAACAATAAATAAACTATCTCATGAAGTAAAACT
AAATGGAGAAGAACTATTACTATCTCCTAAGGAATATGATTTACTTATTTACCTTTCTTCAAATGAAGGAATAGCTTTAT
CAAGGGATAGAATTCTAGATAATGTTTGGGGCTATGATTATTTTGGAGATATAAGAACAGTTGATACGAACATAAAAAGA
CTTAGAGAGAAATTACTAGATAAAGCTAATTATATAGCTACTGTTAGGGGAAGTGGCTATAAGTTTGAGGTGAAATAG

Upstream 100 bases:

>100_bases
TTCGTCTTCATATAAAGATCCTATATTAACACCAATATTTATAGATGCTAACCTTGTATCTTTTTTTATTGTTATAACTT
TTAGCCCATTGGGTAAAATT

Downstream 100 bases:

>100_bases
TGAAAAAAAGTATTTCAAAAAGATTATTTATAATAACTTTTGGTATAATAATATTCTTAACCTTGTTTACAATGATATTC
CAAATTACATTTTTCCAAGA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MVFSSNVHLFIKNSPKIIYINLSFHCIILSKLKQYFLKVGGYMNKTVLIVEDEIRIRFLVRDYFKKEGFNVLEASDGEEA
LRIFSENIVDLAILDIMMPKLDGLAVCRNIREVSNTPIILLTAKSQEEDKLLGYELGADDYMTKPFSPKVLLAKAKALLR
RTGTLNDKNILDFNGLTINKLSHEVKLNGEELLLSPKEYDLLIYLSSNEGIALSRDRILDNVWGYDYFGDIRTVDTNIKR
LREKLLDKANYIATVRGSGYKFEVK

Sequences:

>Translated_265_residues
MVFSSNVHLFIKNSPKIIYINLSFHCIILSKLKQYFLKVGGYMNKTVLIVEDEIRIRFLVRDYFKKEGFNVLEASDGEEA
LRIFSENIVDLAILDIMMPKLDGLAVCRNIREVSNTPIILLTAKSQEEDKLLGYELGADDYMTKPFSPKVLLAKAKALLR
RTGTLNDKNILDFNGLTINKLSHEVKLNGEELLLSPKEYDLLIYLSSNEGIALSRDRILDNVWGYDYFGDIRTVDTNIKR
LREKLLDKANYIATVRGSGYKFEVK
>Mature_265_residues
MVFSSNVHLFIKNSPKIIYINLSFHCIILSKLKQYFLKVGGYMNKTVLIVEDEIRIRFLVRDYFKKEGFNVLEASDGEEA
LRIFSENIVDLAILDIMMPKLDGLAVCRNIREVSNTPIILLTAKSQEEDKLLGYELGADDYMTKPFSPKVLLAKAKALLR
RTGTLNDKNILDFNGLTINKLSHEVKLNGEELLLSPKEYDLLIYLSSNEGIALSRDRILDNVWGYDYFGDIRTVDTNIKR
LREKLLDKANYIATVRGSGYKFEVK

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=37.280701754386, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=35.8078602620087, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=39.0350877192982, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=38.5650224215247, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=36.697247706422, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.9649122807018, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=36, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.6363636363636, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=35.2941176470588, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=34.5132743362832, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=35.4978354978355, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.7777777777778, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790552, Length=215, Percent_Identity=34.4186046511628, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=32.2727272727273, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1788550, Length=101, Percent_Identity=35.6435643564356, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=170, Percent_Identity=27.0588235294118, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=34.6153846153846, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=33.0188679245283, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 30355; Mature: 30355

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFSSNVHLFIKNSPKIIYINLSFHCIILSKLKQYFLKVGGYMNKTVLIVEDEIRIRFLV
CEECCCEEEEEECCCEEEEEEECEEEHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEHHH
RDYFKKEGFNVLEASDGEEALRIFSENIVDLAILDIMMPKLDGLAVCRNIREVSNTPIIL
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
LTAKSQEEDKLLGYELGADDYMTKPFSPKVLLAKAKALLRRTGTLNDKNILDFNGLTINK
EEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEC
LSHEVKLNGEELLLSPKEYDLLIYLSSNEGIALSRDRILDNVWGYDYFGDIRTVDTNIKR
CCEEEEECCHHEEECCCCEEEEEEEECCCCEEEEHHHHHHHHCCCCCCCCEEEEHHHHHH
LREKLLDKANYIATVRGSGYKFEVK
HHHHHHCCCCEEEEEECCCEEEEEC
>Mature Secondary Structure
MVFSSNVHLFIKNSPKIIYINLSFHCIILSKLKQYFLKVGGYMNKTVLIVEDEIRIRFLV
CEECCCEEEEEECCCEEEEEEECEEEHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEHHH
RDYFKKEGFNVLEASDGEEALRIFSENIVDLAILDIMMPKLDGLAVCRNIREVSNTPIIL
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
LTAKSQEEDKLLGYELGADDYMTKPFSPKVLLAKAKALLRRTGTLNDKNILDFNGLTINK
EEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEC
LSHEVKLNGEELLLSPKEYDLLIYLSSNEGIALSRDRILDNVWGYDYFGDIRTVDTNIKR
CCEEEEECCHHEEECCCCEEEEEEEECCCCEEEEHHHHHHHHCCCCCCCCEEEEHHHHHH
LREKLLDKANYIATVRGSGYKFEVK
HHHHHHCCCCEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA