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The map label for this gene is mutS2 [H]

Identifier: 18310863

GI number: 18310863

Start: 2157777

End: 2160137

Strand: Reverse

Name: mutS2 [H]

Synonym: CPE1881

Alternate gene names: 18310863

Gene position: 2160137-2157777 (Counterclockwise)

Preceding gene: 18310864

Following gene: 18310862

Centisome position: 71.26

GC content: 32.06

Gene sequence:

>2361_bases
ATGAACGATAGAGTTTTAAGAGTTTTAGAATTTAATAAAATTAAAGAATTGGTTAAGGGATATGCCATTACAAAATCAGC
TAAGGAGATGGTTTTAGATCTTAAACCATATGATTCTGTTTATGATGTAAAAGAACATTTAGAAGAAACAAAAGAAGCTT
TAGATATTTTAATGAGAAAAGGAAATCCTCCTTTTGAAGGGCTTTATGATGTTAAAGAAGCTATAACAAGGGCTGAAAAA
GGTGGAGTTTTAAGTATAGAAGGCTTACTTAGAATAGGAAACATGTTAGCTGTAACAAGAAAACTTTCTGACTTTTTAGC
TAGAAAAGAAGAGGAAGAAGAACATAGAATCCTAGAAGGAATGAGAGAAGGGCTTATAGTACTTAGGGGAGTAGAAAGTG
CTATATCAAAGGCCATAGTAAGTGAAGATGAAATTGCAGATTCTGCAAGTGATAAACTTTATAGTATAAGAAGAAGCTTA
AAAGAAAAGAATTCATCTATAAGAGATAAAGTTAATTCTATAGTAAGAAGTAATACTCAATATCTTCAAGATTCCTTATA
CACAGTTAGAGGAGATAGATATGTTATTCCTGTAAAAGCTGAATATAAATCTCAAGTTCCAGGACTTGTTCATGATCAAA
GTTCAACAGGGGCTACACTTTTTATAGAACCAACGGCTTTAGTAAACTTAAATAACGAAATAAAAGAGCTTATGCTAAAG
GAAAGAGCTGAGATTGAGAGAATATTAGCAGAATTATCAGTCTTAGTATATAAAAATATTGATGTTATAAAAGTTAACTT
TAATATAATAGTTGAATTAGATTTTATATTTGCAAAGGCTAAATACGGTAGTGATTTAGGTGGAACTCTGCCTATAGTAA
ATGAAGAAGGAGTAATAGATTTAATGGATGCTAGGCATCCACTAATTCCTAAAGATAAAGTTGTTTCTTCTGATATTTAT
TTAGGAAGAGAATTTTCAACATTACTTATAACAGGGCCAAATACTGGTGGTAAAACTGTAACCTTAAAGACTACAGGGCT
TATTGAACTTATGGGCTTAAGTGGACTTTTAATACCAGCAAGTGAAAATTCAAGTATAAGTTTCTTTGAAGAGATATTTG
CAGATATAGGAGATGAGCAAAGTATAGAGCAAAGCTTATCAACTTTCTCTTCTCATATGACTAATATAGTTAGAATAATG
GAGAAGGCAAATAATAAAAGTTTTGTACTTTTTGACGAACTTGGAGCTGGAACAGACCCTACAGAGGGAGCTGCACTTGC
TATTTCAATATTAGAAAATTTAAGAGCAAGAGGATGTAGAATAATGTCTACAACTCACTATAGTGAATTAAAGGGATATG
CATTAAAGACTGAAAATGTTGAGAATGCTTCTGTTGAGTTTAATGTTGAAACCTTAAGACCAACCTATAGACTTTTAATA
GGAGTTCCAGGGAAATCAAATGCTTTTGAAATTTCAAGAAGATTAGGTCTTAAAGACAATGTTATAGAAGAGGCTAAAAA
GGTTATTTCTACTGAATCACTTCAATTTGAAGATTTAATACAATCACTTCAAGAAAAGAGTATAAAAGCAGAAAATGATG
CTAGGGAAGCTGCTATATTAAGAAATGATGCAGAAAAATATAAGAATAGATATAAAGAGAAATTTGAAAGAATTGAAAGT
GTAAGAGATAATGTTTATGCAGATGCTAGAAGAGAAGCAAAGCAAATTTTAGATTCAGCCAAGGAAGAAGCTGATGCTAT
TCTTAAAAATATGAGAGACCTAGAAAGAATGGGGATTTCTAGTGATGCAAGAAGAAAGCTTGAGGCTGAAAGAGGAAAGC
TTAGAGATAAGATAAGTGATGCAGAGGCTAGGCTTCAAAAGAAAAAAGAAGAGCAAAAGGGAGAAGAACTTAAAAAGATT
GAGGTTGGAATGGAAGCCTTATTGCCTTCAATAAACCAAAAAGTCATAGTTCTTTCTAAGCCAGATAATAAAGGTGAAGT
TCAAGTTCAAGCTGGAATTATGAAAATAAATGTTAAGGCTAAGGATTTAAGAGTAGCCAAGGAAACTAAAGAAGAAAAGA
AAATTAAGAAGAGAGAAGCGAGATTAAACTTAAGACAGGTGGATCCATCAATAGATTTAAGAGGTATGGATTCAGAAGAA
GCTTGTTACACTGCAGATAAGTATTTAGATGATGCTTACGTTGCAGGAAGAGGAGAAGTAACTTTAGTTCATGGAAAAGG
TACTGGTGTTTTAAGAAAAGCTATAAACGATATGCTAAAAAAACATCCTCATGTAAAATCTCACAGACTAGGTGAGTATG
GAGAGGGTGGAACAGGAGTTACTGTTGTAATATTAAAATAA

Upstream 100 bases:

>100_bases
AGACAGGTAATTGAAGCTCTAAATAAGGAAGAAGCTTTAAGATTAAAGGATTATACTAAAGGTCACTTTAAAAGAGGCGT
TGAGTAAAGGGGATTAAAGT

Downstream 100 bases:

>100_bases
ATTTTTAATATTAAATTATGACTTAACTTAGGTTTTGATTTATATAAATTTAAGTTAAGAATAAATCAATAATAGTTTAA
AAAATAATATTAAGAGTTCG

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MNDRVLRVLEFNKIKELVKGYAITKSAKEMVLDLKPYDSVYDVKEHLEETKEALDILMRKGNPPFEGLYDVKEAITRAEK
GGVLSIEGLLRIGNMLAVTRKLSDFLARKEEEEEHRILEGMREGLIVLRGVESAISKAIVSEDEIADSASDKLYSIRRSL
KEKNSSIRDKVNSIVRSNTQYLQDSLYTVRGDRYVIPVKAEYKSQVPGLVHDQSSTGATLFIEPTALVNLNNEIKELMLK
ERAEIERILAELSVLVYKNIDVIKVNFNIIVELDFIFAKAKYGSDLGGTLPIVNEEGVIDLMDARHPLIPKDKVVSSDIY
LGREFSTLLITGPNTGGKTVTLKTTGLIELMGLSGLLIPASENSSISFFEEIFADIGDEQSIEQSLSTFSSHMTNIVRIM
EKANNKSFVLFDELGAGTDPTEGAALAISILENLRARGCRIMSTTHYSELKGYALKTENVENASVEFNVETLRPTYRLLI
GVPGKSNAFEISRRLGLKDNVIEEAKKVISTESLQFEDLIQSLQEKSIKAENDAREAAILRNDAEKYKNRYKEKFERIES
VRDNVYADARREAKQILDSAKEEADAILKNMRDLERMGISSDARRKLEAERGKLRDKISDAEARLQKKKEEQKGEELKKI
EVGMEALLPSINQKVIVLSKPDNKGEVQVQAGIMKINVKAKDLRVAKETKEEKKIKKREARLNLRQVDPSIDLRGMDSEE
ACYTADKYLDDAYVAGRGEVTLVHGKGTGVLRKAINDMLKKHPHVKSHRLGEYGEGGTGVTVVILK

Sequences:

>Translated_786_residues
MNDRVLRVLEFNKIKELVKGYAITKSAKEMVLDLKPYDSVYDVKEHLEETKEALDILMRKGNPPFEGLYDVKEAITRAEK
GGVLSIEGLLRIGNMLAVTRKLSDFLARKEEEEEHRILEGMREGLIVLRGVESAISKAIVSEDEIADSASDKLYSIRRSL
KEKNSSIRDKVNSIVRSNTQYLQDSLYTVRGDRYVIPVKAEYKSQVPGLVHDQSSTGATLFIEPTALVNLNNEIKELMLK
ERAEIERILAELSVLVYKNIDVIKVNFNIIVELDFIFAKAKYGSDLGGTLPIVNEEGVIDLMDARHPLIPKDKVVSSDIY
LGREFSTLLITGPNTGGKTVTLKTTGLIELMGLSGLLIPASENSSISFFEEIFADIGDEQSIEQSLSTFSSHMTNIVRIM
EKANNKSFVLFDELGAGTDPTEGAALAISILENLRARGCRIMSTTHYSELKGYALKTENVENASVEFNVETLRPTYRLLI
GVPGKSNAFEISRRLGLKDNVIEEAKKVISTESLQFEDLIQSLQEKSIKAENDAREAAILRNDAEKYKNRYKEKFERIES
VRDNVYADARREAKQILDSAKEEADAILKNMRDLERMGISSDARRKLEAERGKLRDKISDAEARLQKKKEEQKGEELKKI
EVGMEALLPSINQKVIVLSKPDNKGEVQVQAGIMKINVKAKDLRVAKETKEEKKIKKREARLNLRQVDPSIDLRGMDSEE
ACYTADKYLDDAYVAGRGEVTLVHGKGTGVLRKAINDMLKKHPHVKSHRLGEYGEGGTGVTVVILK
>Mature_786_residues
MNDRVLRVLEFNKIKELVKGYAITKSAKEMVLDLKPYDSVYDVKEHLEETKEALDILMRKGNPPFEGLYDVKEAITRAEK
GGVLSIEGLLRIGNMLAVTRKLSDFLARKEEEEEHRILEGMREGLIVLRGVESAISKAIVSEDEIADSASDKLYSIRRSL
KEKNSSIRDKVNSIVRSNTQYLQDSLYTVRGDRYVIPVKAEYKSQVPGLVHDQSSTGATLFIEPTALVNLNNEIKELMLK
ERAEIERILAELSVLVYKNIDVIKVNFNIIVELDFIFAKAKYGSDLGGTLPIVNEEGVIDLMDARHPLIPKDKVVSSDIY
LGREFSTLLITGPNTGGKTVTLKTTGLIELMGLSGLLIPASENSSISFFEEIFADIGDEQSIEQSLSTFSSHMTNIVRIM
EKANNKSFVLFDELGAGTDPTEGAALAISILENLRARGCRIMSTTHYSELKGYALKTENVENASVEFNVETLRPTYRLLI
GVPGKSNAFEISRRLGLKDNVIEEAKKVISTESLQFEDLIQSLQEKSIKAENDAREAAILRNDAEKYKNRYKEKFERIES
VRDNVYADARREAKQILDSAKEEADAILKNMRDLERMGISSDARRKLEAERGKLRDKISDAEARLQKKKEEQKGEELKKI
EVGMEALLPSINQKVIVLSKPDNKGEVQVQAGIMKINVKAKDLRVAKETKEEKKIKKREARLNLRQVDPSIDLRGMDSEE
ACYTADKYLDDAYVAGRGEVTLVHGKGTGVLRKAINDMLKKHPHVKSHRLGEYGEGGTGVTVVILK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=456, Percent_Identity=25.219298245614, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI4504191, Length=295, Percent_Identity=28.135593220339, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI284813531, Length=271, Percent_Identity=30.2583025830258, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI4557761, Length=261, Percent_Identity=29.5019157088123, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI26638666, Length=297, Percent_Identity=29.2929292929293, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI4505253, Length=297, Percent_Identity=29.2929292929293, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI26638664, Length=298, Percent_Identity=29.1946308724832, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI262231786, Length=211, Percent_Identity=30.8056872037915, Blast_Score=84, Evalue=7e-16,
Organism=Escherichia coli, GI1789089, Length=323, Percent_Identity=26.3157894736842, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508445, Length=325, Percent_Identity=26.7692307692308, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17534743, Length=383, Percent_Identity=24.2819843342037, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17539736, Length=292, Percent_Identity=23.972602739726, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=236, Percent_Identity=25.8474576271186, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=223, Percent_Identity=28.6995515695067, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319935, Length=223, Percent_Identity=30.0448430493274, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321912, Length=255, Percent_Identity=21.9607843137255, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=186, Percent_Identity=27.4193548387097, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=165, Percent_Identity=29.6969696969697, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320302, Length=251, Percent_Identity=25.4980079681275, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584320, Length=262, Percent_Identity=29.7709923664122, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664545, Length=291, Percent_Identity=27.8350515463918, Blast_Score=100, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 88112; Mature: 88112

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDRVLRVLEFNKIKELVKGYAITKSAKEMVLDLKPYDSVYDVKEHLEETKEALDILMRK
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GNPPFEGLYDVKEAITRAEKGGVLSIEGLLRIGNMLAVTRKLSDFLARKEEEEEHRILEG
CCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
MREGLIVLRGVESAISKAIVSEDEIADSASDKLYSIRRSLKEKNSSIRDKVNSIVRSNTQ
HHCCEEEEECHHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHH
YLQDSLYTVRGDRYVIPVKAEYKSQVPGLVHDQSSTGATLFIEPTALVNLNNEIKELMLK
HHHHHHEEECCCEEEEEEEHHHHHCCCCCEECCCCCCCEEEECCEEEEECCHHHHHHHHH
ERAEIERILAELSVLVYKNIDVIKVNFNIIVELDFIFAKAKYGSDLGGTLPIVNEEGVID
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEEECCCCCCCCCCCCEECCCCCEE
LMDARHPLIPKDKVVSSDIYLGREFSTLLITGPNTGGKTVTLKTTGLIELMGLSGLLIPA
ECCCCCCCCCCCCEECCCEEECCCCCEEEEECCCCCCCEEEEEECCHHEECCCCCEEEEC
SENSSISFFEEIFADIGDEQSIEQSLSTFSSHMTNIVRIMEKANNKSFVLFDELGAGTDP
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
TEGAALAISILENLRARGCRIMSTTHYSELKGYALKTENVENASVEFNVETLRPTYRLLI
CCCHHHHHHHHHHHHHCCEEEEECCCHHHHCCCEEECCCCCCCEEEEEEHHHCCEEEEEE
GVPGKSNAFEISRRLGLKDNVIEEAKKVISTESLQFEDLIQSLQEKSIKAENDAREAAIL
ECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
RNDAEKYKNRYKEKFERIESVRDNVYADARREAKQILDSAKEEADAILKNMRDLERMGIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDARRKLEAERGKLRDKISDAEARLQKKKEEQKGEELKKIEVGMEALLPSINQKVIVLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
PDNKGEVQVQAGIMKINVKAKDLRVAKETKEEKKIKKREARLNLRQVDPSIDLRGMDSEE
CCCCCCEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCH
ACYTADKYLDDAYVAGRGEVTLVHGKGTGVLRKAINDMLKKHPHVKSHRLGEYGEGGTGV
HHHHHHHHCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
TVVILK
EEEEEC
>Mature Secondary Structure
MNDRVLRVLEFNKIKELVKGYAITKSAKEMVLDLKPYDSVYDVKEHLEETKEALDILMRK
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
GNPPFEGLYDVKEAITRAEKGGVLSIEGLLRIGNMLAVTRKLSDFLARKEEEEEHRILEG
CCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
MREGLIVLRGVESAISKAIVSEDEIADSASDKLYSIRRSLKEKNSSIRDKVNSIVRSNTQ
HHCCEEEEECHHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHH
YLQDSLYTVRGDRYVIPVKAEYKSQVPGLVHDQSSTGATLFIEPTALVNLNNEIKELMLK
HHHHHHEEECCCEEEEEEEHHHHHCCCCCEECCCCCCCEEEECCEEEEECCHHHHHHHHH
ERAEIERILAELSVLVYKNIDVIKVNFNIIVELDFIFAKAKYGSDLGGTLPIVNEEGVID
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEEECCCCCCCCCCCCEECCCCCEE
LMDARHPLIPKDKVVSSDIYLGREFSTLLITGPNTGGKTVTLKTTGLIELMGLSGLLIPA
ECCCCCCCCCCCCEECCCEEECCCCCEEEEECCCCCCCEEEEEECCHHEECCCCCEEEEC
SENSSISFFEEIFADIGDEQSIEQSLSTFSSHMTNIVRIMEKANNKSFVLFDELGAGTDP
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
TEGAALAISILENLRARGCRIMSTTHYSELKGYALKTENVENASVEFNVETLRPTYRLLI
CCCHHHHHHHHHHHHHCCEEEEECCCHHHHCCCEEECCCCCCCEEEEEEHHHCCEEEEEE
GVPGKSNAFEISRRLGLKDNVIEEAKKVISTESLQFEDLIQSLQEKSIKAENDAREAAIL
ECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
RNDAEKYKNRYKEKFERIESVRDNVYADARREAKQILDSAKEEADAILKNMRDLERMGIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SDARRKLEAERGKLRDKISDAEARLQKKKEEQKGEELKKIEVGMEALLPSINQKVIVLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
PDNKGEVQVQAGIMKINVKAKDLRVAKETKEEKKIKKREARLNLRQVDPSIDLRGMDSEE
CCCCCCEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCH
ACYTADKYLDDAYVAGRGEVTLVHGKGTGVLRKAINDMLKKHPHVKSHRLGEYGEGGTGV
HHHHHHHHCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
TVVILK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA