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The map label for this gene is clsD [H]

Identifier: 18310412

GI number: 18310412

Start: 1685736

End: 1687166

Strand: Direct

Name: clsD [H]

Synonym: CPE1430

Alternate gene names: 18310412

Gene position: 1685736-1687166 (Clockwise)

Preceding gene: 18310411

Following gene: 18310427

Centisome position: 55.61

GC content: 27.18

Gene sequence:

>1431_bases
ATGCATTTATTTATAAATATGATATTTTTAATAAATATTGTATTTATCATTTCCATAATCTTCATTGAAAGAAGAAATCC
CCAAACTACTTGGGCTTGGATTTTAATATTAACCTTTCTACCCATATTAGGATTTATAATCTACATTTTATTTGGTCAAA
ATATTACCCGTGAAAAAAACTTTAAAAGAAAAATTCTAGATGACAAGACAAAACAAAAATATTTAAATTCATTTAAGTCT
CACTACAAATTAGATAATATTTCTTTAAAATATAAAGACTTAATAATGATGAACTTTAATAATGACAATTCAACCTACAC
TCAACGTAATGATATAGATTTATATTTTGATGCTAATAGTCTTTTTGAAGAAATGATTGATGAAATAAATAAAGCCGAAA
AATTTATTCATATGGAATTTTATATTTTTAAAAGCGATGAAATAGGCAAAAAAATCTTACAAGCCTTAACTAAGAAAGCT
AAAGAAGGTGTTGAAGTAAAATTACTAGTAGATTCTATTGGTAACTCTATACACAAAAAAGATATAGATAAATTAAAGGC
AGCTGGTGGAGATTTTAAAATATTTTTTCCTGGCTTTTGCAAATATATAAACTTAAGAATTAACTATAGAAATCATAGAA
AGATACTTATTATAGATAGCAAAGTTGCTTTTTTAGGTGGATTTAATATAGGTGATGAATATCTTGGAAAAGATAAAAAT
ATTGGTCATTGGCGTGATACTCATACTAAAATAAAGGGACTTGCTATTAATGATCTAGAAGGAAGATTCCTTTTAGATTG
GAGTTATGCTAATGAATCAGATTTAGACATAGATTTAAAAAAATATTTTATAAATCCTCATTCAACTGATTTGCCAAAGA
AGATTATTGGAGCTCAAATAGTTTCCTCTGGTCCTGACCATACTGAACAACAAATAAAAAATGGATATTTTAAAATTATA
AATTCAGCTAAGAAAAATCTTTTTATACAAACGCCTTATTTTGTCCCTGATGAACCTATGCTTGAAGCTTTAAGACTTGC
TGCCTTATCTGGAGTTGATGTAAAAATAATGCTACCTGGTAATCCTGATCATAAATTTATGGGATGGATAGCAAACTCTT
ATTTTGAATCCTTATTAAATGCTGGTGCAAAGATCTACTTATATGAAAAGGGCTTTCTTCACGCTAAAACCATAGTGGCA
GACTCTTCTATATGTAGTGTAGGAACAGCTAACATGGATATAAGAAGCTTTTCTTTAAACTTTGAAAGCAATATATTTAT
ATATAATGAAGCTATTTCAAAATCTATGGAAGAACAATTCTTTAAAGACCTAAAGGTGTGTACTAAAGTAACCCTTGAAA
GTTTTGAAAAACGATCTATTATATCAAGAATTGGAGAATCCATAACAAGATTAGTATCTCCTTTAATGTAG

Upstream 100 bases:

>100_bases
AACAAATATATATAAGGTAACATTTTTAGTTTATCAGTCTAATATATATTAAAAAAAATTTAGACTGATAAACCTTTCTA
AATACAAAGGAGGAATTATT

Downstream 100 bases:

>100_bases
AAAAATACAGTGTATGATAATACACTGTATTTTTTATTAATAATAAATTACAAAACTTTAAATTATATTAATTAACCACT
ATTTTAAAATAATATTGATT

Product: cardiolipin synthase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MHLFINMIFLINIVFIISIIFIERRNPQTTWAWILILTFLPILGFIIYILFGQNITREKNFKRKILDDKTKQKYLNSFKS
HYKLDNISLKYKDLIMMNFNNDNSTYTQRNDIDLYFDANSLFEEMIDEINKAEKFIHMEFYIFKSDEIGKKILQALTKKA
KEGVEVKLLVDSIGNSIHKKDIDKLKAAGGDFKIFFPGFCKYINLRINYRNHRKILIIDSKVAFLGGFNIGDEYLGKDKN
IGHWRDTHTKIKGLAINDLEGRFLLDWSYANESDLDIDLKKYFINPHSTDLPKKIIGAQIVSSGPDHTEQQIKNGYFKII
NSAKKNLFIQTPYFVPDEPMLEALRLAALSGVDVKIMLPGNPDHKFMGWIANSYFESLLNAGAKIYLYEKGFLHAKTIVA
DSSICSVGTANMDIRSFSLNFESNIFIYNEAISKSMEEQFFKDLKVCTKVTLESFEKRSIISRIGESITRLVSPLM

Sequences:

>Translated_476_residues
MHLFINMIFLINIVFIISIIFIERRNPQTTWAWILILTFLPILGFIIYILFGQNITREKNFKRKILDDKTKQKYLNSFKS
HYKLDNISLKYKDLIMMNFNNDNSTYTQRNDIDLYFDANSLFEEMIDEINKAEKFIHMEFYIFKSDEIGKKILQALTKKA
KEGVEVKLLVDSIGNSIHKKDIDKLKAAGGDFKIFFPGFCKYINLRINYRNHRKILIIDSKVAFLGGFNIGDEYLGKDKN
IGHWRDTHTKIKGLAINDLEGRFLLDWSYANESDLDIDLKKYFINPHSTDLPKKIIGAQIVSSGPDHTEQQIKNGYFKII
NSAKKNLFIQTPYFVPDEPMLEALRLAALSGVDVKIMLPGNPDHKFMGWIANSYFESLLNAGAKIYLYEKGFLHAKTIVA
DSSICSVGTANMDIRSFSLNFESNIFIYNEAISKSMEEQFFKDLKVCTKVTLESFEKRSIISRIGESITRLVSPLM
>Mature_476_residues
MHLFINMIFLINIVFIISIIFIERRNPQTTWAWILILTFLPILGFIIYILFGQNITREKNFKRKILDDKTKQKYLNSFKS
HYKLDNISLKYKDLIMMNFNNDNSTYTQRNDIDLYFDANSLFEEMIDEINKAEKFIHMEFYIFKSDEIGKKILQALTKKA
KEGVEVKLLVDSIGNSIHKKDIDKLKAAGGDFKIFFPGFCKYINLRINYRNHRKILIIDSKVAFLGGFNIGDEYLGKDKN
IGHWRDTHTKIKGLAINDLEGRFLLDWSYANESDLDIDLKKYFINPHSTDLPKKIIGAQIVSSGPDHTEQQIKNGYFKII
NSAKKNLFIQTPYFVPDEPMLEALRLAALSGVDVKIMLPGNPDHKFMGWIANSYFESLLNAGAKIYLYEKGFLHAKTIVA
DSSICSVGTANMDIRSFSLNFESNIFIYNEAISKSMEEQFFKDLKVCTKVTLESFEKRSIISRIGESITRLVSPLM

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=470, Percent_Identity=27.2340425531915, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1787007, Length=365, Percent_Identity=25.7534246575342, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 55041; Mature: 55041

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLFINMIFLINIVFIISIIFIERRNPQTTWAWILILTFLPILGFIIYILFGQNITREKN
CCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FKRKILDDKTKQKYLNSFKSHYKLDNISLKYKDLIMMNFNNDNSTYTQRNDIDLYFDANS
HHHHHHCCHHHHHHHHHHHHHCEECCCEEEEEEEEEEEECCCCCCEEECCCEEEEECHHH
LFEEMIDEINKAEKFIHMEFYIFKSDEIGKKILQALTKKAKEGVEVKLLVDSIGNSIHKK
HHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHCCHHHHH
DIDKLKAAGGDFKIFFPGFCKYINLRINYRNHRKILIIDSKVAFLGGFNIGDEYLGKDKN
HHHHHHHCCCCEEEECCCCEEEEEEEEEEECCEEEEEEECCEEEEECCCCCHHHCCCCCC
IGHWRDTHTKIKGLAINDLEGRFLLDWSYANESDLDIDLKKYFINPHSTDLPKKIIGAQI
CCCCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCEEEHHEEECCCCCCCHHHHHHHHH
VSSGPDHTEQQIKNGYFKIINSAKKNLFIQTPYFVPDEPMLEALRLAALSGVDVKIMLPG
HCCCCCHHHHHHHCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECC
NPDHKFMGWIANSYFESLLNAGAKIYLYEKGFLHAKTIVADSSICSVGTANMDIRSFSLN
CCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCHHCCCCCCCEEEEEEEC
FESNIFIYNEAISKSMEEQFFKDLKVCTKVTLESFEKRSIISRIGESITRLVSPLM
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHLFINMIFLINIVFIISIIFIERRNPQTTWAWILILTFLPILGFIIYILFGQNITREKN
CCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
FKRKILDDKTKQKYLNSFKSHYKLDNISLKYKDLIMMNFNNDNSTYTQRNDIDLYFDANS
HHHHHHCCHHHHHHHHHHHHHCEECCCEEEEEEEEEEEECCCCCCEEECCCEEEEECHHH
LFEEMIDEINKAEKFIHMEFYIFKSDEIGKKILQALTKKAKEGVEVKLLVDSIGNSIHKK
HHHHHHHHHHHHHHEEEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEHHHCCHHHHH
DIDKLKAAGGDFKIFFPGFCKYINLRINYRNHRKILIIDSKVAFLGGFNIGDEYLGKDKN
HHHHHHHCCCCEEEECCCCEEEEEEEEEEECCEEEEEEECCEEEEECCCCCHHHCCCCCC
IGHWRDTHTKIKGLAINDLEGRFLLDWSYANESDLDIDLKKYFINPHSTDLPKKIIGAQI
CCCCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCCEEEHHEEECCCCCCCHHHHHHHHH
VSSGPDHTEQQIKNGYFKIINSAKKNLFIQTPYFVPDEPMLEALRLAALSGVDVKIMLPG
HCCCCCHHHHHHHCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECC
NPDHKFMGWIANSYFESLLNAGAKIYLYEKGFLHAKTIVADSSICSVGTANMDIRSFSLN
CCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCHHCCCCCCCEEEEEEEC
FESNIFIYNEAISKSMEEQFFKDLKVCTKVTLESFEKRSIISRIGESITRLVSPLM
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10585141 [H]