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The map label for this gene is clpP

Identifier: 18310375

GI number: 18310375

Start: 1644321

End: 1644905

Strand: Reverse

Name: clpP

Synonym: CPE1393

Alternate gene names: 18310375

Gene position: 1644905-1644321 (Counterclockwise)

Preceding gene: 18310376

Following gene: 18310374

Centisome position: 54.26

GC content: 31.62

Gene sequence:

>585_bases
ATGAGCAATTTAGTACCTATGGTAGTTGAACAAACAAGCAAAGGCGAAAGAAGTTACGATATATTCTCAAGATTATTAAA
AGATAGAATAATAATGTTAAGTGGAGAGGTTAATGATGTAACGGCTAACCTTGTTGTTGCACAATTATTATTCTTAGAAA
GTGAAGATCCAGATAAAGATATACATCTTTACATAAATTCCCCAGGAGGTTCTATAACTTCTGGAATGGCAATTTATGAT
ACTATGCAATATATAAAGCCTGACGTATCTACAATCTGTATAGGTATGGCTGCTTCTATGGGAGCATTCTTATTATCTTC
AGGAGCAAAAGGAAAGAGATTCGCATTACCAAATGCTGAAATAATGATACACCAACCTTTAGGTGGATTCCAAGGGCAAG
CAACTGATATAGATATTCATGCTAAGAGAATATTAAAGATAAAAGATAAATTAAACCAAATCTTAAGTGAAAATACAAAT
CAACCTCTTGAAAAGATAAAAGTAGATGTTGAAAGAGATTATTTCATGGAAGCATCAGAAGCAGTAGAATACGGATTAAT
AGATAAAGTTATAGAAAGAAAATAA

Upstream 100 bases:

>100_bases
AAATATTTATTTTTTTTATATAATAATTATGATAATGTATGTTTTTATGATATATATGGCAATATTATAATTAGAGTTTT
TTTTAAAAGGAGGGAATTTA

Downstream 100 bases:

>100_bases
TCTACAACTTAAATCTTATTGAAAGTTGAGGTGGATAAGATGGGAAAATTTGAAGACAAAAAGCAATTAAGATGTTCTTT
TTGTGGTAAAAATCAGGAAC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSNLVPMVVEQTSKGERSYDIFSRLLKDRIIMLSGEVNDVTANLVVAQLLFLESEDPDKDIHLYINSPGGSITSGMAIYD
TMQYIKPDVSTICIGMAASMGAFLLSSGAKGKRFALPNAEIMIHQPLGGFQGQATDIDIHAKRILKIKDKLNQILSENTN
QPLEKIKVDVERDYFMEASEAVEYGLIDKVIERK

Sequences:

>Translated_194_residues
MSNLVPMVVEQTSKGERSYDIFSRLLKDRIIMLSGEVNDVTANLVVAQLLFLESEDPDKDIHLYINSPGGSITSGMAIYD
TMQYIKPDVSTICIGMAASMGAFLLSSGAKGKRFALPNAEIMIHQPLGGFQGQATDIDIHAKRILKIKDKLNQILSENTN
QPLEKIKVDVERDYFMEASEAVEYGLIDKVIERK
>Mature_193_residues
SNLVPMVVEQTSKGERSYDIFSRLLKDRIIMLSGEVNDVTANLVVAQLLFLESEDPDKDIHLYINSPGGSITSGMAIYDT
MQYIKPDVSTICIGMAASMGAFLLSSGAKGKRFALPNAEIMIHQPLGGFQGQATDIDIHAKRILKIKDKLNQILSENTNQ
PLEKIKVDVERDYFMEASEAVEYGLIDKVIERK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=55.8510638297872, Blast_Score=231, Evalue=4e-61,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=68.0628272251309, Blast_Score=295, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.1505376344086, Blast_Score=209, Evalue=6e-55,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=59.6858638743455, Blast_Score=244, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_CLOP1 (Q0TQK2)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_696088.1
- ProteinModelPortal:   Q0TQK2
- SMR:   Q0TQK2
- STRING:   Q0TQK2
- GeneID:   4203731
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_1647
- TIGR:   CPF_1647
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- BioCyc:   CPER195103:CPF_1647-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21540; Mature: 21409

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 99-99 ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLVPMVVEQTSKGERSYDIFSRLLKDRIIMLSGEVNDVTANLVVAQLLFLESEDPDKD
CCCCCHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
IHLYINSPGGSITSGMAIYDTMQYIKPDVSTICIGMAASMGAFLLSSGAKGKRFALPNAE
EEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCE
IMIHQPLGGFQGQATDIDIHAKRILKIKDKLNQILSENTNQPLEKIKVDVERDYFMEASE
EEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCHHHHHHHHH
AVEYGLIDKVIERK
HHHHHHHHHHHHCC
>Mature Secondary Structure 
SNLVPMVVEQTSKGERSYDIFSRLLKDRIIMLSGEVNDVTANLVVAQLLFLESEDPDKD
CCCCHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
IHLYINSPGGSITSGMAIYDTMQYIKPDVSTICIGMAASMGAFLLSSGAKGKRFALPNAE
EEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCE
IMIHQPLGGFQGQATDIDIHAKRILKIKDKLNQILSENTNQPLEKIKVDVERDYFMEASE
EEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCHHHHHHHHH
AVEYGLIDKVIERK
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA