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The map label for this gene is map [C]

Identifier: 18310364

GI number: 18310364

Start: 1633244

End: 1634113

Strand: Reverse

Name: map [C]

Synonym: CPE1382

Alternate gene names: 18310364

Gene position: 1634113-1633244 (Counterclockwise)

Preceding gene: 18310365

Following gene: 18310362

Centisome position: 53.91

GC content: 31.72

Gene sequence:

>870_bases
ATGAGAATAAATAGAAATGATTTATGCTGGTGTAACAGTGGTAAGAAATATAAAAAATGTCATATGGAATTTGATGAGAG
AATAGAAAATTTAGCTAGAGAAGGATTTGAAGTTCCTACTAGAGATATAATAAAAAATGAAGAACAAATAGAAGGTATAA
GAAAAAGTGCAGAAATAAACAATGCTGTTTTAGATTTAGTTGCAGAGAAAATAAAAGCAGGTATGAGTACTGAAGATATA
AATAAAATAGTACACGATTATACTGTAAGTAGAGGAGCTATTCCAGCACCACTTAACTATGGTGGATTTCCTAAAAGTGT
TTGTACTTCTATAAATGATGAGGTTTGTCATGGAATTCCTGATGAAAATATAATCCTTAAAGAAGGAGATATAATAAACG
TTGATGTATCTACTATATATAATGGATATTATTCAGATGCCTCAAGAATGTTTATTATTGGAGAAGCTAGTGAAAATGCA
AAAAGATTAGTTAAAGTAGCTAAAGAATGCTTAGAAAAAGGTATTGAAGCAGTTAAACCTTGGGGATTTTTAGGAGATAT
AGGAGCTGCAATTCAAGAGCATGCAGAAAAGAATGGATATTCAGTGGTAAGAGATTTTGGAGGTCATGGAGTAGGATTAA
AATTCCATGAGGATCCATTTGTATATCATTATGGAGATGCTGGAGAGGGTATGGTATTAGTACCAGGTATGATATTTACA
ATAGAGCCTATGATAAATGAAGGGAAATATGATGTCTTTGTAGATGCAGATAATGATTGGACTGCATTAACTATGGATGG
ATCACTTTCAGCTCAATGGGAGCATACAATACTAGTTACAGAGGATGGAATTGAAATAATAGCTAAATAA

Upstream 100 bases:

>100_bases
AATAAGGTGTAAACTTGAAAAAAGTATAACTTAGTATATACTTAAAAGTATAGATATATACTTTAAGGTGTATTTAAAGT
TTTTATAAGGAGACAGGAAA

Downstream 100 bases:

>100_bases
TAAAAAATTAAAGCCTTCTAAAATTAATTAGAAGGCTTTAAAAATACATACTTATTGGTGCTATTAGTACAGCTGGTGAT
TTAACTTTAGGTTCTGGACA

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MRINRNDLCWCNSGKKYKKCHMEFDERIENLAREGFEVPTRDIIKNEEQIEGIRKSAEINNAVLDLVAEKIKAGMSTEDI
NKIVHDYTVSRGAIPAPLNYGGFPKSVCTSINDEVCHGIPDENIILKEGDIINVDVSTIYNGYYSDASRMFIIGEASENA
KRLVKVAKECLEKGIEAVKPWGFLGDIGAAIQEHAEKNGYSVVRDFGGHGVGLKFHEDPFVYHYGDAGEGMVLVPGMIFT
IEPMINEGKYDVFVDADNDWTALTMDGSLSAQWEHTILVTEDGIEIIAK

Sequences:

>Translated_289_residues
MRINRNDLCWCNSGKKYKKCHMEFDERIENLAREGFEVPTRDIIKNEEQIEGIRKSAEINNAVLDLVAEKIKAGMSTEDI
NKIVHDYTVSRGAIPAPLNYGGFPKSVCTSINDEVCHGIPDENIILKEGDIINVDVSTIYNGYYSDASRMFIIGEASENA
KRLVKVAKECLEKGIEAVKPWGFLGDIGAAIQEHAEKNGYSVVRDFGGHGVGLKFHEDPFVYHYGDAGEGMVLVPGMIFT
IEPMINEGKYDVFVDADNDWTALTMDGSLSAQWEHTILVTEDGIEIIAK
>Mature_289_residues
MRINRNDLCWCNSGKKYKKCHMEFDERIENLAREGFEVPTRDIIKNEEQIEGIRKSAEINNAVLDLVAEKIKAGMSTEDI
NKIVHDYTVSRGAIPAPLNYGGFPKSVCTSINDEVCHGIPDENIILKEGDIINVDVSTIYNGYYSDASRMFIIGEASENA
KRLVKVAKECLEKGIEAVKPWGFLGDIGAAIQEHAEKNGYSVVRDFGGHGVGLKFHEDPFVYHYGDAGEGMVLVPGMIFT
IEPMINEGKYDVFVDADNDWTALTMDGSLSAQWEHTILVTEDGIEIIAK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=244, Percent_Identity=46.3114754098361, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=42.741935483871, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=47.1544715447154, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1788728, Length=252, Percent_Identity=24.6031746031746, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=249, Percent_Identity=42.570281124498, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=46.7479674796748, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI21355531, Length=252, Percent_Identity=42.4603174603175, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=39.8373983739837, Blast_Score=191, Evalue=4e-49,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32154; Mature: 32154

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRINRNDLCWCNSGKKYKKCHMEFDERIENLAREGFEVPTRDIIKNEEQIEGIRKSAEIN
CCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHH
NAVLDLVAEKIKAGMSTEDINKIVHDYTVSRGAIPAPLNYGGFPKSVCTSINDEVCHGIP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHCCCC
DENIILKEGDIINVDVSTIYNGYYSDASRMFIIGEASENAKRLVKVAKECLEKGIEAVKP
CCCEEEECCCEEEEEHHHHHCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
WGFLGDIGAAIQEHAEKNGYSVVRDFGGHGVGLKFHEDPFVYHYGDAGEGMVLVPGMIFT
CCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCCEEEEECCCCCCEEECCCEEEE
IEPMINEGKYDVFVDADNDWTALTMDGSLSAQWEHTILVTEDGIEIIAK
EEECCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEEEECCEEEECC
>Mature Secondary Structure
MRINRNDLCWCNSGKKYKKCHMEFDERIENLAREGFEVPTRDIIKNEEQIEGIRKSAEIN
CCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHH
NAVLDLVAEKIKAGMSTEDINKIVHDYTVSRGAIPAPLNYGGFPKSVCTSINDEVCHGIP
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCHHHHCCCC
DENIILKEGDIINVDVSTIYNGYYSDASRMFIIGEASENAKRLVKVAKECLEKGIEAVKP
CCCEEEECCCEEEEEHHHHHCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
WGFLGDIGAAIQEHAEKNGYSVVRDFGGHGVGLKFHEDPFVYHYGDAGEGMVLVPGMIFT
CCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCCEEEEECCCCCCEEECCCEEEE
IEPMINEGKYDVFVDADNDWTALTMDGSLSAQWEHTILVTEDGIEIIAK
EEECCCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]