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The map label for this gene is gtcR [H]

Identifier: 18310175

GI number: 18310175

Start: 1390419

End: 1391096

Strand: Reverse

Name: gtcR [H]

Synonym: CPE1193

Alternate gene names: 18310175

Gene position: 1391096-1390419 (Counterclockwise)

Preceding gene: 18310176

Following gene: 18310174

Centisome position: 45.89

GC content: 28.02

Gene sequence:

>678_bases
ATGAATATTTTAATAGCTGAGGATGAACAAGATATAAGAAATCTTTTAGAATTACATTTATTAAAGGAAGGGTACACTGT
ATTTAAGGCTGTAAATGGATTAGAAGCCTTAGATATCTTAAAAAAAGAACACATACATTTAGCCTTATTAGATGTTATGA
TGGATGGAATAGATGGTTTTAATCTATTAAAGATGTTAAGGGAATGGAGTCAGATTCCAGTTATATTTTTAACTGCTAAA
ATTGAGGATGATGATAAAATATTAGGTTTAGGCTTAGGGGCTGATGATTATGTTATAAAACCTTTTAAACCTGTAGAACT
TATGGCTAGGATTAAATCAAATTTAAGAAGATGCTATAAATATTCTGGAGAAAATGAACTTATAAAAATAGGAAATTTAG
AACTTAGCAAAGAAGGATGTACAGTTAAAAAAGATGGAGAAATAGTAACTTTAAACGCAAAGGAATTTAAAATTTTAGAA
ATGCTTATGAGCAACATTGGAAGAGTGTTTACTAAAAAACAAATATATGAAAATGTATGGCAAGAGGAGTATTTAGGTGA
TGACAATACTATAATGGTTCATATAAGCCACTTAAGAGATAAGATAGAAGAAGATCCTAAAAATCCTTGCAAGATAAAAA
CTATAAGAGGGATAGGATATAGGTTTGAAAAAATTTAA

Upstream 100 bases:

>100_bases
ATTAAGCTTAAAAATATCTTAAATAATATAATTTTAAGTTTAGTAAATCTAGAGTTTAATATTATAATGTATTTAAGGAA
TTACTATATAGGAGGGGAAT

Downstream 100 bases:

>100_bases
TCTAGGAAAAAACAGATATAAGGTATCAAATATATTACTTAGGAATTATCTTAAGGTATTTTTACTTATTACTATTATAA
CTGCTACTATATTTCTAATT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MNILIAEDEQDIRNLLELHLLKEGYTVFKAVNGLEALDILKKEHIHLALLDVMMDGIDGFNLLKMLREWSQIPVIFLTAK
IEDDDKILGLGLGADDYVIKPFKPVELMARIKSNLRRCYKYSGENELIKIGNLELSKEGCTVKKDGEIVTLNAKEFKILE
MLMSNIGRVFTKKQIYENVWQEEYLGDDNTIMVHISHLRDKIEEDPKNPCKIKTIRGIGYRFEKI

Sequences:

>Translated_225_residues
MNILIAEDEQDIRNLLELHLLKEGYTVFKAVNGLEALDILKKEHIHLALLDVMMDGIDGFNLLKMLREWSQIPVIFLTAK
IEDDDKILGLGLGADDYVIKPFKPVELMARIKSNLRRCYKYSGENELIKIGNLELSKEGCTVKKDGEIVTLNAKEFKILE
MLMSNIGRVFTKKQIYENVWQEEYLGDDNTIMVHISHLRDKIEEDPKNPCKIKTIRGIGYRFEKI
>Mature_225_residues
MNILIAEDEQDIRNLLELHLLKEGYTVFKAVNGLEALDILKKEHIHLALLDVMMDGIDGFNLLKMLREWSQIPVIFLTAK
IEDDDKILGLGLGADDYVIKPFKPVELMARIKSNLRRCYKYSGENELIKIGNLELSKEGCTVKKDGEIVTLNAKEFKILE
MLMSNIGRVFTKKQIYENVWQEEYLGDDNTIMVHISHLRDKIEEDPKNPCKIKTIRGIGYRFEKI

Specific function: Member of the two-component regulatory system gtcS/gtcR which may act in th control of the transcription of the grs operon which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=36.6515837104072, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=36.8181818181818, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=36.283185840708, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=35.5555555555556, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=34.2342342342342, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=36.1607142857143, Blast_Score=136, Evalue=9e-34,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=34.375, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=35.0877192982456, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.219730941704, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=37.10407239819, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=35.7142857142857, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=219, Percent_Identity=29.6803652968037, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.0172413793103, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=101, Percent_Identity=37.6237623762376, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25995; Mature: 25995

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIAEDEQDIRNLLELHLLKEGYTVFKAVNGLEALDILKKEHIHLALLDVMMDGIDGF
CCEEEECCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
NLLKMLREWSQIPVIFLTAKIEDDDKILGLGLGADDYVIKPFKPVELMARIKSNLRRCYK
HHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHH
YSGENELIKIGNLELSKEGCTVKKDGEIVTLNAKEFKILEMLMSNIGRVFTKKQIYENVW
CCCCCCEEEECCEEECCCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEEYLGDDNTIMVHISHLRDKIEEDPKNPCKIKTIRGIGYRFEKI
HHHHCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEEECCCEEECCC
>Mature Secondary Structure
MNILIAEDEQDIRNLLELHLLKEGYTVFKAVNGLEALDILKKEHIHLALLDVMMDGIDGF
CCEEEECCHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
NLLKMLREWSQIPVIFLTAKIEDDDKILGLGLGADDYVIKPFKPVELMARIKSNLRRCYK
HHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHH
YSGENELIKIGNLELSKEGCTVKKDGEIVTLNAKEFKILEMLMSNIGRVFTKKQIYENVW
CCCCCCEEEECCEEECCCCCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEEYLGDDNTIMVHISHLRDKIEEDPKNPCKIKTIRGIGYRFEKI
HHHHCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7579582 [H]