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The map label for this gene is gtcS [H]

Identifier: 18310174

GI number: 18310174

Start: 1388996

End: 1390432

Strand: Reverse

Name: gtcS [H]

Synonym: CPE1192

Alternate gene names: 18310174

Gene position: 1390432-1388996 (Counterclockwise)

Preceding gene: 18310175

Following gene: 18310172

Centisome position: 45.87

GC content: 25.33

Gene sequence:

>1437_bases
TTGAAAAAATTTAATCTAGGAAAAAACAGATATAAGGTATCAAATATATTACTTAGGAATTATCTTAAGGTATTTTTACT
TATTACTATTATAACTGCTACTATATTTCTAATTTCTTTTATTATAGGGGTTAGTATATATTTAAAAAGTGAGCCAATAG
AAAATGAATCTTCTAAAATACTTGTAGGAGAAATAGAAAATAAAGATTATAACAGCATAGGTAATCAAGATTATGTAACA
GAGCATGGTGGATGGATTGAAATTATAGATAAGGATTTAAATGTAATAGAAACAATTGGGGATCAAAAGGTGAAAAGAGA
TAATTATTCCAGTGAAGAATTCAGTAAAATTTTGGTGGATGAAATGCATGGAGTTAATATAGATGAGGATTACTTATCTT
ATACTGGTTATAGCAAGGAAGGGAGATTCTTTGTAATTACTAGAATACCTGAAGAAAACTTCGGAAAAATGTTTACTAGA
AATCCTAAAATTGGATTTAAGATATTTGTATATATTATGATTTCTTTATATATCTTTATTTTTACAATGAGTCTAATCCT
TTATTCAAAATTAACTTCTAAGACATTTACTAAACCTTTAGATAAGCTTATGAATGGAGTTAGGAAATTATCCTTAGGAG
ATTATTCTACTAGAATTAACATAGAAAAAAACAATGAGTTTGAGGAGCTTGGAGAGGCTTTTAATAATATGGCATCTAAA
ATAGAAGAAGAAAAGAAATTAAAAGAGAAATCAGAAAAGCTAAGGAAAGAATTTGTTAGAAATATAGCCCATGATTTAAA
GACTCCCTTATCAAGTATAATAGGATATTCCAATATTATAAAAAACAATCCAGATATTGAAAAAGAGTCTTTACATAAAT
ACATAAGTATAATTGAGAACAATGGGGAAAGAGCAAATGAAATGATAATGGAACTATTTGAATTTTACACACTTCAAAGT
TCTGAATTTATTTTACATAAAAAATATCAAGATTTAAGCGAATTTTTAAGAAATTTAATAGCTGATTACATATATCTCCT
AGAAGAAAAAGACTTTGATTTTGATTTTGAAATAAGTGAAGATGATCTTTATTTAGAATTTGATAATAAAAGACTTGAAA
GAGCTATAGGCAATTTAATAATAAATAGTGTTAAATATAATAAAAAAGGAACTAAGTTTTTAGTAAGTCTAAAAAAAGAA
GAGGATAAGGTTAAAATAATAGTTAGTGATGATGGTATAGGTTTAAGTGAAGAAATAAAAAAACATATTTTTAATCCTTT
TGTTAGGGAAGAAAAATCAAGAAATTCTAAAAAGGGTGGTTCTGGATTAGGATTAACCATAAGTAAAGAAATTGTAGAAA
AACATGGAGGAACAATCTATTTAAGTGATGGTCCTTTAAAAGGATGCAATTTTGTTATAGAATTACCAATAAAATAA

Upstream 100 bases:

>100_bases
AATACTATAATGGTTCATATAAGCCACTTAAGAGATAAGATAGAAGAAGATCCTAAAAATCCTTGCAAGATAAAAACTAT
AAGAGGGATAGGATATAGGT

Downstream 100 bases:

>100_bases
AAAGGCTTAGCTATTAAAGCTAAGCCTTTTTTATTATGCAGCCCTTCTTGAAGGTCTTTTACTTCTACTATATTTCTTAC
TTGATTTTCTCTTTTTATAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKKFNLGKNRYKVSNILLRNYLKVFLLITIITATIFLISFIIGVSIYLKSEPIENESSKILVGEIENKDYNSIGNQDYVT
EHGGWIEIIDKDLNVIETIGDQKVKRDNYSSEEFSKILVDEMHGVNIDEDYLSYTGYSKEGRFFVITRIPEENFGKMFTR
NPKIGFKIFVYIMISLYIFIFTMSLILYSKLTSKTFTKPLDKLMNGVRKLSLGDYSTRINIEKNNEFEELGEAFNNMASK
IEEEKKLKEKSEKLRKEFVRNIAHDLKTPLSSIIGYSNIIKNNPDIEKESLHKYISIIENNGERANEMIMELFEFYTLQS
SEFILHKKYQDLSEFLRNLIADYIYLLEEKDFDFDFEISEDDLYLEFDNKRLERAIGNLIINSVKYNKKGTKFLVSLKKE
EDKVKIIVSDDGIGLSEEIKKHIFNPFVREEKSRNSKKGGSGLGLTISKEIVEKHGGTIYLSDGPLKGCNFVIELPIK

Sequences:

>Translated_478_residues
MKKFNLGKNRYKVSNILLRNYLKVFLLITIITATIFLISFIIGVSIYLKSEPIENESSKILVGEIENKDYNSIGNQDYVT
EHGGWIEIIDKDLNVIETIGDQKVKRDNYSSEEFSKILVDEMHGVNIDEDYLSYTGYSKEGRFFVITRIPEENFGKMFTR
NPKIGFKIFVYIMISLYIFIFTMSLILYSKLTSKTFTKPLDKLMNGVRKLSLGDYSTRINIEKNNEFEELGEAFNNMASK
IEEEKKLKEKSEKLRKEFVRNIAHDLKTPLSSIIGYSNIIKNNPDIEKESLHKYISIIENNGERANEMIMELFEFYTLQS
SEFILHKKYQDLSEFLRNLIADYIYLLEEKDFDFDFEISEDDLYLEFDNKRLERAIGNLIINSVKYNKKGTKFLVSLKKE
EDKVKIIVSDDGIGLSEEIKKHIFNPFVREEKSRNSKKGGSGLGLTISKEIVEKHGGTIYLSDGPLKGCNFVIELPIK
>Mature_478_residues
MKKFNLGKNRYKVSNILLRNYLKVFLLITIITATIFLISFIIGVSIYLKSEPIENESSKILVGEIENKDYNSIGNQDYVT
EHGGWIEIIDKDLNVIETIGDQKVKRDNYSSEEFSKILVDEMHGVNIDEDYLSYTGYSKEGRFFVITRIPEENFGKMFTR
NPKIGFKIFVYIMISLYIFIFTMSLILYSKLTSKTFTKPLDKLMNGVRKLSLGDYSTRINIEKNNEFEELGEAFNNMASK
IEEEKKLKEKSEKLRKEFVRNIAHDLKTPLSSIIGYSNIIKNNPDIEKESLHKYISIIENNGERANEMIMELFEFYTLQS
SEFILHKKYQDLSEFLRNLIADYIYLLEEKDFDFDFEISEDDLYLEFDNKRLERAIGNLIINSVKYNKKGTKFLVSLKKE
EDKVKIIVSDDGIGLSEEIKKHIFNPFVREEKSRNSKKGGSGLGLTISKEIVEKHGGTIYLSDGPLKGCNFVIELPIK

Specific function: Member of the two-component regulatory system gtcS/gtcR which may act in th control of the transcription of the grs operon which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S. Probably activates gtcR by phosp

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=285, Percent_Identity=27.0175438596491, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787894, Length=314, Percent_Identity=28.0254777070064, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1790346, Length=284, Percent_Identity=28.8732394366197, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788713, Length=285, Percent_Identity=23.5087719298246, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788549, Length=280, Percent_Identity=25, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789149, Length=288, Percent_Identity=25, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=27.5423728813559, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=298, Percent_Identity=24.1610738255034, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786783, Length=280, Percent_Identity=25.7142857142857, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789808, Length=307, Percent_Identity=25.7328990228013, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081816, Length=342, Percent_Identity=21.9298245614035, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=22.7272727272727, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=26.5560165975104, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=25.2173913043478, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790300, Length=249, Percent_Identity=24.0963855421687, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788279, Length=291, Percent_Identity=27.1477663230241, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=306, Percent_Identity=20.5882352941176, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=22.972972972973, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790861, Length=240, Percent_Identity=21.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=304, Percent_Identity=21.7105263157895, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55472; Mature: 55472

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFNLGKNRYKVSNILLRNYLKVFLLITIITATIFLISFIIGVSIYLKSEPIENESSKI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEE
LVGEIENKDYNSIGNQDYVTEHGGWIEIIDKDLNVIETIGDQKVKRDNYSSEEFSKILVD
EEEECCCCCCCCCCCCCCEECCCCEEEEECCCHHHHHHHCCHHHHCCCCCHHHHHHHHHH
EMHGVNIDEDYLSYTGYSKEGRFFVITRIPEENFGKMFTRNPKIGFKIFVYIMISLYIFI
HHCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
FTMSLILYSKLTSKTFTKPLDKLMNGVRKLSLGDYSTRINIEKNNEFEELGEAFNNMASK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
IEEEKKLKEKSEKLRKEFVRNIAHDLKTPLSSIIGYSNIIKNNPDIEKESLHKYISIIEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
NGERANEMIMELFEFYTLQSSEFILHKKYQDLSEFLRNLIADYIYLLEEKDFDFDFEISE
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
DDLYLEFDNKRLERAIGNLIINSVKYNKKGTKFLVSLKKEEDKVKIIVSDDGIGLSEEIK
CCEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHH
KHIFNPFVREEKSRNSKKGGSGLGLTISKEIVEKHGGTIYLSDGPLKGCNFVIELPIK
HHHCCHHHHHHHHCCCCCCCCCCCEEEEHHHHHHCCCEEEEECCCCCCCCEEEEECCC
>Mature Secondary Structure
MKKFNLGKNRYKVSNILLRNYLKVFLLITIITATIFLISFIIGVSIYLKSEPIENESSKI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEE
LVGEIENKDYNSIGNQDYVTEHGGWIEIIDKDLNVIETIGDQKVKRDNYSSEEFSKILVD
EEEECCCCCCCCCCCCCCEECCCCEEEEECCCHHHHHHHCCHHHHCCCCCHHHHHHHHHH
EMHGVNIDEDYLSYTGYSKEGRFFVITRIPEENFGKMFTRNPKIGFKIFVYIMISLYIFI
HHCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
FTMSLILYSKLTSKTFTKPLDKLMNGVRKLSLGDYSTRINIEKNNEFEELGEAFNNMASK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
IEEEKKLKEKSEKLRKEFVRNIAHDLKTPLSSIIGYSNIIKNNPDIEKESLHKYISIIEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
NGERANEMIMELFEFYTLQSSEFILHKKYQDLSEFLRNLIADYIYLLEEKDFDFDFEISE
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
DDLYLEFDNKRLERAIGNLIINSVKYNKKGTKFLVSLKKEEDKVKIIVSDDGIGLSEEIK
CCEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHH
KHIFNPFVREEKSRNSKKGGSGLGLTISKEIVEKHGGTIYLSDGPLKGCNFVIELPIK
HHHCCHHHHHHHHCCCCCCCCCCCEEEEHHHHHHCCCEEEEECCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7579582 [H]