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The map label for this gene is toxA [H]

Identifier: 18309606

GI number: 18309606

Start: 780389

End: 782812

Strand: Direct

Name: toxA [H]

Synonym: CPE0624

Alternate gene names: 18309606

Gene position: 780389-782812 (Clockwise)

Preceding gene: 18309605

Following gene: 18309607

Centisome position: 25.74

GC content: 29.46

Gene sequence:

>2424_bases
TTGATTAAAAAGTTTATTCTTGCTACAGTTATTACTTTAAGTGTAACTTCAATTAATGTTCTAGCTTCAGAGAATGTAAA
TGATAAGTCTGATGAAAGTAAGTCTTCTAGTTTAGTTGGGGAAACTTATGAAATTGTAAAAGAGCCAAATATGTTTTTTT
CAATTCCAGGTGATAATGTAGAAAGCTATAAAGATGAAAATGGAATTGAGAGAGAAGAATTTAAAAAGGATAAAGAAGGT
CAAGAATCTATAAACAGACTTGTTACAAAGACTAAGAGTAAGTATGAGATAGCATTAGCTCATGAAAATGGGAAATATAC
TTTTTTAGATTCTGCAAACACAAAGGAAGAAGCAGAGAAAAAGGTTGAAAATGCAAGTGAAAAATATAATACTTTTGCAG
CAATGCCTGTTGTTTTAAATGATAGTGGACAAGTAGCTTATTCAGAAAAATCAATGGGAAGATTAGTTAAATATAAAAAT
GGAAGTCCAGCTGGATATGGAGAAATAACCAATATATATGCTAATCCTAATTTAACAAATGACTTTACATATATTAATCA
TGGTTATGTAGATGATGTTCCAATAATTGAGGATAGAGGAAATGTTGCCAAAATAGAAGTTGGAGGATATGAAGGTTGGG
TAAATAAAGATACTAGTTCTGGAAATTATGATTTAGTCATAGTACCATTAAACCAAGTAAAAAATCCAAGTTATTATATA
GTTAGAGATGGAGAGTTAATCCATTATATAAGTAGTGATCTTACCAATTATTCTGAAGGTGGATATGAGGTTGTTATAGG
ACCAGCACCTAATTTCTTAAATGAAAATGTAAAATATTATAGTTATGATAACAAATATTTTTATAAAGATTTAAGTACAT
TAATAGGTGATTTACAAAATGATAATCATAATAATTCTGTAAATGCAAATAATCCTTTTTATCCATATTATATCCATTTA
CCATTTAGAAGTAAAACAACATTTACTGCTGAAGAATTAAATAATTTTATTGCTAAAAAGACAAAATCATATAGTAAATT
AAGAGGAACTGGACAAGCTTTTATAGATGCACAAAATAAATATGGAGCAAATGCTCTTTTACTTTTAGGACTAGCGGCTA
ATGAATCAGCTTGGGGGACATCTCAAATAGCTCAACAAAAAAATAATTTGTTTGGAATAAATGCTATTGATTCAAGTCCA
GGAGCATCAGCAAATTCATTTGAAACTGTTGAAGGCTGTATAAATGATTTTGCAAAATATTATATTTCTAGAGGATATTC
AGATCCAGAAGATTGGAGATATTTTGGAGGATACCTTGGAAATAAGGGTAGTGGAGCTAATGTTAAATATGCTTCAGATC
CATTCTGGGGAGAAAAAGCAGGACAAAATGCTTATATAGCTGATTACTGGGCAAGTGGAAAAGGAATAGCAGGTTTAAAA
GATTATAATTACTATCAGCTAGGCATTTATACAGGGGCTAGTAGTGTTACAAATAAAGATAATGAAAAATTATATGATGT
AGGTGGCTTATATACTGAAAGAGTAGAAAAAATAGGAGCTACAACAATTTTAACTAGCAAAGAAAAGATTAGCCACAATG
GAAAAGACTGTTATGAAATAAATCCAGTTAGAACAACTCCTGTAATATCAAATGGATCACCAGTAGCATTCAAAGGTCCA
TATGATTGGAATGATAAAGGTTTTGTAGATGCATCAAAAGTTAAGCTTATAAATGAAGGTAAGCATTCTGAAAATGTTAT
AGGAAAATGGGAATTAAATGATGGCATATGGTACTATTATATAGACGGAAAATATGTTACTGGGTGGAAGAATATAGATA
ATAACAAGTATTATTTTGATCAATCAGGTAAGATGCAAACAGGTTGGCTATGTATAGATAATATATGGTATCATTTTAGA
GATAATGGAACAATAGACATAGGTTGGAGAGAAATAGATGGATATTGGTATTATTTTAATAATGATGGAGAAATGCAAAA
GGGTTGGCAGACAATAGGTAAATATAAGTATTATTTCAATGATAATGGAGTAATGAATATTGGCTGGAGAAAAATAGATA
ATATTTGGTACTATTTTAATATAAATGGAGAAATGCAAACAGGATGGTTATTTGAAAATAATATATGGTATCATTTTGAA
ACTACAGGTTCAATGACTGTAGGATGGAAAAAAATAAATAATGATTGGTACTATTTTAATTCAAATGGAGAAATGCAAAC
AGGATGGCAAAATATTGGTACTCCAAAATATCATTTTAGAGATAATGGTGTAATGGACATTGGATGGAGAGAAATAGATG
GACAATGGCATTATTTTAATGAGAATGGAGAAATGCAAACAGGTTGGCAATATATAAATGGAAATAGTTATTATTTCGAT
GAAAAAGGAATATGGAAACAGTAA

Upstream 100 bases:

>100_bases
TTTCTTAATTTTACTAGTTATTAAAGATGATTGTTTATTAGAAATAATAAATAAATTTACTAAAAAATTAAAAAGATAAA
AAATAAAAGGGGGAGTTTCA

Downstream 100 bases:

>100_bases
TAAAAAGACTGATTAAATTCAGTCTTTTTATTATAGAATAAATTTCTAATATTGATAAATATAACGTAATAAGGTAATAT
TTAAGTATAAGCAAGTTTAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MIKKFILATVITLSVTSINVLASENVNDKSDESKSSSLVGETYEIVKEPNMFFSIPGDNVESYKDENGIEREEFKKDKEG
QESINRLVTKTKSKYEIALAHENGKYTFLDSANTKEEAEKKVENASEKYNTFAAMPVVLNDSGQVAYSEKSMGRLVKYKN
GSPAGYGEITNIYANPNLTNDFTYINHGYVDDVPIIEDRGNVAKIEVGGYEGWVNKDTSSGNYDLVIVPLNQVKNPSYYI
VRDGELIHYISSDLTNYSEGGYEVVIGPAPNFLNENVKYYSYDNKYFYKDLSTLIGDLQNDNHNNSVNANNPFYPYYIHL
PFRSKTTFTAEELNNFIAKKTKSYSKLRGTGQAFIDAQNKYGANALLLLGLAANESAWGTSQIAQQKNNLFGINAIDSSP
GASANSFETVEGCINDFAKYYISRGYSDPEDWRYFGGYLGNKGSGANVKYASDPFWGEKAGQNAYIADYWASGKGIAGLK
DYNYYQLGIYTGASSVTNKDNEKLYDVGGLYTERVEKIGATTILTSKEKISHNGKDCYEINPVRTTPVISNGSPVAFKGP
YDWNDKGFVDASKVKLINEGKHSENVIGKWELNDGIWYYYIDGKYVTGWKNIDNNKYYFDQSGKMQTGWLCIDNIWYHFR
DNGTIDIGWREIDGYWYYFNNDGEMQKGWQTIGKYKYYFNDNGVMNIGWRKIDNIWYYFNINGEMQTGWLFENNIWYHFE
TTGSMTVGWKKINNDWYYFNSNGEMQTGWQNIGTPKYHFRDNGVMDIGWREIDGQWHYFNENGEMQTGWQYINGNSYYFD
EKGIWKQ

Sequences:

>Translated_807_residues
MIKKFILATVITLSVTSINVLASENVNDKSDESKSSSLVGETYEIVKEPNMFFSIPGDNVESYKDENGIEREEFKKDKEG
QESINRLVTKTKSKYEIALAHENGKYTFLDSANTKEEAEKKVENASEKYNTFAAMPVVLNDSGQVAYSEKSMGRLVKYKN
GSPAGYGEITNIYANPNLTNDFTYINHGYVDDVPIIEDRGNVAKIEVGGYEGWVNKDTSSGNYDLVIVPLNQVKNPSYYI
VRDGELIHYISSDLTNYSEGGYEVVIGPAPNFLNENVKYYSYDNKYFYKDLSTLIGDLQNDNHNNSVNANNPFYPYYIHL
PFRSKTTFTAEELNNFIAKKTKSYSKLRGTGQAFIDAQNKYGANALLLLGLAANESAWGTSQIAQQKNNLFGINAIDSSP
GASANSFETVEGCINDFAKYYISRGYSDPEDWRYFGGYLGNKGSGANVKYASDPFWGEKAGQNAYIADYWASGKGIAGLK
DYNYYQLGIYTGASSVTNKDNEKLYDVGGLYTERVEKIGATTILTSKEKISHNGKDCYEINPVRTTPVISNGSPVAFKGP
YDWNDKGFVDASKVKLINEGKHSENVIGKWELNDGIWYYYIDGKYVTGWKNIDNNKYYFDQSGKMQTGWLCIDNIWYHFR
DNGTIDIGWREIDGYWYYFNNDGEMQKGWQTIGKYKYYFNDNGVMNIGWRKIDNIWYYFNINGEMQTGWLFENNIWYHFE
TTGSMTVGWKKINNDWYYFNSNGEMQTGWQNIGTPKYHFRDNGVMDIGWREIDGQWHYFNENGEMQTGWQYINGNSYYFD
EKGIWKQ
>Mature_807_residues
MIKKFILATVITLSVTSINVLASENVNDKSDESKSSSLVGETYEIVKEPNMFFSIPGDNVESYKDENGIEREEFKKDKEG
QESINRLVTKTKSKYEIALAHENGKYTFLDSANTKEEAEKKVENASEKYNTFAAMPVVLNDSGQVAYSEKSMGRLVKYKN
GSPAGYGEITNIYANPNLTNDFTYINHGYVDDVPIIEDRGNVAKIEVGGYEGWVNKDTSSGNYDLVIVPLNQVKNPSYYI
VRDGELIHYISSDLTNYSEGGYEVVIGPAPNFLNENVKYYSYDNKYFYKDLSTLIGDLQNDNHNNSVNANNPFYPYYIHL
PFRSKTTFTAEELNNFIAKKTKSYSKLRGTGQAFIDAQNKYGANALLLLGLAANESAWGTSQIAQQKNNLFGINAIDSSP
GASANSFETVEGCINDFAKYYISRGYSDPEDWRYFGGYLGNKGSGANVKYASDPFWGEKAGQNAYIADYWASGKGIAGLK
DYNYYQLGIYTGASSVTNKDNEKLYDVGGLYTERVEKIGATTILTSKEKISHNGKDCYEINPVRTTPVISNGSPVAFKGP
YDWNDKGFVDASKVKLINEGKHSENVIGKWELNDGIWYYYIDGKYVTGWKNIDNNKYYFDQSGKMQTGWLCIDNIWYHFR
DNGTIDIGWREIDGYWYYFNNDGEMQKGWQTIGKYKYYFNDNGVMNIGWRKIDNIWYYFNINGEMQTGWLFENNIWYHFE
TTGSMTVGWKKINNDWYYFNSNGEMQTGWQNIGTPKYHFRDNGVMDIGWREIDGQWHYFNENGEMQTGWQYINGNSYYFD
EKGIWKQ

Specific function: Only after the enteral delivery of the enterotoxin A may the characteristic disease called pseudomembranous colitis be induced [H]

COG id: COG5263

COG function: function code R; FOG: Glucan-binding domain (YG repeat)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 32 cell wall-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018337
- InterPro:   IPR007577
- InterPro:   IPR020974 [H]

Pfam domain/function: PF01473 CW_binding_1; PF04488 Gly_transf_sug; PF11713 Peptidase_C80 [H]

EC number: NA

Molecular weight: Translated: 92204; Mature: 92204

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKFILATVITLSVTSINVLASENVNDKSDESKSSSLVGETYEIVKEPNMFFSIPGDNV
CCHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHCCCCEEEECCCCCH
ESYKDENGIEREEFKKDKEGQESINRLVTKTKSKYEIALAHENGKYTFLDSANTKEEAEK
HHCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCHHHHHH
KVENASEKYNTFAAMPVVLNDSGQVAYSEKSMGRLVKYKNGSPAGYGEITNIYANPNLTN
HHHHHHHHHCEEEEEEEEECCCCCEEECCCCCCCEEEECCCCCCCCCCEEEEEECCCCCC
DFTYINHGYVDDVPIIEDRGNVAKIEVGGYEGWVNKDTSSGNYDLVIVPLNQVKNPSYYI
CEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEHHHCCCCCEEE
VRDGELIHYISSDLTNYSEGGYEVVIGPAPNFLNENVKYYSYDNKYFYKDLSTLIGDLQN
EECCCEEEEEHHCCCCCCCCCEEEEECCCCCHHCCCCEEEEECCEEHHHHHHHHHHHHCC
DNHNNSVNANNPFYPYYIHLPFRSKTTFTAEELNNFIAKKTKSYSKLRGTGQAFIDAQNK
CCCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
YGANALLLLGLAANESAWGTSQIAQQKNNLFGINAIDSSPGASANSFETVEGCINDFAKY
CCCCEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
YISRGYSDPEDWRYFGGYLGNKGSGANVKYASDPFWGEKAGQNAYIADYWASGKGIAGLK
HHHCCCCCHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCC
DYNYYQLGIYTGASSVTNKDNEKLYDVGGLYTERVEKIGATTILTSKEKISHNGKDCYEI
CCCEEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEEECHHHHCCCCCCEEEE
NPVRTTPVISNGSPVAFKGPYDWNDKGFVDASKVKLINEGKHSENVIGKWELNDGIWYYY
CCCCCCEEECCCCCEEEECCCCCCCCCCEEHHHEEEEECCCCCCCEEEEEEECCCEEEEE
IDGKYVTGWKNIDNNKYYFDQSGKMQTGWLCIDNIWYHFRDNGTIDIGWREIDGYWYYFN
ECCEEEECCCCCCCCEEEECCCCCEEECEEEEECEEEEEECCCEEEEEEEEECCEEEEEC
NDGEMQKGWQTIGKYKYYFNDNGVMNIGWRKIDNIWYYFNINGEMQTGWLFENNIWYHFE
CCCCHHHHHHHHCCEEEEECCCCEEEECEEEECCEEEEEEECCCEEEEEEEECCEEEEEE
TTGSMTVGWKKINNDWYYFNSNGEMQTGWQNIGTPKYHFRDNGVMDIGWREIDGQWHYFN
CCCCEEEEEEEECCCEEEECCCCCEECCHHHCCCCEEEECCCCEEEECEEEECCEEEEEC
ENGEMQTGWQYINGNSYYFDEKGIWKQ
CCCCEEECEEEECCCEEEECCCCCCCC
>Mature Secondary Structure
MIKKFILATVITLSVTSINVLASENVNDKSDESKSSSLVGETYEIVKEPNMFFSIPGDNV
CCHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCHHHHHCCCHHHHHCCCCEEEECCCCCH
ESYKDENGIEREEFKKDKEGQESINRLVTKTKSKYEIALAHENGKYTFLDSANTKEEAEK
HHCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCHHHHHH
KVENASEKYNTFAAMPVVLNDSGQVAYSEKSMGRLVKYKNGSPAGYGEITNIYANPNLTN
HHHHHHHHHCEEEEEEEEECCCCCEEECCCCCCCEEEECCCCCCCCCCEEEEEECCCCCC
DFTYINHGYVDDVPIIEDRGNVAKIEVGGYEGWVNKDTSSGNYDLVIVPLNQVKNPSYYI
CEEEEECCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEHHHCCCCCEEE
VRDGELIHYISSDLTNYSEGGYEVVIGPAPNFLNENVKYYSYDNKYFYKDLSTLIGDLQN
EECCCEEEEEHHCCCCCCCCCEEEEECCCCCHHCCCCEEEEECCEEHHHHHHHHHHHHCC
DNHNNSVNANNPFYPYYIHLPFRSKTTFTAEELNNFIAKKTKSYSKLRGTGQAFIDAQNK
CCCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
YGANALLLLGLAANESAWGTSQIAQQKNNLFGINAIDSSPGASANSFETVEGCINDFAKY
CCCCEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
YISRGYSDPEDWRYFGGYLGNKGSGANVKYASDPFWGEKAGQNAYIADYWASGKGIAGLK
HHHCCCCCHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCC
DYNYYQLGIYTGASSVTNKDNEKLYDVGGLYTERVEKIGATTILTSKEKISHNGKDCYEI
CCCEEEEEEEECCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEEECHHHHCCCCCCEEEE
NPVRTTPVISNGSPVAFKGPYDWNDKGFVDASKVKLINEGKHSENVIGKWELNDGIWYYY
CCCCCCEEECCCCCEEEECCCCCCCCCCEEHHHEEEEECCCCCCCEEEEEEECCCEEEEE
IDGKYVTGWKNIDNNKYYFDQSGKMQTGWLCIDNIWYHFRDNGTIDIGWREIDGYWYYFN
ECCEEEECCCCCCCCEEEECCCCCEEECEEEEECEEEEEECCCEEEEEEEEECCEEEEEC
NDGEMQKGWQTIGKYKYYFNDNGVMNIGWRKIDNIWYYFNINGEMQTGWLFENNIWYHFE
CCCCHHHHHHHHCCEEEEECCCCEEEECEEEECCEEEEEEECCCEEEEEEEECCEEEEEE
TTGSMTVGWKKINNDWYYFNSNGEMQTGWQNIGTPKYHFRDNGVMDIGWREIDGQWHYFN
CCCCEEEEEEEECCCEEEECCCCCEECCHHHCCCCEEEECCCCEEEECEEEECCEEEEEC
ENGEMQTGWQYINGNSYYFDEKGIWKQ
CCCCEEECEEEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2109310; 2105276 [H]