| Definition | Ralstonia solanacearum GMI1000, complete genome. |
|---|---|
| Accession | NC_003295 |
| Length | 3,716,413 |
Click here to switch to the map view.
The map label for this gene is secA [H]
Identifier: 17547553
GI number: 17547553
Start: 3046832
End: 3049636
Strand: Reverse
Name: secA [H]
Synonym: RSc2834
Alternate gene names: 17547553
Gene position: 3049636-3046832 (Counterclockwise)
Preceding gene: 17547554
Following gene: 17547552
Centisome position: 82.06
GC content: 65.24
Gene sequence:
>2805_bases ATGATCACGGGCCTTCTCAAGAAGATTTTCGGCAGCCGCAACGAACGGCTGATCAAACAGTACCGCCGCAAGGTGGTGCA GATCAACGCGCTCGAACCCACGTTCGAGGCGCTTTCCGATGCCGAACTGCAGGCCAAGACCCAGGCATTCCGCGAGCGCT TCGCCAAGGGCGAGACCCTCGACGCGCTGCTGCCCGAAGCATTCGCCGTGTGTCGCGAAGCCAGCAAGCGCGTGATGAAG ATGCGCCATTTCGACGTGCAGCTGATCGGCGGCATGGTGCTGCACGATGGCAAGATCGCCGAAATGCGCACTGGCGAAGG CAAGACGCTGACCGCCACGCTGGCGGTCTACCTGAATGCGATCGCCGGGCTGGGCGTGCACGTGGTGACGGTCAACGACT ACCTGGCCCAGCGCGATGCCGAATGGATGGGCAAGCTCTACAACTGGCTGGGCCTGTCGGTCGGGGTCAACCTGACCACC ATGGCCCACGATGAGAAGCAAGCCGCCTACGCTGCCGACATCACCTACGGTACCAACAACGAGTTCGGCTTCGACTACCT GCGCGACAACATGGTGTACGACGACAGCCAGCGCGTGCAGCGTCCGCTGAACTACGCCATCGTCGACGAGGTGGACTCGA TCCTGATCGATGAAGCCCGCACGCCGCTGATCATCTCCGGCCAGGCCGAGGACCACACCGACCTGTATCGCCGCATGAAC AGCATCCCGCCGCTGCTCACGCGCCAGATCGGCGAAGAGAAGGCCGACGGCACCGGCGTCGAGAAGCCGGGCGACTACTA CGTCGATGAAAAATCCCACCAGGTCTACCTGACCGAAGCGGGGCACGAGAAGGCGGAGCAGATCCTGCTGCAGGCGGGCC TGCTGGCCGAGGGCGAATCGCTGTACGCGCCGCAGAACATCACGCTGATGCACCACCTGTACGCCTCCCTGCGCGCGCAC AGCCTGTTCCACCGCGACCAGCACTACGTGGTGCAGGGCGACGAGGTGATCATCGTCGACGAATTCACCGGCCGCCTGAT GCAGGGCCGCCGCTGGTCCGACGGCCTGCACCAGGCCGTGGAGGCCAAGGAAGGCGTGCAGATCCAGCAGGAAAACCAGA CGCTGGCGACCATCACCTTCCAGAACTACTTCCGCATGTACGCCAAGCTGGCGGGCATGACCGGCACGGCCGATACCGAA GCCTACGAGTTCCAGGAGATCTACGGCCTGGAGACGGTGGTGATCCCGACCAACCGGCAGGCCCAGCGCAAGGACCTGCA GGACCAGATCTACAAGACCTCGAAGGAGCGCTACGACGCCGTCATCCGCGATATCCGCGACTGCTTCGAGCGCGGCCAGC CGGTGCTGGTGGGCACGACTTCCATCGAGAACTCCGAGCTGCTGTCGCACCTGCTGAACCAGGCCCAGCTGCCGCACCAG GTGCTCAACGCCAAGCAGCACGCGCGCGAGGCCGAGATCGTCGCGCAGGCCGGCCGGCCCAAGATGGTCACCATCGCCAC CAACATGGCGGGCCGTGGTACCGACATCGTGCTGGGCGGCAATGTGGAAAAGCAGGCCGGCTTCGTGATGGCCGACGAAT CCCTGTCGGACGAAGAGAAGGCCAGGCGCGTCACGCAACTGCAGGACGAGTGGCAGTCGCTGCACGAGCAGGTCAAGGCC GCGGGCGGTCTGCATATCGTCGGCACCGAGCGCCATGAGTCGCGCCGGATCGACAACCAGCTGCGCGGCCGCGCCGGCCG CCAGGGCGATCCGGGCTCGTCGCGCTTCTACCTGTCGCTCGACGATCAGCTGCTGCGCATCTTCGCCGGCGATCGCGTGC GCGCCATCATGGACCGCCTGAAGATGCCGGAAGGCGAGCCGATCGAGGCGGGCATCGTCACGCGCTCGATCGAGTCCGCG CAGCGCAAGGTCGAGGGCCGCAACTTCGACATTCGCAAGCAACTGCTGCAGTACGACGACGTGGCCAACGACCAGCGCCG CGAGATCTACAAGCTGCGCAACGAAATTCTCGAAGCCGTCGACGCGGGCGATCTGGTCAAGAACCTGCGCGAATCCGTGT TCGTCGAGCTGTTCCGCGCCTACGTGCCGGCCGAGTCCATGGAAGAGCAGTGGGATCTCGCCGGCCTGGAGAAGACGCTG CGTGACGACTGGGGCGTCGAGGTGCCGCTGGTGAAGACGGTGGAGCAGGCGCAGTCGATCGAGGACGAAGAGCTGCTGAC GCAGGTGCAGGAGGCCGTCGAGGCTGTGTATGCGGGCAAGGTGGCGCAGGTCGGCCGCGAGTCCTTTGCCGGCTTCGAGC GTTCGGTGATGCTGCAGAGCCTGGACACGCACTGGCGCGAGCATCTGGCGGCGCTGGACCACCTGCGCCAGGGCATCCAC CTGCGCGGCTATGCGCAGAAGGACCCGAAGCAGGAATACAAGCGTGAGTCGTTCGAGCTGTTCGGCCGCCTGCTGGACAA CATCCGCAACGAAGTGACGCGCATCATCTTCACGGTGCGCATCCAGTCGCAGGCGGAGCTGGAAGAGGCTTCCGAGCAGA TCGAGGAAGACCTGTCCCAGCTGACCAACGTGCAGTACAAGCACGACGAATTCAGCGAACTGGCCGAAGTCGCCGCGGGC GATGCCGAGATCCACGGCGAGACGCCGCCCGTGCCGGCCCATCGGTCGGCCGCGGCTTCCGCCGCTGCGGCACTGGCGGG GCAGGTGCCCAAGGTCGGCCGCAACGACCCGTGCCCATGCGGTTCGGGCAAGAAGTACAAGCAGTGTCACGGCAAGCTGG CCTGA
Upstream 100 bases:
>100_bases TCCCGCCTTTGCGCCAACCCTTTTCGGGCCGTTGCGCCGCCTGCGTTTCGCGTTCGTTTCGCGATCCTTCCGACGGGTGG CACGCCGGTCCCTGCCATCG
Downstream 100 bases:
>100_bases CCGGCCGACTGCCGCGGGCGCCGCGCCGCGCGGCGCCGTTCGTTTCCTGTTGATTCAACGATGCCCGCATTGCGGGCATC CTCGTTTGAAAAGGTGCTCC
Product: preprotein translocase subunit SecA
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 934; Mature: 934
Protein sequence:
>934_residues MITGLLKKIFGSRNERLIKQYRRKVVQINALEPTFEALSDAELQAKTQAFRERFAKGETLDALLPEAFAVCREASKRVMK MRHFDVQLIGGMVLHDGKIAEMRTGEGKTLTATLAVYLNAIAGLGVHVVTVNDYLAQRDAEWMGKLYNWLGLSVGVNLTT MAHDEKQAAYAADITYGTNNEFGFDYLRDNMVYDDSQRVQRPLNYAIVDEVDSILIDEARTPLIISGQAEDHTDLYRRMN SIPPLLTRQIGEEKADGTGVEKPGDYYVDEKSHQVYLTEAGHEKAEQILLQAGLLAEGESLYAPQNITLMHHLYASLRAH SLFHRDQHYVVQGDEVIIVDEFTGRLMQGRRWSDGLHQAVEAKEGVQIQQENQTLATITFQNYFRMYAKLAGMTGTADTE AYEFQEIYGLETVVIPTNRQAQRKDLQDQIYKTSKERYDAVIRDIRDCFERGQPVLVGTTSIENSELLSHLLNQAQLPHQ VLNAKQHAREAEIVAQAGRPKMVTIATNMAGRGTDIVLGGNVEKQAGFVMADESLSDEEKARRVTQLQDEWQSLHEQVKA AGGLHIVGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLDDQLLRIFAGDRVRAIMDRLKMPEGEPIEAGIVTRSIESA QRKVEGRNFDIRKQLLQYDDVANDQRREIYKLRNEILEAVDAGDLVKNLRESVFVELFRAYVPAESMEEQWDLAGLEKTL RDDWGVEVPLVKTVEQAQSIEDEELLTQVQEAVEAVYAGKVAQVGRESFAGFERSVMLQSLDTHWREHLAALDHLRQGIH LRGYAQKDPKQEYKRESFELFGRLLDNIRNEVTRIIFTVRIQSQAELEEASEQIEEDLSQLTNVQYKHDEFSELAEVAAG DAEIHGETPPVPAHRSAAASAAAALAGQVPKVGRNDPCPCGSGKKYKQCHGKLA
Sequences:
>Translated_934_residues MITGLLKKIFGSRNERLIKQYRRKVVQINALEPTFEALSDAELQAKTQAFRERFAKGETLDALLPEAFAVCREASKRVMK MRHFDVQLIGGMVLHDGKIAEMRTGEGKTLTATLAVYLNAIAGLGVHVVTVNDYLAQRDAEWMGKLYNWLGLSVGVNLTT MAHDEKQAAYAADITYGTNNEFGFDYLRDNMVYDDSQRVQRPLNYAIVDEVDSILIDEARTPLIISGQAEDHTDLYRRMN SIPPLLTRQIGEEKADGTGVEKPGDYYVDEKSHQVYLTEAGHEKAEQILLQAGLLAEGESLYAPQNITLMHHLYASLRAH SLFHRDQHYVVQGDEVIIVDEFTGRLMQGRRWSDGLHQAVEAKEGVQIQQENQTLATITFQNYFRMYAKLAGMTGTADTE AYEFQEIYGLETVVIPTNRQAQRKDLQDQIYKTSKERYDAVIRDIRDCFERGQPVLVGTTSIENSELLSHLLNQAQLPHQ VLNAKQHAREAEIVAQAGRPKMVTIATNMAGRGTDIVLGGNVEKQAGFVMADESLSDEEKARRVTQLQDEWQSLHEQVKA AGGLHIVGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLDDQLLRIFAGDRVRAIMDRLKMPEGEPIEAGIVTRSIESA QRKVEGRNFDIRKQLLQYDDVANDQRREIYKLRNEILEAVDAGDLVKNLRESVFVELFRAYVPAESMEEQWDLAGLEKTL RDDWGVEVPLVKTVEQAQSIEDEELLTQVQEAVEAVYAGKVAQVGRESFAGFERSVMLQSLDTHWREHLAALDHLRQGIH LRGYAQKDPKQEYKRESFELFGRLLDNIRNEVTRIIFTVRIQSQAELEEASEQIEEDLSQLTNVQYKHDEFSELAEVAAG DAEIHGETPPVPAHRSAAASAAAALAGQVPKVGRNDPCPCGSGKKYKQCHGKLA >Mature_934_residues MITGLLKKIFGSRNERLIKQYRRKVVQINALEPTFEALSDAELQAKTQAFRERFAKGETLDALLPEAFAVCREASKRVMK MRHFDVQLIGGMVLHDGKIAEMRTGEGKTLTATLAVYLNAIAGLGVHVVTVNDYLAQRDAEWMGKLYNWLGLSVGVNLTT MAHDEKQAAYAADITYGTNNEFGFDYLRDNMVYDDSQRVQRPLNYAIVDEVDSILIDEARTPLIISGQAEDHTDLYRRMN SIPPLLTRQIGEEKADGTGVEKPGDYYVDEKSHQVYLTEAGHEKAEQILLQAGLLAEGESLYAPQNITLMHHLYASLRAH SLFHRDQHYVVQGDEVIIVDEFTGRLMQGRRWSDGLHQAVEAKEGVQIQQENQTLATITFQNYFRMYAKLAGMTGTADTE AYEFQEIYGLETVVIPTNRQAQRKDLQDQIYKTSKERYDAVIRDIRDCFERGQPVLVGTTSIENSELLSHLLNQAQLPHQ VLNAKQHAREAEIVAQAGRPKMVTIATNMAGRGTDIVLGGNVEKQAGFVMADESLSDEEKARRVTQLQDEWQSLHEQVKA AGGLHIVGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLDDQLLRIFAGDRVRAIMDRLKMPEGEPIEAGIVTRSIESA QRKVEGRNFDIRKQLLQYDDVANDQRREIYKLRNEILEAVDAGDLVKNLRESVFVELFRAYVPAESMEEQWDLAGLEKTL RDDWGVEVPLVKTVEQAQSIEDEELLTQVQEAVEAVYAGKVAQVGRESFAGFERSVMLQSLDTHWREHLAALDHLRQGIH LRGYAQKDPKQEYKRESFELFGRLLDNIRNEVTRIIFTVRIQSQAELEEASEQIEEDLSQLTNVQYKHDEFSELAEVAAG DAEIHGETPPVPAHRSAAASAAAALAGQVPKVGRNDPCPCGSGKKYKQCHGKLA
Specific function: Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the pr
COG id: COG0653
COG function: function code U; Preprotein translocase subunit SecA (ATPase, RNA helicase)
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Note=Distribution is 50-50 (By similarity) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the secA family [H]
Homologues:
Organism=Escherichia coli, GI1786287, Length=936, Percent_Identity=58.3333333333333, Blast_Score=1068, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004027 - InterPro: IPR000185 - InterPro: IPR020937 - InterPro: IPR011115 - InterPro: IPR014018 - InterPro: IPR011130 - InterPro: IPR011116 [H]
Pfam domain/function: PF02810 SEC-C; PF07517 SecA_DEAD; PF01043 SecA_PP_bind; PF07516 SecA_SW [H]
EC number: NA
Molecular weight: Translated: 105243; Mature: 105243
Theoretical pI: Translated: 5.24; Mature: 5.24
Prosite motif: PS01312 SECA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MITGLLKKIFGSRNERLIKQYRRKVVQINALEPTFEALSDAELQAKTQAFRERFAKGETL CHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCHH DALLPEAFAVCREASKRVMKMRHFDVQLIGGMVLHDGKIAEMRTGEGKTLTATLAVYLNA HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHHH IAGLGVHVVTVNDYLAQRDAEWMGKLYNWLGLSVGVNLTTMAHDEKQAAYAADITYGTNN HHCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHEEEEEEECCCC EFGFDYLRDNMVYDDSQRVQRPLNYAIVDEVDSILIDEARTPLIISGQAEDHTDLYRRMN CCCHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH SIPPLLTRQIGEEKADGTGVEKPGDYYVDEKSHQVYLTEAGHEKAEQILLQAGLLAEGES CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC LYAPQNITLMHHLYASLRAHSLFHRDQHYVVQGDEVIIVDEFTGRLMQGRRWSDGLHQAV CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHCCCCCHHHHHHHH EAKEGVQIQQENQTLATITFQNYFRMYAKLAGMTGTADTEAYEFQEIYGLETVVIPTNRQ HHHCCCEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEECCCCC AQRKDLQDQIYKTSKERYDAVIRDIRDCFERGQPVLVGTTSIENSELLSHLLNQAQLPHQ HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCHH VLNAKQHAREAEIVAQAGRPKMVTIATNMAGRGTDIVLGGNVEKQAGFVMADESLSDEEK HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCHHCCEEEECCCCCHHHH ARRVTQLQDEWQSLHEQVKAAGGLHIVGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSL HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEH DDQLLRIFAGDRVRAIMDRLKMPEGEPIEAGIVTRSIESAQRKVEGRNFDIRKQLLQYDD HHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC VANDQRREIYKLRNEILEAVDAGDLVKNLRESVFVELFRAYVPAESMEEQWDLAGLEKTL CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH RDDWGVEVPLVKTVEQAQSIEDEELLTQVQEAVEAVYAGKVAQVGRESFAGFERSVMLQS HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH LDTHWREHLAALDHLRQGIHLRGYAQKDPKQEYKRESFELFGRLLDNIRNEVTRIIFTVR HHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE IQSQAELEEASEQIEEDLSQLTNVQYKHDEFSELAEVAAGDAEIHGETPPVPAHRSAAAS ECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHH AAAALAGQVPKVGRNDPCPCGSGKKYKQCHGKLA HHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCC >Mature Secondary Structure MITGLLKKIFGSRNERLIKQYRRKVVQINALEPTFEALSDAELQAKTQAFRERFAKGETL CHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCHH DALLPEAFAVCREASKRVMKMRHFDVQLIGGMVLHDGKIAEMRTGEGKTLTATLAVYLNA HHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEECCCEEEEECCCCCCHHHHHHHHHHH IAGLGVHVVTVNDYLAQRDAEWMGKLYNWLGLSVGVNLTTMAHDEKQAAYAADITYGTNN HHCCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHEEEEEEECCCC EFGFDYLRDNMVYDDSQRVQRPLNYAIVDEVDSILIDEARTPLIISGQAEDHTDLYRRMN CCCHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH SIPPLLTRQIGEEKADGTGVEKPGDYYVDEKSHQVYLTEAGHEKAEQILLQAGLLAEGES CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC LYAPQNITLMHHLYASLRAHSLFHRDQHYVVQGDEVIIVDEFTGRLMQGRRWSDGLHQAV CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHCCCCCHHHHHHHH EAKEGVQIQQENQTLATITFQNYFRMYAKLAGMTGTADTEAYEFQEIYGLETVVIPTNRQ HHHCCCEEEECCCEEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEECCCCC AQRKDLQDQIYKTSKERYDAVIRDIRDCFERGQPVLVGTTSIENSELLSHLLNQAQLPHQ HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCHH VLNAKQHAREAEIVAQAGRPKMVTIATNMAGRGTDIVLGGNVEKQAGFVMADESLSDEEK HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCCHHCCEEEECCCCCHHHH ARRVTQLQDEWQSLHEQVKAAGGLHIVGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSL HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEH DDQLLRIFAGDRVRAIMDRLKMPEGEPIEAGIVTRSIESAQRKVEGRNFDIRKQLLQYDD HHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC VANDQRREIYKLRNEILEAVDAGDLVKNLRESVFVELFRAYVPAESMEEQWDLAGLEKTL CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH RDDWGVEVPLVKTVEQAQSIEDEELLTQVQEAVEAVYAGKVAQVGRESFAGFERSVMLQS HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH LDTHWREHLAALDHLRQGIHLRGYAQKDPKQEYKRESFELFGRLLDNIRNEVTRIIFTVR HHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE IQSQAELEEASEQIEEDLSQLTNVQYKHDEFSELAEVAAGDAEIHGETPPVPAHRSAAAS ECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHH AAAALAGQVPKVGRNDPCPCGSGKKYKQCHGKLA HHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA