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The map label for this gene is zitB [H]

Identifier: 17547491

GI number: 17547491

Start: 2982691

End: 2983611

Strand: Reverse

Name: zitB [H]

Synonym: RSc2772

Alternate gene names: 17547491

Gene position: 2983611-2982691 (Counterclockwise)

Preceding gene: 17547492

Following gene: 17547490

Centisome position: 80.28

GC content: 70.68

Gene sequence:

>921_bases
ATGAGCCACGCCGCCCAGCCGACCCTGCACGGACACGACGCCGCAGCATGGCGCCATTCGCACCGCTTCGTGGAAGACCG
CCCGCGCGCCGAGCGCCGCACGCTGTACGCCGTGCAGCTGACGGCGGCGGTGATGATGGCGGAGATCGTCGGCGGCTGGT
GGACCGGCTCGATGGCGCTGCTGGCCGACGGCTGGCACATGAGCACGCACGTGCTGGCGCTGGGCATCGCGCTGGTGGCC
TACGTGATCGCGCGCCGCCTGGGCGAAGACCCGCGCTTCACCTTCGGCACCTGGAAGATCGAGATCCTCGGCAGCTTCGC
CAGCGCGCTGCTGCTGGGCGTGGTGGGCGTGCTGATGGCGGTGGAGTTGGCGCAGCGTCTGCTCGCGCCGGTCGGCATCC
ATTACAGCGAGGCCCTGTGGGTCACGGCCGTCGGTCTGGCGGTCAACGTCGTCTGCGCCCTGCGGCTGGCCGGCGCGCAC
GACCATGACCACGGCCATGCCCATGCGTCCGGGCCGGCGGCAGGCACGCGCCGCCATGACGACGACCGCGATCGCGACAG
AGAGCGCGACAAGGAGCGCGACGACACCCACGAACACGAGACCCGCCATCGCGACCACGACCGCGACCATCGCCATGAGC
ACGATCACAAGCACGAGCCGGAACACGACCACGATGAGCATCGCCATCGGGACCATCCGCAGGAGGCCGCGTTGCATCGC
CGCAGCCACGCCGCGCGTGCGCACGCGCATGGCGATCATGGCCACCCCCATCATCACCACGACCTGAACCTGCGCGCCGC
CTATCTGCACGTCGTGGCCGATGCGGCGACGTCGGTGCTGGCGGCTGATGGCGCTGTTCGCCGGCAAGTACCTGGGGCTG
CGCTGGATCGACTCGGTGGTCGGGATCGTCGGCGCGGGTGA

Upstream 100 bases:

>100_bases
TTCGCCGACGCCGCCCGCGGTGTCGCGCAGGCCACGCGCGACCAGATCAACCAGTACCGCAACTGACCGGCCAGCCCGGC
CCGGTTGCCGCGAGGACGCC

Downstream 100 bases:

>100_bases
TCGGGCAGTGGGCCTACAGCCTGCTCAGGCGCGCGGGCAGCGTGCTGCTGGATCGCGGCGACGTGCCGGAGCTGCAGGAT
GCCGTCCGGCGCGCGCTGGA

Product: metal transport transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSHAAQPTLHGHDAAAWRHSHRFVEDRPRAERRTLYAVQLTAAVMMAEIVGGWWTGSMALLADGWHMSTHVLALGIALVA
YVIARRLGEDPRFTFGTWKIEILGSFASALLLGVVGVLMAVELAQRLLAPVGIHYSEALWVTAVGLAVNVVCALRLAGAH
DHDHGHAHASGPAAGTRRHDDDRDRDRERDKERDDTHEHETRHRDHDRDHRHEHDHKHEPEHDHDEHRHRDHPQEAALHR
RSHAARAHAHGDHGHPHHHHDLNLRAAYLHVVADAATSVLAADGAVRRQVPGAALDRLGGRDRRRG

Sequences:

>Translated_306_residues
MSHAAQPTLHGHDAAAWRHSHRFVEDRPRAERRTLYAVQLTAAVMMAEIVGGWWTGSMALLADGWHMSTHVLALGIALVA
YVIARRLGEDPRFTFGTWKIEILGSFASALLLGVVGVLMAVELAQRLLAPVGIHYSEALWVTAVGLAVNVVCALRLAGAH
DHDHGHAHASGPAAGTRRHDDDRDRDRERDKERDDTHEHETRHRDHDRDHRHEHDHKHEPEHDHDEHRHRDHPQEAALHR
RSHAARAHAHGDHGHPHHHHDLNLRAAYLHVVADAATSVLAADGAVRRQVPGAALDRLGGRDRRRG
>Mature_305_residues
SHAAQPTLHGHDAAAWRHSHRFVEDRPRAERRTLYAVQLTAAVMMAEIVGGWWTGSMALLADGWHMSTHVLALGIALVAY
VIARRLGEDPRFTFGTWKIEILGSFASALLLGVVGVLMAVELAQRLLAPVGIHYSEALWVTAVGLAVNVVCALRLAGAHD
HDHGHAHASGPAAGTRRHDDDRDRDRERDKERDDTHEHETRHRDHDRDHRHEHDHKHEPEHDHDEHRHRDHPQEAALHRR
SHAARAHAHGDHGHPHHHHDLNLRAAYLHVVADAATSVLAADGAVRRQVPGAALDRLGGRDRRRG

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=278, Percent_Identity=23.3812949640288, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI40255009, Length=278, Percent_Identity=23.3812949640288, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786966, Length=120, Percent_Identity=37.5, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI32564488, Length=122, Percent_Identity=36.0655737704918, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=255, Percent_Identity=28.2352941176471, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=260, Percent_Identity=25.7692307692308, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585900, Length=276, Percent_Identity=23.5507246376812, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24585898, Length=276, Percent_Identity=23.5507246376812, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24585896, Length=276, Percent_Identity=23.5507246376812, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921672, Length=276, Percent_Identity=23.5507246376812, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34206; Mature: 34074

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHAAQPTLHGHDAAAWRHSHRFVEDRPRAERRTLYAVQLTAAVMMAEIVGGWWTGSMAL
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHH
LADGWHMSTHVLALGIALVAYVIARRLGEDPRFTFGTWKIEILGSFASALLLGVVGVLMA
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECEEEHHHHHHHHHHHHHHHHHHHHH
VELAQRLLAPVGIHYSEALWVTAVGLAVNVVCALRLAGAHDHDHGHAHASGPAAGTRRHD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
DDRDRDRERDKERDDTHEHETRHRDHDRDHRHEHDHKHEPEHDHDEHRHRDHPQEAALHR
CCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHH
RSHAARAHAHGDHGHPHHHHDLNLRAAYLHVVADAATSVLAADGAVRRQVPGAALDRLGG
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHCCC
RDRRRG
CCCCCC
>Mature Secondary Structure 
SHAAQPTLHGHDAAAWRHSHRFVEDRPRAERRTLYAVQLTAAVMMAEIVGGWWTGSMAL
CCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHH
LADGWHMSTHVLALGIALVAYVIARRLGEDPRFTFGTWKIEILGSFASALLLGVVGVLMA
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECEEEHHHHHHHHHHHHHHHHHHHHH
VELAQRLLAPVGIHYSEALWVTAVGLAVNVVCALRLAGAHDHDHGHAHASGPAAGTRRHD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
DDRDRDRERDKERDDTHEHETRHRDHDRDHRHEHDHKHEPEHDHDEHRHRDHPQEAALHR
CCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHH
RSHAARAHAHGDHGHPHHHHDLNLRAAYLHVVADAATSVLAADGAVRRQVPGAALDRLGG
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHCCC
RDRRRG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]