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The map label for this gene is maeB2 [H]

Identifier: 17547486

GI number: 17547486

Start: 2977669

End: 2980014

Strand: Reverse

Name: maeB2 [H]

Synonym: RSc2767

Alternate gene names: 17547486

Gene position: 2980014-2977669 (Counterclockwise)

Preceding gene: 17547490

Following gene: 17547485

Centisome position: 80.19

GC content: 65.9

Gene sequence:

>2346_bases
ATGACCACGGTGGATACCCAGCCTCAACAGCCCGCCCGCACGGACGAAGAACTCAAGGCGCAACAACGCGCCGCCTTGCG
CAAGGCCGCGCTGGAGTACCACGAGTTTCCGACCCCGGGCAAGATTTCCGTGACGCCGACCAAGCCGCTGTCCAACCAGC
GCGACCTGGCCCTGGCGTACTCCCCCGGCGTCGCCGCGGCCTGCGAAGAGATCGTCGCCGACGTCTCCAACTCCTTCCGC
TACACCGCCCGCGGCAACCTGGTCGCCGTGGTGACCAACGGCACCGCCGTGCTCGGCCTGGGCGATATCGGCCCCGAAGC
CGCCAAGCCGGTCATGGAAGGCAAGGCGGGCCTGTTCAAGAAGTTTGCCGGGATCGATGTGTTTGACATCGAGATCAACG
AAAAAGACCCGCAGAAGCTGGTCGATATCGTCGCTTCGCTGGAGCCGACCTTCGGCGGCATCAACCTGGAAGACATCAAG
GCGCCGGAGTGCTTCTTCGTCGAGCGCGAGCTGCGCAAGCGCATGAAGATTCCCGTCTTCCACGATGACCAGCACGGCAC
CGCCATCGTGGTGGGCGCAGGCATCACCAACGCGCTGAAGGTGGTCGGCAAGGACATCAAGCAGGTCAAGCTGGTGGCCT
CGGGCGCCGGCGCGGCCGCGCTGGCCTGCCTGGACCTGCTGGTCGACCTGGGCCTGCCGCGCGAGAACATCTGGGTGACG
GACCTGGCCGGCGTGGTCTACGAGGGCCGTACCGAGCTGATGGACCCGGACAAGGCCGTCTTCGCGCAAAAAACCGACAA
GCGCACGCTGGCCGAGGTCATCGACGGCGCCGACATCTTCCTGGGCCTGTCCGCCGCCGGCGTGCTCAAGCAGGACATGG
TCAAGCGCATGGCCGACCGGCCGATCATCTTCGCGTTGGCCAACCCGAACCCGGAAATCATGCCGGAGCTGGCCAAGGAA
GTGCGCCCGGACGTCATCATGGGCACCGGCCGCACCGATTACCCGAACCAGGTCAACAACGTCCTGTGCTTCCCGTTCAT
CTTCCGCGGCGCGCTGGACGTGGGCGCGACCACCATCACGCGCGAGATGGAAGTCGCCGCCGTGCACGCCGTGGCCGAGC
TGGCCCGCCAGGAGCAGAGCGACATCGTTGCCACGGCGTACGGCATCCAGGACCTGTCGTTCGGACCGGAATACCTGATT
CCGAAGCCCTTCGATCCGCGCCTGATCGTGAAGATCGCGCCGGCGGTGGCGCAGGCCGCCATGGACTCCGGCGTGGCGCA
GCGCCCGATCGAGGACATGGACGCCTATCGCCAGCACCTGCAGCAGTTCGTCTACCACTCGGGCACGCTGATGAAGCCGA
TCTTCTCGACGGCCAAGAAGGTGCCGATGGAGCACAAGCGCATCGTCTTCGCCGAGGGCGAAGAGGAGCGCGTGCTGCGC
GCCGTGCAGGTCGTCGTCGATGAGAAGCTGGCCAACCCGATCCTGATCGGCCGCCCGGGCGTGATCGCCCATCGCATCGA
GCGCTTCGGCCTGCGCCTGCGCGAGGGCGTCGACTTCACCATCGTCAACCCCGAGCACGACCAGCGGTTCCGCGAGTACT
GGGAGACCTACTACAAGCTGATGGCGCGCAAGGGCGTCACGCCGCAGTACGCCAAGCTAGAGGTGCGCCGCCGCTCCACG
CTGATCGGCGCCGTGATGATCCACAAGGGCGAGGCCGACGGCATGATCTGCGGTACGGTCAGCAACACCGCCGCCCATCT
GCGCTATATCGACCAGGTCATCGGCGGCACCAACTGCGTGTACGCGGCGATGAACGGCCTGGTGCTGCCGGGCCGCCAGA
TCTTCCTGACCGACACGCACGTCAACATCGATCCGAGCGCCGAGCAACTGGCCGAGATCACCATCATGGCCGCTGAAGAG
CTGTGCCGTTTCGGCATCAAGCCGAAGGTGGCGCTGGTCTCGCACTCGAATTTCGGCTCGTCCGAGGCGCCTTCTGCCGC
CAAGATGCGTGAAACCCTCGCCATCCTGCGTGAACGTGCCCCGCAACTGGAAGTGGACGGTGAAATGCACGGCGATGCCG
CGCTCGACCAGAAGCTGCGCGACTCGCTGGTGCCGGATTCCACGCTGACCGGCGAAGCCAACCTGCTGGTGATGCCGAAC
ATCGACGCCGCCAACATCGCCTACAACCTGCTGAAGACGGCGGCCGGCAACAACATCGCCATCGGCCCGATCCTGCTGGG
TGCCAAGCGTCCGGTGCACATCCTGACGCCGTCGGCCACGGTGCGCCGCATTCTGAACATGACGGCACTGACTGTCGTGG
ACGCCGCAGCACAGGCGCAACGCTGA

Upstream 100 bases:

>100_bases
AGGCGGACCGCAATCCCGTGATCCCGTTGTGTGGTGATTCGGTGGCCCGCCGGATGTGACGGTCGACCCGTGTCGACCAC
CCGATGACGAGAGACACCTC

Downstream 100 bases:

>100_bases
AGCAGGGCGCCATGAGGAGGGGAGCGCACGATGCTGCGCTCCCTTTTTTTTGCCTGGAAGGTTTGCGTGCGCTCACATCT
TTGCAGGCTTAATCCCTGAT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MTTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVADVSNSFR
YTARGNLVAVVTNGTAVLGLGDIGPEAAKPVMEGKAGLFKKFAGIDVFDIEINEKDPQKLVDIVASLEPTFGGINLEDIK
APECFFVERELRKRMKIPVFHDDQHGTAIVVGAGITNALKVVGKDIKQVKLVASGAGAAALACLDLLVDLGLPRENIWVT
DLAGVVYEGRTELMDPDKAVFAQKTDKRTLAEVIDGADIFLGLSAAGVLKQDMVKRMADRPIIFALANPNPEIMPELAKE
VRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEVAAVHAVAELARQEQSDIVATAYGIQDLSFGPEYLI
PKPFDPRLIVKIAPAVAQAAMDSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSTAKKVPMEHKRIVFAEGEEERVLR
AVQVVVDEKLANPILIGRPGVIAHRIERFGLRLREGVDFTIVNPEHDQRFREYWETYYKLMARKGVTPQYAKLEVRRRST
LIGAVMIHKGEADGMICGTVSNTAAHLRYIDQVIGGTNCVYAAMNGLVLPGRQIFLTDTHVNIDPSAEQLAEITIMAAEE
LCRFGIKPKVALVSHSNFGSSEAPSAAKMRETLAILRERAPQLEVDGEMHGDAALDQKLRDSLVPDSTLTGEANLLVMPN
IDAANIAYNLLKTAAGNNIAIGPILLGAKRPVHILTPSATVRRILNMTALTVVDAAAQAQR

Sequences:

>Translated_781_residues
MTTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVADVSNSFR
YTARGNLVAVVTNGTAVLGLGDIGPEAAKPVMEGKAGLFKKFAGIDVFDIEINEKDPQKLVDIVASLEPTFGGINLEDIK
APECFFVERELRKRMKIPVFHDDQHGTAIVVGAGITNALKVVGKDIKQVKLVASGAGAAALACLDLLVDLGLPRENIWVT
DLAGVVYEGRTELMDPDKAVFAQKTDKRTLAEVIDGADIFLGLSAAGVLKQDMVKRMADRPIIFALANPNPEIMPELAKE
VRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEVAAVHAVAELARQEQSDIVATAYGIQDLSFGPEYLI
PKPFDPRLIVKIAPAVAQAAMDSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSTAKKVPMEHKRIVFAEGEEERVLR
AVQVVVDEKLANPILIGRPGVIAHRIERFGLRLREGVDFTIVNPEHDQRFREYWETYYKLMARKGVTPQYAKLEVRRRST
LIGAVMIHKGEADGMICGTVSNTAAHLRYIDQVIGGTNCVYAAMNGLVLPGRQIFLTDTHVNIDPSAEQLAEITIMAAEE
LCRFGIKPKVALVSHSNFGSSEAPSAAKMRETLAILRERAPQLEVDGEMHGDAALDQKLRDSLVPDSTLTGEANLLVMPN
IDAANIAYNLLKTAAGNNIAIGPILLGAKRPVHILTPSATVRRILNMTALTVVDAAAQAQR
>Mature_780_residues
TTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVADVSNSFRY
TARGNLVAVVTNGTAVLGLGDIGPEAAKPVMEGKAGLFKKFAGIDVFDIEINEKDPQKLVDIVASLEPTFGGINLEDIKA
PECFFVERELRKRMKIPVFHDDQHGTAIVVGAGITNALKVVGKDIKQVKLVASGAGAAALACLDLLVDLGLPRENIWVTD
LAGVVYEGRTELMDPDKAVFAQKTDKRTLAEVIDGADIFLGLSAAGVLKQDMVKRMADRPIIFALANPNPEIMPELAKEV
RPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEVAAVHAVAELARQEQSDIVATAYGIQDLSFGPEYLIP
KPFDPRLIVKIAPAVAQAAMDSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSTAKKVPMEHKRIVFAEGEEERVLRA
VQVVVDEKLANPILIGRPGVIAHRIERFGLRLREGVDFTIVNPEHDQRFREYWETYYKLMARKGVTPQYAKLEVRRRSTL
IGAVMIHKGEADGMICGTVSNTAAHLRYIDQVIGGTNCVYAAMNGLVLPGRQIFLTDTHVNIDPSAEQLAEITIMAAEEL
CRFGIKPKVALVSHSNFGSSEAPSAAKMRETLAILRERAPQLEVDGEMHGDAALDQKLRDSLVPDSTLTGEANLLVMPNI
DAANIAYNLLKTAAGNNIAIGPILLGAKRPVHILTPSATVRRILNMTALTVVDAAAQAQR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=410, Percent_Identity=27.5609756097561, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI62420880, Length=410, Percent_Identity=27.5609756097561, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI239049447, Length=410, Percent_Identity=27.5609756097561, Blast_Score=91, Evalue=6e-18,
Organism=Homo sapiens, GI4505143, Length=402, Percent_Identity=26.3681592039801, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI4505145, Length=319, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI270265879, Length=319, Percent_Identity=31.0344827586207, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=62.6984126984127, Blast_Score=981, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=317, Percent_Identity=33.1230283911672, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI1788800, Length=321, Percent_Identity=32.0872274143302, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17537199, Length=474, Percent_Identity=25.7383966244726, Blast_Score=77, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=31.7991631799163, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281362672, Length=469, Percent_Identity=27.7185501066098, Blast_Score=96, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281362674, Length=469, Percent_Identity=27.7185501066098, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356279, Length=469, Percent_Identity=27.7185501066098, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=29.7142857142857, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI78707242, Length=405, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI78707238, Length=405, Percent_Identity=27.1604938271605, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=29.7142857142857, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI78707240, Length=427, Percent_Identity=26.9320843091335, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 85026; Mature: 84895

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEE
SPGVAAACEEIVADVSNSFRYTARGNLVAVVTNGTAVLGLGDIGPEAAKPVMEGKAGLFK
CCCHHHHHHHHHHHHHCCEEEEECCCEEEEEECCEEEEEECCCCHHHHHHHHHCCHHHHH
KFAGIDVFDIEINEKDPQKLVDIVASLEPTFGGINLEDIKAPECFFVERELRKRMKIPVF
HHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEE
HDDQHGTAIVVGAGITNALKVVGKDIKQVKLVASGAGAAALACLDLLVDLGLPRENIWVT
ECCCCCCEEEEECCHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEE
DLAGVVYEGRTELMDPDKAVFAQKTDKRTLAEVIDGADIFLGLSAAGVLKQDMVKRMADR
HHHHHHCCCCHHCCCCCHHHHHCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCC
PIIFALANPNPEIMPELAKEVRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTIT
CEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHH
REMEVAAVHAVAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAVAQAA
HHHHHHHHHHHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHH
MDSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSTAKKVPMEHKRIVFAEGEEERVLR
HHCCHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
AVQVVVDEKLANPILIGRPGVIAHRIERFGLRLREGVDFTIVNPEHDQRFREYWETYYKL
HHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
MARKGVTPQYAKLEVRRRSTLIGAVMIHKGEADGMICGTVSNTAAHLRYIDQVIGGTNCV
HHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCEE
YAAMNGLVLPGRQIFLTDTHVNIDPSAEQLAEITIMAAEELCRFGIKPKVALVSHSNFGS
HHHHCCEECCCCEEEEEECEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
SEAPSAAKMRETLAILRERAPQLEVDGEMHGDAALDQKLRDSLVPDSTLTGEANLLVMPN
CCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECC
IDAANIAYNLLKTAAGNNIAIGPILLGAKRPVHILTPSATVRRILNMTALTVVDAAAQAQ
CCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure 
TTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEE
SPGVAAACEEIVADVSNSFRYTARGNLVAVVTNGTAVLGLGDIGPEAAKPVMEGKAGLFK
CCCHHHHHHHHHHHHHCCEEEEECCCEEEEEECCEEEEEECCCCHHHHHHHHHCCHHHHH
KFAGIDVFDIEINEKDPQKLVDIVASLEPTFGGINLEDIKAPECFFVERELRKRMKIPVF
HHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEE
HDDQHGTAIVVGAGITNALKVVGKDIKQVKLVASGAGAAALACLDLLVDLGLPRENIWVT
ECCCCCCEEEEECCHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEE
DLAGVVYEGRTELMDPDKAVFAQKTDKRTLAEVIDGADIFLGLSAAGVLKQDMVKRMADR
HHHHHHCCCCHHCCCCCHHHHHCCCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCC
PIIFALANPNPEIMPELAKEVRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTIT
CEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHH
REMEVAAVHAVAELARQEQSDIVATAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAVAQAA
HHHHHHHHHHHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCCCCCEEEEEECHHHHHHH
MDSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSTAKKVPMEHKRIVFAEGEEERVLR
HHCCHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
AVQVVVDEKLANPILIGRPGVIAHRIERFGLRLREGVDFTIVNPEHDQRFREYWETYYKL
HHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
MARKGVTPQYAKLEVRRRSTLIGAVMIHKGEADGMICGTVSNTAAHLRYIDQVIGGTNCV
HHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCEE
YAAMNGLVLPGRQIFLTDTHVNIDPSAEQLAEITIMAAEELCRFGIKPKVALVSHSNFGS
HHHHCCEECCCCEEEEEECEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
SEAPSAAKMRETLAILRERAPQLEVDGEMHGDAALDQKLRDSLVPDSTLTGEANLLVMPN
CCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECC
IDAANIAYNLLKTAAGNNIAIGPILLGAKRPVHILTPSATVRRILNMTALTVVDAAAQAQ
CCHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]