Click here to switch to the map view.

The map label for this gene is hrcA

Identifier: 17547368

GI number: 17547368

Start: 2850576

End: 2851634

Strand: Reverse

Name: hrcA

Synonym: RSc2649

Alternate gene names: 17547368

Gene position: 2851634-2850576 (Counterclockwise)

Preceding gene: 17547374

Following gene: 17547366

Centisome position: 76.73

GC content: 67.89

Gene sequence:

>1059_bases
ATGGACAAACGCGCCACCATCCTCCTCAAGACGCTGATCGAGCGCTACATCGCCGAGGGCCAGCCCGTGGGCTCGCGCAC
CTTGTCGAAGTATTCCGGGCTCGACCTGTCGCCGGCCACCATCCGCAACGTGATGTCCGACCTGGAGGAGATGGGGTTCA
TCGCCAGCCCGCACACCTCGGCCGGCCGTGTGCCGACGCCGCGCGGCTACCGCCTCTTCGTCGATACGATGCTGACGGCC
GGTCCGCTGGACATCCTCGGCATGCACGACCGCATGGCGCAGCAGATCGCCGGCACGATCGCCGAGCAGGTGCGCGCGCA
GCTTGCCTCGCACGGGTCGGAGTCGTCGCAGCGGGTCATCGCGGCGGCGGCGCAGACGCTGTCCAACCTGTCGCAGTTCG
CCGGCATCGTGATGACGCCGCGCCGCACGCATGCGTTCCGGCAGATCGAATTCCTGCGGTTGTCCGAGACGCGCATCCTG
CTGATCGTCGTCACGCCCGAGGGCGACGTGCAGAACCGCATCATCCATACCGATACGCCGTACACCCCGTCGCAGCTGGT
GGAGGCGGCCAACTACATCAACGCGCACTACGGCGGCATGACGTTCGACGCCGTGCGCGAGCGCCTGCGCGGCGAGCTGA
ACGCGCTGCAGGCCGACATGACCTCGCTGATGCAGGCGGCCGTGGAGGCGGGCAGCAGCGCCGTGTCGGACGAAGACCCG
GTGGTCATCTCCGGCGAGCGCAAGCTGCTCGAGGTGGAGGACCTGTCCTCCTCCATGGACAAGCTGCGCCGGCTGTTCGC
CGTGTTCGAGCAGAAGACCGGCCTGCTGCAGCTGCTCGACGTGTCCAGCCGCGCCGAGGGCGTGCAGATCTTCATCGGCG
GCGAGAGCAGCCTGGTGCCGCACGAGGACATGGCCGTCATCACCGCGCCCTACGAGGTGGACGGCAAGATCGTCGGCACG
CTGGGCGTGATCGGGCCGATGCGGATGGCCTACGAGCGCGTGATCCCGATCGTGGACATCACGGCCAAGCTGCTGTCCAG
CACGCTCAGCCAGCATTGA

Upstream 100 bases:

>100_bases
ATATCGATATGACGGTCGCCATGGCCGGCGCGCGTTTGAAGGTGGAACGTTGTCGCCACCCGGCGCTTCCGGTGTGAATT
TGCGTAAAATCGAATGAATC

Downstream 100 bases:

>100_bases
CCGGGGCCGGCCCGGCCCGCCTCAGAAACTCCCCGTGAACTGATACCGCTCGCCCGGGTGCCACATGGTCGCCACCGAGG
CGACCTGGCCCTGCGACAGC

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MDKRATILLKTLIERYIAEGQPVGSRTLSKYSGLDLSPATIRNVMSDLEEMGFIASPHTSAGRVPTPRGYRLFVDTMLTA
GPLDILGMHDRMAQQIAGTIAEQVRAQLASHGSESSQRVIAAAAQTLSNLSQFAGIVMTPRRTHAFRQIEFLRLSETRIL
LIVVTPEGDVQNRIIHTDTPYTPSQLVEAANYINAHYGGMTFDAVRERLRGELNALQADMTSLMQAAVEAGSSAVSDEDP
VVISGERKLLEVEDLSSSMDKLRRLFAVFEQKTGLLQLLDVSSRAEGVQIFIGGESSLVPHEDMAVITAPYEVDGKIVGT
LGVIGPMRMAYERVIPIVDITAKLLSSTLSQH

Sequences:

>Translated_352_residues
MDKRATILLKTLIERYIAEGQPVGSRTLSKYSGLDLSPATIRNVMSDLEEMGFIASPHTSAGRVPTPRGYRLFVDTMLTA
GPLDILGMHDRMAQQIAGTIAEQVRAQLASHGSESSQRVIAAAAQTLSNLSQFAGIVMTPRRTHAFRQIEFLRLSETRIL
LIVVTPEGDVQNRIIHTDTPYTPSQLVEAANYINAHYGGMTFDAVRERLRGELNALQADMTSLMQAAVEAGSSAVSDEDP
VVISGERKLLEVEDLSSSMDKLRRLFAVFEQKTGLLQLLDVSSRAEGVQIFIGGESSLVPHEDMAVITAPYEVDGKIVGT
LGVIGPMRMAYERVIPIVDITAKLLSSTLSQH
>Mature_352_residues
MDKRATILLKTLIERYIAEGQPVGSRTLSKYSGLDLSPATIRNVMSDLEEMGFIASPHTSAGRVPTPRGYRLFVDTMLTA
GPLDILGMHDRMAQQIAGTIAEQVRAQLASHGSESSQRVIAAAAQTLSNLSQFAGIVMTPRRTHAFRQIEFLRLSETRIL
LIVVTPEGDVQNRIIHTDTPYTPSQLVEAANYINAHYGGMTFDAVRERLRGELNALQADMTSLMQAAVEAGSSAVSDEDP
VVISGERKLLEVEDLSSSMDKLRRLFAVFEQKTGLLQLLDVSSRAEGVQIFIGGESSLVPHEDMAVITAPYEVDGKIVGT
LGVIGPMRMAYERVIPIVDITAKLLSSTLSQH

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_RALSO (Q8XW26)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520770.1
- ProteinModelPortal:   Q8XW26
- SMR:   Q8XW26
- GeneID:   1221496
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2649
- NMPDR:   fig|267608.1.peg.2649
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   RSOL267608:RSC2649-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 38377; Mature: 38377

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRATILLKTLIERYIAEGQPVGSRTLSKYSGLDLSPATIRNVMSDLEEMGFIASPHTS
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECCCCC
AGRVPTPRGYRLFVDTMLTAGPLDILGMHDRMAQQIAGTIAEQVRAQLASHGSESSQRVI
CCCCCCCCCCEEEEEHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AAAAQTLSNLSQFAGIVMTPRRTHAFRQIEFLRLSETRILLIVVTPEGDVQNRIIHTDTP
HHHHHHHHHHHHHHCEEECCHHHHHHHHHHHEEECCCEEEEEEECCCCCCCCCEEECCCC
YTPSQLVEAANYINAHYGGMTFDAVRERLRGELNALQADMTSLMQAAVEAGSSAVSDEDP
CCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VVISGERKLLEVEDLSSSMDKLRRLFAVFEQKTGLLQLLDVSSRAEGVQIFIGGESSLVP
EEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEECCCCCCCC
HEDMAVITAPYEVDGKIVGTLGVIGPMRMAYERVIPIVDITAKLLSSTLSQH
CCCCEEEECCEEECCEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKRATILLKTLIERYIAEGQPVGSRTLSKYSGLDLSPATIRNVMSDLEEMGFIASPHTS
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECCCCC
AGRVPTPRGYRLFVDTMLTAGPLDILGMHDRMAQQIAGTIAEQVRAQLASHGSESSQRVI
CCCCCCCCCCEEEEEHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AAAAQTLSNLSQFAGIVMTPRRTHAFRQIEFLRLSETRILLIVVTPEGDVQNRIIHTDTP
HHHHHHHHHHHHHHCEEECCHHHHHHHHHHHEEECCCEEEEEEECCCCCCCCCEEECCCC
YTPSQLVEAANYINAHYGGMTFDAVRERLRGELNALQADMTSLMQAAVEAGSSAVSDEDP
CCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VVISGERKLLEVEDLSSSMDKLRRLFAVFEQKTGLLQLLDVSSRAEGVQIFIGGESSLVP
EEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEECCCCCCCC
HEDMAVITAPYEVDGKIVGTLGVIGPMRMAYERVIPIVDITAKLLSSTLSQH
CCCCEEEECCEEECCEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852