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The map label for this gene is hutU

Identifier: 17547366

GI number: 17547366

Start: 2847903

End: 2849708

Strand: Reverse

Name: hutU

Synonym: RSc2647

Alternate gene names: 17547366

Gene position: 2849708-2847903 (Counterclockwise)

Preceding gene: 17547368

Following gene: 17547365

Centisome position: 76.68

GC content: 69.71

Gene sequence:

>1806_bases
ATGAACACCATGACCGATGCCGCACATCTGGCCGCCGATCCGCGCTACGACGCGGCGCGCGAGATCCGCGCGCCACGCGG
CACCGAACTGCACTGCAAGAGCTGGCTGACCGAGGCCGCCTACCGCATGCTCCAGAACAACCTCGACCCGGACGTGGCCG
AGAACCCCAAGCACCTCGTCGTCTACGGCGGCATCGGCCGCGCGGCGCGCGACTGGGCCTGCTTCGACAAGATCCTGGAG
ACGCTGCGCGAGCTGAACGACGACGAATCGCTGCTGGTGCAGTCCGGCAAGCCGGTCGGCGTGTTCAAGACGCACCCGGA
CGCGCCGCGCGTGCTGATCGCCAACTCGAACCTGGTGCCCAAGTGGGCCAACTGGGAGCACTTCAACGCGCTGGACCGCA
AGGGCCTGTTCATGTACGGCCAGATGACCGCCGGCAGCTGGATCTACATCGGCAGCCAGGGCATCGTGCAGGGCACCTAC
GAGACCTTTGCCGAGGCCGGCCGCCAGCACTATTCGGACCGCCCCTCGGCCTTGCTGAAACAAGGCCTGTCCCCCGAGGG
GACGGCACCCGGCTCGGGGCGGTCCAGCGCTCAGGTGCCCGGCAGCCATCTCGCCGGCCGCTGGATCCTGACGGCGGGCC
TGGGCGGCATGGGCGGCGCGCAGCCGCTGGCCGCCACGCTGGCCGGCGCGGTGTCGCTCACCATCGAGTGCCAGCAGTCC
AGCATCGATTTCCGCCTGCGCACGCGCTACCTCGATAAGCAGGCCCGGGACATCGACGACGCCCTGAACCTGATCCGGCA
CCATTGCGAGCGCGGCGAGGCCGTGTCGATCGGCCTGCTCGGCAACGCGGCCGAGCTCCTGCCGGAGCTGGTCAGGCGCG
CCCGCGCCGGCGGGCTGAAGCCGGACCTGGTGACCGACCAGACCTCCGCGCACGATCTCGTCAACGGCTACCTGCCGGCC
GGCTGGACAGTCGAGCAATGGCGCGCCGCGCAGCGCGATCCGGCGCAGCACGCGCACCTGAGCGCGGAGGCTGCCAGGTC
ATGCGCCGTGCACGTGCAGGCCATGCTCGACTTCCAGTCGATGGGCATTCCGACCGTCGACTACGGCAACAACATCCGCC
AGGTCGCGTTCGACCAGGGCGTGAAGAACGCCTTCGATTTCCCCGGCTTCGTGCCGGCGTACATCCGCCCGCTGTTCTGC
GAGGGCAGGGGGCCGTTCCGCTGGGTCGCGCTGTCCGGTGACCCCGAAGACATCTACAAGACCGACGCCAAGATCAAGGA
ACTGTTCCCGCACAACGCGCACGTGCATCGCTGGCTCGACATGGCGCGCGAGCGCATCGCCTTCCAGGGCCTGCCCGCGC
GCATCTGCTGGCTGGGCCTGGGCGAGCGCCACGCGGCGGGTCTGGCCTTCAACGAGATGGTGCGCAAGGGCGAGCTGAAG
GCGCCCATCGTGATCGGACGGGATCACCTCGACACCGGCTCCGTCGCCAGCCCCAATCGCGAGACCGAAGCCATGCGCGA
CGGCACCGACGCCGTGTCGGACTGGCCGCTGCTCAATGCGCTGCTGAACACCGCGGGCGGCGCGACGTGGGTCTCGCTGC
ACCACGGTGGCGGCGTCGGCATGGGCTACTCGCAGCACGCGGGCGTCGTGATCGTCGCCGACGGCACGGACGCGGCGGCC
AGGCGCCTCGCGCGCGTGCTGGTCAACGACGCCGGCTCGGGCGTGATGCGCCATGCCGATGCCGGCTACGAGACCGCCGT
CGCCTGCGCCAAGCGCAATGGCCTCAAATTGCCCATGATTGGTTAA

Upstream 100 bases:

>100_bases
TGGCAGCATGATCCGGGTTTGCCGGTGAGTTGTAAAGTTGCCTTGATTTATTTGTATATACAACATAGCATCCACGCATC
CACCGCAGGAGACTTCCGAC

Downstream 100 bases:

>100_bases
CCGGATCCCGCATTGCCATGAATACCATGACCACGCCTTCCATCCTGACGCTGCATCCGGGCGAGATGACCTTTGCCGAC
CTGCGCCGCGTCTGGCTGGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MNTMTDAAHLAADPRYDAAREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLVVYGGIGRAARDWACFDKILE
TLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVPKWANWEHFNALDRKGLFMYGQMTAGSWIYIGSQGIVQGTY
ETFAEAGRQHYSDRPSALLKQGLSPEGTAPGSGRSSAQVPGSHLAGRWILTAGLGGMGGAQPLAATLAGAVSLTIECQQS
SIDFRLRTRYLDKQARDIDDALNLIRHHCERGEAVSIGLLGNAAELLPELVRRARAGGLKPDLVTDQTSAHDLVNGYLPA
GWTVEQWRAAQRDPAQHAHLSAEAARSCAVHVQAMLDFQSMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFC
EGRGPFRWVALSGDPEDIYKTDAKIKELFPHNAHVHRWLDMARERIAFQGLPARICWLGLGERHAAGLAFNEMVRKGELK
APIVIGRDHLDTGSVASPNRETEAMRDGTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTDAAA
RRLARVLVNDAGSGVMRHADAGYETAVACAKRNGLKLPMIG

Sequences:

>Translated_601_residues
MNTMTDAAHLAADPRYDAAREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLVVYGGIGRAARDWACFDKILE
TLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVPKWANWEHFNALDRKGLFMYGQMTAGSWIYIGSQGIVQGTY
ETFAEAGRQHYSDRPSALLKQGLSPEGTAPGSGRSSAQVPGSHLAGRWILTAGLGGMGGAQPLAATLAGAVSLTIECQQS
SIDFRLRTRYLDKQARDIDDALNLIRHHCERGEAVSIGLLGNAAELLPELVRRARAGGLKPDLVTDQTSAHDLVNGYLPA
GWTVEQWRAAQRDPAQHAHLSAEAARSCAVHVQAMLDFQSMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFC
EGRGPFRWVALSGDPEDIYKTDAKIKELFPHNAHVHRWLDMARERIAFQGLPARICWLGLGERHAAGLAFNEMVRKGELK
APIVIGRDHLDTGSVASPNRETEAMRDGTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTDAAA
RRLARVLVNDAGSGVMRHADAGYETAVACAKRNGLKLPMIG
>Mature_601_residues
MNTMTDAAHLAADPRYDAAREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLVVYGGIGRAARDWACFDKILE
TLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVPKWANWEHFNALDRKGLFMYGQMTAGSWIYIGSQGIVQGTY
ETFAEAGRQHYSDRPSALLKQGLSPEGTAPGSGRSSAQVPGSHLAGRWILTAGLGGMGGAQPLAATLAGAVSLTIECQQS
SIDFRLRTRYLDKQARDIDDALNLIRHHCERGEAVSIGLLGNAAELLPELVRRARAGGLKPDLVTDQTSAHDLVNGYLPA
GWTVEQWRAAQRDPAQHAHLSAEAARSCAVHVQAMLDFQSMGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFC
EGRGPFRWVALSGDPEDIYKTDAKIKELFPHNAHVHRWLDMARERIAFQGLPARICWLGLGERHAAGLAFNEMVRKGELK
APIVIGRDHLDTGSVASPNRETEAMRDGTDAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTDAAA
RRLARVLVNDAGSGVMRHADAGYETAVACAKRNGLKLPMIG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=597, Percent_Identity=31.9932998324958, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI260306182, Length=252, Percent_Identity=32.1428571428571, Blast_Score=144, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71997891, Length=610, Percent_Identity=33.6065573770492, Blast_Score=303, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_RALSO (Q8XW28)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520768.1
- ProteinModelPortal:   Q8XW28
- SMR:   Q8XW28
- GeneID:   1221494
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2647
- NMPDR:   fig|267608.1.peg.2647
- HOGENOM:   HBG305285
- OMA:   ECQESRI
- ProtClustDB:   PRK05414
- BioCyc:   RSOL267608:RSC2647-MONOMER
- BRENDA:   4.2.1.49
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 65181; Mature: 65181

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 456-456

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTDAAHLAADPRYDAAREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLV
CCCCCCHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VYGGIGRAARDWACFDKILETLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVP
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCC
KWANWEHFNALDRKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAEAGRQHYSDRPSALLK
CCCCCHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
QGLSPEGTAPGSGRSSAQVPGSHLAGRWILTAGLGGMGGAQPLAATLAGAVSLTIECQQS
CCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCCCCCHHHHHHHHHHEEEEEEECCC
SIDFRLRTRYLDKQARDIDDALNLIRHHCERGEAVSIGLLGNAAELLPELVRRARAGGLK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCC
PDLVTDQTSAHDLVNGYLPAGWTVEQWRAAQRDPAQHAHLSAEAARSCAVHVQAMLDFQS
CCCCCCCCHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGRGPFRWVALSGDPEDIYK
CCCCEECCCCCHHHHHHHHCHHHHCCCCCCCHHHHCEEEECCCCCEEEEEECCCHHHHHH
TDAKIKELFPHNAHVHRWLDMARERIAFQGLPARICWLGLGERHAAGLAFNEMVRKGELK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCHHHHHHHHCCCCC
APIVIGRDHLDTGSVASPNRETEAMRDGTDAVSDWPLLNALLNTAGGATWVSLHHGGGVG
CCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHCHHHHHHHHHCCCCCEEEEEECCCCCC
MGYSQHAGVVIVADGTDAAARRLARVLVNDAGSGVMRHADAGYETAVACAKRNGLKLPMI
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCC
G
C
>Mature Secondary Structure
MNTMTDAAHLAADPRYDAAREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLV
CCCCCCHHHHCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
VYGGIGRAARDWACFDKILETLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVP
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCC
KWANWEHFNALDRKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAEAGRQHYSDRPSALLK
CCCCCHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
QGLSPEGTAPGSGRSSAQVPGSHLAGRWILTAGLGGMGGAQPLAATLAGAVSLTIECQQS
CCCCCCCCCCCCCCCCCCCCCCHHCCCEEEEECCCCCCCCHHHHHHHHHHEEEEEEECCC
SIDFRLRTRYLDKQARDIDDALNLIRHHCERGEAVSIGLLGNAAELLPELVRRARAGGLK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCC
PDLVTDQTSAHDLVNGYLPAGWTVEQWRAAQRDPAQHAHLSAEAARSCAVHVQAMLDFQS
CCCCCCCCHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MGIPTVDYGNNIRQVAFDQGVKNAFDFPGFVPAYIRPLFCEGRGPFRWVALSGDPEDIYK
CCCCEECCCCCHHHHHHHHCHHHHCCCCCCCHHHHCEEEECCCCCEEEEEECCCHHHHHH
TDAKIKELFPHNAHVHRWLDMARERIAFQGLPARICWLGLGERHAAGLAFNEMVRKGELK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCHHHHHHHHCCCCC
APIVIGRDHLDTGSVASPNRETEAMRDGTDAVSDWPLLNALLNTAGGATWVSLHHGGGVG
CCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHCHHHHHHHHHCCCCCEEEEEECCCCCC
MGYSQHAGVVIVADGTDAAARRLARVLVNDAGSGVMRHADAGYETAVACAKRNGLKLPMI
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852