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The map label for this gene is purM

Identifier: 17547342

GI number: 17547342

Start: 2826032

End: 2827093

Strand: Reverse

Name: purM

Synonym: RSc2623

Alternate gene names: 17547342

Gene position: 2827093-2826032 (Counterclockwise)

Preceding gene: 17547352

Following gene: 17547341

Centisome position: 76.07

GC content: 68.17

Gene sequence:

>1062_bases
ATGAGCGCTTCCGAAACCCCCTCCGCATCCGCATCGCGCGGCCTGTCCTACCGTGACGCGGGCGTCGACATCGAGGCCGG
CGACGCCCTGGTCGACCGCATCAAGCCGTTTGCCAAGCGCACCCTGCGCGAAGGCGTGCTGGGCGGCATCGGCGGCTTTG
GCGCGCTGTTCGAGATTTCCAAGAAGTACCAGGAGCCGGTGCTGGTGTCCGGCACCGACGGCGTGGGCACCAAGCTCAAG
CTCGCCTTCGCGCTCAACCGCCACGACACCGTCGGCCAGGACCTGGTCGCGATGAGCGTCAACGACATCCTGGTGCAGGG
CGCCGAGCCGCTGTTCTTCCTCGACTACTTCGCCTGCGGCAAGCTGGATGTCGATACCGCCGCCACCGTCATCAAGGGCA
TCGCCCAGGGCTGCGAACTGGCCGGCTGCGCGCTGATCGGCGGCGAGACGGCCGAGATGCCCAGCATGTACCCCGCCGGC
GAATACGACCTGGCCGGCTTTGCCGTCGGCGCGGTCGAGAAGCGCAAGATCATCGACGGCACCACCATCGCCTGCGGCGA
CGTGGTGCTGGGCCTGGCCTCGTCGGGCGCGCATTCGAACGGCTACTCGCTGGTGCGCAAGATCATCGAGGTGTCGCGCC
CGGACCTGAACGCCGATTTTCACGGCCAGCGCCTGCAGGACGCCATCATGGCGCCGACGCGCATCTACGTGAAGCCGCTG
CTGGCGCTGATCGACAAGCTGCCCGTCAAGGGCATGGCCCACATCACCGGTGGCGGCCTGGTCGAGAACGTGCCGCGCGT
GCTGCCCGAAGGCGTGACCGCCGTGCTGCACCAGGACGCATGGACGCTGCCGCCGCTGTTCCAGTGGCTGCAGAAGGCCG
GCAACGTGGCCGACGACGAGATGCACCGCGTGTTCAACTGCGGCATCGGCATGATCGTCATCGTGTCGGCGGCCGATGCG
CCGGCGGCCATCGCCCACCTGAAGGATGCGGGCGAGACCGTCTACCAGATCGGCGAGATCCGCGCGCGCCAGCCGGGCGA
AGCGCAGACCATCGTGATCTGA

Upstream 100 bases:

>100_bases
GGGGCGGCATCCGGTAAAATCGCGATTTTACTGGACCGGCGGGTCCTGATTTTGTGACTGTCCGCCGCGTGCCGCCGGTT
TTTTCCATTCAGACGACTGT

Downstream 100 bases:

>100_bases
CACGCGCCTCGCGCCCAACGAAAAGCCGCCGGACTGCCCGGCGGCTTTTTTTATTTCACCATGACTCCAGCATCGAACTT
CGCCGGACTACGCCAAAGCC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSASETPSASASRGLSYRDAGVDIEAGDALVDRIKPFAKRTLREGVLGGIGGFGALFEISKKYQEPVLVSGTDGVGTKLK
LAFALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVIKGIAQGCELAGCALIGGETAEMPSMYPAG
EYDLAGFAVGAVEKRKIIDGTTIACGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPL
LALIDKLPVKGMAHITGGGLVENVPRVLPEGVTAVLHQDAWTLPPLFQWLQKAGNVADDEMHRVFNCGIGMIVIVSAADA
PAAIAHLKDAGETVYQIGEIRARQPGEAQTIVI

Sequences:

>Translated_353_residues
MSASETPSASASRGLSYRDAGVDIEAGDALVDRIKPFAKRTLREGVLGGIGGFGALFEISKKYQEPVLVSGTDGVGTKLK
LAFALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVIKGIAQGCELAGCALIGGETAEMPSMYPAG
EYDLAGFAVGAVEKRKIIDGTTIACGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPL
LALIDKLPVKGMAHITGGGLVENVPRVLPEGVTAVLHQDAWTLPPLFQWLQKAGNVADDEMHRVFNCGIGMIVIVSAADA
PAAIAHLKDAGETVYQIGEIRARQPGEAQTIVI
>Mature_352_residues
SASETPSASASRGLSYRDAGVDIEAGDALVDRIKPFAKRTLREGVLGGIGGFGALFEISKKYQEPVLVSGTDGVGTKLKL
AFALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVIKGIAQGCELAGCALIGGETAEMPSMYPAGE
YDLAGFAVGAVEKRKIIDGTTIACGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPLL
ALIDKLPVKGMAHITGGGLVENVPRVLPEGVTAVLHQDAWTLPPLFQWLQKAGNVADDEMHRVFNCGIGMIVIVSAADAP
AAIAHLKDAGETVYQIGEIRARQPGEAQTIVI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=52.1489971346705, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=52.1489971346705, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=52.1489971346705, Blast_Score=358, Evalue=4e-99,
Organism=Escherichia coli, GI1788845, Length=340, Percent_Identity=59.7058823529412, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567511, Length=347, Percent_Identity=42.9394812680115, Blast_Score=254, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6321203, Length=354, Percent_Identity=47.7401129943503, Blast_Score=319, Evalue=4e-88,
Organism=Drosophila melanogaster, GI24582400, Length=303, Percent_Identity=42.2442244224422, Blast_Score=234, Evalue=8e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_RALSO (Q8XW52)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520744.1
- ProteinModelPortal:   Q8XW52
- SMR:   Q8XW52
- GeneID:   1221470
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2623
- NMPDR:   fig|267608.1.peg.2623
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   RSOL267608:RSC2623-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37152; Mature: 37021

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASETPSASASRGLSYRDAGVDIEAGDALVDRIKPFAKRTLREGVLGGIGGFGALFEIS
CCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KKYQEPVLVSGTDGVGTKLKLAFALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACG
HHHCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCC
KLDVDTAATVIKGIAQGCELAGCALIGGETAEMPSMYPAGEYDLAGFAVGAVEKRKIIDG
CCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHCCCC
TTIACGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPL
CEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
LALIDKLPVKGMAHITGGGLVENVPRVLPEGVTAVLHQDAWTLPPLFQWLQKAGNVADDE
HHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHH
MHRVFNCGIGMIVIVSAADAPAAIAHLKDAGETVYQIGEIRARQPGEAQTIVI
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC
>Mature Secondary Structure 
SASETPSASASRGLSYRDAGVDIEAGDALVDRIKPFAKRTLREGVLGGIGGFGALFEIS
CCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KKYQEPVLVSGTDGVGTKLKLAFALNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACG
HHHCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCC
KLDVDTAATVIKGIAQGCELAGCALIGGETAEMPSMYPAGEYDLAGFAVGAVEKRKIIDG
CCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHCCCC
TTIACGDVVLGLASSGAHSNGYSLVRKIIEVSRPDLNADFHGQRLQDAIMAPTRIYVKPL
CEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
LALIDKLPVKGMAHITGGGLVENVPRVLPEGVTAVLHQDAWTLPPLFQWLQKAGNVADDE
HHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHH
MHRVFNCGIGMIVIVSAADAPAAIAHLKDAGETVYQIGEIRARQPGEAQTIVI
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852