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The map label for this gene is ywrD [H]

Identifier: 17547220

GI number: 17547220

Start: 2707244

End: 2708902

Strand: Direct

Name: ywrD [H]

Synonym: RSc2501

Alternate gene names: 17547220

Gene position: 2707244-2708902 (Clockwise)

Preceding gene: 17547218

Following gene: 17547222

Centisome position: 72.85

GC content: 70.58

Gene sequence:

>1659_bases
ATGAGCCGCCTCCCTTTCCTCGCGCGCATGTCCCACCATCGCTTCGCCTGGCAGAACCCCTATCCCACCGTGCGCATTCC
GCTGTTCGCGCGCAATGTCGTATCGACCTCGCATCCGCTGGCGGCGCAGGCGGGACTGCGCATGCTGCTGGCCGGCGGCA
GCGCGGTCGACGCGGCGATCGCGGCGGCGGCCATGCTCACCATCGTCGAACCGGTGTCGTGCGGCCTGGGCAGCGATGCT
TTCGCCATCCTGTGGGACGGTGCCCGCCTGTACGGCCTCAATGCGTCGGGCGCCGCGCCGCGGGACTGGAGCCTCGGCTA
CTTCCGCCGCAAGTACGGCGAAGACGCCCACGGCCACCCCAGGCGCCCCACGCGCGGCTGGGACACGGTGACGGTGCCGG
GCGCCGTCTCGGCCTGGGCGACCCTGCATGAACGCTTCGGCAAGCTACCGTTCGCCGATGTGCTGGAGCCGGCGGCGGAG
ATCGCAGAACGCGGCCACGCCATCGCCCCCATCGTCGCGCATAAGTGGGCGGCGGCGATCCCCGAACTGCACGGCCAGCC
CGGCTACGCACAGGCCTTCATGCCGCACGGCCGCGCGCCCGGCGTGGGCGAGAAATTCCTCCTGCGCGATGCGGCCGCCA
CGCTGCGCCGCATCGGCGAAACGCGCGGGCGCGACTTCTATGAAGGCGAGCTTGCCAAGCGCATCGCCGCGCATGCGCAT
GCATGCGGCGGCGCGCTGACCGCGCAAGACCTGCGCGACCACCGGCCCGAATGGGTCACGCCGATCCAGCAGCGCTACCG
CGGCTACGACGTGCACGAGCTTCCGCCCAACGGCCAGGGCATCGCTGCGCTCGCGGCGCTGGGCATCCTCGAGCGCTTCG
ACCTCGGCGCCCTGCCGGTCGATTCGGCGGATACGCTGCACCTGCAGATCGAGGCGATGAAGCTGGCGTTCGCCGATCTC
TACCGCTACGTGGCCGACCCGCGCGCGATGGACGTCACGCCGGAGCAGATGCTCGACGACAGCTACCTCGACGCGCGTGC
CAGGCGCATCGACATGGGCCGCGCCGGCCATCCGGGCTTCGGCATGCCGCGTGCCGGCGGCACCGTCTATCTGAGCGCGG
CCGACGAGCGCGGCATGATGGTCTCGTTCATCCAGTCCAACTACATGGGCTTCGGGTCGGGCGTGGTGGTGCCGGGTACC
GGCATCAGCCTGCAGAACCGGGGCGTCGGCTTCTCGATGGATGCGCGCTCGGCCAACGTGGTGGAAGGCGGCAAGCGGCC
GTTCCATACCATCATCCCGGCGTTCCTGACGCGGGACGGCGCGCCGGTGATGAGCTTCGGCGTGATGGGCGGCGACATGC
AGCCGCAAGGCCATCTGCAAACGCTGGTGCGCATGCTCGACTACCACCAGCAGCCGCAGGCCGCCTGCGATGCGCCGCGC
TGGAAGGTCAACCGCGATTTCACGCTCGACGTGGAAGCCGCGCTGAACGCCGACACCGTCGCCGCCCTGCAGGCGCGGGG
CCACCGGCTCAAGGCGGTGGCCGATCCGTATATGGATTTCGGCGCGGGCCAGTTCATCTGGCGCCTGTCCGACGATGCCG
ACCACGGCTACGTGGCCGCCAGCGACAGCCGCCGCGACGGGCACGCCGTCGGATACTGA

Upstream 100 bases:

>100_bases
GCGGCCTCCAGGCCGAGTGGCAGATACCTCAAGTCTAGGCGCTGACCGTGCCAAGTGTGGTTTCGAGCGCATCGAGTATG
GGCCGAATCACACGTAATCT

Downstream 100 bases:

>100_bases
GCGCCAAACCCATCCGACACATCGCCGCTGGCTCCCAAGCCCCCTGCTCAGGTCGTGCGATGCGCCCGCTCCGCGCCCCC
TTCACGCCCGCGCGCACCGG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MSRLPFLARMSHHRFAWQNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLAGGSAVDAAIAAAAMLTIVEPVSCGLGSDA
FAILWDGARLYGLNASGAAPRDWSLGYFRRKYGEDAHGHPRRPTRGWDTVTVPGAVSAWATLHERFGKLPFADVLEPAAE
IAERGHAIAPIVAHKWAAAIPELHGQPGYAQAFMPHGRAPGVGEKFLLRDAAATLRRIGETRGRDFYEGELAKRIAAHAH
ACGGALTAQDLRDHRPEWVTPIQQRYRGYDVHELPPNGQGIAALAALGILERFDLGALPVDSADTLHLQIEAMKLAFADL
YRYVADPRAMDVTPEQMLDDSYLDARARRIDMGRAGHPGFGMPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGVVVPGT
GISLQNRGVGFSMDARSANVVEGGKRPFHTIIPAFLTRDGAPVMSFGVMGGDMQPQGHLQTLVRMLDYHQQPQAACDAPR
WKVNRDFTLDVEAALNADTVAALQARGHRLKAVADPYMDFGAGQFIWRLSDDADHGYVAASDSRRDGHAVGY

Sequences:

>Translated_552_residues
MSRLPFLARMSHHRFAWQNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLAGGSAVDAAIAAAAMLTIVEPVSCGLGSDA
FAILWDGARLYGLNASGAAPRDWSLGYFRRKYGEDAHGHPRRPTRGWDTVTVPGAVSAWATLHERFGKLPFADVLEPAAE
IAERGHAIAPIVAHKWAAAIPELHGQPGYAQAFMPHGRAPGVGEKFLLRDAAATLRRIGETRGRDFYEGELAKRIAAHAH
ACGGALTAQDLRDHRPEWVTPIQQRYRGYDVHELPPNGQGIAALAALGILERFDLGALPVDSADTLHLQIEAMKLAFADL
YRYVADPRAMDVTPEQMLDDSYLDARARRIDMGRAGHPGFGMPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGVVVPGT
GISLQNRGVGFSMDARSANVVEGGKRPFHTIIPAFLTRDGAPVMSFGVMGGDMQPQGHLQTLVRMLDYHQQPQAACDAPR
WKVNRDFTLDVEAALNADTVAALQARGHRLKAVADPYMDFGAGQFIWRLSDDADHGYVAASDSRRDGHAVGY
>Mature_551_residues
SRLPFLARMSHHRFAWQNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLAGGSAVDAAIAAAAMLTIVEPVSCGLGSDAF
AILWDGARLYGLNASGAAPRDWSLGYFRRKYGEDAHGHPRRPTRGWDTVTVPGAVSAWATLHERFGKLPFADVLEPAAEI
AERGHAIAPIVAHKWAAAIPELHGQPGYAQAFMPHGRAPGVGEKFLLRDAAATLRRIGETRGRDFYEGELAKRIAAHAHA
CGGALTAQDLRDHRPEWVTPIQQRYRGYDVHELPPNGQGIAALAALGILERFDLGALPVDSADTLHLQIEAMKLAFADLY
RYVADPRAMDVTPEQMLDDSYLDARARRIDMGRAGHPGFGMPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGVVVPGTG
ISLQNRGVGFSMDARSANVVEGGKRPFHTIIPAFLTRDGAPVMSFGVMGGDMQPQGHLQTLVRMLDYHQQPQAACDAPRW
KVNRDFTLDVEAALNADTVAALQARGHRLKAVADPYMDFGAGQFIWRLSDDADHGYVAASDSRRDGHAVGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=552, Percent_Identity=26.6304347826087, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI73915090, Length=552, Percent_Identity=26.6304347826087, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI73915096, Length=552, Percent_Identity=26.6304347826087, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI73915094, Length=552, Percent_Identity=26.6304347826087, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI113429324, Length=551, Percent_Identity=25.9528130671506, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=25.7194244604317, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI109148539, Length=519, Percent_Identity=29.2870905587669, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI153266885, Length=550, Percent_Identity=24.7272727272727, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=24.8638838475499, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI153266907, Length=548, Percent_Identity=24.0875912408759, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI30581157, Length=207, Percent_Identity=29.4685990338164, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI30581155, Length=207, Percent_Identity=29.4685990338164, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789856, Length=504, Percent_Identity=27.7777777777778, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI72000294, Length=515, Percent_Identity=25.0485436893204, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI212646519, Length=515, Percent_Identity=25.2427184466019, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17506189, Length=560, Percent_Identity=24.4642857142857, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17542894, Length=566, Percent_Identity=23.8515901060071, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24642670, Length=568, Percent_Identity=23.943661971831, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24642666, Length=568, Percent_Identity=23.943661971831, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI161077880, Length=568, Percent_Identity=24.1197183098592, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI161077878, Length=568, Percent_Identity=23.943661971831, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45551474, Length=568, Percent_Identity=23.943661971831, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI18859893, Length=485, Percent_Identity=24.7422680412371, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18859741, Length=562, Percent_Identity=25.4448398576512, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077496, Length=512, Percent_Identity=22.65625, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59825; Mature: 59693

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLPFLARMSHHRFAWQNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLAGGSAVDAAI
CCCCCHHHHHHCCCCCCCCCCCEEEEEHHHHHHHCCCCCHHHHHCCEEEEECCCHHHHHH
AAAAMLTIVEPVSCGLGSDAFAILWDGARLYGLNASGAAPRDWSLGYFRRKYGEDAHGHP
HHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCC
RRPTRGWDTVTVPGAVSAWATLHERFGKLPFADVLEPAAEIAERGHAIAPIVAHKWAAAI
CCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
PELHGQPGYAQAFMPHGRAPGVGEKFLLRDAAATLRRIGETRGRDFYEGELAKRIAAHAH
HHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ACGGALTAQDLRDHRPEWVTPIQQRYRGYDVHELPPNGQGIAALAALGILERFDLGALPV
HCCCCCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
DSADTLHLQIEAMKLAFADLYRYVADPRAMDVTPEQMLDDSYLDARARRIDMGRAGHPGF
CCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCC
GMPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGVGFSMDARSANV
CCCCCCCEEEEEECCCCCCCCEEHHHCCCCCCCCEEECCCCCEECCCCCCEEECCCCCCH
VEGGKRPFHTIIPAFLTRDGAPVMSFGVMGGDMQPQGHLQTLVRMLDYHQQPQAACDAPR
HCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCC
WKVNRDFTLDVEAALNADTVAALQARGHRLKAVADPYMDFGAGQFIWRLSDDADHGYVAA
EECCCCEEEEEHHHCCCHHHHHHHHCCCEEEHHHCHHHHCCCCEEEEEECCCCCCCEEEE
SDSRRDGHAVGY
CCCCCCCCCCCC
>Mature Secondary Structure 
SRLPFLARMSHHRFAWQNPYPTVRIPLFARNVVSTSHPLAAQAGLRMLLAGGSAVDAAI
CCCCHHHHHHCCCCCCCCCCCEEEEEHHHHHHHCCCCCHHHHHCCEEEEECCCHHHHHH
AAAAMLTIVEPVSCGLGSDAFAILWDGARLYGLNASGAAPRDWSLGYFRRKYGEDAHGHP
HHHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCC
RRPTRGWDTVTVPGAVSAWATLHERFGKLPFADVLEPAAEIAERGHAIAPIVAHKWAAAI
CCCCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHH
PELHGQPGYAQAFMPHGRAPGVGEKFLLRDAAATLRRIGETRGRDFYEGELAKRIAAHAH
HHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ACGGALTAQDLRDHRPEWVTPIQQRYRGYDVHELPPNGQGIAALAALGILERFDLGALPV
HCCCCCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
DSADTLHLQIEAMKLAFADLYRYVADPRAMDVTPEQMLDDSYLDARARRIDMGRAGHPGF
CCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCC
GMPRAGGTVYLSAADERGMMVSFIQSNYMGFGSGVVVPGTGISLQNRGVGFSMDARSANV
CCCCCCCEEEEEECCCCCCCCEEHHHCCCCCCCCEEECCCCCEECCCCCCEEECCCCCCH
VEGGKRPFHTIIPAFLTRDGAPVMSFGVMGGDMQPQGHLQTLVRMLDYHQQPQAACDAPR
HCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCC
WKVNRDFTLDVEAALNADTVAALQARGHRLKAVADPYMDFGAGQFIWRLSDDADHGYVAA
EECCCCEEEEEHHHCCCHHHHHHHHCCCEEEHHHCHHHHCCCCEEEEEECCCCCCCEEEE
SDSRRDGHAVGY
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]