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The map label for this gene is emrY [H]

Identifier: 17547218

GI number: 17547218

Start: 2705172

End: 2706728

Strand: Direct

Name: emrY [H]

Synonym: RSc2499

Alternate gene names: 17547218

Gene position: 2705172-2706728 (Clockwise)

Preceding gene: 17547214

Following gene: 17547220

Centisome position: 72.79

GC content: 69.69

Gene sequence:

>1557_bases
ATGTCGCTGCAAATCCTGCCGCCCGCGTCGATGCGGGCATTCCCGCATTTCTCGTCCGCCCGCATCCACGCCTTCGGCCT
GGCGATGGGGCTGTCGACCGGGCTCGATTTCGTGTCGTCGCAGATGATGGCCGTGGCGGGGCAGCATATCCAGGGCGGCG
TGCACGCCGATCCGCAGGCGTACCTGTACGCCGTCACCGCCTATGCCGTGGCGGCGGTGGTCGCCAACCTGGCCATCGGA
CGGATCGCGGCGCGCATCGGCTACCGCATGTTCTCGCTGATCGGCATTGTGCTGTTCGGCGTCGGCTGCGTGGTGTGCGC
GCAGTCCAACAGCATCGACATGCTCGTCGCCGGCCGGGCCATCCAGGGGCTGGGCGCGGGCGGGCTGTTCTCGGCGTCGC
GCATCCTGGTGCAGCTGACCACCGACCCCGACGAGCGCATCGCCCCCATGCTGATGTTCAGCGTCGGCCTGTTCGGCCTG
ACCACCATCGCGCCCTGGATCTGCGCCGAGGTGCTCGAATACAGCGAGTGGCGCGTGATCTTCTGGCTGGAGCTGCTGCT
GGCGGCGGCGGCCTGGCTGGCGATGTTCTTCCTGCCGCCGGAGCGCCACCAGCCGCGCACCCGCGCCGCGCGCCGGCCAC
ACGAGGCGCCGCCGGCCGAGGGCCGCCTGGACTGGATCGGCGTGGGCGCGATCGCGATCGGCGCGCTGGCGTTCCTGATG
GGCCTGTCGGAGCTGCGCTACAACCGGCTGACCGCTACGCCCGCGATTCCCCTGCTGCTGCTCGGCGGCGCGGCCGGGCT
GCTGCTGGCTGTGCACCGCCTGCGCACGCATCCGGACCCATGGCTGGACCTGACGCGCCTGAACGGCCGCCGCTACCTGT
GGGGCATCGGCTTCTACGGCATCTATTACCTGATGAGCGGGATCTGGTCGTACCTGTTCCCGGCGGTGTCGCAGGGCGGG
CTGGGCTTCACGTTTCGCACCACCACGCTGTTCCTGATGATCAGCGGCGCGGTGTCGATGGTGGTGGCGATGATCTTCAC
GATCTGGCTGCCGTTCTTCTTCCGCAAGCGCCGGGTGATCGCCATCGGCTTCGGCATCTACGCGGCCGCGGCGCTGCTGC
TGGCGACCAGCCTGATGCCGGGGGCGCCGGACTATGCCTTCTTCCCGGTGTCGTTCCTGGAAGGCATGACGCCGGGCGCG
GTGATGATCCAGGTGGCGATGATGACCTACCTCGACCTCGACCGCGAAGACTTCGCGCATGGCTACCAGATGAAGAACAT
CGCGCGCCAGTTCGCCACGGCGGTCGGCACCGGGCTGGCGGCCACGATGCTGCAGACGCAGCAGGCGGAATCGCGCGCGC
TGATCGTCGCGCATGTCACGCGCTTCACGGCAGACCTGCAAGCCGCCGGCCCGCTGACGGCCGACCGGCTGGCGCGCCTG
TCGGCCGAGATCGACCGCCAGGCCACGCTGCTGGCCGGCACGCAGCTGTTCAGCGGGTTCGCCGTGGCGTGCGGCGTGTT
CGCGGTGGTGGTGATGGTCCAGCGCTCGCTGCGCTGA

Upstream 100 bases:

>100_bases
AAGGTCTCCCAGTCGTTCCACTCCATTGTTCGCATGACTGGACAGTGTTCCCAGAGTTGAGCGTTTATCCGGCGGGCGGC
CAAGTTTATGCTCGGCTCCC

Downstream 100 bases:

>100_bases
GCGCTAGGATTTCTGCAACGCGTACTTGCCCGCGCCCGTCACGGACAGCAGGATCAGGCCGCCCATGATGCTGAGGTTCT
TGTAGAACTGCACCATGTTG

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSLQILPPASMRAFPHFSSARIHAFGLAMGLSTGLDFVSSQMMAVAGQHIQGGVHADPQAYLYAVTAYAVAAVVANLAIG
RIAARIGYRMFSLIGIVLFGVGCVVCAQSNSIDMLVAGRAIQGLGAGGLFSASRILVQLTTDPDERIAPMLMFSVGLFGL
TTIAPWICAEVLEYSEWRVIFWLELLLAAAAWLAMFFLPPERHQPRTRAARRPHEAPPAEGRLDWIGVGAIAIGALAFLM
GLSELRYNRLTATPAIPLLLLGGAAGLLLAVHRLRTHPDPWLDLTRLNGRRYLWGIGFYGIYYLMSGIWSYLFPAVSQGG
LGFTFRTTTLFLMISGAVSMVVAMIFTIWLPFFFRKRRVIAIGFGIYAAAALLLATSLMPGAPDYAFFPVSFLEGMTPGA
VMIQVAMMTYLDLDREDFAHGYQMKNIARQFATAVGTGLAATMLQTQQAESRALIVAHVTRFTADLQAAGPLTADRLARL
SAEIDRQATLLAGTQLFSGFAVACGVFAVVVMVQRSLR

Sequences:

>Translated_518_residues
MSLQILPPASMRAFPHFSSARIHAFGLAMGLSTGLDFVSSQMMAVAGQHIQGGVHADPQAYLYAVTAYAVAAVVANLAIG
RIAARIGYRMFSLIGIVLFGVGCVVCAQSNSIDMLVAGRAIQGLGAGGLFSASRILVQLTTDPDERIAPMLMFSVGLFGL
TTIAPWICAEVLEYSEWRVIFWLELLLAAAAWLAMFFLPPERHQPRTRAARRPHEAPPAEGRLDWIGVGAIAIGALAFLM
GLSELRYNRLTATPAIPLLLLGGAAGLLLAVHRLRTHPDPWLDLTRLNGRRYLWGIGFYGIYYLMSGIWSYLFPAVSQGG
LGFTFRTTTLFLMISGAVSMVVAMIFTIWLPFFFRKRRVIAIGFGIYAAAALLLATSLMPGAPDYAFFPVSFLEGMTPGA
VMIQVAMMTYLDLDREDFAHGYQMKNIARQFATAVGTGLAATMLQTQQAESRALIVAHVTRFTADLQAAGPLTADRLARL
SAEIDRQATLLAGTQLFSGFAVACGVFAVVVMVQRSLR
>Mature_517_residues
SLQILPPASMRAFPHFSSARIHAFGLAMGLSTGLDFVSSQMMAVAGQHIQGGVHADPQAYLYAVTAYAVAAVVANLAIGR
IAARIGYRMFSLIGIVLFGVGCVVCAQSNSIDMLVAGRAIQGLGAGGLFSASRILVQLTTDPDERIAPMLMFSVGLFGLT
TIAPWICAEVLEYSEWRVIFWLELLLAAAAWLAMFFLPPERHQPRTRAARRPHEAPPAEGRLDWIGVGAIAIGALAFLMG
LSELRYNRLTATPAIPLLLLGGAAGLLLAVHRLRTHPDPWLDLTRLNGRRYLWGIGFYGIYYLMSGIWSYLFPAVSQGGL
GFTFRTTTLFLMISGAVSMVVAMIFTIWLPFFFRKRRVIAIGFGIYAAAALLLATSLMPGAPDYAFFPVSFLEGMTPGAV
MIQVAMMTYLDLDREDFAHGYQMKNIARQFATAVGTGLAATMLQTQQAESRALIVAHVTRFTADLQAAGPLTADRLARLS
AEIDRQATLLAGTQLFSGFAVACGVFAVVVMVQRSLR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=504, Percent_Identity=21.4285714285714, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789042, Length=512, Percent_Identity=22.265625, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081983, Length=177, Percent_Identity=30.5084745762712, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790195, Length=406, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56054; Mature: 55923

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQILPPASMRAFPHFSSARIHAFGLAMGLSTGLDFVSSQMMAVAGQHIQGGVHADPQA
CCEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
YLYAVTAYAVAAVVANLAIGRIAARIGYRMFSLIGIVLFGVGCVVCAQSNSIDMLVAGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECHH
IQGLGAGGLFSASRILVQLTTDPDERIAPMLMFSVGLFGLTTIAPWICAEVLEYSEWRVI
HHCCCCCCHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FWLELLLAAAAWLAMFFLPPERHQPRTRAARRPHEAPPAEGRLDWIGVGAIAIGALAFLM
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHH
GLSELRYNRLTATPAIPLLLLGGAAGLLLAVHRLRTHPDPWLDLTRLNGRRYLWGIGFYG
HHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEHHHHHH
IYYLMSGIWSYLFPAVSQGGLGFTFRTTTLFLMISGAVSMVVAMIFTIWLPFFFRKRRVI
HHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AIGFGIYAAAALLLATSLMPGAPDYAFFPVSFLEGMTPGAVMIQVAMMTYLDLDREDFAH
EEEHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
GYQMKNIARQFATAVGTGLAATMLQTQQAESRALIVAHVTRFTADLQAAGPLTADRLARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCHHHHHHH
SAEIDRQATLLAGTQLFSGFAVACGVFAVVVMVQRSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLQILPPASMRAFPHFSSARIHAFGLAMGLSTGLDFVSSQMMAVAGQHIQGGVHADPQA
CEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
YLYAVTAYAVAAVVANLAIGRIAARIGYRMFSLIGIVLFGVGCVVCAQSNSIDMLVAGRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECHH
IQGLGAGGLFSASRILVQLTTDPDERIAPMLMFSVGLFGLTTIAPWICAEVLEYSEWRVI
HHCCCCCCHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FWLELLLAAAAWLAMFFLPPERHQPRTRAARRPHEAPPAEGRLDWIGVGAIAIGALAFLM
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHH
GLSELRYNRLTATPAIPLLLLGGAAGLLLAVHRLRTHPDPWLDLTRLNGRRYLWGIGFYG
HHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEECCCEEEEHHHHHH
IYYLMSGIWSYLFPAVSQGGLGFTFRTTTLFLMISGAVSMVVAMIFTIWLPFFFRKRRVI
HHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AIGFGIYAAAALLLATSLMPGAPDYAFFPVSFLEGMTPGAVMIQVAMMTYLDLDREDFAH
EEEHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
GYQMKNIARQFATAVGTGLAATMLQTQQAESRALIVAHVTRFTADLQAAGPLTADRLARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCCCCCCHHHHHHH
SAEIDRQATLLAGTQLFSGFAVACGVFAVVVMVQRSLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]