Click here to switch to the map view.

The map label for this gene is cobD [H]

Identifier: 17547111

GI number: 17547111

Start: 2599557

End: 2600552

Strand: Direct

Name: cobD [H]

Synonym: RSc2392

Alternate gene names: 17547111

Gene position: 2599557-2600552 (Clockwise)

Preceding gene: 17547110

Following gene: 17547112

Centisome position: 69.95

GC content: 75.5

Gene sequence:

>996_bases
ATGACGGCGTGGACGGGCAGTGTCTTCGATCTGGGCCCGATGGCGATCGCCGCCGCCGCGCTGGCCGGCGTGGGGCTGGA
CCGCCTGCTGGGCGAGGCGCCGCGCTGGCATCCGCTGGTCGGCTTCGGCCGGGTGGCCGCATGGATCGAGCGCGGGCTCA
ATCGCCGGCCCGCCGCGCGCGTGCTGTCCCGCGCGGCCGGCATGGTGGCGTGGTGCCTTGCCGTATTGCCCGGCGTAGCC
ATCGCCGCGTGGATCACCGCGCTGGCGCCGGACACGGCCCGGCTGGGCGCCTGGATCGCCGACGTCGTCGCGCTGTACTT
CGCCGTCGGTGCCCGCAGCCTGCGCGACCACATCGCGCCCATCGCCGAAGCGCTGCAGGCGGGCGACCTGCCCCGCGCGC
GCGGCCTGGCCTCGCGCATCGTCTCGCGCGATCTGCATGACGCGGACGAGGAGGCCATCGCCCGCGCCGCGGTGGAGTCG
GCGCTGGAGAACGGCAGCGACGCCATCTTCGCGCCGCTGTTCTGGCTCGTCGTCGGCGGCGCGCCCGGCGTGGTGCTGTA
TCGCCTGGCCAATACCCTCGATGCCATGTGGGGCTATCGCAATGCCCGCTTCGGCCGCTTCGGCTGGGCGGCCGCGCGCA
TCGACGACGTGCTGAACTGGATGCCCGCGCGCCTGACCGCCGCAAGCTATGCACTGCTCGGCCACACCGCGGACGCGCTG
CGCTGCTGGCGTGCACAGGCGCCCCGGTGGTCGAGCCCGAACGCCGGACCGGTGATGGCCTCGGGCGCCGGCAGCCTGCG
CGTGCAGCTGGGCGGCATGGCACGCTACGACGGCATCGACGAAACCCGCCCGCCGCTCGGCATCGGCCGCCCCGCCCGCG
CCGCGGATATCCGGCGCGCGCTGGCGCTGGTCTCGCGCACGCTCGGTCTCTGGCTGGCGGTCCTGGCGGCGGGCGGCGCG
CTGGCCTTCGCCGGCCTCGCGCGGCAGGGCCTATGA

Upstream 100 bases:

>100_bases
TGAACCAGCGCCTGGCCGCCCAGGCCGACCGCGTGCACCTGCTGGTGGCGGGCATTCCGATGCCGGTCAAGGGCCCCGCC
ATTCCCCCCGCCGAGCAGCC

Downstream 100 bases:

>100_bases
GCGCCGCGCCCCGCTTCACCATCGCCCACGGCGGCAACCTGGCCGCCGCGCGTGCGCGCCACGGTGAGCCGTCCGGCGGC
TGGGTCGACCTGTCCACCGG

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTAWTGSVFDLGPMAIAAAALAGVGLDRLLGEAPRWHPLVGFGRVAAWIERGLNRRPAARVLSRAAGMVAWCLAVLPGVA
IAAWITALAPDTARLGAWIADVVALYFAVGARSLRDHIAPIAEALQAGDLPRARGLASRIVSRDLHDADEEAIARAAVES
ALENGSDAIFAPLFWLVVGGAPGVVLYRLANTLDAMWGYRNARFGRFGWAAARIDDVLNWMPARLTAASYALLGHTADAL
RCWRAQAPRWSSPNAGPVMASGAGSLRVQLGGMARYDGIDETRPPLGIGRPARAADIRRALALVSRTLGLWLAVLAAGGA
LAFAGLARQGL

Sequences:

>Translated_331_residues
MTAWTGSVFDLGPMAIAAAALAGVGLDRLLGEAPRWHPLVGFGRVAAWIERGLNRRPAARVLSRAAGMVAWCLAVLPGVA
IAAWITALAPDTARLGAWIADVVALYFAVGARSLRDHIAPIAEALQAGDLPRARGLASRIVSRDLHDADEEAIARAAVES
ALENGSDAIFAPLFWLVVGGAPGVVLYRLANTLDAMWGYRNARFGRFGWAAARIDDVLNWMPARLTAASYALLGHTADAL
RCWRAQAPRWSSPNAGPVMASGAGSLRVQLGGMARYDGIDETRPPLGIGRPARAADIRRALALVSRTLGLWLAVLAAGGA
LAFAGLARQGL
>Mature_330_residues
TAWTGSVFDLGPMAIAAAALAGVGLDRLLGEAPRWHPLVGFGRVAAWIERGLNRRPAARVLSRAAGMVAWCLAVLPGVAI
AAWITALAPDTARLGAWIADVVALYFAVGARSLRDHIAPIAEALQAGDLPRARGLASRIVSRDLHDADEEAIARAAVESA
LENGSDAIFAPLFWLVVGGAPGVVLYRLANTLDAMWGYRNARFGRFGWAAARIDDVLNWMPARLTAASYALLGHTADALR
CWRAQAPRWSSPNAGPVMASGAGSLRVQLGGMARYDGIDETRPPLGIGRPARAADIRRALALVSRTLGLWLAVLAAGGAL
AFAGLARQGL

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 34815; Mature: 34683

Theoretical pI: Translated: 11.14; Mature: 11.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAWTGSVFDLGPMAIAAAALAGVGLDRLLGEAPRWHPLVGFGRVAAWIERGLNRRPAAR
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
VLSRAAGMVAWCLAVLPGVAIAAWITALAPDTARLGAWIADVVALYFAVGARSLRDHIAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAEALQAGDLPRARGLASRIVSRDLHDADEEAIARAAVESALENGSDAIFAPLFWLVVGG
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
APGVVLYRLANTLDAMWGYRNARFGRFGWAAARIDDVLNWMPARLTAASYALLGHTADAL
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RCWRAQAPRWSSPNAGPVMASGAGSLRVQLGGMARYDGIDETRPPLGIGRPARAADIRRA
HHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCHHHHHHHH
LALVSRTLGLWLAVLAAGGALAFAGLARQGL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC
>Mature Secondary Structure 
TAWTGSVFDLGPMAIAAAALAGVGLDRLLGEAPRWHPLVGFGRVAAWIERGLNRRPAAR
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
VLSRAAGMVAWCLAVLPGVAIAAWITALAPDTARLGAWIADVVALYFAVGARSLRDHIAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAEALQAGDLPRARGLASRIVSRDLHDADEEAIARAAVESALENGSDAIFAPLFWLVVGG
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
APGVVLYRLANTLDAMWGYRNARFGRFGWAAARIDDVLNWMPARLTAASYALLGHTADAL
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
RCWRAQAPRWSSPNAGPVMASGAGSLRVQLGGMARYDGIDETRPPLGIGRPARAADIRRA
HHHHHCCCCCCCCCCCCEEECCCCCEEEEECCCHHCCCCCCCCCCCCCCCCCHHHHHHHH
LALVSRTLGLWLAVLAAGGALAFAGLARQGL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA