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The map label for this gene is cobP [H]

Identifier: 17547110

GI number: 17547110

Start: 2598979

End: 2599560

Strand: Direct

Name: cobP [H]

Synonym: RSc2391

Alternate gene names: 17547110

Gene position: 2598979-2599560 (Clockwise)

Preceding gene: 17547107

Following gene: 17547111

Centisome position: 69.93

GC content: 71.13

Gene sequence:

>582_bases
ATGTCACGCCGTCTCACGCTCGTTCTCGGTGGCGCCCGCTCGGGCAAGAGCCATCACGCCGAACAGCTCGCGCTGCAGTG
CGCGGGCCCGGTCACCTACATCGCCACCGCCCGCGAGAGCGATGAGGAGATGCAACTGCGCATCGCCCTGCACCGCGCGC
GCCGGCCCGAACAGTGGAGCGTCGTCGAAGAGCCCGTGCGCCTGGCCGAAACGCTGTACGCCCACGCGCGCCACGGCGGC
TGCGTGCTGGTCGATTGCCTGACGCTGTGGCTCAACAACCTGCTGTTCGCCGGCGGCCACGCGTATCCGGAGACCGGCCC
CATCACCCCGCCCGAAGCCTGGTCCGCCGAAATCGAAGCCCTGCTCACCGCGCTGCCGCTGCTGCCCGGCGAGGTGATCC
TCGTCAGCAACGAGATCGGCCTGGGCGTGGTGCCGATGGGCGCCGTCACGCGCTTCTACGTGGACGAGCTGGGCCGCCTG
AACCAGCGCCTGGCCGCCCAGGCCGACCGCGTGCACCTGCTGGTGGCGGGCATTCCGATGCCGGTCAAGGGCCCCGCCAT
TCCCCCCGCCGAGCAGCCATGA

Upstream 100 bases:

>100_bases
CCTGGATCATCAGCGTGCCGCGCGGCGGCCCGGAAAACGGCGAGGTCGACATGCGCGGATTATCGCACCCGCCGGTGGCC
GCCCTCGCTAGAATGCTGGG

Downstream 100 bases:

>100_bases
CGGCGTGGACGGGCAGTGTCTTCGATCTGGGCCCGATGGCGATCGCCGCCGCCGCGCTGGCCGGCGTGGGGCTGGACCGC
CTGCTGGGCGAGGCGCCGCG

Product: cobalamin biosynthesis bifunctional protein: cobinamide kinase and cobinamide phosphate guanylyltransferase

Products: NA

Alternate protein names: Adenosylcobinamide kinase; Adenosylcobinamide-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSRRLTLVLGGARSGKSHHAEQLALQCAGPVTYIATARESDEEMQLRIALHRARRPEQWSVVEEPVRLAETLYAHARHGG
CVLVDCLTLWLNNLLFAGGHAYPETGPITPPEAWSAEIEALLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRL
NQRLAAQADRVHLLVAGIPMPVKGPAIPPAEQP

Sequences:

>Translated_193_residues
MSRRLTLVLGGARSGKSHHAEQLALQCAGPVTYIATARESDEEMQLRIALHRARRPEQWSVVEEPVRLAETLYAHARHGG
CVLVDCLTLWLNNLLFAGGHAYPETGPITPPEAWSAEIEALLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRL
NQRLAAQADRVHLLVAGIPMPVKGPAIPPAEQP
>Mature_192_residues
SRRLTLVLGGARSGKSHHAEQLALQCAGPVTYIATARESDEEMQLRIALHRARRPEQWSVVEEPVRLAETLYAHARHGGC
VLVDCLTLWLNNLLFAGGHAYPETGPITPPEAWSAEIEALLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRLN
QRLAAQADRVHLLVAGIPMPVKGPAIPPAEQP

Specific function: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate [H]

COG id: COG2087

COG function: function code H; Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788302, Length=181, Percent_Identity=43.646408839779, Blast_Score=134, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003203 [H]

Pfam domain/function: PF02283 CobU [H]

EC number: =2.7.1.156; =2.7.7.62 [H]

Molecular weight: Translated: 20879; Mature: 20748

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRLTLVLGGARSGKSHHAEQLALQCAGPVTYIATARESDEEMQLRIALHRARRPEQWS
CCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCH
VVEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFAGGHAYPETGPITPPEAWSAEIEA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
LLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRLNQRLAAQADRVHLLVAGIPM
HHHHHCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PVKGPAIPPAEQP
CCCCCCCCCCCCC
>Mature Secondary Structure 
SRRLTLVLGGARSGKSHHAEQLALQCAGPVTYIATARESDEEMQLRIALHRARRPEQWS
CCEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCH
VVEEPVRLAETLYAHARHGGCVLVDCLTLWLNNLLFAGGHAYPETGPITPPEAWSAEIEA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
LLTALPLLPGEVILVSNEIGLGVVPMGAVTRFYVDELGRLNQRLAAQADRVHLLVAGIPM
HHHHHCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PVKGPAIPPAEQP
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]