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The map label for this gene is cobC [H]

Identifier: 17547112

GI number: 17547112

Start: 2600549

End: 2601601

Strand: Direct

Name: cobC [H]

Synonym: RSc2393

Alternate gene names: 17547112

Gene position: 2600549-2601601 (Clockwise)

Preceding gene: 17547111

Following gene: 17547113

Centisome position: 69.97

GC content: 74.36

Gene sequence:

>1053_bases
ATGAGCGCCGCGCCCCGCTTCACCATCGCCCACGGCGGCAACCTGGCCGCCGCGCGTGCGCGCCACGGTGAGCCGTCCGG
CGGCTGGGTCGACCTGTCCACCGGCATCAACCCGCACGGCTATCCCGTCCCGCCGATCCCGCCCGAGGCATGGCTGCGCC
TGCCCGAAGACGATGGCCTCGAAGCCGCGGCAGCCTCGCACTACGGTGTCGCAAGCGCAGATGCGGTCCTGGCGGTGGCC
GGCTCGCAGGCGGCCATCCGCGCGCTGCCGCTGTTGCTGCCGCGCGGCCGGGTGGGCATCGCCCGCATCGGCTACAGCGA
ATACGCCCCCGCCTTTGCCCGCGCCGGCCACGACGTCGTGCTGCTGGATGAGCGGGACTTCCTCGACGCGACGCTCCCCG
ACGCGCTGACGCATCTCGTCGTCGTCAATCCGAACAACCCGACCGCGCGCTGCCTGCCGGCCGCCACGCTGCGCGACTGG
CATGCGCGGCTGTCCGCGCGCGGCGGCACGTTGATCGTCGACGAGGCGTTCATCGAGACGCTGGACGCGCCGCCCTCGCT
GGCTCCGCTGGCCGGCGCGCCGGGGCTGATCGTGCTGCGCTCGATCGGCAAGTTCTATGGGCTGGCCGGCGCGCGCATCG
GCTTCGTGCTGGGACCGCCGGCGTGTCTGGCGGCGCTGCGCGAGGCGCTGGGCCACTGGACCGTCAACGGCCCGGCGCGG
GCCGTGGTCCGGGCCGCGCTGGCCGATACGGCCTGGCAAAGCGCCACGCGCGCGCGCCTGCGTGCCGAAGGCGCCCGCCT
GTCCGCGCGGCTCGCCCGTCATGGCCTGCCGAATGCATCCACGCCGCTGTTTGCGTGGGTGCCCACGCCGGACGCCGCCG
CCCTGCACGCGGCACTGGCACGGCAGGGTCTCTGGACCCGATTGTTCGATGTACCCGGCACGCCGCCCGTGCAGGGCCTG
CGCCTTGGCCTGCCGCCGGATGCCTTCGGGTGGCAGCGCCTCGACGATGCGCTGGCCTCGCTGCCGCTGTCCGCTGAAAC
CACGTCCCGATGA

Upstream 100 bases:

>100_bases
GGCGCGCGCTGGCGCTGGTCTCGCGCACGCTCGGTCTCTGGCTGGCGGTCCTGGCGGCGGGCGGCGCGCTGGCCTTCGCC
GGCCTCGCGCGGCAGGGCCT

Downstream 100 bases:

>100_bases
CCGCTCATCTCGCCCGCTGCCTGCGCGTGCTCGGCCTGGCCGCGCTGCTGGCCATCGCCCTGCCGGTCCAGGCCGCCCTC
TCCGTCACCGACGATACCGG

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSAAPRFTIAHGGNLAAARARHGEPSGGWVDLSTGINPHGYPVPPIPPEAWLRLPEDDGLEAAAASHYGVASADAVLAVA
GSQAAIRALPLLLPRGRVGIARIGYSEYAPAFARAGHDVVLLDERDFLDATLPDALTHLVVVNPNNPTARCLPAATLRDW
HARLSARGGTLIVDEAFIETLDAPPSLAPLAGAPGLIVLRSIGKFYGLAGARIGFVLGPPACLAALREALGHWTVNGPAR
AVVRAALADTAWQSATRARLRAEGARLSARLARHGLPNASTPLFAWVPTPDAAALHAALARQGLWTRLFDVPGTPPVQGL
RLGLPPDAFGWQRLDDALASLPLSAETTSR

Sequences:

>Translated_350_residues
MSAAPRFTIAHGGNLAAARARHGEPSGGWVDLSTGINPHGYPVPPIPPEAWLRLPEDDGLEAAAASHYGVASADAVLAVA
GSQAAIRALPLLLPRGRVGIARIGYSEYAPAFARAGHDVVLLDERDFLDATLPDALTHLVVVNPNNPTARCLPAATLRDW
HARLSARGGTLIVDEAFIETLDAPPSLAPLAGAPGLIVLRSIGKFYGLAGARIGFVLGPPACLAALREALGHWTVNGPAR
AVVRAALADTAWQSATRARLRAEGARLSARLARHGLPNASTPLFAWVPTPDAAALHAALARQGLWTRLFDVPGTPPVQGL
RLGLPPDAFGWQRLDDALASLPLSAETTSR
>Mature_349_residues
SAAPRFTIAHGGNLAAARARHGEPSGGWVDLSTGINPHGYPVPPIPPEAWLRLPEDDGLEAAAASHYGVASADAVLAVAG
SQAAIRALPLLLPRGRVGIARIGYSEYAPAFARAGHDVVLLDERDFLDATLPDALTHLVVVNPNNPTARCLPAATLRDWH
ARLSARGGTLIVDEAFIETLDAPPSLAPLAGAPGLIVLRSIGKFYGLAGARIGFVLGPPACLAALREALGHWTVNGPARA
VVRAALADTAWQSATRARLRAEGARLSARLARHGLPNASTPLFAWVPTPDAAALHAALARQGLWTRLFDVPGTPPVQGLR
LGLPPDAFGWQRLDDALASLPLSAETTSR

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36553; Mature: 36422

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPRFTIAHGGNLAAARARHGEPSGGWVDLSTGINPHGYPVPPIPPEAWLRLPEDDGL
CCCCCCEEEEECCCEEEHHHCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHEECCCCCCC
EAAAASHYGVASADAVLAVAGSQAAIRALPLLLPRGRVGIARIGYSEYAPAFARAGHDVV
CHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCHHHCCHHHHCCCCEE
LLDERDFLDATLPDALTHLVVVNPNNPTARCLPAATLRDWHARLSARGGTLIVDEAFIET
EECCCCCCCHHHHHHEEEEEEECCCCCCCHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHH
LDAPPSLAPLAGAPGLIVLRSIGKFYGLAGARIGFVLGPPACLAALREALGHWTVNGPAR
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCHHH
AVVRAALADTAWQSATRARLRAEGARLSARLARHGLPNASTPLFAWVPTPDAAALHAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHH
RQGLWTRLFDVPGTPPVQGLRLGLPPDAFGWQRLDDALASLPLSAETTSR
HCCHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SAAPRFTIAHGGNLAAARARHGEPSGGWVDLSTGINPHGYPVPPIPPEAWLRLPEDDGL
CCCCCEEEEECCCEEEHHHCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHEECCCCCCC
EAAAASHYGVASADAVLAVAGSQAAIRALPLLLPRGRVGIARIGYSEYAPAFARAGHDVV
CHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEECCCHHHCCHHHHCCCCEE
LLDERDFLDATLPDALTHLVVVNPNNPTARCLPAATLRDWHARLSARGGTLIVDEAFIET
EECCCCCCCHHHHHHEEEEEEECCCCCCCHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHH
LDAPPSLAPLAGAPGLIVLRSIGKFYGLAGARIGFVLGPPACLAALREALGHWTVNGPAR
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCHHH
AVVRAALADTAWQSATRARLRAEGARLSARLARHGLPNASTPLFAWVPTPDAAALHAALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHH
RQGLWTRLFDVPGTPPVQGLRLGLPPDAFGWQRLDDALASLPLSAETTSR
HCCHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]