Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 17546778

GI number: 17546778

Start: 2233216

End: 2234469

Strand: Reverse

Name: nuoD [H]

Synonym: RSc2059

Alternate gene names: 17546778

Gene position: 2234469-2233216 (Counterclockwise)

Preceding gene: 17546779

Following gene: 17546777

Centisome position: 60.12

GC content: 63.48

Gene sequence:

>1254_bases
ATGGCTGACATCAAGAACTACACCCTCAACTTCGGCCCGCAGCACCCGGCCGCGCACGGCGTGCTGCGTCTGGTGCTGGA
GCTGGATGGCGAAGTCATCCAGCGCGCCGACCCGCACATCGGCCTGCTGCACCGTGCGACCGAGAAGCTCGCCGAGCAGA
AGACCTGGATTCAGAACGTGCCGTACATGGACCGTCTCGACTACGTGTCGATGATGGTCAACGAGCATGCCTACGTGATG
GCCATCGAGCGCCTGCTCGGCATCGACGTGCCGCTGCGCGCGCAGTACATCCGCGTGATGTTCGACGAGATCACGCGGAT
CATGAACCACCTGATGTGGATCGGCGCTCACGCGCTGGACGTCGGTGCCATGGCGGTGTTCCTGTACGCCTTCCGCGAGC
GCGAAGACCTGTTTGACATGTACGAGGCCGTGTCGGGCGCACGCATGCACGCGGCGTATTACCGTCCGGGCGGCGTCTAC
CGCGACCTGCCGGACTCGATGCCGCAGTACAAGGCATCGAAAGTGCGCAACGAGAAGGCACTGGCGGCCATGAACGAAAC
GCGTTCGGGATCGCTGCTGGACTTCATCGAGGCCTTCACCGACCGCTTCCCGACGTACGTCGACGAATACGAAACGCTGC
TGACCGACAACCGGATCTGGAAGCAGCGCCTGGTCGGCATCGGCGTGGTGACGCCCGAGCGCGCATTGCAGAAGGGCATG
ACCGGGCCGATGCTGCGTGGCTCCGGCATTGCGTGGGACGTGCGCAAGAAGCAGCCGTACGAAGTGTACGACCGCGTCGA
TTTCGACATCCCGGTGGGCGTGAACGGCGATTGCTACGACCGTTACCTGGTGCGCGTGGAAGAGATGCGCCAGAGCAACC
GCATCGTCCGCCAGTGCGTGGAATGGCTGCGCAAGAACCCGGGCCCGGTGATCACCGACAACCACAAGGTGGCACCGCCG
TCGCGCGTCGAGATGAAAACCAACATGGAAGAGCTGATCCACCACTTCAAGCTCTTCACCGAAGGCATGCACGTGCCCGA
GGGCGAAGCGTATGCCGCCGTCGAGCATCCGAAGGGCGAGTTCGGCATCTACGTGATCTCGGACGGCGCCAACAAGCCGT
ATCGCCTGAAGATCCGCGCGCCGGGTTTCGCGCACCTGGCGGCGCTCGACGAGATGGCCAAGGGGCACATGATCGCCGAT
GCGGTGACGATCATCGGTACGCAAGACATCGTGTTCGGCGAGATCGACCGCTGA

Upstream 100 bases:

>100_bases
GTGATCTACCAGCCGGTGACCATCGAGCCGCGCGAGATTACGCCGCGTGTGATCCGCGAGGATCAATACGGTGGCCTGAA
GCACTGAAGGGCGCCTGATC

Downstream 100 bases:

>100_bases
GCCGACAGGAAACAACGGTTTGACGCGCTGGCAGGCGCGGCTGTGAATCGAGGACGCACGCCGGGGCGCGAGCCCCGCGT
CCCGCACCAATCGCAACGAA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQNVPYMDRLDYVSMMVNEHAYVM
AIERLLGIDVPLRAQYIRVMFDEITRIMNHLMWIGAHALDVGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVY
RDLPDSMPQYKASKVRNEKALAAMNETRSGSLLDFIEAFTDRFPTYVDEYETLLTDNRIWKQRLVGIGVVTPERALQKGM
TGPMLRGSGIAWDVRKKQPYEVYDRVDFDIPVGVNGDCYDRYLVRVEEMRQSNRIVRQCVEWLRKNPGPVITDNHKVAPP
SRVEMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYVISDGANKPYRLKIRAPGFAHLAALDEMAKGHMIAD
AVTIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQNVPYMDRLDYVSMMVNEHAYVM
AIERLLGIDVPLRAQYIRVMFDEITRIMNHLMWIGAHALDVGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVY
RDLPDSMPQYKASKVRNEKALAAMNETRSGSLLDFIEAFTDRFPTYVDEYETLLTDNRIWKQRLVGIGVVTPERALQKGM
TGPMLRGSGIAWDVRKKQPYEVYDRVDFDIPVGVNGDCYDRYLVRVEEMRQSNRIVRQCVEWLRKNPGPVITDNHKVAPP
SRVEMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYVISDGANKPYRLKIRAPGFAHLAALDEMAKGHMIAD
AVTIIGTQDIVFGEIDR
>Mature_416_residues
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQNVPYMDRLDYVSMMVNEHAYVMA
IERLLGIDVPLRAQYIRVMFDEITRIMNHLMWIGAHALDVGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVYR
DLPDSMPQYKASKVRNEKALAAMNETRSGSLLDFIEAFTDRFPTYVDEYETLLTDNRIWKQRLVGIGVVTPERALQKGMT
GPMLRGSGIAWDVRKKQPYEVYDRVDFDIPVGVNGDCYDRYLVRVEEMRQSNRIVRQCVEWLRKNPGPVITDNHKVAPPS
RVEMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGEFGIYVISDGANKPYRLKIRAPGFAHLAALDEMAKGHMIADA
VTIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=61.3526570048309, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=60.5392156862745, Blast_Score=505, Evalue=1e-143,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.5365853658537, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1789076, Length=422, Percent_Identity=27.7251184834123, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=26.4705882352941, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17555284, Length=416, Percent_Identity=58.8942307692308, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568379, Length=416, Percent_Identity=57.6923076923077, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=61.2048192771084, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221459469, Length=409, Percent_Identity=54.0342298288509, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47674; Mature: 47542

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQNV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
PYMDRLDYVSMMVNEHAYVMAIERLLGIDVPLRAQYIRVMFDEITRIMNHLMWIGAHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVYRDLPDSMPQYKASKVRNEKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHH
LAAMNETRSGSLLDFIEAFTDRFPTYVDEYETLLTDNRIWKQRLVGIGVVTPERALQKGM
HHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHCCC
TGPMLRGSGIAWDVRKKQPYEVYDRVDFDIPVGVNGDCYDRYLVRVEEMRQSNRIVRQCV
CCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVITDNHKVAPPSRVEMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYVISDGANKPYRLKIRAPGFAHLAALDEMAKGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHEEECCCEEECCCCC
>Mature Secondary Structure 
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQNV
CCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
PYMDRLDYVSMMVNEHAYVMAIERLLGIDVPLRAQYIRVMFDEITRIMNHLMWIGAHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAMAVFLYAFREREDLFDMYEAVSGARMHAAYYRPGGVYRDLPDSMPQYKASKVRNEKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHH
LAAMNETRSGSLLDFIEAFTDRFPTYVDEYETLLTDNRIWKQRLVGIGVVTPERALQKGM
HHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHCCC
TGPMLRGSGIAWDVRKKQPYEVYDRVDFDIPVGVNGDCYDRYLVRVEEMRQSNRIVRQCV
CCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EWLRKNPGPVITDNHKVAPPSRVEMKTNMEELIHHFKLFTEGMHVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCC
FGIYVISDGANKPYRLKIRAPGFAHLAALDEMAKGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHHEEECCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA