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The map label for this gene is nuoE [H]

Identifier: 17546777

GI number: 17546777

Start: 2232611

End: 2233114

Strand: Reverse

Name: nuoE [H]

Synonym: RSc2058

Alternate gene names: 17546777

Gene position: 2233114-2232611 (Counterclockwise)

Preceding gene: 17546778

Following gene: 17546776

Centisome position: 60.09

GC content: 61.9

Gene sequence:

>504_bases
ATGCTATCAGCAGAAGCTCTCAAGGAAATCGACCGGGCGGTCGCGAAATATCCCGCCGACCAGAAGCAGTCCGCCGTGAT
GGCGGCGCTGGCGGTCGCGCAGAGCGAGAAAGGCTGGGTCTCGCCCGAAGTCATGCAGTTCGTGGCCGAGTATCTCGAAA
TGCCGCCGGTGTGGGTCGAGGAAGTGGCGACGTTCTACAACATGTACGACACCAAGCCGGTGGGCCGCTTCAAGCTGACC
GTGTGCACGAACCTGCCGTGTGCGCTGTCGGGCGGCGAGCGCGCGGCCGATTACCTGAAGCAGAAGCTGGGTATCGGCTT
CAACGAGACGACCGCGGACGGCACCTTCACGCTCAAGGAAGGCGAGTGCATGGGCGCATGTGGCGATGCTCCGGTCATGA
TCGTCAACAACACCCATATGTGCAGCTTCATGAGCAACGAGAAGCTCGACGCGCTGATCGCCGACCTGAAGGCGAAGGCG
CCCGCCAATGGAGCAGGCAAGTAA

Upstream 100 bases:

>100_bases
CCGACAGGAAACAACGGTTTGACGCGCTGGCAGGCGCGGCTGTGAATCGAGGACGCACGCCGGGGCGCGAGCCCCGCGTC
CCGCACCAATCGCAACGAAA

Downstream 100 bases:

>100_bases
ATGACCTCCCTGCACGATCGACACATCCAGCCGCTGATTCTCGCCGGCCTGAACGGCGACAACTGGCACCTCGAAGACTA
TGTCAAGCGCGGCGGTTACC

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 2; NDH-1 subunit E 2 [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MLSAEALKEIDRAVAKYPADQKQSAVMAALAVAQSEKGWVSPEVMQFVAEYLEMPPVWVEEVATFYNMYDTKPVGRFKLT
VCTNLPCALSGGERAADYLKQKLGIGFNETTADGTFTLKEGECMGACGDAPVMIVNNTHMCSFMSNEKLDALIADLKAKA
PANGAGK

Sequences:

>Translated_167_residues
MLSAEALKEIDRAVAKYPADQKQSAVMAALAVAQSEKGWVSPEVMQFVAEYLEMPPVWVEEVATFYNMYDTKPVGRFKLT
VCTNLPCALSGGERAADYLKQKLGIGFNETTADGTFTLKEGECMGACGDAPVMIVNNTHMCSFMSNEKLDALIADLKAKA
PANGAGK
>Mature_167_residues
MLSAEALKEIDRAVAKYPADQKQSAVMAALAVAQSEKGWVSPEVMQFVAEYLEMPPVWVEEVATFYNMYDTKPVGRFKLT
VCTNLPCALSGGERAADYLKQKLGIGFNETTADGTFTLKEGECMGACGDAPVMIVNNTHMCSFMSNEKLDALIADLKAKA
PANGAGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=164, Percent_Identity=40.8536585365854, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1788621, Length=157, Percent_Identity=31.8471337579618, Blast_Score=83, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17561328, Length=164, Percent_Identity=38.4146341463415, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI18859877, Length=168, Percent_Identity=38.0952380952381, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355353, Length=156, Percent_Identity=36.5384615384615, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 17996; Mature: 17996

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSAEALKEIDRAVAKYPADQKQSAVMAALAVAQSEKGWVSPEVMQFVAEYLEMPPVWVE
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHH
EVATFYNMYDTKPVGRFKLTVCTNLPCALSGGERAADYLKQKLGIGFNETTADGTFTLKE
HHHHHHHHHCCCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEC
GECMGACGDAPVMIVNNTHMCSFMSNEKLDALIADLKAKAPANGAGK
CCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLSAEALKEIDRAVAKYPADQKQSAVMAALAVAQSEKGWVSPEVMQFVAEYLEMPPVWVE
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHH
EVATFYNMYDTKPVGRFKLTVCTNLPCALSGGERAADYLKQKLGIGFNETTADGTFTLKE
HHHHHHHHHCCCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEC
GECMGACGDAPVMIVNNTHMCSFMSNEKLDALIADLKAKAPANGAGK
CCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]