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The map label for this gene is gltA [H]

Identifier: 17546710

GI number: 17546710

Start: 2168327

End: 2169628

Strand: Reverse

Name: gltA [H]

Synonym: RSc1991

Alternate gene names: 17546710

Gene position: 2169628-2168327 (Counterclockwise)

Preceding gene: 17546711

Following gene: 17546709

Centisome position: 58.38

GC content: 62.6

Gene sequence:

>1302_bases
ATGACGCCGTCCGATGTGAAAGCCACCCTATCGTTTTCCGATGGCTCGCCCAGCGTCGAGTTGCCGATCTACACGGGCAC
GGTTGGCCCGGACGTGATCGACATCCGCAAGCTGTACGGCCAGACGGGCAAGTTCACCTACGACCCCGGCTTCATGTCGA
CCGCGTCGTGCAACTCCAAGATCACCTATATCGATGGCGACAAGGGCGAGCTGCTCTATCGCGGCTACGCCATCGACGAT
CTGGCGGGCAAGTGCGACTTCCTGGAAATCTGCTACCTGCTGCTCAAGGGCGAGCTGCCCAACGCCAAGCAGAAGGATGA
GTTCAACAGCACCGTCATGAACCACACCATGGTGCATGAGCAGATGCAGTTCTTCCTGCGCGGCTTCCGTCGCGATGCGC
ATCCGATGGCCGTGCTGACCGGCCTGGTGGGCGCCATGAGCGCGTTCTATCCGGATGCCGCCAACATCAACGATTCGCGC
GAGCGCGAGATCTCGCAGATCCGCCTGATCGCCAAGCTGCCGACACTGGTGGCGATGGCCTACAAGTACAACATCGGCCA
GCCGCTGATCTACCCGCAGAACAACCTGTCCTACACCGGCAACTTCATGCGCATGATGTTCGCCACGCCGTGCGAGGACT
ACAAGGTCAACCCGGTGCTTGAGCGCGCGCTCGACCGCATCTTCATCCTGCACGCCGACCACGAGCAGAACGCCTCGACC
TCGACGGTGCGCCTGGCTGGCTCCTCGGGCACCAACCCGATCGCCGCCATTGCAGCCGGCATCGCCTGCCTGTGGGGCCC
GGCGCACGGCGGCGCGAACGAAGCGGCGCTGAACATGCTGGAAGAGATCGGCAGCGTCGACAAGATCGATGAGTTCATCA
AGCAGGTCAAGGACAAGAACAGCGGCGTGCGCCTGATGGGCTTCGGCCACCGCGTGTACAAGAACTACGATCCGCGCGCC
AAGCTGATGCGTGAGACCTGCCATGAAGTGCTGCAGGAACTCGGCCTGGAGAACGATCGCCTGTTCAAGCTGGCCATGGC
GCTCGAGAAGATCGCGCTGGAAGACGAATACTTCGTCAGCCGCAAGCTGTATCCGAACGTCGATTTCTACTCGGGCATCG
TGCAGCGCGCGCTGGGCATCCCGACCTCGATGTTCACCTGCATCTTCGCGCTGGCCCGCTCGGTGGGCTGGATCGCGCAG
TGGGAAGAGATGATCACCGATCCGGAATACAAGATCGGCCGTCCGCGCCAGCTGTTCAACGGCGCCGCCACCCGCGCGGT
GCCCGAGCTGGGCAAGCGCTGA

Upstream 100 bases:

>100_bases
GTTGCCGCAAGGCGAATCGCTCTGGCCCCCGGTTTTGTGCGATCCGTCTAGCGGGAGACTCCCGAGTCCATTTTTATAAA
CAGCAGAGAAGGAAACCGAC

Downstream 100 bases:

>100_bases
TCCGTTCGGCGCACATGGCGTGCGAAACCCCGCCCGGGCGACCGGCGGGGTTTTTTGTTGCCCGCGGCCTTCGCAAAACG
ACGAAACCCCCTTTCGCCAG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTPSDVKATLSFSDGSPSVELPIYTGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSKITYIDGDKGELLYRGYAIDD
LAGKCDFLEICYLLLKGELPNAKQKDEFNSTVMNHTMVHEQMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDSR
EREISQIRLIAKLPTLVAMAYKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLERALDRIFILHADHEQNAST
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGSVDKIDEFIKQVKDKNSGVRLMGFGHRVYKNYDPRA
KLMRETCHEVLQELGLENDRLFKLAMALEKIALEDEYFVSRKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWIAQ
WEEMITDPEYKIGRPRQLFNGAATRAVPELGKR

Sequences:

>Translated_433_residues
MTPSDVKATLSFSDGSPSVELPIYTGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSKITYIDGDKGELLYRGYAIDD
LAGKCDFLEICYLLLKGELPNAKQKDEFNSTVMNHTMVHEQMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDSR
EREISQIRLIAKLPTLVAMAYKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLERALDRIFILHADHEQNAST
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGSVDKIDEFIKQVKDKNSGVRLMGFGHRVYKNYDPRA
KLMRETCHEVLQELGLENDRLFKLAMALEKIALEDEYFVSRKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWIAQ
WEEMITDPEYKIGRPRQLFNGAATRAVPELGKR
>Mature_432_residues
TPSDVKATLSFSDGSPSVELPIYTGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSKITYIDGDKGELLYRGYAIDDL
AGKCDFLEICYLLLKGELPNAKQKDEFNSTVMNHTMVHEQMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDSRE
REISQIRLIAKLPTLVAMAYKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLERALDRIFILHADHEQNASTS
TVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGSVDKIDEFIKQVKDKNSGVRLMGFGHRVYKNYDPRAK
LMRETCHEVLQELGLENDRLFKLAMALEKIALEDEYFVSRKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWIAQW
EEMITDPEYKIGRPRQLFNGAATRAVPELGKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=421, Percent_Identity=27.5534441805226, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1786939, Length=422, Percent_Identity=64.6919431279621, Blast_Score=586, Evalue=1e-169,
Organism=Escherichia coli, GI1786527, Length=379, Percent_Identity=30.6068601583113, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17555174, Length=397, Percent_Identity=26.448362720403, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=337, Percent_Identity=28.1899109792285, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324328, Length=363, Percent_Identity=26.4462809917355, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=407, Percent_Identity=27.027027027027, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24640126, Length=424, Percent_Identity=27.8301886792453, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24640124, Length=426, Percent_Identity=27.6995305164319, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21356863, Length=426, Percent_Identity=26.2910798122066, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48346; Mature: 48215

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSDVKATLSFSDGSPSVELPIYTGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSK
CCCCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCEECCCCCE
ITYIDGDKGELLYRGYAIDDLAGKCDFLEICYLLLKGELPNAKQKDEFNSTVMNHTMVHE
EEEEECCCCCEEEECEEEHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDSREREISQIRLIAKLPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLERALDRIFILHADHEQNAST
HHHCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGSVDKIDEFIKQVKDKN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
SGVRLMGFGHRVYKNYDPRAKLMRETCHEVLQELGLENDRLFKLAMALEKIALEDEYFVS
CCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
RKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWIAQWEEMITDPEYKIGRPRQLFN
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
GAATRAVPELGKR
CHHHHHHHHHCCC
>Mature Secondary Structure 
TPSDVKATLSFSDGSPSVELPIYTGTVGPDVIDIRKLYGQTGKFTYDPGFMSTASCNSK
CCCCCEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCEECCCCCE
ITYIDGDKGELLYRGYAIDDLAGKCDFLEICYLLLKGELPNAKQKDEFNSTVMNHTMVHE
EEEEECCCCCEEEECEEEHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
QMQFFLRGFRRDAHPMAVLTGLVGAMSAFYPDAANINDSREREISQIRLIAKLPTLVAMA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YKYNIGQPLIYPQNNLSYTGNFMRMMFATPCEDYKVNPVLERALDRIFILHADHEQNAST
HHHCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEEECCCCCCCCC
STVRLAGSSGTNPIAAIAAGIACLWGPAHGGANEAALNMLEEIGSVDKIDEFIKQVKDKN
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
SGVRLMGFGHRVYKNYDPRAKLMRETCHEVLQELGLENDRLFKLAMALEKIALEDEYFVS
CCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
RKLYPNVDFYSGIVQRALGIPTSMFTCIFALARSVGWIAQWEEMITDPEYKIGRPRQLFN
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
GAATRAVPELGKR
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]