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The map label for this gene is iorA2 [H]

Identifier: 17546609

GI number: 17546609

Start: 2076328

End: 2076795

Strand: Reverse

Name: iorA2 [H]

Synonym: RSc1890

Alternate gene names: 17546609

Gene position: 2076795-2076328 (Counterclockwise)

Preceding gene: 17546612

Following gene: 17546608

Centisome position: 55.88

GC content: 73.5

Gene sequence:

>468_bases
ATGGACCTGGACGTCAATCGCCGGCCGGTCAAGGTCGAGTGCGACCCCGCGACGCCGCTGCTGTGGGTGCTGCGAGACCA
CCTGAGCCTCACCGGCACGAAGTTCGGCTGCGGCGTGGCCGCCTGCGGGGCCTGCACCGTGCACGTGGACGGCGCGGCCG
TGCGGTCGTGCGTGCTGCCGGTGGCGGCCGTGGCCGGCCGGCGCATCACGACCATCGAGGGGCTGGCCGAGGCGCCGGGC
AAGCGCCACGCGCTGCAGCAGGCCTGGATCGACGAGCAGGTGCCGCAATGCGGCTATTGCCAGTCGGGCATGCTGATGGC
CGCGGCGGACCTGCTGGCCAGGCAGCCCGACCCCAGCGACGCCGACATCGATGCCGCCATCACCAACCTGTGCCGCTGCG
GCACGTATCCGCGCGTGCGGACCGCCATCAAGCGTGCCGCGCAGGCGCTGCGGGAGGGCCGCGCATGA

Upstream 100 bases:

>100_bases
ACCGGCCGCCCGGTGGGGCACTCGAATGGAACCACTATTGCGGGCGCCGTGCGTTTGAACGTAGCCTTGGCCGACAACAA
GACAGACGAGGAGACCGCCC

Downstream 100 bases:

>100_bases
CGGCCGACGCAACCGCACCGCGCCGCGGACGGCGCCGCTTCCTGCTGGGCGCGCTCGGCATCGGCGGGGCGCTGGTAGTG
GGCTGGGGCGTGCTGCCGCC

Product: isoquinoline 1-oxidoreductase alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLPVAAVAGRRITTIEGLAEAPG
KRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSDADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA

Sequences:

>Translated_155_residues
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLPVAAVAGRRITTIEGLAEAPG
KRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSDADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA
>Mature_155_residues
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLPVAAVAGRRITTIEGLAEAPG
KRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSDADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=141, Percent_Identity=35.4609929078014, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI71773480, Length=149, Percent_Identity=32.8859060402685, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786480, Length=167, Percent_Identity=36.5269461077844, Blast_Score=99, Evalue=1e-22,
Organism=Escherichia coli, GI1789232, Length=146, Percent_Identity=36.986301369863, Blast_Score=90, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17540638, Length=140, Percent_Identity=37.8571428571429, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539860, Length=153, Percent_Identity=35.2941176470588, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566215, Length=154, Percent_Identity=36.3636363636364, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737937, Length=141, Percent_Identity=36.1702127659575, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647195, Length=163, Percent_Identity=32.5153374233129, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647197, Length=163, Percent_Identity=32.5153374233129, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647193, Length=136, Percent_Identity=31.6176470588235, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16479; Mature: 16479

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
5.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHCEEEEEECHHHHHHHHHH
VAAVAGRRITTIEGLAEAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC
ADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLDVNRRPVKVECDPATPLLWVLRDHLSLTGTKFGCGVAACGACTVHVDGAAVRSCVLP
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHCEEEEEECHHHHHHHHHH
VAAVAGRRITTIEGLAEAPGKRHALQQAWIDEQVPQCGYCQSGMLMAAADLLARQPDPSD
HHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC
ADIDAAITNLCRCGTYPRVRTAIKRAAQALREGRA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]