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The map label for this gene is lysP [H]

Identifier: 17546477

GI number: 17546477

Start: 1882496

End: 1884034

Strand: Reverse

Name: lysP [H]

Synonym: RSc1758

Alternate gene names: 17546477

Gene position: 1884034-1882496 (Counterclockwise)

Preceding gene: 17546490

Following gene: 17546476

Centisome position: 50.69

GC content: 69.27

Gene sequence:

>1539_bases
ATGTCAGAACACACCACCGCGTCCGCCGGGACGCCGGGCTTGCGCCGGACTTTGCGTGCGCGCCACCTCACCATGATCGC
CATCGGCGGGTCGATCGGCACCGGGCTGTTCGTCGCCTCGGGCGCGTCGGTGTCGCAGGCCGGCCCCGGCGGCGCGCTGG
CCGCCTACGTGCTGATCGGGACGATGGTCTACTTTCTGATGACCAGCCTCGGCGAGCTCGCCGCCTACATGCCGGTGCCG
GGCTCGTTCGCCACCTACGGCGCGCGCTACGTGGACGAAGGCTTCGGCTTCGCGCTGGGCTGGAACTACTGGTACAACTG
GGCGGTGACGATCGCGGTGGAGCTGGCCGCCGCGCAGCTGGTCATGCACTACTGGTTTCCCGAGGTGCCGGGCGTGCTGT
GGAGCGCGGGCTTCCTGGCGGTGATGTTCCTGCTCAACGCGATCTCCGTGCGCGGCTTCGGCGAGGCGGAATACTGGTTC
GCGCTCATCAAGGTCGTCACCGTGCTGTGCTTCATCGCGATCGGCCTGGCGATGATCTTCGGCATCATCAAGGGCGCGCC
GGCATCGGGCCTGCACAACCTGACCCTCGGCGAGGCGCCGTTCGTGGGCGGGCTGCCGGCGATGATCGGCGTGGCGATGA
TCGCCGGGTTCTCGTTCCAGGGCACCGAGCTGATCGGCGTGGCGGCGGGCGAATCGGCCGACCCGGCGCGCACCATTCCG
CGCGCGGTCCGGCAGGTGTTCTGGCGCATCCTGCTGTTCTATGTGCTGGCGATCTTCATCATCGGCGCGCTGGTGCCGTA
CACCGATCCGAACCTGCTGTCGACGGAGGTCGCCAACATCGGCGTGAGCCCGTTCACGCTGGTCTTCCGCCATGCCGGCC
TGGCCTTTGCCGCCGGGCTGATGAACGCGGTGATCCTGACGGCGGTGCTGTCGGCGGGCAATTCGGGCATGTATGCGTCC
ACGCGCATGCTCTACAACCTCGCCACCGAAGGCCGCGCGCCGCGCCTGTTCGCGCGGCTATCGAAGAACGGCGTGCCGCG
CAATGCGCTGCTGGCCACCACCGCCGTGGGCGCGCTGTGCTTCCTGAGCTCGCTGTACGGCGACAAGACCGTCTACCTGT
GGCTGCTCAACACCTCGGGCATGACCGGCTTCGTCGCGTGGCTGGGCATCGCGATCAGCCATTACCGCTTCCGCAAGGGC
CTGGTGCTGCAGGGCCACGACCCGGCGCTGCTGCCCTACCGCTCGCCGTTCTTTCCGTACGGCCCGCTGTTCGCGTTCGG
GTTGTGCCTGGTCATCACCCTGGGCCAGAACTACCAGGCCTTCGCCAGCGGCCGGGTCGACTGGGCCGAGGTGACCGCCA
CCTATATCGGCATCCCGATCTTCTTCGCGGTCTGGCTAGGCTACCGGCTGGTGCGCGGCGGCGGCATCATCCGCTACCAG
GACATGCGCTTCCCGCGCCCGCCCGTCACGCGCGACCCGCCGGGCGAAGCGCCCGCCGCCCCCGGGCTGCCGGCCGCCGC
GACGAGCCCGCAGCGTTGA

Upstream 100 bases:

>100_bases
GCGCCTTTCGTCCCGTGGCACCTACCGGGCAGCGGGAACGCTCCATCACATTAGACGGATTTCGTTCGCGATCCGATCGG
AACCGTCCGATTCTGCATCC

Downstream 100 bases:

>100_bases
GGTTCCGGCCAGCCGGGTGCCCAGGGTGCCCGGCTGGCATTTGATTGATGGACGTCCCGCAGAGGCGCCACCCACTATGC
ATACACCGATCACCCCCACC

Product: lysine-specific permease transmembrane protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSEHTTASAGTPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYVLIGTMVYFLMTSLGELAAYMPVP
GSFATYGARYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMHYWFPEVPGVLWSAGFLAVMFLLNAISVRGFGEAEYWF
ALIKVVTVLCFIAIGLAMIFGIIKGAPASGLHNLTLGEAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
RAVRQVFWRILLFYVLAIFIIGALVPYTDPNLLSTEVANIGVSPFTLVFRHAGLAFAAGLMNAVILTAVLSAGNSGMYAS
TRMLYNLATEGRAPRLFARLSKNGVPRNALLATTAVGALCFLSSLYGDKTVYLWLLNTSGMTGFVAWLGIAISHYRFRKG
LVLQGHDPALLPYRSPFFPYGPLFAFGLCLVITLGQNYQAFASGRVDWAEVTATYIGIPIFFAVWLGYRLVRGGGIIRYQ
DMRFPRPPVTRDPPGEAPAAPGLPAAATSPQR

Sequences:

>Translated_512_residues
MSEHTTASAGTPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYVLIGTMVYFLMTSLGELAAYMPVP
GSFATYGARYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMHYWFPEVPGVLWSAGFLAVMFLLNAISVRGFGEAEYWF
ALIKVVTVLCFIAIGLAMIFGIIKGAPASGLHNLTLGEAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
RAVRQVFWRILLFYVLAIFIIGALVPYTDPNLLSTEVANIGVSPFTLVFRHAGLAFAAGLMNAVILTAVLSAGNSGMYAS
TRMLYNLATEGRAPRLFARLSKNGVPRNALLATTAVGALCFLSSLYGDKTVYLWLLNTSGMTGFVAWLGIAISHYRFRKG
LVLQGHDPALLPYRSPFFPYGPLFAFGLCLVITLGQNYQAFASGRVDWAEVTATYIGIPIFFAVWLGYRLVRGGGIIRYQ
DMRFPRPPVTRDPPGEAPAAPGLPAAATSPQR
>Mature_511_residues
SEHTTASAGTPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYVLIGTMVYFLMTSLGELAAYMPVPG
SFATYGARYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMHYWFPEVPGVLWSAGFLAVMFLLNAISVRGFGEAEYWFA
LIKVVTVLCFIAIGLAMIFGIIKGAPASGLHNLTLGEAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIPR
AVRQVFWRILLFYVLAIFIIGALVPYTDPNLLSTEVANIGVSPFTLVFRHAGLAFAAGLMNAVILTAVLSAGNSGMYAST
RMLYNLATEGRAPRLFARLSKNGVPRNALLATTAVGALCFLSSLYGDKTVYLWLLNTSGMTGFVAWLGIAISHYRFRKGL
VLQGHDPALLPYRSPFFPYGPLFAFGLCLVITLGQNYQAFASGRVDWAEVTATYIGIPIFFAVWLGYRLVRGGGIIRYQD
MRFPRPPVTRDPPGEAPAAPGLPAAATSPQR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=486, Percent_Identity=73.6625514403292, Blast_Score=735, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=450, Percent_Identity=42, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1786789, Length=419, Percent_Identity=37.2315035799523, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=38.1578947368421, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI1786302, Length=401, Percent_Identity=36.4089775561097, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=33.0232558139535, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081915, Length=418, Percent_Identity=34.9282296650718, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1790653, Length=396, Percent_Identity=35.8585858585859, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786602, Length=390, Percent_Identity=35.1282051282051, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI87081869, Length=409, Percent_Identity=23.4718826405868, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082023, Length=346, Percent_Identity=24.5664739884393, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=483, Percent_Identity=35.6107660455487, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324061, Length=481, Percent_Identity=36.5904365904366, Blast_Score=322, Evalue=6e-89,
Organism=Saccharomyces cerevisiae, GI6324990, Length=487, Percent_Identity=34.2915811088296, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6324059, Length=482, Percent_Identity=35.6846473029046, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6322892, Length=476, Percent_Identity=35.5042016806723, Blast_Score=286, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6324924, Length=480, Percent_Identity=33.9583333333333, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=433, Percent_Identity=36.0277136258661, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321629, Length=497, Percent_Identity=31.3883299798793, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322967, Length=469, Percent_Identity=34.1151385927505, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6320717, Length=471, Percent_Identity=28.6624203821656, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319824, Length=482, Percent_Identity=29.045643153527, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6321053, Length=512, Percent_Identity=30.078125, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6319542, Length=467, Percent_Identity=27.1948608137045, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324981, Length=466, Percent_Identity=33.9055793991416, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320251, Length=516, Percent_Identity=26.5503875968992, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6319543, Length=474, Percent_Identity=28.4810126582279, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6319608, Length=485, Percent_Identity=26.5979381443299, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320364, Length=559, Percent_Identity=25.4025044722719, Blast_Score=173, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54632; Mature: 54500

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHTTASAGTPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYVLIG
CCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
TMVYFLMTSLGELAAYMPVPGSFATYGARYVDEGFGFALGWNYWYNWAVTIAVELAAAQL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHH
VMHYWFPEVPGVLWSAGFLAVMFLLNAISVRGFGEAEYWFALIKVVTVLCFIAIGLAMIF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIIKGAPASGLHNLTLGEAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHH
RAVRQVFWRILLFYVLAIFIIGALVPYTDPNLLSTEVANIGVSPFTLVFRHAGLAFAAGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRLFARLSKNGVPRNALLATTAVGALC
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
FLSSLYGDKTVYLWLLNTSGMTGFVAWLGIAISHYRFRKGLVLQGHDPALLPYRSPFFPY
HHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCC
GPLFAFGLCLVITLGQNYQAFASGRVDWAEVTATYIGIPIFFAVWLGYRLVRGGGIIRYQ
HHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
DMRFPRPPVTRDPPGEAPAAPGLPAAATSPQR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEHTTASAGTPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYVLIG
CCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
TMVYFLMTSLGELAAYMPVPGSFATYGARYVDEGFGFALGWNYWYNWAVTIAVELAAAQL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHH
VMHYWFPEVPGVLWSAGFLAVMFLLNAISVRGFGEAEYWFALIKVVTVLCFIAIGLAMIF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIIKGAPASGLHNLTLGEAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHH
RAVRQVFWRILLFYVLAIFIIGALVPYTDPNLLSTEVANIGVSPFTLVFRHAGLAFAAGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRLFARLSKNGVPRNALLATTAVGALC
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
FLSSLYGDKTVYLWLLNTSGMTGFVAWLGIAISHYRFRKGLVLQGHDPALLPYRSPFFPY
HHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCC
GPLFAFGLCLVITLGQNYQAFASGRVDWAEVTATYIGIPIFFAVWLGYRLVRGGGIIRYQ
HHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
DMRFPRPPVTRDPPGEAPAAPGLPAAATSPQR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]