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The map label for this gene is gbd1 [H]

Identifier: 17546490

GI number: 17546490

Start: 1898075

End: 1899223

Strand: Reverse

Name: gbd1 [H]

Synonym: RSc1771

Alternate gene names: 17546490

Gene position: 1899223-1898075 (Counterclockwise)

Preceding gene: 17546499

Following gene: 17546477

Centisome position: 51.1

GC content: 72.5

Gene sequence:

>1149_bases
ATGGCCCTCATCTTCTACCTCACCCACGTCCACCTCGGCTTCGGCACGCTCGGCGAGCTCGGCAGCGAATGCGCGCGAGT
CGGCATCCGCCGGCCGCTGGTCGTCACCGACCGCGGCGTGGCGGCCGCCGGCCTGGCCCAGCGCGCCATCGACGCCACCG
GCGGCCTGCCCGTCACCGTGTTCGACGAGACGCCGTCCAACCCCACCGAGGCGATGGTCAGGAAGGCCACGGCGCAATAC
CGGGACGCCGGCTGCGACGGGCTGATCGCCATCGGCGGCGGCTCGTCGATCGACCTGGCCAAGGGGATCGCCATCGCAGC
GACGCACCCCGGGCCGCTCACCGCCTACGCCACCATCGAAGGCGGCAGCGGCAAGATCACCGATGCGGCCGCGCCGCTGA
TCGCCATCCCCACCACGGCCGGCACCGGCAGCGAAGTGGCGCGGGGCGCGATCCTGATCCTGGAGGACGGCCGCAAGCTG
GGCTTCCACTCCTGGCATCTGCTGCCGAAATCGGCCCTCTGCGACCCCGCGCTTACGCTCGGCCTGCCGCCCCTGCTGAC
GGCCGCCACCGGGATGGACGCCATCGCGCACTGCATCGAGACCTTCCTCGCGCCGGCCTTCAACCCGCCCGCCGACGGCA
TCGCGCTCGACGGTCTGGAGCGCGCCTGGGCCCACATCGAGCGCGCCACGCGCGACGGCGCCGACCGCGAGGCCCGGCTC
AACATGATGAGCGCCTCGATGCAGGGGGCGATGGCGTTCCAGAAGGGGCTGGGCTGCGTGCATTCGCTGTCGCACCCGCT
GGGCGGCGTGAAGGTGGACGGCAAGACCGGGCTGCACCACGGCACGCTCAACGCGGTGGTGCTGCCGGCGGTGCTGCGCT
TCAATGCGACGGCGGAATCGGTGGTGCGCGAGCATCGCTACGCCCGCATGCGCCGCGCGATGAACCTGCCGGCCGACGCC
GACCTCGCCCAGGCCGTGCACGACATGACCGCGCGGCTGGGCCTGCCCACCGGCCTGCGCCAGATGGGCGTGCCGGACGA
TGCGCTGGAGCACGTGGTGCGTGGCGCCCTGCTCGACCACTGCCACAAGACCAATCCGCGCGAGGCCACGGCGGACGATT
ACCGCCGGATGCTGGCGGAGTCGATGTAG

Upstream 100 bases:

>100_bases
GGCATGGGACGTAACTGAACGATCGTTCTTATTTGACTATCATCGGAGTATCCATTGAACCACGTCCGCAAGACAAGACG
GACGGCTCCGGAGACACCCC

Downstream 100 bases:

>100_bases
CCGGCGACGGCTATTCCACGAACGGCCGGATCAGCGCCGTGATGCGCTCCGGCTGCTCATGCACCACCCAGTGCGTGCCG
TTGGGAATGCGCTCGATGCG

Product: NAD-dependent 4-hydroxybutyrate dehydrogenase oxidoreductase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MALIFYLTHVHLGFGTLGELGSECARVGIRRPLVVTDRGVAAAGLAQRAIDATGGLPVTVFDETPSNPTEAMVRKATAQY
RDAGCDGLIAIGGGSSIDLAKGIAIAATHPGPLTAYATIEGGSGKITDAAAPLIAIPTTAGTGSEVARGAILILEDGRKL
GFHSWHLLPKSALCDPALTLGLPPLLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATRDGADREARL
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTGLHHGTLNAVVLPAVLRFNATAESVVREHRYARMRRAMNLPADA
DLAQAVHDMTARLGLPTGLRQMGVPDDALEHVVRGALLDHCHKTNPREATADDYRRMLAESM

Sequences:

>Translated_382_residues
MALIFYLTHVHLGFGTLGELGSECARVGIRRPLVVTDRGVAAAGLAQRAIDATGGLPVTVFDETPSNPTEAMVRKATAQY
RDAGCDGLIAIGGGSSIDLAKGIAIAATHPGPLTAYATIEGGSGKITDAAAPLIAIPTTAGTGSEVARGAILILEDGRKL
GFHSWHLLPKSALCDPALTLGLPPLLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATRDGADREARL
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTGLHHGTLNAVVLPAVLRFNATAESVVREHRYARMRRAMNLPADA
DLAQAVHDMTARLGLPTGLRQMGVPDDALEHVVRGALLDHCHKTNPREATADDYRRMLAESM
>Mature_381_residues
ALIFYLTHVHLGFGTLGELGSECARVGIRRPLVVTDRGVAAAGLAQRAIDATGGLPVTVFDETPSNPTEAMVRKATAQYR
DAGCDGLIAIGGGSSIDLAKGIAIAATHPGPLTAYATIEGGSGKITDAAAPLIAIPTTAGTGSEVARGAILILEDGRKLG
FHSWHLLPKSALCDPALTLGLPPLLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATRDGADREARLN
MMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTGLHHGTLNAVVLPAVLRFNATAESVVREHRYARMRRAMNLPADAD
LAQAVHDMTARLGLPTGLRQMGVPDDALEHVVRGALLDHCHKTNPREATADDYRRMLAESM

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=419, Percent_Identity=26.9689737470167, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI48994951, Length=380, Percent_Identity=33.4210526315789, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789163, Length=374, Percent_Identity=31.283422459893, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI87082107, Length=370, Percent_Identity=33.5135135135135, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787493, Length=407, Percent_Identity=28.009828009828, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789386, Length=317, Percent_Identity=28.391167192429, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17537053, Length=388, Percent_Identity=27.8350515463918, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321181, Length=375, Percent_Identity=34.1333333333333, Blast_Score=195, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24657991, Length=416, Percent_Identity=30.2884615384615, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 39974; Mature: 39843

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIFYLTHVHLGFGTLGELGSECARVGIRRPLVVTDRGVAAAGLAQRAIDATGGLPVTV
CEEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEE
FDETPSNPTEAMVRKATAQYRDAGCDGLIAIGGGSSIDLAKGIAIAATHPGPLTAYATIE
ECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCEEEEECCCCCEEEEEEEE
GGSGKITDAAAPLIAIPTTAGTGSEVARGAILILEDGRKLGFHSWHLLPKSALCDPALTL
CCCCCCCCCCCCEEEECCCCCCCHHHHCCEEEEEECCCCCCCCCEECCCHHHHCCCHHHH
GLPPLLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATRDGADREARL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHH
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTGLHHGTLNAVVLPAVLRFNATAES
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCHHHH
VVREHRYARMRRAMNLPADADLAQAVHDMTARLGLPTGLRQMGVPDDALEHVVRGALLDH
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHH
CHKTNPREATADDYRRMLAESM
HHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALIFYLTHVHLGFGTLGELGSECARVGIRRPLVVTDRGVAAAGLAQRAIDATGGLPVTV
EEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEE
FDETPSNPTEAMVRKATAQYRDAGCDGLIAIGGGSSIDLAKGIAIAATHPGPLTAYATIE
ECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCEEEEECCCCCEEEEEEEE
GGSGKITDAAAPLIAIPTTAGTGSEVARGAILILEDGRKLGFHSWHLLPKSALCDPALTL
CCCCCCCCCCCCEEEECCCCCCCHHHHCCEEEEEECCCCCCCCCEECCCHHHHCCCHHHH
GLPPLLTAATGMDAIAHCIETFLAPAFNPPADGIALDGLERAWAHIERATRDGADREARL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHH
NMMSASMQGAMAFQKGLGCVHSLSHPLGGVKVDGKTGLHHGTLNAVVLPAVLRFNATAES
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCHHHH
VVREHRYARMRRAMNLPADADLAQAVHDMTARLGLPTGLRQMGVPDDALEHVVRGALLDH
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHH
CHKTNPREATADDYRRMLAESM
HHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]