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The map label for this gene is lysP [H]

Identifier: 17546476

GI number: 17546476

Start: 1880890

End: 1882419

Strand: Reverse

Name: lysP [H]

Synonym: RSc1757

Alternate gene names: 17546476

Gene position: 1882419-1880890 (Counterclockwise)

Preceding gene: 17546477

Following gene: 17546474

Centisome position: 50.65

GC content: 67.52

Gene sequence:

>1530_bases
ATGCATACACCGATCACCCCCACCGGCCTCGAGGGCCAGTCCGAACTGCGCCGGCGCCTGCGCGCGCGCCACCTGACGAT
GATCGCCCTCGGCGGCGCCATCGGCACCGGGCTGTTCGTCGCCTCCGGCGCCTCCATCGCGCAGGCCGGCCCGGGCGGCG
CCCTGTTCACCTACACGCTGATCGGCGTGATGGTCTACTGCCTGATGACGAGCCTCGGCGAGCTGGCGGTGCACCTGCCG
GTGTCGGGCTCCTTCGTCACGTACAGCCGGCTGTACGTGGAGGAAGGGTTCGGCTTTGCGCTGGGGTGGAATTACTGGTT
TGCGCTGGCGGTGTCCGTGGCGGTGGAGCTGGCGGCGGCGCAGCTGGTGATGAAGTACTGGTTCCCCGGCGTCTCGGGCA
TGGTCTGGAGCGCCGCCTTCCTGCTGCTGATGTTCGTGCTCAACGCGTTCTCGGTGCGCGGCTTCGGTGAGGCGGAATAC
TGGTTCTCGATGATCAAGGTGGTGACCATCGTCGTGTTCCTGCTGATCGGGCTGGCGATGATCTTCGGCATCATGAAAGG
CGGGCCGCAGTCGGGCTGGCACAACTTCACGGTGGGCGACGCGCCGTTCGTGGGCGGACTGCCTGCGATGATCGGCGTGG
CGATGATCGCCGGGTTCTCGTTCCAGGGCGTCGAGACCATCGGCGTGGCCGCCGGCGAGGCGGAGAACCCCGCCCGCACC
ATTCCGCGCGGCATCCGCCAGACCTTCTGGCGCATCCTGCTGTTCTACGTGCTGGCGATCCTGATCATCGCCGTGCTGCT
GCCGTACACCGATCCGAACCTGCTGCGCAACGAGGCCACCGACATCGGCGTAAGCCCGTTCGCGCTGGTGTTCCAGCATG
CCGGCCTCGCCTTCGCCGCCGGCATGATGAACGCGGTGGTGCTGACCGCGCTGCTGTCGTCCGGCACCTCGAGCCTGTAT
GTCTCGACGCGCATCCTCTACGACCTCGCGCTTGAAGGCCAGGCGCCGCGGTGGTTCGCCAGGGTCTCGGGCAACGGCGT
GCCGCACCGGGCGCTGCTGGCCACCTCGGCGGTGGGCGCGCTGTGCTTCTTCAGCTCGCTCTTCGGCGACCAGGTCGTGT
ACCTGTGGCTGCTCAATACCTCGGCGGTGACGTGCTTCATCGCCTGGTTCGGCATCGCGCTGGCGCACTACCGCTTCCGC
AAGGGCTTTCTGCATCAGGGCCACACGGTCGATCAGCTCGAATACCGCTCGCCCTTCTTCCCGTTCGGGCCGATCCTGGT
GGCCGCCCTGTGCGTGATCATCATCCTCGGGCAGAACACCAAGGCGCTGTTCGCGCCGATCGACAACTTCGGCGCCTTCG
TCGCCACGTATTGCGGGGTGTTTCTGTTCGTGGCGATCTGGCTGGGGTACCGGTGGCGCTACAAGACGCGGTTTGTGCGG
TACGAGCAGATGCAGTTCAGCCCGCGGCACATCCGGGCGGCGCAGGCCGGGGATGGCGGGGCCGCGCTGCCGGGCGTGGC
CGCGGATTAG

Upstream 100 bases:

>100_bases
GCCGCGACGAGCCCGCAGCGTTGAGGTTCCGGCCAGCCGGGTGCCCAGGGTGCCCGGCTGGCATTTGATTGATGGACGTC
CCGCAGAGGCGCCACCCACT

Downstream 100 bases:

>100_bases
CCTGCCGAGGCGCGGCGCGCCACGCGCCACGCGCCGCGCGGCTGCCGTCATTGACGCCGGGCCCTGGCCGGCACCGCGCG
CCAATCGGAGCGGGCGGCGC

Product: lysine-specific permease transmembrane protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MHTPITPTGLEGQSELRRRLRARHLTMIALGGAIGTGLFVASGASIAQAGPGGALFTYTLIGVMVYCLMTSLGELAVHLP
VSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAAQLVMKYWFPGVSGMVWSAAFLLLMFVLNAFSVRGFGEAEY
WFSMIKVVTIVVFLLIGLAMIFGIMKGGPQSGWHNFTVGDAPFVGGLPAMIGVAMIAGFSFQGVETIGVAAGEAENPART
IPRGIRQTFWRILLFYVLAILIIAVLLPYTDPNLLRNEATDIGVSPFALVFQHAGLAFAAGMMNAVVLTALLSSGTSSLY
VSTRILYDLALEGQAPRWFARVSGNGVPHRALLATSAVGALCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFR
KGFLHQGHTVDQLEYRSPFFPFGPILVAALCVIIILGQNTKALFAPIDNFGAFVATYCGVFLFVAIWLGYRWRYKTRFVR
YEQMQFSPRHIRAAQAGDGGAALPGVAAD

Sequences:

>Translated_509_residues
MHTPITPTGLEGQSELRRRLRARHLTMIALGGAIGTGLFVASGASIAQAGPGGALFTYTLIGVMVYCLMTSLGELAVHLP
VSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAAQLVMKYWFPGVSGMVWSAAFLLLMFVLNAFSVRGFGEAEY
WFSMIKVVTIVVFLLIGLAMIFGIMKGGPQSGWHNFTVGDAPFVGGLPAMIGVAMIAGFSFQGVETIGVAAGEAENPART
IPRGIRQTFWRILLFYVLAILIIAVLLPYTDPNLLRNEATDIGVSPFALVFQHAGLAFAAGMMNAVVLTALLSSGTSSLY
VSTRILYDLALEGQAPRWFARVSGNGVPHRALLATSAVGALCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFR
KGFLHQGHTVDQLEYRSPFFPFGPILVAALCVIIILGQNTKALFAPIDNFGAFVATYCGVFLFVAIWLGYRWRYKTRFVR
YEQMQFSPRHIRAAQAGDGGAALPGVAAD
>Mature_509_residues
MHTPITPTGLEGQSELRRRLRARHLTMIALGGAIGTGLFVASGASIAQAGPGGALFTYTLIGVMVYCLMTSLGELAVHLP
VSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAAQLVMKYWFPGVSGMVWSAAFLLLMFVLNAFSVRGFGEAEY
WFSMIKVVTIVVFLLIGLAMIFGIMKGGPQSGWHNFTVGDAPFVGGLPAMIGVAMIAGFSFQGVETIGVAAGEAENPART
IPRGIRQTFWRILLFYVLAILIIAVLLPYTDPNLLRNEATDIGVSPFALVFQHAGLAFAAGMMNAVVLTALLSSGTSSLY
VSTRILYDLALEGQAPRWFARVSGNGVPHRALLATSAVGALCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFR
KGFLHQGHTVDQLEYRSPFFPFGPILVAALCVIIILGQNTKALFAPIDNFGAFVATYCGVFLFVAIWLGYRWRYKTRFVR
YEQMQFSPRHIRAAQAGDGGAALPGVAAD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=396, Percent_Identity=24.2424242424242, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4507047, Length=458, Percent_Identity=24.8908296943231, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=477, Percent_Identity=63.5220125786163, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=484, Percent_Identity=36.5702479338843, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1786789, Length=460, Percent_Identity=34.3478260869565, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1786302, Length=434, Percent_Identity=34.5622119815668, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI48994972, Length=432, Percent_Identity=36.3425925925926, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI87081915, Length=410, Percent_Identity=35.8536585365854, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1786602, Length=410, Percent_Identity=33.4146341463415, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1790653, Length=413, Percent_Identity=33.8983050847458, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1789017, Length=415, Percent_Identity=29.1566265060241, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI87081869, Length=409, Percent_Identity=23.4718826405868, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=479, Percent_Identity=35.4906054279749, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6324061, Length=510, Percent_Identity=34.3137254901961, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6324059, Length=490, Percent_Identity=33.8775510204082, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6322892, Length=490, Percent_Identity=33.6734693877551, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324990, Length=510, Percent_Identity=30.3921568627451, Blast_Score=267, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6324553, Length=431, Percent_Identity=33.1786542923434, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6321629, Length=415, Percent_Identity=32.289156626506, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6324924, Length=493, Percent_Identity=31.0344827586207, Blast_Score=239, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6322967, Length=476, Percent_Identity=32.563025210084, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6321053, Length=500, Percent_Identity=29.4, Blast_Score=232, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6320717, Length=478, Percent_Identity=29.0794979079498, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6319824, Length=499, Percent_Identity=28.8577154308617, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324981, Length=432, Percent_Identity=34.9537037037037, Blast_Score=222, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6319543, Length=487, Percent_Identity=28.5420944558522, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6319542, Length=475, Percent_Identity=27.7894736842105, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=499, Percent_Identity=28.0561122244489, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320251, Length=484, Percent_Identity=27.0661157024793, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6320364, Length=548, Percent_Identity=26.2773722627737, Blast_Score=163, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55141; Mature: 55141

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTPITPTGLEGQSELRRRLRARHLTMIALGGAIGTGLFVASGASIAQAGPGGALFTYTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCHHCCCCCCHHHHHHH
IGVMVYCLMTSLGELAVHLPVSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAA
HHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
QLVMKYWFPGVSGMVWSAAFLLLMFVLNAFSVRGFGEAEYWFSMIKVVTIVVFLLIGLAM
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IFGIMKGGPQSGWHNFTVGDAPFVGGLPAMIGVAMIAGFSFQGVETIGVAAGEAENPART
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHH
IPRGIRQTFWRILLFYVLAILIIAVLLPYTDPNLLRNEATDIGVSPFALVFQHAGLAFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GMMNAVVLTALLSSGTSSLYVSTRILYDLALEGQAPRWFARVSGNGVPHRALLATSAVGA
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
LCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFRKGFLHQGHTVDQLEYRSPFF
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCC
PFGPILVAALCVIIILGQNTKALFAPIDNFGAFVATYCGVFLFVAIWLGYRWRYKTRFVR
CHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
YEQMQFSPRHIRAAQAGDGGAALPGVAAD
HHHHCCCHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHTPITPTGLEGQSELRRRLRARHLTMIALGGAIGTGLFVASGASIAQAGPGGALFTYTL
CCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCHHCCCCCCHHHHHHH
IGVMVYCLMTSLGELAVHLPVSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAA
HHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
QLVMKYWFPGVSGMVWSAAFLLLMFVLNAFSVRGFGEAEYWFSMIKVVTIVVFLLIGLAM
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IFGIMKGGPQSGWHNFTVGDAPFVGGLPAMIGVAMIAGFSFQGVETIGVAAGEAENPART
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCHHH
IPRGIRQTFWRILLFYVLAILIIAVLLPYTDPNLLRNEATDIGVSPFALVFQHAGLAFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GMMNAVVLTALLSSGTSSLYVSTRILYDLALEGQAPRWFARVSGNGVPHRALLATSAVGA
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
LCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFRKGFLHQGHTVDQLEYRSPFF
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCC
PFGPILVAALCVIIILGQNTKALFAPIDNFGAFVATYCGVFLFVAIWLGYRWRYKTRFVR
CHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
YEQMQFSPRHIRAAQAGDGGAALPGVAAD
HHHHCCCHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]