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The map label for this gene is ppx [H]

Identifier: 17546256

GI number: 17546256

Start: 1642415

End: 1643998

Strand: Direct

Name: ppx [H]

Synonym: RSc1537

Alternate gene names: 17546256

Gene position: 1642415-1643998 (Clockwise)

Preceding gene: 17546254

Following gene: 17546263

Centisome position: 44.19

GC content: 66.98

Gene sequence:

>1584_bases
GTGTCGTGCATCACAATCCCCCTGCGTATTTACCCGTATCCATCCATGAGTCCCACCCCCCGTCTGCTGGCAGCTGTCGA
CATGGGTTCCAACAGCTTCCGGCTGATGATCGGCCGCGTCGACGAGACGATCACCGCGAGCGGCAACAGCAGCAGCCAGA
TCTTCCAGGTCGATGCGCTGCGCGAACCGGTCCGGCTGGCGGCCGGGCTTACGCAAGATAAGTACCTGGACCAGCCCGCG
CGCCGTCGCGGCGTCGACGCACTGCGCCGCTTCGGCGACCGCCTGCGCGATTTCGCGCCCGAGCAGGTGCGCGCGGTGGC
GACCAACACGCTGCGCGTGGCCAAGAACGCGCAGGATTTCCTGATCGAGGCGGAGGCCGCGCTCGGCTTCCCCATCGAGG
TGATCGCGGGCCGCGAAGAGGCCCGCCTGATCTATCTCGGTGCGTCGCACGATGCGCCGGCGTGCCAGGGCAACCGGCTG
GTGGTCGATATCGGCGGCGGGTCCACGGAGTTCATCATCGGCAACGGCTACAAGCCCAAGCTGATGGAGAGCCTCTATAT
CGGTTGCGTTTCGCACAGCCGTCACTTCTTCCCGAATGGCAATGTCGACGATTATGCGATGAAGCAGGCCGAGCTGGCCG
CGCGTCGCGAGATCCAGGTGCTGGTGCAGCCGTACCGCACGGCGGGCTGGAAGCAGTCGGTGGGCTCGTCCGGCACGGCC
CGCGCGCTGGCCGAACTGATCGAGCTCAACGGCTTCAACGACAAGAGCAGCGAGCACGGCATCACGCGCGAAGGGCTGGA
GCGCCTGAAGCGCGCGCTGGTCAAGGCCGAGAATGCCAACCGCCTCAAGCTGAGCGGCCTCAAGCCGGACCGCATCCCCG
TGCTGCCCGGTGGCCTGTCGATCATGCTGGGCGTCTTCGATGAGCTCGACATCGATCGCATGGACGTCACCGATGGCGCG
CTGCGCCTGGGCGTGCTGTACGACCTGCTGGGCCGCAGCCATCACGAAGACATGCGCACCGTGACGATCGAGCAGTTCAT
GCGCCGCTACAGCGTGGACCGCGCGCAGGCGCACCGGGTGCGGGACGCGGCGACGGCGCTGCTGTCGCAGTTTCCCGATC
CGCCCGATGAGCGGCGCGAGGACAATCTCGCGCTGCTCGGCTGGGCCGCGAACCTGCACGAGATCGGCATGAGCATCTCG
CACAGCAGCTACCACAAGCACTCGGCCTATATCGCCAGCCATGCCGACATGCCGGGGTTTTCCAAGACCGACCAGGCCCG
CCTGGCGACGCTGCTGCTGGGGCACGCGGGCAAGCTCGGCAAGCTGGCCGGTGGCGGCAAGTTCCTCGACTGGCGCATGC
TGTTCAGCCTGCGGCTGGCCTTCGTGCTGTGCCGGCGGCGCGGGGTAATCCAGTTGCCGGGCCTGCGCGTGCGGCATACC
GAGGGTGAACTCAACGAGGGCGGCTTCGAGGTGGAGCTGCCGAAGAGCTGGGTTGAGCAGAATCCGCTGGTCGAGTACAG
CCTGGCGCAGGAGGCCGACGAGTGGGAGCGCATCGGCCGGCGCTACAAGGTCGTCTACGTTTGA

Upstream 100 bases:

>100_bases
CGAATGACTATCCGGCCACTTTTTCATAGTCGCGTGTCAAGTTTGTGACGCATTAGAATTGTCACGCATAGGACACAACA
AAGACATATTTTGTTGCCCT

Downstream 100 bases:

>100_bases
GCGTCGCCGGTTCGTGATGCAAGCAGAACGGCCCGGTCTTTCGATCCGGGCCGTTCTGTTTTGCCGTCAGGCGGGTCGGC
GTCAGCCGCGCAGGAAGTGG

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSCITIPLRIYPYPSMSPTPRLLAAVDMGSNSFRLMIGRVDETITASGNSSSQIFQVDALREPVRLAAGLTQDKYLDQPA
RRRGVDALRRFGDRLRDFAPEQVRAVATNTLRVAKNAQDFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRL
VVDIGGGSTEFIIGNGYKPKLMESLYIGCVSHSRHFFPNGNVDDYAMKQAELAARREIQVLVQPYRTAGWKQSVGSSGTA
RALAELIELNGFNDKSSEHGITREGLERLKRALVKAENANRLKLSGLKPDRIPVLPGGLSIMLGVFDELDIDRMDVTDGA
LRLGVLYDLLGRSHHEDMRTVTIEQFMRRYSVDRAQAHRVRDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSIS
HSSYHKHSAYIASHADMPGFSKTDQARLATLLLGHAGKLGKLAGGGKFLDWRMLFSLRLAFVLCRRRGVIQLPGLRVRHT
EGELNEGGFEVELPKSWVEQNPLVEYSLAQEADEWERIGRRYKVVYV

Sequences:

>Translated_527_residues
MSCITIPLRIYPYPSMSPTPRLLAAVDMGSNSFRLMIGRVDETITASGNSSSQIFQVDALREPVRLAAGLTQDKYLDQPA
RRRGVDALRRFGDRLRDFAPEQVRAVATNTLRVAKNAQDFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRL
VVDIGGGSTEFIIGNGYKPKLMESLYIGCVSHSRHFFPNGNVDDYAMKQAELAARREIQVLVQPYRTAGWKQSVGSSGTA
RALAELIELNGFNDKSSEHGITREGLERLKRALVKAENANRLKLSGLKPDRIPVLPGGLSIMLGVFDELDIDRMDVTDGA
LRLGVLYDLLGRSHHEDMRTVTIEQFMRRYSVDRAQAHRVRDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSIS
HSSYHKHSAYIASHADMPGFSKTDQARLATLLLGHAGKLGKLAGGGKFLDWRMLFSLRLAFVLCRRRGVIQLPGLRVRHT
EGELNEGGFEVELPKSWVEQNPLVEYSLAQEADEWERIGRRYKVVYV
>Mature_526_residues
SCITIPLRIYPYPSMSPTPRLLAAVDMGSNSFRLMIGRVDETITASGNSSSQIFQVDALREPVRLAAGLTQDKYLDQPAR
RRGVDALRRFGDRLRDFAPEQVRAVATNTLRVAKNAQDFLIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRLV
VDIGGGSTEFIIGNGYKPKLMESLYIGCVSHSRHFFPNGNVDDYAMKQAELAARREIQVLVQPYRTAGWKQSVGSSGTAR
ALAELIELNGFNDKSSEHGITREGLERLKRALVKAENANRLKLSGLKPDRIPVLPGGLSIMLGVFDELDIDRMDVTDGAL
RLGVLYDLLGRSHHEDMRTVTIEQFMRRYSVDRAQAHRVRDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSISH
SSYHKHSAYIASHADMPGFSKTDQARLATLLLGHAGKLGKLAGGGKFLDWRMLFSLRLAFVLCRRRGVIQLPGLRVRHTE
GELNEGGFEVELPKSWVEQNPLVEYSLAQEADEWERIGRRYKVVYV

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=520, Percent_Identity=38.4615384615385, Blast_Score=329, Evalue=3e-91,
Organism=Escherichia coli, GI48994966, Length=508, Percent_Identity=35.2362204724409, Blast_Score=287, Evalue=9e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 58614; Mature: 58483

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCITIPLRIYPYPSMSPTPRLLAAVDMGSNSFRLMIGRVDETITASGNSSSQIFQVDAL
CCEEEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECCCCCCEEEEEHHH
REPVRLAAGLTQDKYLDQPARRRGVDALRRFGDRLRDFAPEQVRAVATNTLRVAKNAQDF
HHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
LIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRLVVDIGGGSTEFIIGNGYKPK
EEEEHHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCHH
LMESLYIGCVSHSRHFFPNGNVDDYAMKQAELAARREIQVLVQPYRTAGWKQSVGSSGTA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHH
RALAELIELNGFNDKSSEHGITREGLERLKRALVKAENANRLKLSGLKPDRIPVLPGGLS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEECCCCHH
IMLGVFDELDIDRMDVTDGALRLGVLYDLLGRSHHEDMRTVTIEQFMRRYSVDRAQAHRV
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSISHSSYHKHSAYIASHADMPGF
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHCCCCCCCCCHHHHHEEEECCCCCCC
SKTDQARLATLLLGHAGKLGKLAGGGKFLDWRMLFSLRLAFVLCRRRGVIQLPGLRVRHT
CCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCEEEECC
EGELNEGGFEVELPKSWVEQNPLVEYSLAQEADEWERIGRRYKVVYV
CCCCCCCCEEEECCHHHHCCCCCEEEHHHHCHHHHHHCCCEEEEEEC
>Mature Secondary Structure 
SCITIPLRIYPYPSMSPTPRLLAAVDMGSNSFRLMIGRVDETITASGNSSSQIFQVDAL
CEEEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECCCCCCEEEEEHHH
REPVRLAAGLTQDKYLDQPARRRGVDALRRFGDRLRDFAPEQVRAVATNTLRVAKNAQDF
HHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHH
LIEAEAALGFPIEVIAGREEARLIYLGASHDAPACQGNRLVVDIGGGSTEFIIGNGYKPK
EEEEHHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCCHH
LMESLYIGCVSHSRHFFPNGNVDDYAMKQAELAARREIQVLVQPYRTAGWKQSVGSSGTA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHH
RALAELIELNGFNDKSSEHGITREGLERLKRALVKAENANRLKLSGLKPDRIPVLPGGLS
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEECCCCHH
IMLGVFDELDIDRMDVTDGALRLGVLYDLLGRSHHEDMRTVTIEQFMRRYSVDRAQAHRV
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RDAATALLSQFPDPPDERREDNLALLGWAANLHEIGMSISHSSYHKHSAYIASHADMPGF
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHCCCCCCCCCHHHHHEEEECCCCCCC
SKTDQARLATLLLGHAGKLGKLAGGGKFLDWRMLFSLRLAFVLCRRRGVIQLPGLRVRHT
CCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCEEEECC
EGELNEGGFEVELPKSWVEQNPLVEYSLAQEADEWERIGRRYKVVYV
CCCCCCCCEEEECCHHHHCCCCCEEEHHHHCHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]