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The map label for this gene is phoR [H]

Identifier: 17546254

GI number: 17546254

Start: 1638718

End: 1640049

Strand: Direct

Name: phoR [H]

Synonym: RSc1535

Alternate gene names: 17546254

Gene position: 1638718-1640049 (Clockwise)

Preceding gene: 17546253

Following gene: 17546256

Centisome position: 44.09

GC content: 66.97

Gene sequence:

>1332_bases
ATGAACATCATCTGGACCCGCTTCGTCGTCGCCGTTGCCCTGATGGGGCTGGTGACGCTGGGGTTGTACTTCTTTGTCGG
CCACGCGGTCGCCTTTGCGGCGTTCAGCGCGATGCTGCTGACGATGCTGCTGTACTACGTCTATCAGCTCCAGCGGCTGT
GGCGCGTGCTGGAGTCGCCTGCCTATGGCGAGATTCCCAGCGCGCTCGGCCTGTGGGGCGAGGTGTATTACCGCCTACAC
CGGCTGATGAAGGGCTGGCGCACGCAGGTGCTGCAGGTCGAGCAGCAGCACAGCCGCTTCATCCAGGCGATTCAGGCCTC
GCCCAACGGGGTGCTGATGCTCGACGGCGAAGACCAGATCGAGTGGTGTAACGCCGTCGCCGAGGAGCACTTCGGCCTGT
CTGCCAAGCGCGACCTGCGCCAGCGCATCACCCACCTGATCCGCCGACCGGAATTCGTCCGCTATCTTGCGCGCGGCGAG
TTCGAGGAGCCCCTCACCATGCGTGACATGGGCCCGCACAAGCAGAGTATCGTGTCCGCCCAGGTGCTGCCCTACGGCGA
GGACCGCAAGCTGCTGGTGTCGCAGGACATCACCAAGCTCGAGAACACCGAGGCGATGCGGCGCGATTTCGTCGCCAACG
TTTCACACGAACTGAAGACGCCGCTGACGGTGCTGTCCGGTTTTCTCGAGACCGTGCGCGACCTGCCGCTGTCAGAGGAC
GACAAGCGGCGCTACCTGGACATGATGCACGTGCAGGCCACGCGCATGCAGCACTTGGTGGAGGACCTGCTGGCGCTGGC
CACGCTGGAGGGCAATTCCGAGCCGCCCTCGATCACGCCGGTGCCGATGCAGCGCGTGATGCTCCAGCTGCAGCACGATG
CCGAGGCGCTGTCCGCCGGCCGGCACGCGATCAGCATGACCTGCGATGCGTCGGTGAGCGTGTGCGGGGCCGAGCTGGAG
CTGCTGTCGGCCTTCAGCAACCTGGTCTCCAATGCCATCCGCTACACGCCCGAGGGCGGCCGGATCAGCCTGGACTGGTC
GGCCAGGGAGGGGCACGCGGTGTTTTCCGTGACCGATACCGGCATCGGCATCGCGCCCGAACATATCCCGCGCCTGACCG
AGCGCTTCTACCGGGTGGATCGCAGCCGCTCGCGCGATACCGGCGGCACCGGCCTCGGCCTGGCGATCGTCAAGCACGTG
CTGTCGCGGCACGGAGCCGACCTGCAGGTCGTCAGCGAGCGCGGCAAGGGTAGTACGTTCCGCGCGAGCTTTCCGCCGGA
GCGCACGGTGGTGCGCGGCACGGGGGACTCAGGCGCCGAGCGCGCGGCCTGA

Upstream 100 bases:

>100_bases
ATCCCGGACAGTAACCCGGCATCGACACTTGTGGGGACCCCGTACCCATCGTCGGCGGGGTCTGTTCCGCACCCGCAGGT
CCAGCGCTTAGAATGGCCTC

Downstream 100 bases:

>100_bases
CGGCTTCGGGCTTTTCCGCCCTTCAAGCAAAAACGCACGCCGTTCGGGCGTGCGTTTTTTGTTGGCGGGTCGGGGCGTTC
AGCCCGCGGAGATTTCCGCG

Product: phosphate regulon two-component sensor kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNIIWTRFVVAVALMGLVTLGLYFFVGHAVAFAAFSAMLLTMLLYYVYQLQRLWRVLESPAYGEIPSALGLWGEVYYRLH
RLMKGWRTQVLQVEQQHSRFIQAIQASPNGVLMLDGEDQIEWCNAVAEEHFGLSAKRDLRQRITHLIRRPEFVRYLARGE
FEEPLTMRDMGPHKQSIVSAQVLPYGEDRKLLVSQDITKLENTEAMRRDFVANVSHELKTPLTVLSGFLETVRDLPLSED
DKRRYLDMMHVQATRMQHLVEDLLALATLEGNSEPPSITPVPMQRVMLQLQHDAEALSAGRHAISMTCDASVSVCGAELE
LLSAFSNLVSNAIRYTPEGGRISLDWSAREGHAVFSVTDTGIGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LSRHGADLQVVSERGKGSTFRASFPPERTVVRGTGDSGAERAA

Sequences:

>Translated_443_residues
MNIIWTRFVVAVALMGLVTLGLYFFVGHAVAFAAFSAMLLTMLLYYVYQLQRLWRVLESPAYGEIPSALGLWGEVYYRLH
RLMKGWRTQVLQVEQQHSRFIQAIQASPNGVLMLDGEDQIEWCNAVAEEHFGLSAKRDLRQRITHLIRRPEFVRYLARGE
FEEPLTMRDMGPHKQSIVSAQVLPYGEDRKLLVSQDITKLENTEAMRRDFVANVSHELKTPLTVLSGFLETVRDLPLSED
DKRRYLDMMHVQATRMQHLVEDLLALATLEGNSEPPSITPVPMQRVMLQLQHDAEALSAGRHAISMTCDASVSVCGAELE
LLSAFSNLVSNAIRYTPEGGRISLDWSAREGHAVFSVTDTGIGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LSRHGADLQVVSERGKGSTFRASFPPERTVVRGTGDSGAERAA
>Mature_443_residues
MNIIWTRFVVAVALMGLVTLGLYFFVGHAVAFAAFSAMLLTMLLYYVYQLQRLWRVLESPAYGEIPSALGLWGEVYYRLH
RLMKGWRTQVLQVEQQHSRFIQAIQASPNGVLMLDGEDQIEWCNAVAEEHFGLSAKRDLRQRITHLIRRPEFVRYLARGE
FEEPLTMRDMGPHKQSIVSAQVLPYGEDRKLLVSQDITKLENTEAMRRDFVANVSHELKTPLTVLSGFLETVRDLPLSED
DKRRYLDMMHVQATRMQHLVEDLLALATLEGNSEPPSITPVPMQRVMLQLQHDAEALSAGRHAISMTCDASVSVCGAELE
LLSAFSNLVSNAIRYTPEGGRISLDWSAREGHAVFSVTDTGIGIAPEHIPRLTERFYRVDRSRSRDTGGTGLGLAIVKHV
LSRHGADLQVVSERGKGSTFRASFPPERTVVRGTGDSGAERAA

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=411, Percent_Identity=37.4695863746959, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=29.1970802919708, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=34.1666666666667, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI145693157, Length=360, Percent_Identity=27.7777777777778, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI48994928, Length=380, Percent_Identity=25.7894736842105, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=30.7053941908714, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790861, Length=203, Percent_Identity=34.4827586206897, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=28.3261802575107, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788713, Length=267, Percent_Identity=26.9662921348315, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790346, Length=215, Percent_Identity=28.3720930232558, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789403, Length=271, Percent_Identity=29.520295202952, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=27.4774774774775, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081816, Length=233, Percent_Identity=27.4678111587983, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=235, Percent_Identity=31.9148936170213, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=354, Percent_Identity=22.316384180791, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788279, Length=216, Percent_Identity=25.462962962963, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=24.8888888888889, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1790551, Length=213, Percent_Identity=30.0469483568075, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49670; Mature: 49670

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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ECCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure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ECCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]